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Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 2, pp. 194 - 201
Journal Article
Biochemical journal, ISSN 1470-8728, 2014, Volume 462, Issue 3, pp. 475 - 487
Metformin is a widely prescribed anti-diabetic, but its mode of action is disputed. It has been proposed to inhibit respiratory complex I. We show how... 
ATP synthase | Complex I | Biguanide | Metformin | Reactive oxygen species (ROS) | Nadh:quinone oxidoreductase | CELLS | FLAVIN | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NADH:quinone oxidoreductase | biguanide | metformin | reactive oxygen species (ROS) | RAT-LIVER MITOCHONDRIA | HEART | NADH | INHIBITION | METABOLISM | OXIDOREDUCTASE COMPLEX-I | PURIFICATION | complex I | Biguanides - pharmacology | Triazines - pharmacology | Electron Transport Complex I - antagonists & inhibitors | Metformin - therapeutic use | Biguanides - therapeutic use | Humans | Metformin - pharmacology | Rats | Plasmodium - drug effects | Mitochondria, Heart - drug effects | Electron Transport Complex I - drug effects | Mitochondrial Proton-Translocating ATPases - metabolism | Antimalarials - pharmacology | Hep G2 Cells | Mitochondria, Liver - drug effects | Oxidative Phosphorylation - drug effects | Animals | Reperfusion Injury - prevention & control | Cattle | Antineoplastic Agents - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Mitochondrial Proton-Translocating ATPases - antagonists & inhibitors | Proguanil - pharmacology | SMP, submitochondrial particle | HAR, hexaammineruthenium(III) | OCR, oxygen consumption rate | AMPK, AMP-activated protein kinase | DMEM, Dulbecco’s modified Eagle’s medium | ECAR, extracellular acidification rate | FeCN, ferricyanide | ROS, reactive oxygen species | OCT1, organic cation transporter 1
Journal Article
Molecular cell, ISSN 1097-2765, 2007, Volume 25, Issue 4, pp. 543 - 557
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 11, p. e49112
Multiple phosphorylation sites of Drp1 have been characterized for their functional importance... 
APOPTOSIS | GTPASE DRP1 | VARIANTS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | DEPENDENT PROTEIN-KINASE | NEURODEGENERATION | DEGRADATION | FISSION | AUTOPHAGY | Mitochondria - enzymology | Dynamins - metabolism | Hydrolysis - drug effects | Apoptosis - drug effects | Humans | Molecular Sequence Data | Glycogen Synthase Kinase 3 beta | Protein Transport - drug effects | Autophagy - drug effects | Protein Binding - drug effects | HEK293 Cells | Lysine - metabolism | Phosphorylation - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Hydrogen Peroxide - pharmacology | Mutant Proteins - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Glycogen Synthase Kinase 3 - metabolism | Phosphoserine - metabolism | Two-Hybrid System Techniques | GTP Phosphohydrolases - metabolism | Mitochondrial Dynamics - drug effects | Dynamins - chemistry | Models, Biological | Mutant Proteins - chemistry | HeLa Cells | Oxidative Stress - drug effects | Cytochrome c | Cytochrome | Protein kinase A | Oxidative stress | Phosphorylation | Hydrogen peroxide | Laboratories | Lithium chloride | Serine | Biochemistry | Mitochondrial DNA | Neurosurgery | Kinases | Autophagy | Proteins | Mitochondria | Localization | Elongation | Threonine | Molecular interactions | Poly(ADP-ribose) polymerase | Guanosine triphosphatases | Substrates | Mutants | Medicine | Signaling | Hospitals | Morphology | Alzheimers disease | Phagocytosis | Apoptosis | Guanosinetriphosphatase
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 567, Issue 7748, pp. 341 - 346
... phosphorylation complexes in a manner that is dependent on the proton gradient of the inner mitochondrial membrane... 
