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Genes and Development, ISSN 0890-9369, 02/2009, Volume 23, Issue 4, pp. 496 - 511
Rictor is a component of the target of rapamycin complex 2 (TORC2). While TORC2 has been implicated in insulin and other growth factor signaling pathways, the... 
AKT | Fat metabolism | C. Elegans | Life span | Insulin/IGF | NERVOUS-SYSTEM | C. elegans | AKT/PKB | life span | DEVELOPMENTAL BIOLOGY | AGE-1 PI3 KINASE | CELL BIOLOGY | INSULIN | RAPTOR | MTOR COMPLEX-2 | LONGEVITY | SIGNALING PATHWAY | insulin/IGF | GENETICS & HEREDITY | C-ELEGANS | fat metabolism | TRANSCRIPTION FACTOR | Caenorhabditis elegans Proteins - metabolism | Reproduction - physiology | Fixatives - metabolism | Intestines - metabolism | Adipose Tissue - metabolism | Caenorhabditis elegans - physiology | Immediate-Early Proteins - metabolism | Oxazines - metabolism | Oncogene Protein v-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Somatomedins - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Boron Compounds - metabolism | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - growth & development | Signal Transduction | Caenorhabditis elegans - genetics | Mutation - genetics | Feeding Behavior - physiology | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Insulin - metabolism | Animals | Carrier Proteins - metabolism | Diet | Caenorhabditis elegans Proteins - genetics | Longevity - physiology | Lipid Metabolism - physiology | Life spans (Biology) | Caenorhabditis elegans | Immune response | Physiological aspects | Genetic aspects | Rapamycin | Research | insulin | IGF | Research Paper
Journal Article
Blood, ISSN 0006-4971, 06/2010, Volume 115, Issue 22, pp. 4497 - 4506
The microenvironment provides essential growth and survival signals to chronic lymphocytic leukemia (CLL) cells and contributes to their resistance to... 
B-CELL RECEPTOR | MIGRATION | ALPHA-4-BETA-1 INTEGRIN | IN-VITRO | ACTIVATION | SYK | MCL-1 EXPRESSION | CD38 EXPRESSION | DRUG-RESISTANCE | HEMATOLOGY | GENE MUTATION STATUS | RNA, Small Interfering - genetics | Prognosis | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Coculture Techniques | Humans | Middle Aged | Actins - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Receptors, Antigen, B-Cell - metabolism | Integrins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Tyrosine Kinases - genetics | Stromal Cells - drug effects | Female | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Oxazines - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Stromal Cells - metabolism | Chemotaxis | Fibronectins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Animals | Chemokine CXCL12 - metabolism | Integrin alpha4 - metabolism | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Myeloid Cell Leukemia Sequence 1 Protein | Aged | Chemokines - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Vascular Cell Adhesion Molecule-1 - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 09/2011, Volume 194, Issue 5, pp. 679 - 687
Much like other microorganisms, wild yeasts preferentially form surface-associated communities, such as biofilms and colonies, that are well protected against... 
CELL ADHESION | PROTEIN | GENE | BUDDING YEAST | PDR1 | CANDIDA-ALBICANS BIOFILMS | ABC TRANSPORTERS | FLUCONAZOLE RESISTANCE | SACCHAROMYCES-CEREVISIAE | EXPRESSION | CELL BIOLOGY | Metallothionein - metabolism | Galactose - metabolism | Membrane Glycoproteins - metabolism | Biofilms - growth & development | Galactokinase - genetics | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Oxazines - metabolism | ATP-Binding Cassette Transporters - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Profilins - genetics | Extracellular Matrix - physiology | Gene Deletion | Copper - metabolism | ATP-Binding Cassette Transporters - metabolism | Cell Cycle Proteins - genetics | Multidrug Resistance-Associated Proteins - genetics | Permeability | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Membrane Glycoproteins - genetics | Saccharomyces cerevisiae - cytology | Transcription Factors - metabolism | Metallothionein - genetics | Galactokinase - metabolism | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Recombinant Fusion Proteins - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Multidrug Resistance-Associated Proteins - metabolism | Saccharomyces cerevisiae - growth & development | Yeast fungi | Physiological aspects | Microbial colonies
Journal Article
Journal Article
Toxicology in Vitro, ISSN 0887-2333, 2007, Volume 21, Issue 3, pp. 438 - 448
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 12/2006, Volume 46, Issue 12, pp. 1426 - 1438
Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of drugs such as bupropion, efavirenz, propofol, and selegiline, among others. More than 200... 
