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Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
and mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate... 
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1844 - 1844
In this study, the anti-melanogenic effects of Heracleum moellendorffii Hance extract (HmHe) and the mechanisms through which it inhibits melanogenesis in... 
MITF | Heracleum moellendorffii | Melanogenesis | Melanin | Tyrosinase | ERK | MELANIN SYNTHESIS | melanin | BIOCHEMISTRY & MOLECULAR BIOLOGY | melanogenesis | tyrosinase | CHEMISTRY, MULTIDISCIPLINARY | INHIBITION | NITRIC-OXIDE | DEGRADATION | EXPRESSION | PIGMENTATION | MODULATION | EXTRACT | MELANOCYTES | Oxidoreductases - antagonists & inhibitors | Membrane Glycoproteins - metabolism | Nitriles - pharmacology | Plant Extracts - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Intramolecular Oxidoreductases - antagonists & inhibitors | Melanocytes - metabolism | Fungal Proteins - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | Indoles - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Melanocytes - cytology | Melanocytes - drug effects | Protective Agents - pharmacology | Mitogen-Activated Protein Kinase 1 - genetics | Phosphorylation - drug effects | Intramolecular Oxidoreductases - metabolism | Cell Line | Butadienes - pharmacology | Melanins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Oxidoreductases - metabolism | Signal Transduction | Oxidoreductases - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Heracleum - chemistry | Plant Extracts - isolation & purification | Protective Agents - isolation & purification | Membrane Glycoproteins - genetics | Animals | Intramolecular Oxidoreductases - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Mice | Indoles - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - genetics | Agaricales - chemistry | Fungal Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Proteins | Protein expression | Transcription factors | Phosphorylation
Journal Article
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 09/2013, Volume 59, pp. 521 - 526
In this study, the potent skin-whitening effects of Octaphlorethol A (OPA) isolated from was investigated through inhibitory effect of melanin synthesis and... 
Octaphlorethol A (OPA) | B16F10 melanoma cells | Anti-melanogenesis | MITF | ERK | APOPTOSIS | ACTIVATED PROTEIN-KINASE | TYROSINASE | FOOD SCIENCE & TECHNOLOGY | P38 MAPK | HUMAN PIGMENTATION | SIGNALING PATHWAY | TOXICOLOGY | LEUKEMIA | EXPRESSION | MELANOCYTES | Oxidoreductases - antagonists & inhibitors | Phenols - isolation & purification | Membrane Glycoproteins - metabolism | Intramolecular Oxidoreductases - antagonists & inhibitors | Melanocytes - metabolism | Neoplasm Proteins - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Neoplasm Proteins - metabolism | alpha-MSH - metabolism | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | Skin Lightening Preparations - adverse effects | Membrane Glycoproteins - antagonists & inhibitors | Melanocytes - drug effects | Phenols - antagonists & inhibitors | Intramolecular Oxidoreductases - metabolism | Phenols - pharmacology | Cell Survival - drug effects | Melanocytes - enzymology | Melanins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Pigmentation - drug effects | Oxidoreductases - metabolism | Neoplasm Proteins - biosynthesis | Skin Lightening Preparations - chemistry | Skin Lightening Preparations - pharmacology | Down-Regulation - drug effects | Drug Discovery | Phaeophyta - chemistry | alpha-MSH - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Phenols - adverse effects | Skin Lightening Preparations - isolation & purification | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2015, Volume 35, Issue 2, pp. 389 - 398
OBJECTIVE—Interaction of the activating sequence in thrombospondin-1 (TSP-1) with the conserved sequence (leucine-serine-lysine-leucine [LSKL]) in the... 
transforming growth factor-β1 | LSKL | thrombospondin-1 | angiotensin II | abdominal aortic aneurysm | LYSYL OXIDASE | TGF-BETA ACTIVITY | DOWN-REGULATION | ACCELERATES ATHEROSCLEROSIS | transforming growth factor-beta 1 | HEPATIC STELLATE CELLS | INTERFERON-GAMMA | LATENCY-ASSOCIATED PEPTIDE | MARFAN-SYNDROME | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | TRANSFORMING-GROWTH-FACTOR | HEMATOLOGY | Aortic Aneurysm, Abdominal - chemically induced | Phosphorylation | Apolipoproteins E - deficiency | Thrombospondin 1 - antagonists & inhibitors | Atherosclerosis - genetics | Male | Smad3 Protein - metabolism | Aorta - metabolism | Amino Acid Oxidoreductases - metabolism | Aortic Aneurysm, Abdominal - blood | Peptides - administration & dosage | Peptides - toxicity | Time Factors | Angiotensin II | Transforming Growth Factor beta1 - blood | Aortic Aneurysm, Abdominal - pathology | Protein-Serine-Threonine Kinases - metabolism | Cytokines - blood | Disease Models, Animal | Elastin - metabolism | Atherosclerosis - pathology | Aorta - drug effects | Atherosclerosis - chemically induced | Inflammation Mediators - blood | Injections, Intraperitoneal | Smad2 Protein - metabolism | Aortic Aneurysm, Abdominal - genetics | Disease Progression | Mice, Knockout | Aorta - pathology | Atherosclerosis - blood | Animals | Receptors, Transforming Growth Factor beta - metabolism | Apolipoproteins E - genetics | Thrombospondin 1 - metabolism
Journal Article
International Journal of Oncology, ISSN 1019-6439, 6/2016, Volume 48, Issue 6, pp. 2303 - 2309
Journal Article
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 2015, Volume 15, Issue 3, pp. 253 - 269
Natural products are compounds that are isolated from plants, provide a variety of lead structures for the development of new drugs by the pharmaceutical... 
