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Bioorganic & medicinal chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 8, pp. 1653 - 1664
[Display omitted] Both the inhibition of inflammatory flares and the treatment of hyperuricemia itself are included in the management of gout. Extending our... 
Xanthine oxidase | NOD-like receptor 3 | Anti-hyperuricemia | Gout | Toll-like receptor 4 | Oxidases | Purines | Iron compounds | Pharmacy | Sensors | Drug therapy | Index Medicus
Journal Article
Journal of heterocyclic chemistry, ISSN 0022-152X, 02/2020, Volume 57, Issue 2, pp. 724 - 730
A series of (E)‐2‐((1H‐imidazol‐1‐yl)methyl)‐2‐((benzyloxy)methyl)‐2,3‐dihydro‐1H‐inden‐1‐one O‐benzyl oximes (6a‐j) were prepared and evaluated for their in... 
Oximes
Journal Article
Chemistry of heterocyclic compounds (New York, N.Y. 1965), ISSN 1573-8353, 03/2020, Volume 56, Issue 2, pp. 208 - 212
The reaction of α-hydroxyamino oximes with ethyl acetoacetate and ethyl α-methylacetoacetate yields 2-[2-(hydroxyimino)alkyl]-1,2-oxazol-5(2H)-ones. In the... 
Oximes
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 11798 - 11809
Journal Article
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 12/2014, Volume 281, Issue 3, pp. 254 - 265
The currently fielded pre-hospital therapeutic regimen for the treatment of organophosphorus (OP) poisoning in the United States (U.S.) is the administration... 
Oxime | Efficacy | Guinea pig | Intramuscular | Toxicity | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Atropine - therapeutic use | Cholinesterase Reactivators - administration & dosage | Cholinesterase Inhibitors - toxicity | Atropine - adverse effects | Oximes - adverse effects | Muscarinic Antagonists - adverse effects | Cholinesterase Inhibitors - chemistry | Oximes - administration & dosage | Pyridinium Compounds - administration & dosage | Pyridinium Compounds - therapeutic use | Oximes - therapeutic use | Male | Organophosphate Poisoning - drug therapy | Pyridinium Compounds - adverse effects | Antidotes - administration & dosage | Muscarinic Antagonists - therapeutic use | Chemical Warfare Agents - chemistry | Cholinesterases - blood | Organophosphate Poisoning - physiopathology | Drug Therapy, Combination - adverse effects | Injections, Subcutaneous | Cholinesterase Reactivators - adverse effects | Guinea Pigs | Drug Administration Schedule | Cholinesterase Reactivators - therapeutic use | Injections, Intramuscular | Pesticides - antagonists & inhibitors | Random Allocation | Muscarinic Antagonists - administration & dosage | Animals | Cholinesterase Inhibitors - administration & dosage | Pesticides - toxicity | Organophosphate Poisoning - blood | Antidotes - adverse effects | Atropine - administration & dosage | Chemical Warfare Agents - toxicity | Drug Monitoring | Antidotes - therapeutic use | Analysis | Enzyme inhibitors | Pesticides | Index Medicus | CHOLINESTERASE | ATROPINE | GUINEA PIGS | CHLORINE | BLOOD-BRAIN BARRIER | CENTRAL NERVOUS SYSTEM | SYMPTOMS | TOXICITY | STANDARD OF LIVING | US FDA | 60 APPLIED LIFE SCIENCES | MOLECULAR WEIGHT | PESTICIDES | LETHAL DOSES | OXIMES | THERAPY | CHEMICAL WARFARE AGENTS | POISONING | BLOOD | toxicity | intramuscular | guinea pig | oxime | efficacy
Journal Article
The New England journal of medicine, ISSN 1533-4406, 11/2017, Volume 377, Issue 19, pp. 1813 - 1823
In patients with surgically resected melanoma, those with BRAF mutations who received 1 year of oral adjuvant therapy with dabrafenib and trametinib had a 53%... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Skin Neoplasms - drug therapy | Oximes - adverse effects | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Oximes - therapeutic use | Male | Adjuvants, Immunologic - adverse effects | Young Adult | Melanoma - genetics | Skin Neoplasms - mortality | Aged, 80 and over | Adult | Female | Imidazoles - therapeutic use | Adjuvants, Immunologic - therapeutic use | Skin Neoplasms - surgery | Double-Blind Method | Imidazoles - adverse effects | Pyrimidinones - adverse effects | Pyrimidinones - therapeutic use | Neoplasm Recurrence, Local | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Adolescent | Survival Analysis | Aged | Pyridones - therapeutic use | Melanoma - surgery | Mutation | Neoplasm Staging | Pyridones - adverse effects | Melanoma - mortality | Usage | Relapse | Patient outcomes | Analysis | Melanoma | Adjuvant treatment | Outcome and process assessment (Health Care) | Reports | Drug therapy | Cancer | Diseases | Medical imaging | Oncology | Metastasis | FDA approval | Kinases | Cancer therapies | Survival | Skin cancer | Metastases | Medical prognosis | Immunotherapy | Drug dosages | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article