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Publication DateCell Metabolism, ISSN 1550-4131, 12/2013, Volume 18, Issue 6, pp. 844 - 859
Accumulating evidence suggests that changes in the metabolic signature of astrocytes underlie their response to neuroinflammation, but how proinflammatory...
FUNCTIONAL RECOVERY | S-NITROSYLATION | BAX ACTIVATION | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | NITRIC-OXIDE | REACTIVE ASTROCYTES | SPINAL-CORD-INJURY | FISSION | ENERGY-METABOLISM | OXIDATIVE-METABOLISM | CELL BIOLOGY | Inflammation - pathology | Dynamins - metabolism | Phosphorylation | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Male | Autophagy | Inflammation - metabolism | Interleukin-1beta - metabolism | Astrocytes - cytology | Astrocytes - drug effects | Lipopolysaccharides - toxicity | Cytokines - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Mitochondria - metabolism | Mitochondria - drug effects | Autophagy-Related Protein 7 | Animals | Mitochondrial Dynamics - drug effects | Mice | Interferon-gamma - pharmacology | Astrocytes - metabolism | Nitric Oxide Synthase Type II - metabolism | Neurosciences | Inflammation | Mitochondrial DNA | Architecture | Cells
FUNCTIONAL RECOVERY | S-NITROSYLATION | BAX ACTIVATION | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | NITRIC-OXIDE | REACTIVE ASTROCYTES | SPINAL-CORD-INJURY | FISSION | ENERGY-METABOLISM | OXIDATIVE-METABOLISM | CELL BIOLOGY | Inflammation - pathology | Dynamins - metabolism | Phosphorylation | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Male | Autophagy | Inflammation - metabolism | Interleukin-1beta - metabolism | Astrocytes - cytology | Astrocytes - drug effects | Lipopolysaccharides - toxicity | Cytokines - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Mitochondria - metabolism | Mitochondria - drug effects | Autophagy-Related Protein 7 | Animals | Mitochondrial Dynamics - drug effects | Mice | Interferon-gamma - pharmacology | Astrocytes - metabolism | Nitric Oxide Synthase Type II - metabolism | Neurosciences | Inflammation | Mitochondrial DNA | Architecture | Cells
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Regulatory role for the arginine–nitric oxide pathway in metabolism of energy substrates
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 2006, Volume 17, Issue 9, pp. 571 - 588
Nitric oxide (NO) is synthesized from -arginine by NO synthase in virtually all cell types. Emerging evidence shows that NO regulates the metabolism of...
Amino acids | Mitochondria | Oxidation | Glucose | Nitric oxide | Lipid | glucose | nitric oxide | ACTIVATED PROTEIN-KINASE | MITOCHONDRIAL BIOGENESIS | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | amino acids | oxidation | SKELETAL-MUSCLE GLUCOSE | ACETYL-COA CARBOXYLASE | DIABETIC-RATS | lipid | ISOLATED RAT HEPATOCYTES | ADIPOSE-TISSUE LIPOLYSIS | NUTRITION & DIETETICS | FATTY-ACID OXIDATION | INSULIN-RESISTANCE | STIMULATES GLUCOSE-TRANSPORT | Humans | Multienzyme Complexes - metabolism | Muscle, Skeletal - metabolism | Glycolysis - drug effects | AMP-Activated Protein Kinases | Adipose Tissue - metabolism | Amino Acids - metabolism | Myocardium - metabolism | Metabolic Syndrome - physiopathology | Nitric Oxide Synthase Type III - metabolism | Energy Metabolism - physiology | Lipolysis - physiology | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Liver - metabolism | Gene Expression Regulation - physiology | Nitric Oxide - physiology | Animals | Nitric Oxide Synthase Type I - metabolism | Lipid Metabolism - drug effects | Glucose - metabolism | Nitric Oxide Synthase - metabolism | Intestine, Small - metabolism | Mitochondria - physiology | Nitric Oxide - metabolism | Arginine - metabolism | Nitric Oxide Synthase Type II - metabolism | Phosphates | Glycogen | Guanosine | Dietary supplements | Glycerol | Mitochondrial DNA | Biosynthesis | Lipase | Fatty acids | Dextrose | Glycerin | Glucose metabolism | Arginine | Physiological aspects | Diabetes | Universities and colleges | Protein binding
