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Development, ISSN 0950-1991, 06/2000, Volume 127, Issue 11, pp. 2407 - 2420
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 01/2017, Volume 69, Issue 1, pp. 52 - 65
Journal Article
Science, ISSN 0036-8075, 2/2003, Volume 299, Issue 5608, pp. 896 - 899
Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric... 
Mitochondria | Food intake | Cell lines | HeLa cells | Fluorescence | Brown adipocytes | Reports | Mice | Mitochondrial DNA | Female animals | White adipocytes | SYNTHASE | THERMOGENESIS | ACTIVATION | ADIPOCYTES | RECEPTOR-GAMMA COACTIVATOR-1 | GENE | MULTIDISCIPLINARY SCIENCES | NECROSIS-FACTOR-ALPHA | DIFFERENTIATION | EXPRESSION | CULTURE | High Mobility Group Proteins | Humans | Male | Penicillamine - analogs & derivatives | Mitochondrial Proteins | Motor Activity | Nitric Oxide Synthase - genetics | RNA, Messenger - metabolism | Mitochondria - ultrastructure | Nitric Oxide Synthase Type II | Nuclear Respiratory Factors | DNA-Binding Proteins - metabolism | Quinoxalines - pharmacology | Oxadiazoles - pharmacology | U937 Cells | Adipose Tissue, Brown - ultrastructure | Adipocytes - ultrastructure | Female | Weight Gain | Eating | Cold Temperature | Oligonucleotides, Antisense - pharmacology | DNA, Mitochondrial - metabolism | Signal Transduction | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Penicillamine - pharmacology | RNA, Messenger - genetics | Nitric Oxide Synthase Type III | Oxygen Consumption | Rats | Nitric Oxide - physiology | Nuclear Proteins - metabolism | Mitochondria - metabolism | Mice, Knockout | Transcription Factors - metabolism | Adipose Tissue, Brown - cytology | Animals | Cyclic GMP - metabolism | Energy Metabolism | Adipocytes - metabolism | NF-E2-Related Factor 1 | Trans-Activators - metabolism | Adipose Tissue, Brown - metabolism | Nitric Oxide Synthase - metabolism | HeLa Cells | 3T3 Cells | Genetic aspects | Observations | Mice as laboratory animals | Mammals | Nitric oxide | Cells
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 12, pp. 8505 - 8518
Hormone-sensitive lipase (HSL) catalyzes the hydrolysis of cholesteryl esters in steroidogenic tissues and, thus, facilitates cholesterol availability for... 
B TYPE-I | SCAVENGER RECEPTOR | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHOLESTEROL ESTER | TUMOR-CELLS | DIFFERENTIAL REGULATION | LIVER-X-RECEPTOR | HIGH-DENSITY-LIPOPROTEIN | MOLECULAR-MECHANISMS | MEDIATED REGULATION | RNA, Small Interfering - genetics | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Leydig Cells - enzymology | Cholesterol - blood | Sterol Esterase - metabolism | Male | Orphan Nuclear Receptors - metabolism | Phosphoproteins - metabolism | Cholesterol Esters - blood | Gene Knockdown Techniques | Cholesterol Side-Chain Cleavage Enzyme - genetics | Cyclic AMP - physiology | ATP-Binding Cassette Transporters - genetics | Leydig Cells - metabolism | Oxadiazoles - pharmacology | Liver X Receptors | ATP-Binding Cassette Transporters - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Progesterone - biosynthesis | ATP Binding Cassette Transporter 1 | Cyclic AMP - metabolism | Retinoid X Receptors - metabolism | Second Messenger Systems | Sterol Regulatory Element Binding Protein 1 - metabolism | Carbamates - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Promoter Regions, Genetic | Orphan Nuclear Receptors - agonists | Cells, Cultured | Gene Expression Regulation | Scavenger Receptors, Class B - genetics | Nicotinic Acids - pharmacology | Phosphoproteins - genetics | Orphan Nuclear Receptors - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Sterol Esterase - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Retinoid X Receptors - agonists | Tetrahydronaphthalenes - pharmacology | Sterol Esterase - physiology | Bucladesine - pharmacology | Mice | Scavenger Receptors, Class B - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Perilipin-1 | Testis | Signal Transduction | Molecular Cell Biology | Cell Signaling | StAR Protein | Steroidogenesis | Steroidogenic Tissues | Cyclic AMP (cAMP)
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 02/2008, Volume 35, Issue 2, pp. 192 - 200
SUMMARY • The present study evaluated the effect of diabetes, hypercholesterolaemia and their combination on the contribution of nitric oxide (NO) and... 
