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Xenobiotica, ISSN 0049-8254, 6/2013, Volume 43, Issue 6, pp. 498 - 508
1. This work investigated the drug interaction potential of GSK1292263, a novel GPR119 agonist, with the HMG-coA reductase inhibitors simvastatin and... 
P-glycoprotein | BCRP | transporters | Cytochrome P450 | OATP | dyslipidemia | diabetes | pharmacogenetics | Pharmacogenetics | Dyslipidemia | Transporters | Diabetes | POLYMORPHISM MARKEDLY AFFECTS | SLCO1B1 POLYMORPHISM | ATORVASTATIN | INHIBITION | PHARMACOKINETICS | FLUVASTATIN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | SIMVASTATIN | Fluorobenzenes - pharmacokinetics | Pyrroles - pharmacokinetics | Simvastatin - adverse effects | Pyrimidines - blood | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Middle Aged | Male | Heptanoic Acids - adverse effects | Simvastatin - pharmacology | Fluorobenzenes - pharmacology | Young Adult | Drug Interactions | Piperidines - pharmacology | Oxadiazoles - pharmacology | Madin Darby Canine Kidney Cells | Pyrroles - adverse effects | Oxadiazoles - pharmacokinetics | Heptanoic Acids - pharmacology | Mesylates - blood | Troleandomycin - adverse effects | Rosuvastatin Calcium | Mesylates - adverse effects | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Simvastatin - analogs & derivatives | Sulfonamides - pharmacokinetics | Oxadiazoles - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cytochrome P-450 CYP3A - metabolism | Adolescent | Atorvastatin | Pyrimidines - pharmacokinetics | Oxadiazoles - blood | Demography | Heptanoic Acids - pharmacokinetics | Mesylates - pharmacokinetics | Simvastatin - blood | Piperidines - blood | Troleandomycin - pharmacokinetics | Dose-Response Relationship, Drug | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Sulfonamides - blood | Reference Standards | Adult | Female | Piperidines - pharmacokinetics | Troleandomycin - pharmacology | Fluorobenzenes - blood | Pyrroles - blood | Simvastatin - pharmacokinetics | Pyrroles - pharmacology | Animals | Cytochrome P-450 CYP3A Inhibitors | Mesylates - pharmacology | Piperidines - adverse effects | Dogs | Pyrimidines - adverse effects | Sulfonamides - adverse effects | Aged | Fluorobenzenes - adverse effects | Heptanoic Acids - blood | Index Medicus
Journal Article
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 03/2017, Volume 83, Issue 3, pp. 540 - 553
Journal Article
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 9/2014, Volume 70, Issue 9, pp. 1059 - 1071
Journal Article
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 08/2016, Volume 56, Issue 8, pp. 988 - 998
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 05/2017, Volume 323, pp. 9 - 15
Journal Article
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 5/2017, Volume 390, Issue 5, pp. 457 - 470
A pharmacokinetic-pharmacodynamic (PK-PD) model was developed to describe the time course of blood pressure following oral administration of azilsartan... 
Neurosciences | Pharmacodynamics | Biomedicine | PK-PD model | Indirect response models | Noncompetitive interaction | Pharmacology/Toxicology | Pharmacokinetics | Synergism | MECHANISM | EFFICACY | BLOOD-PRESSURE | RECEPTOR BLOCKER | THERAPY | TRANSLATIONAL PHARMACOLOGY | PHARMACOLOGY & PHARMACY | FIXED-DOSE COMBINATION | 4 BASIC MODELS | IRBESARTAN | Oxadiazoles - administration & dosage | Chlorthalidone - pharmacokinetics | Antihypertensive Agents - administration & dosage | Hypertension - drug therapy | Drug Monitoring - methods | Angiotensin II Type 1 Receptor Blockers - pharmacokinetics | Tandem Mass Spectrometry | Benzimidazoles - administration & dosage | Computer Simulation | Sodium Chloride Symporter Inhibitors - administration & dosage | Chromatography, Liquid | Blood Pressure - drug effects | Drug Therapy, Combination | Hypertension - diagnosis | Oxadiazoles - pharmacokinetics | Angiotensin II Type 1 Receptor Blockers - administration & dosage | Disease Models, Animal | Rats, Inbred SHR | Sodium Chloride Symporter Inhibitors - pharmacokinetics | Administration, Oral | Benzimidazoles - pharmacokinetics | Antihypertensive Agents - pharmacokinetics | Hypertension - physiopathology | Drug Synergism | Animals | Chlorthalidone - administration & dosage | Models, Biological | Hypertension | Models | Liquid chromatography | Chlorthalidone | Mass spectrometry | Index Medicus
Journal Article
Journal Article