Amino acids | Mitochondria | Oxidation | Glucose | Nitric oxide | Lipid | glucose | nitric oxide | ACTIVATED PROTEIN-KINASE | MITOCHONDRIAL BIOGENESIS | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | amino acids | oxidation | SKELETAL-MUSCLE GLUCOSE | ACETYL-COA CARBOXYLASE | DIABETIC-RATS | lipid | ISOLATED RAT HEPATOCYTES | ADIPOSE-TISSUE LIPOLYSIS | NUTRITION & DIETETICS | FATTY-ACID OXIDATION | INSULIN-RESISTANCE | STIMULATES GLUCOSE-TRANSPORT | Humans | Multienzyme Complexes - metabolism | Muscle, Skeletal - metabolism | Glycolysis - drug effects | AMP-Activated Protein Kinases | Adipose Tissue - metabolism | Amino Acids - metabolism | Myocardium - metabolism | Metabolic Syndrome - physiopathology | Nitric Oxide Synthase Type III - metabolism | Energy Metabolism - physiology | Lipolysis - physiology | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Liver - metabolism | Gene Expression Regulation - physiology | Nitric Oxide - physiology | Animals | Nitric Oxide Synthase Type I - metabolism | Lipid Metabolism - drug effects | Glucose - metabolism | Nitric Oxide Synthase - metabolism | Intestine, Small - metabolism | Mitochondria - physiology | Nitric Oxide - metabolism | Arginine - metabolism | Nitric Oxide Synthase Type II - metabolism | Phosphates | Glycogen | Guanosine | Dietary supplements | Glycerol | Mitochondrial DNA | Biosynthesis | Lipase | Fatty acids | Dextrose | Glycerin | Glucose metabolism | Arginine | Physiological aspects | Diabetes | Universities and colleges | Protein binding
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Loading RightsPlant Physiology and Biochemistry, ISSN 0981-9428, 01/2017, Volume 110, pp. 167 - 177
Understanding the adverse impact of nanoparticles in crop plants has emerged as one of the most interesting fields of plant research. Therefore, this study has...
Pea seedlings | Oxidative stress | Anatomical structures | Nitric oxide | Silver nanoparticles | ASSAY | TOXICITY | CHROMIUM | PLANT SCIENCES | RESPONSES | ANTIOXIDANT SYSTEMS | PROTECTIVE ROLE | GROWTH | PLANTS | Nitroprusside - metabolism | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Glutathione Reductase - metabolism | Fluorescence | Nitroprusside - pharmacology | Ascorbic Acid - metabolism | Plant Roots - drug effects | Ascorbate Peroxidases - metabolism | X-Ray Diffraction | Plant Shoots - drug effects | Silver - toxicity | Plant Leaves - drug effects | Plant Proteins - metabolism | Nitric Oxide Donors - pharmacology | Peas - metabolism | Superoxide Dismutase - metabolism | Metal Nanoparticles - ultrastructure | Malondialdehyde - metabolism | Microscopy, Electron, Transmission | Plant Roots - metabolism | Metal Nanoparticles - chemistry | Nitric Oxide Donors - metabolism | Silver - chemistry | Peas - drug effects | Chlorophyll - metabolism | Seedlings - drug effects | Hydrogen Peroxide - metabolism | Chlorophyll - chemistry | Metal Nanoparticles - toxicity | Plant Leaves - metabolism | Photosynthesis - drug effects | Plant Shoots - metabolism | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Seedlings - metabolism | Nanoparticles | Chlorophyll | Silver | Peas | Phytochemistry | Superoxide | Photosynthesis | Nanotechnology
Pea seedlings | Oxidative stress | Anatomical structures | Nitric oxide | Silver nanoparticles | ASSAY | TOXICITY | CHROMIUM | PLANT SCIENCES | RESPONSES | ANTIOXIDANT SYSTEMS | PROTECTIVE ROLE | GROWTH | PLANTS | Nitroprusside - metabolism | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Glutathione Reductase - metabolism | Fluorescence | Nitroprusside - pharmacology | Ascorbic Acid - metabolism | Plant Roots - drug effects | Ascorbate Peroxidases - metabolism | X-Ray Diffraction | Plant Shoots - drug effects | Silver - toxicity | Plant Leaves - drug effects | Plant Proteins - metabolism | Nitric Oxide Donors - pharmacology | Peas - metabolism | Superoxide Dismutase - metabolism | Metal Nanoparticles - ultrastructure | Malondialdehyde - metabolism | Microscopy, Electron, Transmission | Plant Roots - metabolism | Metal Nanoparticles - chemistry | Nitric Oxide Donors - metabolism | Silver - chemistry | Peas - drug effects | Chlorophyll - metabolism | Seedlings - drug effects | Hydrogen Peroxide - metabolism | Chlorophyll - chemistry | Metal Nanoparticles - toxicity | Plant Leaves - metabolism | Photosynthesis - drug effects | Plant Shoots - metabolism | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Seedlings - metabolism | Nanoparticles | Chlorophyll | Silver | Peas | Phytochemistry | Superoxide | Photosynthesis | Nanotechnology
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Loading RightsClinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 09/2007, Volume 34, Issue 9, pp. 906 - 911
SUMMARY • Arginase is the focal enzyme of the urea cycle hydrolysingl-arginine to urea andl-ornithine. Emerging studies have identified arginase in the...
