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Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 5, p. 1153
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2018, Volume 18, Issue 8, pp. 674 - 699
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 13, pp. 3416 - 3427
Purpose: To generate and characterize a murine GITR ligand fusion protein (mGITRL-FP) designed to maximize valency and the potential to agonize the GITR... 
EFFECTOR | RESPONSES | ACTIVATION | FC-GAMMA RECEPTORS | ONCOLOGY | IN-VIVO | REGULATORY T-CELLS | CANCER-IMMUNOTHERAPY | SUPPRESSION | TNF | TUMOR-IMMUNITY | Tumor Necrosis Factors - agonists | Tumor Necrosis Factors - genetics | Humans | Melanoma, Experimental - therapy | Membrane Glycoproteins - agonists | Glucocorticoid-Induced TNFR-Related Protein - administration & dosage | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Oncogene Proteins, Fusion - administration & dosage | CTLA-4 Antigen - immunology | Tumor Necrosis Factors - immunology | B7-H1 Antigen - immunology | Oncogene Proteins, Fusion - immunology | Animals | B7-H1 Antigen - antagonists & inhibitors | Melanoma, Experimental - genetics | Melanoma, Experimental - immunology | CD8-Positive T-Lymphocytes - drug effects | Glucocorticoid-Induced TNFR-Related Protein - immunology | Mice | Membrane Glycoproteins - immunology | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Disease Models, Animal | Cell proliferation | Animal models | PD-1 protein | CD8 antigen | Antibodies | Antagonists | Lymphocytes T | Immunity | Anticancer properties | Proteins | CTLA-4 protein | Lymphocytes | Immunotherapy | Fusion protein | Valency | CD4 antigen | Ox40L protein | Immune checkpoint | Experimental design | Tumor necrosis factor | PD-L1 protein | Antitumor activity | Ligands | Cancer | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0124089
Schistosomiasis is a common debilitating human parasitic disease in (sub) tropical areas, however, schistosome infections can also protect against a variety of... 
TH2 RESPONSES | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | C-TYPE LECTINS | INFLAMMATORY PHENOTYPE | RECOGNITION | HELMINTH | DC-SIGN | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | LEWIS-X | INFECTION | Mannose-Binding Lectins - metabolism | Dendritic Cells - parasitology | Gene Expression | OX40 Ligand - genetics | OX40 Ligand - metabolism | Humans | Transcriptional Activation | Cells, Cultured | Receptors, Cell Surface - metabolism | Suppressor of Cytokine Signaling 1 Protein | Suppressor of Cytokine Signaling Proteins - genetics | Schistosoma mansoni - immunology | B7-H1 Antigen - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Lectins, C-Type - metabolism | Antigens, Helminth - immunology | B7-H1 Antigen - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Lipopolysaccharides - pharmacology | Ovum - immunology | Host-Parasite Interactions | Suppressor of Cytokine Signaling Proteins - metabolism | Dendritic Cells - metabolism | Proteins | Antigens | Polysaccharides | Cytokines | Dendritic cells | Denaturation | Bone morphogenetic proteins | Transforming growth factors | T cells | Health aspects | Sugars | Monosaccharides | Regulators | Multiple sclerosis | SHP-1 protein | Disease | Transforming growth factor | Antibodies | Mannose | Lymphocytes T | Biology | Infections | Inflammatory diseases | Lipopolysaccharides | Schistosomiasis | Genotype & phenotype | Immunology | Parasitic diseases | Lymphocytes | Toll-like receptors | Oxidation | Immune system | Tyrosine | Secretion | SOCS-1 protein | TLR4 protein | Costimulator | Inflammatory bowel disease | Signaling | Ox40L protein | Tumor necrosis factor | Internalization | PD-L1 protein | Lectins | Ligands | Regulation | Protein-tyrosine-phosphatase | Apoptosis
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 05/2017, Volume 214, Issue 5, pp. 1529 - 1546
Journal Article
by Lee, DW and Ryu, HS and Jin, MS and Lee, KH and Suh, KJ and Youk, J and Kim, JY and Min, A and Lee, HB and Moon, HG and Kim, TY and Han, SW and Oh, DY and Han, W and Park, IA and Noh, DY and Im, SA
BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 07/2019, Volume 121, Issue 3, pp. 230 - 236
BACKGROUND: Immune cells in the tumour microenvironment play an essential role in tumorigenesis. This study aimed to evaluate the immunoregulatory protein... 
