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Journal Article
PLOS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0125021
The aim of combination drug treatment in cancer therapy is to improve response rate and to decrease the probability of the development of drug resistance.... 
COLON-CANCER | MELANOMA | MEK INHIBITION | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | SYNTHETIC LETHAL INTERACTION | RESISTANCE | BRAF | KINASE INHIBITOR | BETA-CATENIN | EGFR | Triazoles - administration & dosage | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Oximes - administration & dosage | Imidazoles - administration & dosage | Aza Compounds - pharmacology | Cell Line, Tumor - drug effects | Indazoles - administration & dosage | Quinolines - administration & dosage | Indoles - administration & dosage | Quinolines - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pyridones - administration & dosage | Benzimidazoles - administration & dosage | Melanoma - genetics | Indoles - pharmacology | Pyrimidinones - pharmacology | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Aza Compounds - administration & dosage | Imidazoles - pharmacology | Melanoma - pathology | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Indazoles - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Triazoles - pharmacology | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Oxazoles - administration & dosage | Oximes - pharmacology | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Oxazoles - pharmacology | Proto-Oncogene Proteins c-myc - genetics | Pyrimidinones - administration & dosage | Mutation | Pyridones - pharmacology | Sulfonamides - administration & dosage | Drug therapy, Combination | Drug resistance | Drug therapy | Health aspects | Analysis | Melanoma
Journal Article
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 09/2017, Volume 39, Issue 9, pp. 1849 - 1857
Tedizolid phosphate is a next-generation oxazolidinone prodrug that is transformed into the active moiety tedizolid. Its indication is acute bacterial skin and... 
healthy Korean subjects | pharmacokinetics | oxazolidinone | tedizolid | bioavailability | MULTIDRUG-RESISTANT | RESISTANT STREPTOCOCCUS-PNEUMONIAE | ANTIMICROBIAL RESISTANCE | METHICILLIN-RESISTANT | ASIAN COUNTRIES | ACUTE BACTERIAL SKIN | SKIN-STRUCTURE INFECTIONS | SOUTH-KOREA | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | Prodrugs - administration & dosage | Organophosphates - adverse effects | Anti-Bacterial Agents - blood | Humans | Half-Life | Biological Availability | Male | Healthy Volunteers | Young Adult | Oxazoles - blood | Oxazoles - adverse effects | Adult | Anti-Bacterial Agents - adverse effects | Republic of Korea | Organophosphates - administration & dosage | Organophosphates - pharmacokinetics | Double-Blind Method | Administration, Oral | Organophosphates - blood | Oxazoles - pharmacokinetics | Cross-Over Studies | Prodrugs - adverse effects | Administration, Intravenous | Prodrugs - pharmacokinetics | Oxazoles - administration & dosage | Anti-Bacterial Agents - pharmacokinetics | Anti-Bacterial Agents - administration & dosage | Phosphates | Safety and security measures | Analysis | Pathogens | Bacterial infections | Oral administration | Dietary supplements | Staphylococcus infections | Pharmacology | FDA approval | Bioavailability | Metabolism | Switching | Proteins | Multidrug resistant organisms | Antibiotics | Metabolites | Protein synthesis | Linearity | Skin | Kinetics | Pharmacokinetics | Drug therapy | Drug dosages
Journal Article
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2016, Volume 38, Issue 8, pp. 1869 - 1879
Journal Article
Journal Article
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 10/2015, Volume 61, Issue 8, pp. 1315 - 1321
Tedizolid phosphate is the second commercially available oxazolidinone antibiotic, although the first one in class that is dosed once daily. It is a prodrug... 
Linezolid | Oxazolidinone | ABSSSI | Tedizolid | MRSA | INFECTIOUS DISEASES | MANAGEMENT | TOREZOLID TR-700 | MICROBIOLOGY | IMMUNOLOGY | RESISTANT STAPHYLOCOCCUS-AUREUS | oxazolidinone | linezolid | ACUTE BACTERIAL SKIN | SKIN-STRUCTURE INFECTIONS | PNEUMONIA MODEL | PHOSPHATE TR-701 | tedizolid | GRAM-POSITIVE PATHOGENS | IN-VITRO ACTIVITY | PRODRUG TR-701 | Organophosphates - administration & dosage | Organophosphates - adverse effects | Skin Diseases, Bacterial - microbiology | Humans | Methicillin-Resistant Staphylococcus aureus - drug effects | Drug Resistance, Bacterial | Skin Diseases, Bacterial - drug therapy | Oxazoles - chemistry | Organophosphates - pharmacology | Clinical Trials, Phase III as Topic | Staphylococcal Skin Infections - drug therapy | Drug Interactions | Anti-Bacterial Agents - chemistry | Oxazoles - administration & dosage | Gram-Positive Bacterial Infections - microbiology | Linezolid - administration & dosage | Oxazoles - adverse effects | Organophosphates - chemistry | Anti-Bacterial Agents - adverse effects | Anti-Bacterial Agents - pharmacology | Oxazoles - pharmacology | Gram-Positive Bacterial Infections - drug therapy | Anti-Bacterial Agents - administration & dosage | Staphylococcal Skin Infections - microbiology | Care and treatment | Usage | Antibiotics | Clinical trials | Dosage and administration | Research | Staphylococcus aureus | Bacterial skin diseases
Journal Article
Endocrinology, ISSN 0013-7227, 01/2016, Volume 157, Issue 1, pp. 292 - 303
Estrogens are well known for their enhancing effects on hippocampus-sensitive cognition. However, estrogens can also impair learning and memory, particularly... 