smooth muscle cell proliferation | arginine | nitric oxide synthase | diabetes | endothelial dysfunction | hypertension | arginase | Hypertension | Arginine | Endothelial dysfunction | Smooth muscle cell proliferation | Arginase | Nitric oxide synthase | Diabetes | PHYSIOLOGY | LIVER ARGINASE | TRANSLATIONAL CONTROL | AMINO-ACID TRANSPORTER | INTIMAL HYPERPLASIA | ENDOTHELIAL-CELLS | SYNTHASE ACTIVITY | ARTERIAL-HYPERTENSION | L-ARGININE TRANSPORT | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | ISCHEMIA-REPERFUSION | Cardiovascular Diseases - physiopathology | Cell Proliferation | Reactive Oxygen Species - metabolism | Cardiovascular Diseases - metabolism | Muscle, Smooth, Vascular - metabolism | Humans | Arginase - metabolism | Endothelium, Vascular - physiopathology | Homeostasis | Cardiovascular Diseases - enzymology | Endothelium, Vascular - enzymology | Muscle, Smooth, Vascular - physiopathology | Arginine - analogs & derivatives | Collagen - metabolism | Animals | Endothelium, Vascular - metabolism | Urea - metabolism | Nitric Oxide Synthase Type III - metabolism | Nitric Oxide - metabolism | Muscle, Smooth, Vascular - enzymology | Arginine - metabolism | Muscle, Smooth, Vascular, metabolism | Collagen, metabolism | Endothelium, Vascular, physiopathology | Arginine, analogs and derivatives | Nitric Oxide, metabolism | Endothelium, Vascular, metabolism | Urea, metabolism | Nitric Oxide Synthase Type III, metabolism | Arginine, metabolism | Cardiovascular Diseases, enzymology | Endothelium, Vascular, enzymology | Muscle, Smooth, Vascular, physiopathology | Cardiovascular Diseases, physiopathology | Cardiovascular Diseases, metabolism | Arginase, metabolism | Muscle, Smooth, Vascular, enzymology | Reactive Oxygen Species, metabolism | Deicing chemicals | Physiological aspects | Endothelium-derived relaxing factors | Nitric oxide
smooth muscle cell proliferation | arginine | nitric oxide synthase | diabetes | endothelial dysfunction | hypertension | arginase | Hypertension | Arginine | Endothelial dysfunction | Smooth muscle cell proliferation | Arginase | Nitric oxide synthase | Diabetes | PHYSIOLOGY | LIVER ARGINASE | TRANSLATIONAL CONTROL | AMINO-ACID TRANSPORTER | INTIMAL HYPERPLASIA | ENDOTHELIAL-CELLS | SYNTHASE ACTIVITY | ARTERIAL-HYPERTENSION | L-ARGININE TRANSPORT | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | ISCHEMIA-REPERFUSION | Cardiovascular Diseases - physiopathology | Cell Proliferation | Reactive Oxygen Species - metabolism | Cardiovascular Diseases - metabolism | Muscle, Smooth, Vascular - metabolism | Humans | Arginase - metabolism | Endothelium, Vascular - physiopathology | Homeostasis | Cardiovascular Diseases - enzymology | Endothelium, Vascular - enzymology | Muscle, Smooth, Vascular - physiopathology | Arginine - analogs & derivatives | Collagen - metabolism | Animals | Endothelium, Vascular - metabolism | Urea - metabolism | Nitric Oxide Synthase Type III - metabolism | Nitric Oxide - metabolism | Muscle, Smooth, Vascular - enzymology | Arginine - metabolism | Muscle, Smooth, Vascular, metabolism | Collagen, metabolism | Endothelium, Vascular, physiopathology | Arginine, analogs and derivatives | Nitric Oxide, metabolism | Endothelium, Vascular, metabolism | Urea, metabolism | Nitric Oxide Synthase Type III, metabolism | Arginine, metabolism | Cardiovascular Diseases, enzymology | Endothelium, Vascular, enzymology | Muscle, Smooth, Vascular, physiopathology | Cardiovascular Diseases, physiopathology | Cardiovascular Diseases, metabolism | Arginase, metabolism | Muscle, Smooth, Vascular, enzymology | Reactive Oxygen Species, metabolism | Deicing chemicals | Physiological aspects | Endothelium-derived relaxing factors | Nitric oxide