endothelium-derived hyperpolarising factor | diabetes | endothelium-dependent relaxation | hypercholesterolaemia | superoxide anion | endothelium‐derived hyperpolarising factor | endothelium‐dependent relaxation | Superoxide anion | Diabetes | Hypercholesterolaemia | Endothelium-dependent relaxation | Endothelium-derived hyperpolarising factor | PHYSIOLOGY | ACETYLCHOLINE | NITRIC-OXIDE SYNTHASE | MESENTERIC-ARTERY | MELLITUS | SODIUM-NITROPRUSSIDE | NAD(P)H OXIDASE | DISEASE | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | DYSFUNCTION | Body Weight | Oxidative Stress | Cholesterol - blood | Diabetes Mellitus, Type 1 - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Male | Guanylate Cyclase - antagonists & inhibitors | Nitroprusside - pharmacology | Apamin - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Potassium Channels, Calcium-Activated - metabolism | Superoxides - metabolism | Aorta, Thoracic - drug effects | Biological Factors - metabolism | Diabetes Mellitus, Experimental - metabolism | Potassium Channel Blockers - pharmacology | Diabetes Mellitus, Experimental - physiopathology | Disease Models, Animal | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Diabetes Mellitus, Type 1 - physiopathology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Rats | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Aorta, Thoracic - physiopathology | Rats, Sprague-Dawley | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nitroarginine - pharmacology | Aorta, Thoracic - enzymology | Animals | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Hypercholesterolemia - physiopathology | Nitric Oxide Synthase - metabolism | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | Blood Glucose - metabolism | Nitric Oxide - metabolism | Hypercholesterolemia - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Charybdotoxin, pharmacology | Diabetes Mellitus, Type 1, physiopathology | Nitric Oxide Synthase, antagonists and inhibitors | Aorta, Thoracic, physiopathology | Potassium Channels, Calcium-Activated, antagonists and inhibitors | Hypercholesterolemia, metabolism | Quinoxalines, pharmacology | Enzyme Inhibitors, pharmacology | Aorta, Thoracic, drug effects | Aorta, Thoracic, metabolism | Receptors, Cytoplasmic and Nuclear, antagonists and inhibitors | Vasodilator Agents, pharmacology | Vasodilation | Nitric Oxide Synthase, metabolism | Cyclooxygenase Inhibitors, pharmacology | Apamin, pharmacology | Nitroarginine, pharmacology | Potassium Channel Blockers, pharmacology | Vasodilation, drug effects | Cholesterol, blood | Receptors, Cytoplasmic and Nuclear, metabolism | Biological Factors, metabolism | Diabetes Mellitus, Experimental, physiopathology | Nitric Oxide, metabolism | Acetylcholine, pharmacology | Diabetes Mellitus, Experimental, metabolism | Nitroprusside, pharmacology | Oxadiazoles, pharmacology | Blood Glucose, metabolism | Potassium Channels, Calcium-Activated, metabolism | Aorta, Thoracic, enzymology | Hypercholesterolemia, physiopathology | Diabetes Mellitus, Type 1, metabolism | Guanylate Cyclase, antagonists and inhibitors | Guanylate Cyclase, metabolism | Superoxides, metabolism | Indomethacin, pharmacology | Superoxide | Hypercholesterolemia | Endothelium-derived relaxing factors | Type 1 diabetes | Endothelium
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 04/2014, Volume 426, Issue 8, pp. 1848 - 1860
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, p. e0116799
Oral mucositis (OM) is a common complication of treatments for head and neck cancer, particularly radiotherapy with or without chemotherapy. OM is... 
