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Cancer cell, ISSN 1535-6108, 01/2011, Volume 19, Issue 1, pp. 17 - 30
...). Hence, tumor-derived IDH1 and IDH2 mutations reduce α-KG and accumulate an α-KG antagonist, 2-HG, leading to genome-wide histone... 
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism | Index Medicus
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 11/2016, Volume 17, Issue 11, pp. 1844 - 1844
In this study, the anti-melanogenic effects of Heracleum moellendorffii Hance extract (HmHe) and the mechanisms through which it inhibits melanogenesis in... 
MITF | Heracleum moellendorffii | Melanogenesis | Melanin | Tyrosinase | ERK | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Oxidoreductases - antagonists & inhibitors | Membrane Glycoproteins - metabolism | Nitriles - pharmacology | Plant Extracts - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Intramolecular Oxidoreductases - antagonists & inhibitors | Melanocytes - metabolism | Fungal Proteins - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | Indoles - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Melanocytes - cytology | Melanocytes - drug effects | Protective Agents - pharmacology | Mitogen-Activated Protein Kinase 1 - genetics | Phosphorylation - drug effects | Intramolecular Oxidoreductases - metabolism | Cell Line | Butadienes - pharmacology | Melanins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Oxidoreductases - metabolism | Signal Transduction | Oxidoreductases - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Heracleum - chemistry | Plant Extracts - isolation & purification | Protective Agents - isolation & purification | Membrane Glycoproteins - genetics | Animals | Intramolecular Oxidoreductases - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Mice | Indoles - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - genetics | Agaricales - chemistry | Fungal Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Proteins | Protein expression | Transcription factors | Phosphorylation | Index Medicus | melanogenesis | tyrosinase | melanin
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 10/2017, Volume 12, Issue 10, pp. e0186450 - e0186450
Journal Article