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1. Full Text Doxorubicin pathways: pharmacodynamics and adverse effects
by Thorn, Caroline F and Oshiro, Connie and Marsh, Sharon and Hernandez-Boussard, Tina and McLeod, Howard and Klein, Teri E and Altman, Russ B
Pharmacogenetics and Genomics, ISSN 1744-6872, 07/2011, Volume 21, Issue 7, pp. 440 - 446
ABCC1 | ABCC2 | NCF4 | CYBA | cardiotoxicity | pharmacogenomics | PharmGKBpathways | CAT | RAC2 | anthracyclines | doxorubicin | drug resistance | CBR3 | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | BREAST-CANCER PATIENTS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | PHARMACOGENETICS | ANTHRACYCLINE CARDIOTOXICITY | TOPOISOMERASE-II | GENETIC POLYMORPHISMS | LUNG-CANCER | CONGESTIVE-HEART-FAILURE | MULTIDRUG-RESISTANCE | Pharmacogenetics | Phenotype | Antibiotics, Antineoplastic - pharmacology | Intercalating Agents - adverse effects | Humans | Antibiotics, Antineoplastic - adverse effects | Drug Resistance, Neoplasm | Intercalating Agents - pharmacology | Doxorubicin - adverse effects | Doxorubicin - pharmacology | Polymorphism, Genetic | PharmGKB pathways
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2. Full Text Nano-CeO2 Exhibits Adverse Effects at Environmental Relevant Concentrations
by Zhang, Haifeng and He, Xiao and Zhang, Zhiyong and Zhang, Peng and Li, Yuanyuan and Ma, Yuhui and Kuang, Yashu and Zhao, Yuliang and Chai, Zhifang
Environmental Science & Technology, ISSN 0013-936X, 04/2011, Volume 45, Issue 8, pp. 3725 - 3730
Ceria nanoparticles (nano-CeO2), due to their widespread applications, have attracted a lot of concern about their toxic effects on both human health and the... 
Ecotoxicology and Human Environmental Health | ECOTOXICITY | LIFE-SPAN | ENVIRONMENTAL SCIENCES | OXIDATIVE STRESS | MUTANTS | ENGINEERING, ENVIRONMENTAL | CERIUM OXIDE NANOPARTICLES | ENGINEERED NANOPARTICLES | CEO2 NANOPARTICLES | TOXICITY | NEMATODE CAENORHABDITIS-ELEGANS | DAMAGE | Dose-Response Relationship, Drug | Cerium - toxicity | Metal Nanoparticles - toxicity | Animals | Caenorhabditis elegans - drug effects | Caenorhabditis elegans - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Environmental Pollutants - toxicity | Index Medicus
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3. Full Text Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease
by Besler, Christian and Heinrich, Kathrin and Rohrer, Lucia and Doerries, Carola and Riwanto, Meliana and Shih, Diana M and Chroni, Angeliki and Yonekawa, Keiko and Stein, Sokrates and Schaefer, Nicola and Mueller, Maja and Akhmedov, Alexander and Daniil, Georgios and Manes, Costantina and Templin, Christian and Wyss, Christophe and Maier, Willibald and Tanner, Felix C and Matter, Christian M and Corti, Roberto and Furlong, Clement and Lusis, Aldons J and Von Eckardstein, Arnold and Fogelman, Alan M and Lüscher, Thomas F and Landmesser, Ulf
Journal of Clinical Investigation, ISSN 0021-9738, 07/2011, Volume 121, Issue 7, pp. 2693 - 2708
Therapies that raise levels of HDL, which is thought to exert atheroprotective effects via effects on endothelium, are being examined for the treatment or... 
