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1. Full Text Comparison of dabrafenib and trametinib combination therapy with vemurafenib monotherapy on health-related quality of life in patients with unresectable or metastatic cutaneous BRAF Val600-mutation-positive melanoma (COMBI-v): results of a phase 3, open-label, randomised trial
by Grob, Jean Jacques, Prof and Amonkar, Mayur M, PhD and Karaszewska, Boguslawa, MD and Schachter, Jacob, Prof and Dummer, Reinhard, Prof and Mackiewicz, Andrzej, Prof and Stroyakovskiy, Daniil, MD and Drucis, Kamil, MD and Grange, Florent, MD and Chiarion-Sileni, Vanna, MD and Rutkowski, Piotr, Prof and Lichinitser, Mikhail, Prof and Levchenko, Evgeny, MD and Wolter, Pascal, MD and Hauschild, Axel, Prof and Long, Georgina V, MD and Nathan, Paul, MD and Ribas, Antoni, Prof and Flaherty, Keith, MD and Sun, Peng, PhD and Legos, Jeffrey J, PhD and McDowell, Diane Opatt, MD and Mookerjee, Bijoyesh, MD and Schadendorf, Dirk, Prof and Robert, Caroline, MD
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 13, pp. 1389 - 1398
Summary Background In the COMBI-v trial, patients with previously untreated BRAF Val600Glu or Val600Lys mutant unresectable or metastatic melanoma who were... 
Hematology, Oncology and Palliative Medicine | SURVIVAL | EQ-5D | QUESTIONNAIRE QLQ-C30 | ONCOLOGY | SCORES | RELIABILITY | EUROPEAN-ORGANIZATION | CANCER | VALIDITY | Prospective Studies | Skin Neoplasms - drug therapy | Oximes - adverse effects | Humans | Oximes - administration & dosage | Protein Kinase Inhibitors - adverse effects | Indoles - administration & dosage | Time Factors | DNA Mutational Analysis | Imidazoles - therapeutic use | MAP Kinase Kinase Kinases - antagonists & inhibitors | Genetic Predisposition to Disease | Administration, Oral | Imidazoles - adverse effects | Pyrimidinones - adverse effects | Pyrimidinones - therapeutic use | Risk Factors | MAP Kinase Kinase Kinases - metabolism | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Phenotype | Indoles - adverse effects | Intention to Treat Analysis | Quality of Life | Indoles - therapeutic use | Biomarkers, Tumor - genetics | Pyrimidinones - administration & dosage | Mutation | Sulfonamides - administration & dosage | Melanoma - mortality | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Imidazoles - administration & dosage | Oximes - therapeutic use | Pyridones - administration & dosage | Melanoma - genetics | Skin Neoplasms - mortality | Surveys and Questionnaires | Skin Neoplasms - pathology | Drug Administration Schedule | Treatment Outcome | Melanoma - secondary | Disease-Free Survival | Sulfonamides - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Sulfonamides - adverse effects | Pyridones - therapeutic use | Pyridones - adverse effects | Care and treatment | Hospitals | Metastasis | Gene mutations | Comparative analysis
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2. Full Text Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial
by Falchook, Gerald S, Dr and Long, Georgina V, PhD and Kurzrock, Razelle, Prof and Kim, Kevin B, MD and Arkenau, Tobias H, PhD and Brown, Michael P, PhD and Hamid, Omid, MD and Infante, Jeffrey R, MD and Millward, Michael, MD and Pavlick, Anna C, MD and O’Day, Steven J, MD and Blackman, Samuel C, PhD and Curtis, C Martin, BA and Lebowitz, Peter, PhD and Ma, Bo, PhD and Ouellet, Daniele, PhD and Kefford, Richard F, Prof
Lancet, The, ISSN 0140-6736, 2012, Volume 379, Issue 9829, pp. 1893 - 1901
Summary Background Dabrafenib is an inhibitor of BRAF kinase that is selective for mutant BRAF. We aimed to assess its safety and tolerability and to establish... 