HPLC/MS/MS | P450 2B6 | rhCYP2B6 | Drug‐drug interactions | in vitro | Drug-drug interactions | In vitro | Raloxifene Hydrochloride - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Humans | Microsomes, Liver - metabolism | Sertraline - chemistry | Bupropion - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Antifungal Agents - chemistry | Xenobiotics - pharmacology | Reverse Transcriptase Inhibitors - chemistry | Xenobiotics - classification | Clotrimazole - metabolism | Platelet Aggregation Inhibitors - pharmacology | Oxazines - pharmacology | Antifungal Agents - pharmacology | Itraconazole - metabolism | Serotonin Uptake Inhibitors - metabolism | Clotrimazole - pharmacology | Serotonin Uptake Inhibitors - chemistry | Antidepressive Agents, Second-Generation - pharmacology | Clotrimazole - chemistry | Itraconazole - chemistry | Selective Estrogen Receptor Modulators - metabolism | Ticlopidine - analogs & derivatives | Raloxifene Hydrochloride - metabolism | Platelet Aggregation Inhibitors - chemistry | Oxazines - chemistry | Kinetics | Serotonin Uptake Inhibitors - pharmacology | Selective Estrogen Receptor Modulators - pharmacology | Bupropion - metabolism | Ticlopidine - pharmacology | Area Under Curve | Reverse Transcriptase Inhibitors - pharmacology | Ticlopidine - chemistry | Benzoxazines | Xenobiotics - pharmacokinetics | Itraconazole - pharmacology | Oxazines - metabolism | Microsomes, Liver - drug effects | Antifungal Agents - metabolism | Ticlopidine - metabolism | Molecular Structure | Platelet Aggregation Inhibitors - metabolism | Sertraline - metabolism | Sertraline - pharmacology | Selective Estrogen Receptor Modulators - chemistry | Algorithms | Bupropion - pharmacology | Reverse Transcriptase Inhibitors - metabolism | Antidepressive Agents, Second-Generation - metabolism | Raloxifene Hydrochloride - chemistry | Cytochrome P-450 CYP2B6 | Cytochromes | Research | Health aspects | Drug interactions
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2005, Volume 70, Issue 10, pp. 1527 - 1535
Oxidative metabolism of bilirubin (BR) – a breakdown product of haem with cytoprotective and toxic properties – is an important route of detoxification in... 
Cadmium | Oxidative stress | Alternative pathway of bilirubin degradation | Haem oxygenase 1 | Bilirubin | Cytochrome P450 2A5 | haem oxygenase 1 | MOUSE-LIVER | cytochrome P450 2A5 | COUMARIN 7-HYDROXYLASE | ANTIOXIDANT PROPERTIES | DEGRADING SYSTEM | TRANSCRIPTION FACTOR NRF2 | HEME OXYGENASE | alternative pathway of bilirubin degradation | bilirubin | cadmium | CYP2A5 EXPRESSION | PHARMACOLOGY & PHARMACY | CARCINOGEN METABOLIZING ENZYMES | oxidative stress | CONJUGATED BILIRUBIN | Oxidoreductases - antagonists & inhibitors | Cytochrome P-450 CYP2A6 | Heme Oxygenase-1 - metabolism | Bilirubin - metabolism | Cytochrome P-450 Enzyme Inhibitors | Microsomes, Liver - metabolism | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Male | Mixed Function Oxygenases - metabolism | Cadmium Chloride - administration & dosage | Cytochrome P450 Family 2 | Heme Oxygenase-1 - genetics | Oxazines - metabolism | Liver - drug effects | Time Factors | Microsomes, Liver - drug effects | Oxazines - antagonists & inhibitors | Mice, Inbred DBA | Membrane Proteins - metabolism | Cadmium Chloride - metabolism | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - pharmacology | Heme Oxygenase-1 - biosynthesis | Inactivation, Metabolic - physiology | Mixed Function Oxygenases - pharmacology | Oxidoreductases - metabolism | Bilirubin - chemistry | Membrane Proteins - genetics | Cadmium Chloride - adverse effects | Liver - metabolism | Injections, Intraperitoneal | Mixed Function Oxygenases - antagonists & inhibitors | Microsomes, Liver - chemistry | Liver - chemistry | Aryl Hydrocarbon Hydroxylases - metabolism | Up-Regulation - drug effects | Animals | Inactivation, Metabolic - genetics | Mice | Oxidative Stress - drug effects | Mixed Function Oxygenases - genetics | RNA, Messenger | Herbicides | Messenger RNA | Dioxin | Cytochrome P-450 | Heme | Physiological aspects | Monoclonal antibodies | Hydrocarbons | Up-Regulation/drug effects | Bilirubin/chemistry/metabolism | Injections; Intraperitoneal | Comparative Study | Membrane Proteins/genetics/metabolism | Mice; Inbred DBA | RNA; Messenger | Mixed Function Oxygenases/antagonists & inhibitors/genetics/metabolism/pharmacology | Microsomes; Liver/chemistry/drug effects/metabolism | Oxazines/antagonists & inhibitors/metabolism | Cytochrome P-450 Enzyme System/antagonists & inhibitors/metabolism | Cadmium Chloride/administration & dosage/adverse effects/metabolism | Aryl Hydrocarbon Hyd