CARCINOMA-CELLS | PERMEABILITY TRANSITION PORE | METFORMIN | COMPLEX | METABOLISM | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | GROWTH | RESISTANCE | RISK | CANCER | Astrocytes - cytology | Astrocytes - drug effects | Neoplasm Transplantation | Mitochondrial Membrane Transport Proteins - metabolism | Humans | Organ Specificity | Mitochondrial Membranes - metabolism | Mitochondrial Membranes - drug effects | Oxidative Phosphorylation - drug effects | Proton-Translocating ATPases - metabolism | Xenograft Model Antitumor Assays | Allografts | Animals | Fibroblasts - drug effects | Cell Line, Tumor | Glioblastoma - metabolism | Fibroblasts - cytology | Mice | Mitochondrial Membranes - enzymology | Glioblastoma - drug therapy | Proton-Translocating ATPases - antagonists & inhibitors | Proton-Motive Force - drug effects | Hydrogen-Ion Concentration | Prevention | Care and treatment | Phosphorylation | Chemical inhibitors | Usage | Glioblastoma multiforme | Health aspects | Permeability | Bone grafts | Neonates | Animal models | Mitochondrial permeability transition pore | Toxicity | Xenotransplantation | Membrane permeability | pH effects | Cancer therapies | Signal transduction | ATP synthase | Mitochondria | Xenografts | Cell cycle | Fibroblasts | Oxygen | Astrocytes | Oxygen consumption | Embryo fibroblasts | Tumor cell lines | Metabolism | F0F1 ATP synthase | Embryos | Mode of action | Oxidative phosphorylation | Reagents | Stem cells | Glioblastoma cells | Mutation | Tumors | Cancer | Apoptosis
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2012, Volume 32, Issue 26, pp. 8940 - 8951
Journal Article
Molecular and cellular biology, ISSN 0270-7306, 2007, Volume 27, Issue 13, pp. 4953 - 4967
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
CELLS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | GENE-EXPRESSION | TRANSCRIPTIONAL COACTIVATOR | DIFFERENTIATION | MICROARRAY DATA | TRANSGENIC MICE | CELL BIOLOGY | Gene Expression Regulation, Enzymologic - drug effects | Acetyltransferases - metabolism | Multienzyme Complexes - metabolism | Adipocytes - drug effects | Glucose Intolerance | AMP-Activated Protein Kinases | Oxidative Phosphorylation - drug effects | Adipose Tissue, White - cytology | Body Composition - drug effects | Isoenzymes - metabolism | Adenosine Triphosphate - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Trans-Activators - genetics | Food Deprivation | p38 Mitogen-Activated Protein Kinases - metabolism | Homeostasis - drug effects | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Isoenzymes - genetics | Hydrogen Peroxide - pharmacology | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Multienzyme Complexes - genetics | Macrophages - cytology | Mitochondria - drug effects | Feeding Behavior - drug effects | Polyamines - metabolism | Macrophages - metabolism | Organ Size - drug effects | Animals | Adipocytes - metabolism | Fibroblasts - drug effects | Adipose Tissue, White - enzymology | Adipose Tissue, White - growth & development | Glucose - metabolism | Macrophages - drug effects | Trans-Activators - metabolism | Mice | Transcription Factors | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | White/cytology/drug effects/enzymology/growth | Hydrogen Peroxide/pharmacology | Macrophages/cytology/drug effects/metabolism | Mitochondria/drug effects/metabolism | Fibroblasts/drug effects/metabolism | p38 Mitogen-Activated Protein Kinases/metabolism | MEDICIN OCH HÄLSOVETENSKAP | Homeostasis/drug effects | Multienzyme Complexes/genetics/metabolism | Protein-Serine-Threonine Kinases/genetics/metabolism | Trans-Activators/genetics/metabolism | Enzymologic/drug effects | Glucose/metabolism | Adipose Tissue | Feeding Behavior/drug effects | Organ Size/drug effects | Oxidative Phosphorylation/drug effects | MEDICAL AND HEALTH SCIENCES | development | Acetyltransferases/metabolism | Adipocytes/drug effects/metabolism | Gene Expression Regulation | Adenosine Triphosphate/metabolism | Body Composition/drug effects | Polyamines/metabolism | Energy Metabolism/drug effects | Isoenzymes/genetics/metabolism | Phosphorylation/drug effects
Journal Article
Journal Article