MEDICINE, RESEARCH & EXPERIMENTAL | ENDOTHELIAL PROGENITOR CELLS | REENDOTHELIALIZATION | SERUM PARAOXONASE | NITRIC-OXIDE SYNTHASE | CHOLESTEROL EFFLUX | EXPRESSION | BINDING | SCAVENGER RECEPTOR-BI | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-A-I | Tumor Necrosis Factor-alpha - metabolism | Nitric Oxide - biosynthesis | Coronary Artery Disease - metabolism | Humans | Middle Aged | Lipoproteins, HDL - metabolism | Male | NF-kappa B - metabolism | Aryldialkylphosphatase - metabolism | Animals | Coronary Artery Disease - physiopathology | Endothelium, Vascular - metabolism | Adult | Female | Aged | Mice | Nitric Oxide Synthase Type III - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Prevention | Enzymes | Care and treatment | High density lipoproteins | Physiological aspects | Research | Coronary heart disease | Endothelium
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4. Full Text Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
by Yuri Y. Sautin and Takahiko Nakagawa and Sergey Zharikov and Richard J. Johnson
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2007, Volume 293, Issue 2, pp. 584 - 596
Uric acid is considered a major antioxidant in human blood that may protect against aging and oxidative stress. Despite its proposed protective properties,... 
Redox signaling | Reactive oxygen species | Nitric oxide | nitric oxide | METABOLIC SYNDROME | OXIDATIVE STRESS | PHYSIOLOGY | ENDOTHELIAL DYSFUNCTION | LOW-DENSITY-LIPOPROTEIN | MAP KINASE ACTIVATION | CELL BIOLOGY | redox signaling | SMOOTH-MUSCLE | NAD(P)H OXIDASE | REACTIVE OXYGEN | reactive oxygen species | NITRIC-OXIDE | MUSCLE-CELL-PROLIFERATION | Reactive Oxygen Species - metabolism | Antioxidants - metabolism | NADPH Oxidases - metabolism | Adipocytes - enzymology | Hyperuricemia - metabolism | Adipocytes - drug effects | Time Factors | Isoenzymes - metabolism | Cell Differentiation | p38 Mitogen-Activated Protein Kinases - metabolism | Hyperuricemia - complications | Cardiovascular Diseases - etiology | Uric Acid - metabolism | Cardiovascular Diseases - metabolism | Oxidation-Reduction | Uric Acid - toxicity | Reactive Nitrogen Species - metabolism | 3T3-L1 Cells | Nitrosation | Antioxidants - toxicity | Phenotype | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Adipocytes - metabolism | Mice | Enzyme Activation | Oxidative Stress - drug effects | Lipid Peroxidation | Nitric Oxide - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
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5. Full Text Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract
by Sostres, Carlos, MD and Gargallo, Carla J., MD and Arroyo, Maria T., MD, DSc and Lanas, Angel, MD, DSc
Best Practice & Research: Clinical Gastroenterology, ISSN 1521-6918, 2009, Volume 24, Issue 2, pp. 121 - 132
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely prescribed medication in the world. Their main benefit derives from their... 
Gastroenterology and Hepatology | proton pump inhibitors | coxibs | GI damage | NSAIDs | RHEUMATOID-ARTHRITIS | Gl damage | RANDOMIZED CONTROLLED-TRIAL | INDUCED GASTRIC DAMAGE | PEPTIC-ULCER DISEASE | LOW-DOSE ASPIRIN | HELICOBACTER-PYLORI INFECTION | DOUBLE-BLIND | GASTROENTEROLOGY & HEPATOLOGY | NITRIC-OXIDE DONATOR | CARDIOVASCULAR RISK | Risk Assessment | Gastrointestinal Diseases - prevention & control | Humans | Risk Factors | Gastric Mucosa - pathology | Gastrointestinal Tract - drug effects | Gastrointestinal Tract - pathology | Patient Selection | Cyclooxygenase 2 Inhibitors - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Aspirin - adverse effects | Gastric Mucosa - drug effects | Gastrointestinal Diseases - pathology | Gastrointestinal Diseases - chemically induced | Cytoprotection | Hypertension | Complications and side effects | Aspirin | Gastrointestinal diseases | Misoprostol | Risk factors | Prostanoids
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6. Full Text Adverse Effects of Cigarette Smoke on NO Bioavailability: Role of Arginine Metabolism and Oxidative Stress
by Zhang, Wei-Zheng and Venardos, Kylie and Chin-Dusting, Jaye and Kaye, David M
Hypertension, ISSN 0194-911X, 08/2006, Volume 48, Issue 2, pp. 278 - 285
Endothelial dysfunction is a hallmark of cardiovascular disease, and the l-arginine:NO pathway plays a critical role in determining endothelial function.... 