DIFFERENTIAL REINFORCEMENT | ER-BETA | SPATIAL MEMORY TASK | MIDDLE-AGED RATS | ENDOCRINOLOGY & METABOLISM | METABOTROPIC GLUTAMATE RECEPTORS | CENTRAL-NERVOUS-SYSTEM | BETA MESSENGER-RNA | RADIAL-ARM MAZE | OVARIECTOMIZED RATS | WORKING-MEMORY | Ovariectomy - adverse effects | Learning Disorders - prevention & control | Rats, Long-Evans | Selective Estrogen Receptor Modulators - adverse effects | Propionates - administration & dosage | Toxicity Tests, Acute | Hippocampus - drug effects | Corpus Striatum - metabolism | Learning Disorders - etiology | Dose-Response Relationship, Drug | Estrogen Receptor beta - metabolism | Nitriles - administration & dosage | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | Oxazoles - adverse effects | Estrogen Receptor alpha - metabolism | Female | Neurons - metabolism | Neuroprotective Agents - adverse effects | Neurons - drug effects | Neuroprotective Agents - administration & dosage | Pyrazoles - adverse effects | Nerve Tissue Proteins - agonists | Spatial Learning - drug effects | Neurotoxicity Syndromes - prevention & control | Selective Estrogen Receptor Modulators - administration & dosage | Maze Learning - drug effects | Estrogen Replacement Therapy - adverse effects | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Pyrazoles - administration & dosage | Animals | Phenols - adverse effects | Propionates - adverse effects | Oxazoles - administration & dosage | Neurotoxicity Syndromes - physiopathology | Corpus Striatum - drug effects | Phenols - administration & dosage | Nitriles - adverse effects | Original Research
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 11/2014, Volume 475, Issue 1-2, pp. 97 - 109
The aim of the present work was to design a pH-modified solid dispersion (pH -SD) that can improve the dissolution and bioavailability of poorly water-soluble... 
Poorly water-soluble drug | Solid dispersion | Microenvironmental pH | Acidifier | Bioavailability | VITRO | DESIGN | DELIVERY SYSTEMS | MECHANISM | RELEASE | FORMULATION | SOLUBILITY PARAMETERS | MATRIX TABLETS | PHARMACOLOGY & PHARMACY | PARTICLE-SIZE | Poorly water soluble drug | MODULATION | Tablets | Drugs, Investigational - pharmacokinetics | Imidazoles - administration & dosage | Biological Availability | Male | Antineoplastic Agents - administration & dosage | Imidazoles - pharmacokinetics | Thiohydantoins - analysis | Drugs, Investigational - analysis | Nitriles - pharmacokinetics | Nitriles - administration & dosage | Citric Acid - chemistry | Excipients - chemistry | Oxazoles - blood | Drug Compounding | Antineoplastic Agents - pharmacokinetics | Thiohydantoins - blood | Cinnamates - chemistry | Nitriles - analysis | Prostatic Neoplasms - drug therapy | Suspensions | Oxazoles - analysis | Oxazoles - pharmacokinetics | Solubility | Fumarates - chemistry | Antineoplastic Agents - analysis | Random Allocation | Thiohydantoins - pharmacokinetics | Thiohydantoins - administration & dosage | Imidazoles - blood | Povidone - chemistry | Animals | Succinic Acid - chemistry | Oxazoles - administration & dosage | Dogs | Animals, Inbred Strains | Antineoplastic Agents - blood | Drugs, Investigational - administration & dosage | Nitriles - blood | Imidazoles - analysis | Hydrogen-Ion Concentration | Antimitotic agents | Antineoplastic agents | Prostate cancer | Pharmacy
Journal Article