Internal Medicine | SURVIVAL | IRRADIATION | MEDICINE, GENERAL & INTERNAL | PATHWAY | RAF INHIBITOR RESISTANCE | B-RAF | MUTATIONS | CANCER | BRAF(V600E) | VEMURAFENIB | Oximes - adverse effects | Humans | Middle Aged | Carcinoma, Squamous Cell - chemically induced | Oximes - administration & dosage | Imidazoles - administration & dosage | Male | Fatigue - chemically induced | Antineoplastic Agents - administration & dosage | Fever - chemically induced | Indoles - administration & dosage | Brain Neoplasms - secondary | Neoplasms - genetics | Antineoplastic Agents - adverse effects | Melanoma - genetics | Adult | Female | Drug Administration Schedule | Imidazoles - adverse effects | Genotype | Treatment Outcome | Skin Neoplasms - chemically induced | Brain Neoplasms - drug therapy | Mutation - genetics | Melanoma - secondary | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Maximum Tolerated Dose | Indoles - adverse effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Sulfonamides - adverse effects | Sulfonamides - administration & dosage | Antimitotic agents | Complications and side effects | Melanoma | Dosage and administration | Metastasis | Antineoplastic agents | Drug therapy | Clinical trials | Medical research | Chemotherapy | Mutation | Toxicity | Tumors
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3. Full Text Comparative profile of cutaneous adverse events: BRAF/MEK inhibitor combination therapy versus BRAF monotherapy in melanoma
by Sanlorenzo, Martina, MD and Choudhry, Aditi, MD and Vujic, Igor, MD and Posch, Christian, MD and Chong, Kim, MD and Johnston, Katia, BSc and Meier, Melissa, MD and Osella-Abate, Simona, MSc and Quaglino, Pietro, MD and Daud, Adil, MD and Algazi, Alain, MD and Rappersberger, Klemens, MD and Ortiz-Urda, Susana, MD, PhD
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2014, Volume 71, Issue 6, pp. 1102 - 1109.e1
Background BRAF inhibitor (BRAFi) and MEK inhibitor (MEKi) frequently cause cutaneous adverse events. Objective We sought to investigate the cutaneous safety... 
Dermatology | cutaneous adverse event | rash | histology | inflammation | therapy | squamous cell carcinoma | squamous cell carcinoma therapy | ACTIVATION | IMPROVED SURVIVAL | OPEN-LABEL | DERMATOLOGY | METASTATIC MELANOMA | MEK INHIBITION | PATHWAY | RESISTANCE | RAF INHIBITORS | MUTATIONS | VEMURAFENIB | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Skin Neoplasms - drug therapy | Follow-Up Studies | Oximes - adverse effects | Humans | Middle Aged | Oximes - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Imidazoles - administration & dosage | Male | Protein Kinase Inhibitors - adverse effects | Indoles - administration & dosage | Young Adult | Pyridones - administration & dosage | Carcinoma, Squamous Cell - mortality | Skin Neoplasms - mortality | Aged, 80 and over | Adult | Female | Retrospective Studies | Piperidines - administration & dosage | Imidazoles - adverse effects | Pyrimidinones - adverse effects | Azetidines - adverse effects | Kaplan-Meier Estimate | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Azetidines - administration & dosage | Carcinoma, Squamous Cell - drug therapy | Indoles - adverse effects | Melanoma - drug therapy | Piperidines - adverse effects | Adolescent | Sulfonamides - adverse effects | Aged | Pyrimidinones - administration & dosage | Pyridones - adverse effects | Sulfonamides - administration & dosage | Melanoma - mortality | Complications and side effects | Medical colleges | Melanoma
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4. Full Text Selective Targeting of CTNBB1-, KRAS-or MYC-Driven Cell Growth by Combinations of Existing Drugs
by Uitdehaag, JCM and de Roos, JADM and van Doornmalen, AM and Prinsen, MBW and Spijkers-Hagelstein, JAP and de Vetter, JRF and de Man, J and Buijsman, RC and Zaman, GJR
PLOS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0125021
The aim of combination drug treatment in cancer therapy is to improve response rate and to decrease the probability of the development of drug resistance.... 