Metabolism | Endothelium | Smoking | endothelium | ARTERY ENDOTHELIAL-CELLS | ISOFORMS | NITRIC-OXIDE SYNTHASE | AMINO-ACID TRANSPORTERS | PEPTIDE | ASYMMETRICAL DIMETHYLARGININE | PLASMA | smoking | PERIPHERAL VASCULAR DISEASE | metabolism | DYSFUNCTION | EXPRESSION | EXTRACT | Smoking - adverse effects | Arginine - pharmacokinetics | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Biological Availability | Cationic Amino Acid Transporter 1 - metabolism | Male | Arginine - analogs & derivatives | Cotinine - blood | Cattle | Adult | Biological Transport - drug effects | Citrulline - blood | Culture Media - chemistry | Smoking - blood | Endothelial Cells - metabolism | Smoke - adverse effects | Cells, Cultured | Antioxidants - pharmacology | Enzyme Activation - drug effects | Tobacco | Animals | Endothelial Cells - cytology | Arginine - blood | Culture Media - pharmacology | Nitric Oxide Synthase - metabolism | Nitric Oxide - metabolism | Arginine - metabolism | Endothelial Cells - drug effects
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7. Full Text Adverse effects of interlayer-gliding in layered transition-metal oxides on electrochemical sodium-ion storage
by Sun, Yang and Guo, Shaohua and Zhou, Haoshen
Energy and Environmental Science, ISSN 1754-5692, 3/2019, Volume 12, Issue 3, pp. 825 - 84
Layered sodium transition-metal oxides are the most widely investigated electrodes for sodium-ion batteries (SIBs), which are a promising technology for... 
ENERGY & FUELS | PHASE-TRANSITIONS | X-RAY-DIFFRACTION | CRYSTAL-STRUCTURES | TOTAL-ENERGY CALCULATIONS | CATHODE MATERIALS | POSITIVE ELECTRODE MATERIALS | CHEMISTRY, MULTIDISCIPLINARY | HIGH-VOLTAGE | ENGINEERING, CHEMICAL | ENVIRONMENTAL SCIENCES | STRUCTURAL EVOLUTION | DENSITY-FUNCTIONAL THEORY | LESS-THAN | Interlayers | Transition metals | Electrochemical analysis | Metals | Ion transport | Transition metal oxides | Oxides | Lithium | Batteries | Intercalation | Phase transitions | Storage batteries | Ion storage | Rechargeable batteries | Electrodes | Metal oxides | Sodium | Electrochemistry | Energy efficiency | Slabs | Gliding | Energy storage
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8. Full Text Electromagnetic fields act via activation of voltage‐gated calcium channels to produce beneficial or adverse effects
by Pall, Martin L
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 08/2013, Volume 17, Issue 8, pp. 958 - 965
The direct targets of extremely low and microwave frequency range electromagnetic fields (EMFs) in producing non‐thermal effects have not been clearly... 
intracellular Ca2 | nitric oxide | voltage‐gated calcium channels | calcium channel blockers | oxidative stress | low frequency electromagnetic field exposure | Low frequency electromagnetic field exposure | Oxidative stress | Voltage-gated calcium channels | Calcium channel blockers | Intracellular Ca | Nitric oxide | MEDICINE, RESEARCH & EXPERIMENTAL | DNA STRAND BREAKS | DEPENDENT PROTEIN-KINASES | CA2+ CHANNELS | RAT-BRAIN CELLS | LEVEL 50 HZ | CELL BIOLOGY | IN-VITRO | DIRTY ELECTRICITY | HZ MAGNETIC-FIELDS | voltage-gated calcium channels | NITRIC-OXIDE | DNA Breaks, Single-Stranded | Osteogenesis - physiology | Animals | Electromagnetic Fields | Calcium Channels - metabolism | Signal Transduction | Humans | Ion Channel Gating | Calcium-binding proteins | Calcium channels | Electric potential | Calcium oxide | Calcium | Downstream effects | Protein kinase G | DNA damage | Electromagnetic induction | Stimulation | Microwave frequencies | Biology | Kinases | Low frequency | Channels | Cell adhesion & migration | Proteins | Electrical currents | Biological effects | Bone growth | Electricity | Temperature effects | Calcium-binding protein | Cyclic GMP | Voltage | Digital technology | Electric fields | Frequency ranges | Deoxyribonucleic acid--DNA | Calmodulin | Peroxynitrite | Electromagnetism | Bioassay | Cytokines | Calcium channels (voltage-gated) | Roles | Electromagnetic fields | Studies | Reviews | Damage detection | Protein kinase | Magnetic fields | Calcium ions
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9. Full Text Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications
by Sheetz, Matthew J and King, George L
JAMA, ISSN 0098-7484, 11/2002, Volume 288, Issue 20, pp. 2579 - 2588
Diabetic complications are the major cause of morbidity and mortality in persons with diabetes. Chronic hyperglycemia is a major initiator of diabetic... 
