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Biochemical Pharmacology, ISSN 0006-2952, 08/2018, Volume 154, pp. 28 - 38
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2014, Volume 462, Issue 3, pp. 475 - 487
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of... 
ATP synthase | Complex I | Biguanide | Metformin | Reactive oxygen species (ROS) | Nadh:quinone oxidoreductase | CELLS | FLAVIN | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NADH:quinone oxidoreductase | biguanide | metformin | reactive oxygen species (ROS) | RAT-LIVER MITOCHONDRIA | HEART | NADH | INHIBITION | METABOLISM | OXIDOREDUCTASE COMPLEX-I | PURIFICATION | complex I | Biguanides - pharmacology | Triazines - pharmacology | Electron Transport Complex I - antagonists & inhibitors | Metformin - therapeutic use | Biguanides - therapeutic use | Humans | Metformin - pharmacology | Rats | Plasmodium - drug effects | Mitochondria, Heart - drug effects | Electron Transport Complex I - drug effects | Mitochondrial Proton-Translocating ATPases - metabolism | Antimalarials - pharmacology | Hep G2 Cells | Mitochondria, Liver - drug effects | Oxidative Phosphorylation - drug effects | Animals | Reperfusion Injury - prevention & control | Cattle | Antineoplastic Agents - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Mitochondrial Proton-Translocating ATPases - antagonists & inhibitors | Proguanil - pharmacology | SMP, submitochondrial particle | HAR, hexaammineruthenium(III) | OCR, oxygen consumption rate | AMPK, AMP-activated protein kinase | DMEM, Dulbecco’s modified Eagle’s medium | ECAR, extracellular acidification rate | FeCN, ferricyanide | ROS, reactive oxygen species | OCT1, organic cation transporter 1
Journal Article
The Plant Cell, ISSN 1040-4651, 8/2013, Volume 25, Issue 8, pp. 2925 - 2943
Compared with small heat shock proteins (sHSPs) in other organisms, those in plants are the most abundant and diverse. However, the molecular mechanisms by... 
Proteins | Heat stress disorders | Chloroplasts | RNA | RESEARCH ARTICLES | Genes | Promoter regions | Plants | Plastids | Seedlings | Plant cells | OXIDATIVE STRESS | ENCODED RNA-POLYMERASE | QUATERNARY DYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHLOROPHYLL BIOSYNTHESIS | DISULFIDE OXIDOREDUCTASE ACTIVITIES | DNA-BINDING PROTEIN | CHAPERONE FUNCTION | PLANT SCIENCES | CELL BIOLOGY | HIGHER-PLANTS | GENE-EXPRESSION | PHOTOSYSTEM-II | Heat-Shock Response - drug effects | Sequence Deletion | Arabidopsis - physiology | Protein Disulfide-Isomerases - metabolism | Protein Transport - drug effects | Heat-Shock Response - radiation effects | Seedlings - growth & development | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Light | Plants, Genetically Modified | Protein Binding - drug effects | Chloroplasts - radiation effects | Protein Binding - radiation effects | Carrier Proteins - chemistry | Chloroplasts - drug effects | Chloroplasts - genetics | Protein Structure, Tertiary | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Subcellular Fractions - drug effects | Heat-Shock Proteins - metabolism | Seedlings - drug effects | Mutation - genetics | Subcellular Fractions - metabolism | Chloroplasts - metabolism | Heat-Shock Response - genetics | Arabidopsis - genetics | DNA, Chloroplast - metabolism | Gene Expression Regulation, Plant - drug effects | Phenotype | Carrier Proteins - metabolism | Arabidopsis Proteins - chemistry | Genes, Plant - genetics | Protein Transport - radiation effects | Subcellular Fractions - radiation effects | Zinc - pharmacology | Seedlings - radiation effects | Heat-Shock Proteins - chemistry | Seedlings - metabolism | Plant proteins | Arabidopsis thaliana | Physiological aspects | Heat shock proteins | Research | Protein-protein interactions
Journal Article
Plant Physiology, ISSN 0032-0889, 2/2014, Volume 164, Issue 2, pp. 1068 - 1076
One of the two branches of the a-linolenic acid metabolism pathway is catalyzed by 12-oxophytodienoic acid reductase I, and the other is involved in jasmonic... 