TUMOR-INFILTRATING LYMPHOCYTES | TARGET | PEMBROLIZUMAB | THERAPY | ONCOLOGY | IMMUNOTHERAPY | PROGNOSIS | MARKER | B7-H3 LIGAND EXPRESSION | CELL | CHEMOTHERAPY | Risk groups | PD-1 protein | Immunoregulation | Markers | Breast cancer | Multivariate analysis | Risk analysis | ErbB-2 protein | B7 antigen | Proteins | Ox40L protein | Tumor necrosis factor | Lymphocytes | PD-L1 protein | Breast | Protein expression | Tumorigenesis | Tumors | Immune system
Journal Article
Vaccine, ISSN 0264-410X, 2011, Volume 30, Issue 4, pp. 691 - 702
Highlights ► Multimeric soluble BAFF, 4-1BBL, LIGHT, and CD70 can adjuvant HIV-1 DNA vaccines. ► CD40L, LIGHT, OX40L, and 4-1BBL enhance memory T cell avidity... 
Allergy and Immunology | DNA vaccine | TNF superfamily ligand | HIV vaccine | FACTOR-RECEPTOR | MEDICINE, RESEARCH & EXPERIMENTAL | T-CELL MEMORY | DENDRITIC CELLS | CD40 LIGAND | IMMUNOLOGY | VIRUS CHALLENGE | BOOST VACCINE | IN-VITRO | CANARYPOX VACCINE | PLASMID DNA | GITR LIGAND | Recombinant Fusion Proteins - immunology | Tumor Necrosis Factor-alpha - metabolism | Vaccines, DNA - genetics | Cell Proliferation | Humans | AIDS Vaccines - immunology | Vaccines, DNA - immunology | Vaccines, DNA - administration & dosage | Adjuvants, Immunologic - metabolism | Tumor Necrosis Factor-alpha - immunology | Adjuvants, Immunologic - genetics | Female | gag Gene Products, Human Immunodeficiency Virus - genetics | Injections, Intramuscular | HIV-1 - genetics | HIV-1 - immunology | Animals | Recombinant Fusion Proteins - genetics | AIDS Vaccines - genetics | Ligands | Mice | Mice, Inbred BALB C | AIDS Vaccines - administration & dosage | CD8-Positive T-Lymphocytes - immunology | gag Gene Products, Human Immunodeficiency Virus - immunology | AIDS vaccines | Immune response | HIV (Viruses) | T cells | Tumor necrosis factor | DNA | Antigens | Vaccines | Acquired immune deficiency syndrome--AIDS | Plasmids | Human immunodeficiency virus--HIV | Immune system | Cell proliferation | CD40 antigen | CD8 antigen | Immunoglobulin G | Helper cells | Antibodies | Clinical trials | DNA vaccines | Lymphocytes T | LIGHT protein | CD70 antigen | CD40L protein | Gag protein | Interleukin 2 | Fusion protein | TRANCE protein | Immunological memory | Memory cells | Cytokines | Adjuvants | Data processing | OX40L protein | surfactant protein D | CD4 antigen | Lymphocytes B | BLyS protein | Avidity | TNF Superfamily Ligand
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 05/2018, Volume 17, Issue 5, pp. 1024 - 1038
Ligation of OX40 (CD134, TNFRSF4) on activated T cells by its natural ligand (OX40L, CD252, TNFSF4) enhances cellular survival, proliferation, and effector... 