EPITHELIUM-DERIVED FACTOR | MEDICINE, GENERAL & INTERNAL | PROTEIN-KINASE-C | NERVE-CONDUCTION-VELOCITY | ELEVATED GLUCOSE-LEVELS | NITRIC-OXIDE SYNTHASE | PKC-BETA INHIBITOR | ALDOSE REDUCTASE INHIBITOR | VITAMIN-E SUPPLEMENTATION | ENDOTHELIAL GROWTH-FACTOR | GLYCATION END-PRODUCTS | Hyperglycemia - prevention & control | Reactive Oxygen Species | Diabetic Neuropathies - etiology | Diabetic Neuropathies - prevention & control | Signal Transduction | Diabetic Nephropathies - etiology | Humans | Oxidative Phosphorylation | Diabetic Angiopathies - etiology | Glycosylation | Protein Kinase C - metabolism | Glycation End Products, Advanced - metabolism | Glycolysis | Aldehyde Reductase - metabolism | Diabetic Angiopathies - prevention & control | Hyperglycemia - physiopathology | Diabetic Nephropathies - prevention & control | Physiological aspects | Hyperglycemia | Diabetes | Complications | Blood vessels | Glucose | Metabolism | Neurons
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10. Full Text Adverse effects of interlayer-gliding in layered transition-metal oxides on electrochemical sodium-ion storage
by Sun, Yang and Guo, Shaohua and Zhou, Haoshen
Energy & Environmental Science, ISSN 1754-5692, 03/2019, Volume 12, Issue 3, pp. 825 - 840
Layered sodium transition-metal oxides are the most widely investigated electrodes for sodium-ion batteries (SIBs), which are a promising technology for... 
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11. Full Text Nitrate removal, communities of denitrifiers and adverse effects in different carbon substrates for use in denitrification beds
by Warneke, Sören and Schipper, Louis A and Matiasek, Michael G and Scow, Kate M and Cameron, Stewart and Bruesewitz, Denise A and McDonald, Ian R
Water Research, ISSN 0043-1354, 2011, Volume 45, Issue 17, pp. 5463 - 5475
Denitrification beds are containers filled with wood by-products that serve as a carbon and energy source to denitrifiers, which reduce nitrate (NO ) from... 
Denitrification | Bioreactor | Denitrification genes | Controlling factors | nir | Nir | SYSTEM | BACTERIA | WATER RESOURCES | PARAMETERS | SOLUBILITY | NIRK | ENVIRONMENTAL SCIENCES | NOSZ GENES | ENGINEERING, ENVIRONMENTAL | WASTE-WATER | DIVERSITY | EMISSION | NITROUS-OXIDE REDUCTASE | Solubility - drug effects | Gene Dosage - genetics | Temperature | Genes, Bacterial - genetics | Nitrate Reductase - genetics | Oxidoreductases - genetics | Bacteria - drug effects | Greenhouse Effect | Methane - analysis | Denitrification - drug effects | Bacteria - genetics | Bacteria - growth & development | Nitrous Oxide - analysis | RNA, Ribosomal, 16S - genetics | Denitrification - genetics | Nitrates - isolation & purification | Nitrogen - isolation & purification | Water Purification - instrumentation | Water Purification - methods | Carbon - pharmacology | Methane | Complications and side effects | Ammonia | Corn | Air pollution | Nitrous oxide | Aquatic resources | Greenhouse gases | Atmospheric carbon dioxide | Microorganisms | Nitrous oxides | Genes | Cob | Bacteria | Maize | Carbon | Dissolution
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