PATHOGENESIS | TELMISARTAN | CYTOKINES | THERAPY | RADIOCHEMOTHERAPY | CELL-MIGRATION | MULTIDISCIPLINARY SCIENCES | GROWTH-FACTORS | WOUND MACROPHAGES | PREVENTION | CHEMOTHERAPY | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | Cricetinae | Cytokines - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Stomatitis - metabolism | Fibroblast Growth Factors - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Bacteremia - metabolism | Fibroblast Growth Factor 7 - metabolism | Oxadiazoles - adverse effects | Animals | Stomatitis - pathology | Interleukin-1beta - metabolism | Stomatitis - chemically induced | Interleukin-10 - metabolism | Benzimidazoles - adverse effects | Transforming Growth Factor alpha - metabolism | Leukocytes - metabolism | Disease Models, Animal | Peroxidase - metabolism | Immunohistochemistry | Transcription factors | 5-Fluorouracil | Pathogenesis | Mucosa | Transforming growth factor | Damage prevention | Cancer therapies | Metastases | Fibroblasts | Vascular endothelial growth factor | Public health | Head | Wound healing | Mucositis | Granulation | Cytokines | Keratinocyte growth factor | Chemotherapy | Morphology | Interleukin 10 | Infiltration | Animal welfare | Erythema | Fibroblast growth factor | Cheek | Interleukin | Kinases | Ethics | Pain | Rodents | Interleukin 1 | Tumor necrosis factor-TNF | Peroxidase | Angiotensin II | Enzyme-linked immunosorbent assay | Hypertension | Neutrophils | Inflammation | Pharmacology | Radiation therapy | Biophysics | Variance analysis | Hamsters | Angiotensin | Head and neck cancer | Cheek pouch | Zidovudine | Tumors | Cancer
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 715 - 727
Journal Article
Cellular Signalling, ISSN 0898-6568, 12/2011, Volume 23, Issue 12, pp. 2086 - 2096
Endothelial cell (EC) barrier dysfunction induced by inflammatory agonists is a frequent pathophysiologic event in multiple diseases. The platelet-derived... 
ERM | Cytoskeleton | S1P | Rac1 | Barrier function | Endothelial cells | ERM PROTEINS | TYROSINE PHOSPHORYLATION | PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE | KINASE-C | PLASMA-MEMBRANE | CELL BIOLOGY | FOCAL ADHESION | RHO GTPASES | CYTOSKELETAL REARRANGEMENT | CORTICAL CYTOSKELETON | ACTIN CYTOSKELETON | Protein Kinase C - genetics | Phosphorylation | rho GTP-Binding Proteins - antagonists & inhibitors | Cadherins - metabolism | Cytoskeletal Proteins - genetics | Humans | Actins - metabolism | rho-Associated Kinases - antagonists & inhibitors | Antigens, CD - metabolism | Gene Knockdown Techniques | RNA Interference | rho-Associated Kinases - metabolism | Oxadiazoles - pharmacology | Protein Kinase C - metabolism | Egtazic Acid - analogs & derivatives | Lysophospholipids - pharmacology | Receptors, Lysosphingolipid - genetics | Cytoskeletal Proteins - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Receptors, Lysosphingolipid - metabolism | Microfilament Proteins - genetics | Endothelial Cells - physiology | Amides - pharmacology | Endothelial Cells - metabolism | Membrane Proteins - genetics | Sphingosine - physiology | Cells, Cultured | Thiophenes - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | Chelating Agents - pharmacology | Electric Impedance | Permeability | Pulmonary Artery - cytology | Pulmonary Artery - physiology | Sphingosine - pharmacology | Bacterial Proteins - pharmacology | Sphingosine - analogs & derivatives | Egtazic Acid - pharmacology | Bacterial Toxins - pharmacology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | rho GTP-Binding Proteins - metabolism | Cytoskeleton - metabolism | Pyridines - pharmacology | Lysophospholipids - physiology | Phosphates | Proteins | Sphingosine | Endothelium
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 9988 - 10001
Neuronal nicotinic acetylcholine receptors (nAChRs) are promising drug targets to manage several neurological disorders and nicotine addiction. Growing... 