Oxidative stress | Enzymes | Genes | Plant roots | Oxides | SIGNALING AND RESPONSE | Plants | Transgenic plants | Wheat | Salinity | Seedlings | ASYMMETRIC SOMATIC HYBRIDIZATION | PLANT STRESS-RESPONSE | ARABIDOPSIS-THALIANA | 12-OXOPHYTODIENOIC ACID | OXIDATIVE STRESS | BIOSYNTHESIS | DROUGHT | TRANSDUCTION | WOUND RESPONSE | SALT TOLERANCE | PLANT SCIENCES | Arabidopsis - physiology | Genes, Plant | Triticum - physiology | Adaptation, Physiological - drug effects | Molecular Sequence Data | Seedlings - genetics | Phylogeny | Salt-Tolerance - drug effects | Arabidopsis Proteins - metabolism | Adaptation, Physiological - genetics | Plants, Genetically Modified | Salt-Tolerance - genetics | Plant Leaves - drug effects | Plant Proteins - metabolism | Triticum - enzymology | Intramolecular Oxidoreductases - metabolism | Arabidopsis - drug effects | Stress, Physiological - genetics | Hydrogen Peroxide - pharmacology | Signal Transduction - genetics | Osmosis - drug effects | Seedlings - drug effects | Arabidopsis - genetics | Triticum - genetics | Up-Regulation - drug effects | Oxylipins - metabolism | Plant Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Phenotype | Intramolecular Oxidoreductases - genetics | Signal Transduction - drug effects | Models, Biological | Cyclopentanes - metabolism | Plant Growth Regulators - pharmacology | Plant Leaves - physiology | Triticum - drug effects | Arabidopsis thaliana | Botanical research | Linolenic acids | Physiological aspects | Jasmonates
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 11/2015, Volume 289, Issue 1, pp. 40 - 47
Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds. These compounds stimulate the development of... 
Chemotherapy-associated steatohepatitis | Carnitine palmitoyltransferase-I | Mitochondrial toxicity | Drug-induced steatohepatitis | Cationic amphiphilic drugs | MITOCHONDRIAL BETA-OXIDATION | AMIODARONE | DEFICIENCY PROTECTS | FATTY-ACIDS | VALPROIC ACID | METHOTREXATE METABOLISM | LONG-CHAIN | ELECTRON-TRANSPORT CHAIN | MICROVESICULAR STEATOSIS | SERIAL LIVER BIOPSIES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Camptothecin - adverse effects | Mitochondria, Liver - pathology | Fatty Liver - pathology | Humans | Liver - metabolism | Tetracycline - adverse effects | Hepatocytes - metabolism | Fatty Liver - chemically induced | Mitochondria, Liver - drug effects | Amiodarone - adverse effects | Methotrexate - adverse effects | Animals | Liver - drug effects | Lipid Metabolism - drug effects | Tamoxifen - adverse effects | Chemical and Drug Induced Liver Injury - pathology | Valproic Acid - adverse effects | Hepatocytes - drug effects | Organoplatinum Compounds - adverse effects | Perhexiline - adverse effects | Camptothecin - analogs & derivatives | Disease Models, Animal | Enzymes | Chemotherapy | Mitochondrial DNA | Synthesis | Fatty acids | Cancer | Index Medicus | OXIDATION | TRANSCRIPTION FACTORS | CARNITINE | CITROVORUM FACTOR | MITOCHONDRIA | METHOTREXATE | PHOSPHOLIPIDS | TRIGLYCERIDES | 60 APPLIED LIFE SCIENCES | CHEMOTHERAPY | FLUOROURACILS | CARBOXYLASE | ORNITHINE | LIVER CELLS | PHOSPHOTRANSFERASES | OXIDOREDUCTASES | carnitine palmitoyltransferase-I | mitochondrial toxicity
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1449 - 1449
The C-terminal binding protein (CtBP) is a NADH-dependent transcriptional repressor that links carbohydrate metabolism to epigenetic regulation by recruiting... 
SUBTYPE | CELLS | MOLECULAR PORTRAITS | NADH CONCENTRATION | PROTEIN | COREPRESSOR CTBP | MULTIDISCIPLINARY SCIENCES | LSD1 | CO-REPRESSOR | MESENCHYMAL TRANSITION | EXPRESSION | Small Molecule Libraries - pharmacology | Epithelial Cells - metabolism | Prognosis | Caloric Restriction | Neoplastic Stem Cells - drug effects | Epithelial Cells - drug effects | Humans | Epithelial-Mesenchymal Transition - drug effects | DNA Repair - genetics | Epithelial-Mesenchymal Transition - genetics | Breast Neoplasms - metabolism | Alcohol Oxidoreductases - genetics | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | MCF-7 Cells | Neoplastic Stem Cells - metabolism | Genomic Instability - drug effects | Neoplastic Stem Cells - pathology | Female | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Breast Neoplasms - classification | Epithelium - drug effects | DNA Repair - drug effects | Epithelium - pathology | Gene Regulatory Networks - genetics | Epithelium - metabolism | Neoplasm Invasiveness | Alcohol Oxidoreductases - metabolism | Epithelial Cells - pathology | Up-Regulation - genetics | Glucose - pharmacology | DNA-Binding Proteins - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Genome, Human - genetics | Up-Regulation - drug effects | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Differentiation - drug effects | Survival Analysis | Cluster Analysis
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2006, Volume 22, Issue 2, pp. 404 - 420