EFFECTOR | ONCOLOGY | BLOCKS | EXPANSION | REGULATORY T-CELLS | COSTIMULATION | SUPPRESSION | CD134 | CUTTING EDGE | Recombinant Fusion Proteins - immunology | T-Lymphocytes, Regulatory - metabolism | Receptors, OX40 - agonists | OX40 Ligand - genetics | Recombinant Fusion Proteins - pharmacology | Immunoglobulin Fc Fragments - metabolism | OX40 Ligand - metabolism | Humans | Protein Multimerization - immunology | Macaca mulatta | Receptors, OX40 - immunology | T-Lymphocytes, Regulatory - immunology | Lymphocyte Activation - immunology | Receptors, OX40 - metabolism | Immunoglobulin Fc Fragments - immunology | T-Lymphocytes - metabolism | Immunoglobulin G - immunology | HEK293 Cells | Female | Cytotoxicity, Immunologic - drug effects | Cytokines - immunology | Cytokines - metabolism | Recombinant Fusion Proteins - chemistry | Animals | Immunoglobulin G - genetics | OX40 Ligand - immunology | Lymphocyte Activation - drug effects | Cell Line, Tumor | T-Lymphocytes - immunology | Cytotoxicity, Immunologic - immunology | Immunoglobulin Fc Fragments - genetics | Immunoglobulin G - metabolism | Cytolytic activity | Cell proliferation | Toxicity | CD8 antigen | Cytotoxicity | Lymphocytes T | Immunity | Proteins | Receptors | Cell growth | Lymphocytes | Peripheral blood | Primates | CD25 antigen | Fusion protein | Recombinant | Immunological memory | Memory cells | Cell survival | Cytokines | Immunomodulation | T cell receptors | CD134 antigen | CD4 antigen | Fc receptors | Ox40L protein | Lymphocytes B | Tumor necrosis factor | Ligands | Cancer | Tumors | OX40 | fusion protein | OX40 ligand | MEDI6383 | immunotherapy
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2018, Volume 115, Issue 4, p. E686
The B-lymphotropic Epstein-Barr virus (EBV), pandemic in humans, is rapidly controlled on initial infection by T cell surveillance; thereafter, the virus... 
Transformation | Toxicity | CD8 antigen | LMP1 protein | Cytotoxicity | Viruses | Lymphocytes T | Infections | CD70 antigen | Immunity | Adoptive transfer | Molecules | Lymphocytes | Rodents | Immunotherapy | Antigen presentation | Transgenic mice | Latent infection | Immunosurveillance | T cell receptors | CD4 antigen | Signaling | Ox40L protein | Surveillance | Lymphocytes B | Tumor necrosis factor | Ligands | Lymphomas
Journal Article
Scandinavian Journal of Immunology, ISSN 0300-9475, 05/2018, Volume 87, Issue 5, pp. e12662 - n/a
B cells play a key role in the pathogenesis of primary Sjögren's syndrome (pSS). The aim of this study was to analyse the transcriptome of CD19+ B cells from... 
AUTOANTIBODIES | BAFF | AUTOIMMUNE | CYTOKINES | GENE | CALPROTECTIN | LYMPHOID ORGANIZATION | LOCI | IMMUNOLOGY | ASSOCIATION | MINOR SALIVARY-GLANDS | RNA, Small Cytoplasmic - immunology | Gene Expression Regulation - immunology | OX40 Ligand - metabolism | Humans | Middle Aged | Sjogren's Syndrome - immunology | Gene Expression Profiling | Transcriptome - genetics | Transcriptional Activation - immunology | Interferon Type I - immunology | Signal Transduction - immunology | Autoantibodies - immunology | B-Lymphocytes - immunology | CX3C Chemokine Receptor 1 - metabolism | Autoantigens - immunology | Interferon-gamma - immunology | Receptors, CCR1 - metabolism | Ribonucleoproteins - immunology | Adult | Female | Aged | Antigens, CD19 - metabolism | Chemokine CCL5 - metabolism | Viral antibodies | RNA | Genes | Antibodies | Interferon | Genetic transcription | B cells | Biological response modifiers | Blood donors | Lymphocyte receptors | CC chemokine receptors | Sjogren's syndrome | Transcription | RANTES | Pathogenesis | CX3CR1 protein | CD70 antigen | Gene sequencing | CCR1 protein | Receptors | Toll-like receptors | Fractalkine | Stat1 protein | Stat2 protein | CD19 antigen | TLR7 protein | T cell receptors | Gene expression | Ribonucleic acid--RNA | Patients | Chemokine receptors | Suppressors | Signaling | Ox40L protein | Lymphocytes B | Tumor necrosis factor | BLyS protein | Chemokines | Rheumatology and Autoimmunity | Basic Medicine | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reumatologi och inflammation | Medicinska och farmaceutiska grundvetenskaper | Immunologi inom det medicinska området | Klinisk medicin | Immunology in the medical area
Journal Article