Docking | Target | Enzyme | Natural products | Leishmania | Random Forest | enzyme | CHEMISTRY, MEDICINAL | ARGINASE | ACTIVE-SITE | N-MYRISTOYLTRANSFERASE INHIBITORS | REDETERMINATION | COMPLEXES | FLAVONOIDS | DISCOVERY | target | natural products | BINDING | SELECTIVITY | CONSTITUENTS | Acyltransferases - antagonists & inhibitors | Oxidoreductases - antagonists & inhibitors | Area Under Curve | Protozoan Proteins - antagonists & inhibitors | Humans | Arginase - metabolism | Peptidylprolyl Isomerase - antagonists & inhibitors | Biological Products - pharmacology | Acyltransferases - metabolism | Oxidoreductases Acting on CH-CH Group Donors - antagonists & inhibitors | Adenine Phosphoribosyltransferase - metabolism | Leishmania - enzymology | Protozoan Proteins - metabolism | Adenine Phosphoribosyltransferase - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Leishmania - drug effects | Peptidylprolyl Isomerase - metabolism | Arginase - antagonists & inhibitors | Binding Sites | Protein Structure, Tertiary | Enzyme Inhibitors - metabolism | Oxidoreductases - metabolism | Enzyme Inhibitors - pharmacology | Oxidoreductases Acting on CH-CH Group Donors - metabolism | Biological Products - chemistry | Biological Products - metabolism | Protein Binding | ROC Curve | Molecular Docking Simulation | Computer-Aided Design
Journal Article
Cancer Research, ISSN 0008-5472, 1997, Volume 57, Issue 6, pp. 1116 - 1123
N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo[2,3-d]pyrimidine-based... 
ACID | HUMAN DIHYDROFOLATE-REDUCTASE | DENOVO PURINE SYNTHESIS | ONCOLOGY | THYMIDYLATE SYNTHASE INHIBITOR | BIOLOGICAL-ACTIVITY | SYNTHETASE | METHOTREXATE POLYGLUTAMATES | METHYLENETETRAHYDROFOLATE DEHYDROGENASE | BREAST CANCER-CELLS | CCRF-CEM | Acyltransferases - antagonists & inhibitors | Methotrexate - pharmacology | Oxidoreductases - antagonists & inhibitors | Guanine - analogs & derivatives | Humans | Methylenetetrahydrofolate Reductase (NADPH2) | Tetrahydrofolate Dehydrogenase - drug effects | Glutamates - chemistry | Polyglutamic Acid - pharmacology | Guanine - pharmacology | Antimetabolites, Antineoplastic - pharmacology | Guanine - chemistry | Phosphoribosylglycinamide Formyltransferase | 5,10-Methylenetetrahydrofolate Reductase (FADH2) | Aminohydrolases - antagonists & inhibitors | Molecular Structure | Phosphoribosylaminoimidazolecarboxamide Formyltransferase | Methylenetetrahydrofolate Dehydrogenase (NADP) - antagonists & inhibitors | Hydroxymethyl and Formyl Transferases | Tumor Cells, Cultured - drug effects | Thiophenes - pharmacology | Multienzyme Complexes - antagonists & inhibitors | Pemetrexed | Formate-Tetrahydrofolate Ligase - antagonists & inhibitors | Glutamates - pharmacology | Tetrahydrofolates - pharmacology | Thymidylate Synthase - antagonists & inhibitors | Quinazolines - pharmacology | Folic Acid Antagonists - pharmacology
Journal Article
Mini reviews in medicinal chemistry, ISSN 1389-5575, 2003, Volume 3, Issue 2, pp. 115 - 127
Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis... 
diaminopimelate | CHEMISTRY, MEDICINAL |