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Loading RightsNature Communications, ISSN 2041-1723, 01/2016, Volume 7, Issue 1, p. 10242
Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer's disease (AD). The molecular mechanism for this association remains...
GLUTAMATE NEUROTOXICITY | METABOLIC SYNDROME | INSULIN-DEGRADING ENZYME | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | A-BETA | COGNITIVE IMPAIRMENT | SYNAPTIC PLASTICITY | NEURODEGENERATIVE DISEASES | MITOCHONDRIAL FISSION | Dynamins - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Cerebral Cortex - pathology | Immunoblotting | Male | Metabolic Syndrome - metabolism | Reactive Nitrogen Species | Diabetes Mellitus, Type 2 - metabolism | Cerebral Cortex - cytology | Case-Control Studies | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Brain - metabolism | Nitroso Compounds - metabolism | Synapses - metabolism | Mitochondrial Proteins - metabolism | Dendritic Spines | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Adult | Female | Neurons - metabolism | Disease Models, Animal | Insulysin - metabolism | Brain - cytology | Memantine - pharmacology | Oxygen Consumption | Rats | Mice, Transgenic | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - pathology | Hippocampus - cytology | Hyperglycemia - metabolism | Hippocampus - metabolism | Insulin - metabolism | Animals | GTP Phosphohydrolases - metabolism | Alzheimer Disease - metabolism | Long-Term Potentiation | Brain - pathology | Glucose - metabolism | Aged | Mice | Nitric Oxide - metabolism | Induced Pluripotent Stem Cells
GLUTAMATE NEUROTOXICITY | METABOLIC SYNDROME | INSULIN-DEGRADING ENZYME | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | A-BETA | COGNITIVE IMPAIRMENT | SYNAPTIC PLASTICITY | NEURODEGENERATIVE DISEASES | MITOCHONDRIAL FISSION | Dynamins - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Cerebral Cortex - pathology | Immunoblotting | Male | Metabolic Syndrome - metabolism | Reactive Nitrogen Species | Diabetes Mellitus, Type 2 - metabolism | Cerebral Cortex - cytology | Case-Control Studies | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Brain - metabolism | Nitroso Compounds - metabolism | Synapses - metabolism | Mitochondrial Proteins - metabolism | Dendritic Spines | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Adult | Female | Neurons - metabolism | Disease Models, Animal | Insulysin - metabolism | Brain - cytology | Memantine - pharmacology | Oxygen Consumption | Rats | Mice, Transgenic | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - pathology | Hippocampus - cytology | Hyperglycemia - metabolism | Hippocampus - metabolism | Insulin - metabolism | Animals | GTP Phosphohydrolases - metabolism | Alzheimer Disease - metabolism | Long-Term Potentiation | Brain - pathology | Glucose - metabolism | Aged | Mice | Nitric Oxide - metabolism | Induced Pluripotent Stem Cells
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Loading RightsJournal of Clinical Investigation, ISSN 0021-9738, 12/2005, Volume 115, Issue 12, pp. 3318 - 3325
Osteoporosis is a disorder in which loss of bone strength leads to fragility fractures. This review examines the fundamental pathogenetic mechanisms underlying...
MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | OSTEOBLAST DIFFERENTIATION | BONE-MINERAL DENSITY | SERUM PARATHYROID-HORMONE | RECEPTOR-RELATED PROTEIN-5 | DOSE MICRONIZED 17-BETA-ESTRADIOL | RANDOMIZED CONTROLLED-TRIAL | VITAMIN-D STATUS | LDL-RECEPTOR-RELATED-PROTEIN-5 LRP5 GENE | POSTMENOPAUSAL WOMEN | Calcium - metabolism | Humans | Leptin - metabolism | Glycoproteins - metabolism | Fractures, Bone | NF-kappa B - metabolism | Osteoporosis, Postmenopausal - pathology | Osteoprotegerin | Osteoporosis - metabolism | Parathyroid Hormone - metabolism | Bone and Bones - metabolism | Cell Differentiation | Neurons - metabolism | Osteoblasts - cytology | Estrogens - metabolism | Osteoporosis - physiopathology | Receptors, Tumor Necrosis Factor - metabolism | Bone Density | Collagen - metabolism | Animals | Hormones - metabolism | Osteoporosis - pathology | Models, Biological | Hematopoietic Stem Cells - cytology | Ligands | Vitamin D - metabolism | Mice | Vitamin D Deficiency - metabolism | Nitric Oxide - metabolism | Bone Remodeling | Prostaglandins - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Science in Medicine
MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | OSTEOBLAST DIFFERENTIATION | BONE-MINERAL DENSITY | SERUM PARATHYROID-HORMONE | RECEPTOR-RELATED PROTEIN-5 | DOSE MICRONIZED 17-BETA-ESTRADIOL | RANDOMIZED CONTROLLED-TRIAL | VITAMIN-D STATUS | LDL-RECEPTOR-RELATED-PROTEIN-5 LRP5 GENE | POSTMENOPAUSAL WOMEN | Calcium - metabolism | Humans | Leptin - metabolism | Glycoproteins - metabolism | Fractures, Bone | NF-kappa B - metabolism | Osteoporosis, Postmenopausal - pathology | Osteoprotegerin | Osteoporosis - metabolism | Parathyroid Hormone - metabolism | Bone and Bones - metabolism | Cell Differentiation | Neurons - metabolism | Osteoblasts - cytology | Estrogens - metabolism | Osteoporosis - physiopathology | Receptors, Tumor Necrosis Factor - metabolism | Bone Density | Collagen - metabolism | Animals | Hormones - metabolism | Osteoporosis - pathology | Models, Biological | Hematopoietic Stem Cells - cytology | Ligands | Vitamin D - metabolism | Mice | Vitamin D Deficiency - metabolism | Nitric Oxide - metabolism | Bone Remodeling | Prostaglandins - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Science in Medicine
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Loading RightsBiological Chemistry, ISSN 1431-6730, 11/2010, Volume 391, Issue 11, pp. 1249 - 1264
Alcoholic liver disease (ALD) remains a major cause of morbidity and mortality worldwide. For example, the Veterans Administration Cooperative Studies reported...