NONCANONICAL SUBUNIT INTERFACES | NERVOUS-SYSTEM | AGONIST BINDING-SITE | SUBTYPES | PHARMACOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-2 SUBUNIT | SENSITIVITY | THERAPEUTIC TARGETS | MODULATOR | NS9283 | Hydrocarbons, Brominated - metabolism | Nicotinic Agonists - metabolism | Pyridines - chemistry | Humans | Hydrocarbons, Brominated - pharmacology | Nicotinic Agonists - chemistry | Nerve Tissue Proteins - chemistry | Pyrazoles - chemistry | Receptors, Nicotinic - chemistry | Oxadiazoles - pharmacology | Oocytes - drug effects | Hydrocarbons, Brominated - chemistry | Protein Interaction Domains and Motifs | Indole Alkaloids - chemistry | Oxadiazoles - chemistry | Nicotinic Agonists - pharmacology | Pyrazoles - pharmacology | Recombinant Proteins - metabolism | Receptors, Nicotinic - metabolism | Oocytes - metabolism | Isoxazoles - metabolism | Nerve Tissue Proteins - agonists | Xenopus laevis | Models, Molecular | Recombinant Proteins - chemistry | Isoxazoles - chemistry | Pyrazoles - metabolism | Nerve Tissue Proteins - genetics | Isoxazoles - pharmacology | Nerve Tissue Proteins - metabolism | Point Mutation | Patch-Clamp Techniques | Animals | Pyridines - metabolism | Indole Alkaloids - pharmacology | Ligands | Protein Conformation | Molecular Docking Simulation | Pyridines - pharmacology | Structural Homology, Protein | Indole Alkaloids - metabolism | Receptors, Nicotinic - genetics | Amino Acid Substitution | Oxadiazoles - metabolism | Index Medicus | nicotinic acetylcholine receptors (nAChR) | electrophysiology | Positive allosteric modulators | drug design | ion channel | Neurobiology | drug development | pentameric ligand-gated ion channel | CMPI | dFBr
Journal Article
Vascular Pharmacology, ISSN 1537-1891, 2012, Volume 57, Issue 1, pp. 56 - 64
Abstract Objectives Sphingosine 1-phosphate (S1P) – a lysosphingolipid present in HDL – exerts atheroprotective effects in vitro , while FTY720, a... 
Cardiovascular | Sphingosine 1-phosphate (S1P) | Inflammation | High density lipoproteins (HDL) | Atherosclerosis | CHOLESTEROL | ENDOTHELIAL CELL-ADHESION | SPHINGOSINE-1-PHOSPHATE ANALOG | HYPERCHOLESTEROLEMIA | HIGH-DENSITY-LIPOPROTEIN | MACROPHAGE ACCUMULATION | INTERFERON-GAMMA | INSULIN-RESISTANCE | PHARMACOLOGY & PHARMACY | ADIPOSE-TISSUE | Spleen - immunology | Spleen - drug effects | Body Weight - immunology | Antigens, CD - metabolism | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Oxadiazoles - pharmacology | Serine Endopeptidases - immunology | CD8-Positive T-Lymphocytes - metabolism | Lymph Nodes - drug effects | Receptors, Lysosphingolipid - metabolism | Interleukin-6 - metabolism | Lymphocytes - metabolism | Propylene Glycols - pharmacology | Atherosclerosis - immunology | CD4-Positive T-Lymphocytes - metabolism | Lymph Nodes - metabolism | Receptors, LDL - metabolism | Lymph Nodes - immunology | Receptors, LDL - immunology | Atherosclerosis - metabolism | Sphingosine - pharmacology | Macrophages - metabolism | Sphingosine - analogs & derivatives | Interleukin-6 - immunology | Receptors, Lysosphingolipid - agonists | Mice | CD8-Positive T-Lymphocytes - immunology | Antigens, CD - immunology | Genes, MHC Class II - immunology | Interleukin-2 - immunology | Lymphocytes - immunology | Female | Propylene Glycols - immunology | Antigens, Differentiation, Myelomonocytic - immunology | Macrophages - immunology | Interleukin-2 - metabolism | Atherosclerosis - drug therapy | CD11b Antigen - immunology | Mice, Inbred C57BL | Proprotein Convertases - metabolism | Fingolimod Hydrochloride | Sphingosine - immunology | Proprotein Convertases - immunology | Receptors, Lysosphingolipid - immunology | Animals | Spleen - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | CD8-Positive T-Lymphocytes - drug effects | Lymphocytes - drug effects | Macrophages - drug effects | Serine Endopeptidases - metabolism | CD11b Antigen - metabolism | CD4-Positive T-Lymphocytes - drug effects | Indans - pharmacology | Hypercholesterolemia | Blood lipids | Mitogens | Low density lipoproteins | Sphingosine
Journal Article