alcoholic liver disease | alcohol metabolism | cytokines | inflammation | oxidative stress | RAT-LIVER | LIPID-PEROXIDATION | MESSENGER-RNA EXPRESSION | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | NECROSIS-FACTOR-ALPHA | S-ADENOSYLMETHIONINE | HEPATIC STELLATE CELLS | METHIONINE METABOLISM | Reactive Oxygen Species - metabolism | Humans | Cytochrome P-450 Enzyme System - metabolism | NF-kappa B - metabolism | Alcoholism - prevention & control | Cytochrome P-450 CYP2E1 - metabolism | Fatty Liver, Alcoholic - metabolism | Molecular Targeted Therapy | Hepatitis, Alcoholic - etiology | Superoxides - metabolism | Alcoholism - complications | Alcohol Dehydrogenase - metabolism | Hepatitis, Alcoholic - metabolism | Ethanol - metabolism | Free Radical Scavengers - metabolism | Signal Transduction | Reactive Nitrogen Species - metabolism | Liver Cirrhosis, Alcoholic - etiology | Risk Factors | Gene Expression Regulation | Rats | Alcohol Oxidoreductases - metabolism | Catalase - metabolism | Animals | Alcoholism - metabolism | Mice | Liver Cirrhosis, Alcoholic - metabolism | Nitric Oxide - metabolism | Chronic Disease | S-Adenosylmethionine - metabolism | Cellular signal transduction | Alcohol metabolism | Research
alcoholic liver disease | alcohol metabolism | cytokines | inflammation | oxidative stress | RAT-LIVER | LIPID-PEROXIDATION | MESSENGER-RNA EXPRESSION | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | NECROSIS-FACTOR-ALPHA | S-ADENOSYLMETHIONINE | HEPATIC STELLATE CELLS | METHIONINE METABOLISM | Reactive Oxygen Species - metabolism | Humans | Cytochrome P-450 Enzyme System - metabolism | NF-kappa B - metabolism | Alcoholism - prevention & control | Cytochrome P-450 CYP2E1 - metabolism | Fatty Liver, Alcoholic - metabolism | Molecular Targeted Therapy | Hepatitis, Alcoholic - etiology | Superoxides - metabolism | Alcoholism - complications | Alcohol Dehydrogenase - metabolism | Hepatitis, Alcoholic - metabolism | Ethanol - metabolism | Free Radical Scavengers - metabolism | Signal Transduction | Reactive Nitrogen Species - metabolism | Liver Cirrhosis, Alcoholic - etiology | Risk Factors | Gene Expression Regulation | Rats | Alcohol Oxidoreductases - metabolism | Catalase - metabolism | Animals | Alcoholism - metabolism | Mice | Liver Cirrhosis, Alcoholic - metabolism | Nitric Oxide - metabolism | Chronic Disease | S-Adenosylmethionine - metabolism | Cellular signal transduction | Alcohol metabolism | Research
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Loading RightsBiological Chemistry, ISSN 1431-6730, 11/2010, Volume 391, Issue 11
Abstract Alcoholic liver disease (ALD) remains a major cause of morbidity and mortality worldwide. For example, the Veterans Administration Cooperative Studies...
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Loading RightsAmerican Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2007, Volume 293, Issue 4, pp. 2210 - 2218
Targeting cannabinoid-2 (CB2) receptors with selective agonists may represent a novel therapeutic avenue in various inflammatory diseases, but the mechanisms...
Adhesion molecules | Inflammation | RhoA | Endothelial activation | C-REACTIVE PROTEIN | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MOLECULE EXPRESSION | ATHEROSCLEROSIS | NECROSIS-FACTOR-ALPHA | KNOCKOUT MICE | endothelial activation | CANNABINOID RECEPTORS | inflammation | adhesion molecules | NITRIC-OXIDE | THERAPEUTIC TARGETS | PERIPHERAL VASCULAR DISEASE | POTENTIAL ROLE | CB2 RECEPTOR ACTIVATION | Inflammation - chemically induced | Leukocyte Rolling - drug effects | Tumor Necrosis Factor-alpha - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Male | Monocytes - metabolism | NF-kappa B - metabolism | rhoA GTP-Binding Protein - metabolism | Aorta - metabolism | RNA, Messenger - metabolism | Receptor, Cannabinoid, CB2 - genetics | Coronary Vessels - metabolism | Lipopolysaccharides | Dose-Response Relationship, Drug | Inflammation - metabolism | Anti-Inflammatory Agents - therapeutic use | Chemokine CCL2 - metabolism | Disease Models, Animal | Coronary Vessels - drug effects | Anti-Inflammatory Agents - pharmacology | Endothelial Cells - metabolism | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Cannabinoids - pharmacology | Monocytes - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Intercellular Adhesion Molecule-1 - metabolism | Animals | Signal Transduction - drug effects | Inflammation - prevention & control | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Endothelial Cells - drug effects
Adhesion molecules | Inflammation | RhoA | Endothelial activation | C-REACTIVE PROTEIN | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MOLECULE EXPRESSION | ATHEROSCLEROSIS | NECROSIS-FACTOR-ALPHA | KNOCKOUT MICE | endothelial activation | CANNABINOID RECEPTORS | inflammation | adhesion molecules | NITRIC-OXIDE | THERAPEUTIC TARGETS | PERIPHERAL VASCULAR DISEASE | POTENTIAL ROLE | CB2 RECEPTOR ACTIVATION | Inflammation - chemically induced | Leukocyte Rolling - drug effects | Tumor Necrosis Factor-alpha - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Male | Monocytes - metabolism | NF-kappa B - metabolism | rhoA GTP-Binding Protein - metabolism | Aorta - metabolism | RNA, Messenger - metabolism | Receptor, Cannabinoid, CB2 - genetics | Coronary Vessels - metabolism | Lipopolysaccharides | Dose-Response Relationship, Drug | Inflammation - metabolism | Anti-Inflammatory Agents - therapeutic use | Chemokine CCL2 - metabolism | Disease Models, Animal | Coronary Vessels - drug effects | Anti-Inflammatory Agents - pharmacology | Endothelial Cells - metabolism | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Cannabinoids - pharmacology | Monocytes - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Intercellular Adhesion Molecule-1 - metabolism | Animals | Signal Transduction - drug effects | Inflammation - prevention & control | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Endothelial Cells - drug effects
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Loading RightsFASEB Journal, ISSN 0892-6638, 2005, Volume 19, Issue 13, pp. 1890 - 1892
We investigated a possible beneficial role for bilirubin, one of the products of heme degradation by the cytoprotective enzyme heme oxygenase-1 in...
nitric oxide | OXIDATIVE STRESS | SUPEROXIDE | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | BILIVERDIN | CELL BIOLOGY | SYNTHASE EXPRESSION | ANTIOXIDANT | IN-VIVO | BIOLOGY | HEME OXYGENASE-1 | oxygen free radicals | SERUM BILIRUBIN | Nitric Oxide Synthase Type II - biosynthesis | Bilirubin - metabolism | Antioxidants - metabolism | Kidney - enzymology | Malondialdehyde - chemistry | NADPH Oxidases - metabolism | Male | Aorta - metabolism | Kidney - metabolism | Time Factors | Myocardium - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-6 - metabolism | Glutathione Peroxidase - metabolism | Free Radicals | Down-Regulation | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Rats, Sprague-Dawley | Blotting, Western | Nitrates - metabolism | Macrophages - metabolism | Rats, Gunn | Models, Biological | Lipopolysaccharides - chemistry | Mice | Nitric Oxide Synthase - metabolism | Blood Pressure | Jaundice - pathology | Tumor Necrosis Factor-alpha - metabolism | Nitric Oxide Synthase Type II - chemistry | Nitrites - metabolism | Shock, Septic - prevention & control | Oxygen - metabolism | Shock, Septic - metabolism | Heme - chemistry | Escherichia coli - metabolism | Shock, Septic - drug therapy | Interleukin-10 - metabolism | Aorta - enzymology | Superoxide Dismutase - metabolism | Cell Line | Bilirubin - chemistry | Models, Statistical | Homozygote | Myocardium - enzymology | Animals | Nitric Oxide - metabolism
nitric oxide | OXIDATIVE STRESS | SUPEROXIDE | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | BILIVERDIN | CELL BIOLOGY | SYNTHASE EXPRESSION | ANTIOXIDANT | IN-VIVO | BIOLOGY | HEME OXYGENASE-1 | oxygen free radicals | SERUM BILIRUBIN | Nitric Oxide Synthase Type II - biosynthesis | Bilirubin - metabolism | Antioxidants - metabolism | Kidney - enzymology | Malondialdehyde - chemistry | NADPH Oxidases - metabolism | Male | Aorta - metabolism | Kidney - metabolism | Time Factors | Myocardium - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-6 - metabolism | Glutathione Peroxidase - metabolism | Free Radicals | Down-Regulation | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Rats, Sprague-Dawley | Blotting, Western | Nitrates - metabolism | Macrophages - metabolism | Rats, Gunn | Models, Biological | Lipopolysaccharides - chemistry | Mice | Nitric Oxide Synthase - metabolism | Blood Pressure | Jaundice - pathology | Tumor Necrosis Factor-alpha - metabolism | Nitric Oxide Synthase Type II - chemistry | Nitrites - metabolism | Shock, Septic - prevention & control | Oxygen - metabolism | Shock, Septic - metabolism | Heme - chemistry | Escherichia coli - metabolism | Shock, Septic - drug therapy | Interleukin-10 - metabolism | Aorta - enzymology | Superoxide Dismutase - metabolism | Cell Line | Bilirubin - chemistry | Models, Statistical | Homozygote | Myocardium - enzymology | Animals | Nitric Oxide - metabolism
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Loading RightsPLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0136822
Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The...
AMINO-ACID-METABOLISM | OXIDATIVE STRESS | DNA METHYLATION | LIQUID-CHROMATOGRAPHY | NITRIC-OXIDE SYNTHASE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | FOLLOW-UP | STEATOHEPATITIS | ONE-CARBON METABOLISM | MASS-SPECTROMETRY | Glycine N-Methyltransferase - metabolism | Blood Chemical Analysis | Homocysteine - metabolism | Glutathione - biosynthesis | Diet, High-Fat | Female | Metabolic Networks and Pathways - physiology | Cysteine - metabolism | Dipeptides - metabolism | Betaine-Homocysteine S-Methyltransferase - metabolism | Acyl Coenzyme A - metabolism | B-Lymphocytes - metabolism | Methionine - metabolism | Liver - metabolism | Mice, Inbred C57BL | Metabolome | Adenosylhomocysteinase - metabolism | Methionine Adenosyltransferase - metabolism | DNA Methylation - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Cystathionine beta-Synthase - metabolism | Random Allocation | Animals | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - metabolism | Mice | Fatty liver | Physiological aspects | Development and progression | Genetic aspects | Research | Homocysteine | Amino acid metabolism | Transcription factors | Adenosylmethionine | High cholesterol diet | Bcl-2 protein | Laboratories | Liver | Glycine | Caspase-3 | Proteins | Elevation | Arginine | Betaine | Rodents | DNA methylation | Deoxyribonucleic acid--DNA | Glutathione | Phosphatidylethanolamine | Liver diseases | Nutrition | 5-Methyltetrahydrofolate-homocysteine S-methyltransferase | Methionine | Glycine N-methyltransferase | c-Jun protein | Caspase | Betaine-homocysteine S-methyltransferase | Gene expression | Metabolism | Fatty acids | Lymphoma | Fatty-acid synthase | Cholesterol | Molecular chains | Substrates | Depletion | Lymphocytes B | Diet | Nitric oxide | Fibrosis | DNA methyltransferase | Methylation | Nuclear reactions | Polymethyl methacrylate | B-cell lymphoma | Deoxyribonucleic acid | DNA
AMINO-ACID-METABOLISM | OXIDATIVE STRESS | DNA METHYLATION | LIQUID-CHROMATOGRAPHY | NITRIC-OXIDE SYNTHASE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | FOLLOW-UP | STEATOHEPATITIS | ONE-CARBON METABOLISM | MASS-SPECTROMETRY | Glycine N-Methyltransferase - metabolism | Blood Chemical Analysis | Homocysteine - metabolism | Glutathione - biosynthesis | Diet, High-Fat | Female | Metabolic Networks and Pathways - physiology | Cysteine - metabolism | Dipeptides - metabolism | Betaine-Homocysteine S-Methyltransferase - metabolism | Acyl Coenzyme A - metabolism | B-Lymphocytes - metabolism | Methionine - metabolism | Liver - metabolism | Mice, Inbred C57BL | Metabolome | Adenosylhomocysteinase - metabolism | Methionine Adenosyltransferase - metabolism | DNA Methylation - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Cystathionine beta-Synthase - metabolism | Random Allocation | Animals | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - metabolism | Mice | Fatty liver | Physiological aspects | Development and progression | Genetic aspects | Research | Homocysteine | Amino acid metabolism | Transcription factors | Adenosylmethionine | High cholesterol diet | Bcl-2 protein | Laboratories | Liver | Glycine | Caspase-3 | Proteins | Elevation | Arginine | Betaine | Rodents | DNA methylation | Deoxyribonucleic acid--DNA | Glutathione | Phosphatidylethanolamine | Liver diseases | Nutrition | 5-Methyltetrahydrofolate-homocysteine S-methyltransferase | Methionine | Glycine N-methyltransferase | c-Jun protein | Caspase | Betaine-homocysteine S-methyltransferase | Gene expression | Metabolism | Fatty acids | Lymphoma | Fatty-acid synthase | Cholesterol | Molecular chains | Substrates | Depletion | Lymphocytes B | Diet | Nitric oxide | Fibrosis | DNA methyltransferase | Methylation | Nuclear reactions | Polymethyl methacrylate | B-cell lymphoma | Deoxyribonucleic acid | DNA
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