COLON-CANCER | MELANOMA | MEK INHIBITION | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | SYNTHETIC LETHAL INTERACTION | RESISTANCE | BRAF | KINASE INHIBITOR | BETA-CATENIN | EGFR | Triazoles - administration & dosage | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Oximes - administration & dosage | Imidazoles - administration & dosage | Aza Compounds - pharmacology | Cell Line, Tumor - drug effects | Indazoles - administration & dosage | Quinolines - administration & dosage | Indoles - administration & dosage | Quinolines - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pyridones - administration & dosage | Benzimidazoles - administration & dosage | Melanoma - genetics | Indoles - pharmacology | Pyrimidinones - pharmacology | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Aza Compounds - administration & dosage | Imidazoles - pharmacology | Melanoma - pathology | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Indazoles - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Triazoles - pharmacology | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Oxazoles - administration & dosage | Oximes - pharmacology | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Oxazoles - pharmacology | Proto-Oncogene Proteins c-myc - genetics | Pyrimidinones - administration & dosage | Mutation | Pyridones - pharmacology | Sulfonamides - administration & dosage | Drug therapy, Combination | Drug resistance | Drug therapy | Health aspects | Analysis | Melanoma
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5. Full Text Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study
by Long, G.V and Flaherty, K.T and Stroyakovskiy, D and Gogas, H and Levchenko, E and de Braud, F and Larkin, J and Garbe, C and Jouary, T and Hauschild, A and Chiarion-Sileni, V and Lebbe, C and Mandalà, M and Millward, M and Arance, A and Bondarenko, I and Haanen, J.B.A.G and Hansson, J and Utikal, J and Ferraresi, V and Mohr, P and Probachai, V and Schadendorf, D and Nathan, P and Robert, C and Ribas, A and Davies, M.A and Lane, S.R and Legos, J.J and Mookerjee, B and Grob, J-J
Annals of oncology : official journal of the European Society for Medical Oncology, ISSN 0923-7534, 07/2017, Volume 28, Issue 7, pp. 1631 - 1639
Background: Previous analysis of COMBI-d (NCT01584648) demonstrated improved progression-free survival (PFS) and overall survival (OS) with combination... 
trametinib | melanoma | durable outcomes | BRAF | metastatic | dabrafenib | MULTICENTER | OPEN-LABEL | COMBINATION | TRIAL | MEK INHIBITION | ONCOLOGY | DOUBLE-BLIND | POOLED ANALYSIS | NIVOLUMAB | IPILIMUMAB | VEMURAFENIB | Skin Neoplasms - drug therapy | Oximes - pharmacokinetics | Oximes - adverse effects | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Oximes - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Imidazoles - administration & dosage | Imidazoles - pharmacokinetics | Protein Kinase Inhibitors - adverse effects | Pyridones - administration & dosage | Time Factors | Melanoma - genetics | Skin Neoplasms - mortality | Protein Kinase Inhibitors - pharmacokinetics | Skin Neoplasms - pathology | Double-Blind Method | Drug Administration Schedule | Pyridones - pharmacokinetics | Imidazoles - adverse effects | Pyrimidinones - adverse effects | Risk Factors | Kaplan-Meier Estimate | Treatment Outcome | Disease Progression | Melanoma - secondary | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Pyrimidinones - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Biomarkers, Tumor - genetics | Pyrimidinones - administration & dosage | Mutation | Pyridones - adverse effects | Melanoma - mortality | Original
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6. Full Text Antimüllerian hormone levels decrease in women using combined contraception independently of administration route
by Kallio, Sanna, M.D and Puurunen, Johanna, M.D and Ruokonen, Aimo, M.D., Ph.D and Vaskivuo, Tommi, M.D., Ph.D and Piltonen, Terhi, M.D., Ph.D and Tapanainen, Juha S., M.D., Ph.D
Fertility and Sterility, ISSN 0015-0282, 2013, Volume 99, Issue 5, pp. 1305 - 1310
Objective To compare the effects of continuous use of oral (OC), transdermal, and vaginal combined contraceptives on the pituitary-ovarian axis and inhibition... 
Internal Medicine | Obstetrics and Gynecology | combined contraception | follicle development | Antimüllerian hormone | FSH | inhibin B | POLYCYSTIC-OVARY-SYNDROME | INHIBIN-B | ANTI-MULLERIAN HORMONE | HUMAN MENSTRUAL-CYCLE | OBSTETRICS & GYNECOLOGY | Antimullerian hormone | REPRODUCTIVE BIOLOGY | PILL-FREE INTERVAL | SERUM-LEVELS | FOLLICLE-STIMULATING-HORMONE | COMBINED ORAL-CONTRACEPTIVES | REPRODUCTIVE AGE | GONADOTROPIN | Norgestrel - administration & dosage | Prospective Studies | Humans | Contraceptive Devices, Female | Oximes - administration & dosage | Administration, Cutaneous | Follicle Stimulating Hormone, Human - blood | Young Adult | Desogestrel - administration & dosage | Ovarian Follicle - drug effects | Adult | Female | Norgestrel - analogs & derivatives | Ethinyl Estradiol - administration & dosage | Anti-Mullerian Hormone - blood | Contraceptives, Oral, Combined - administration & dosage | Estrogens - administration & dosage | Pituitary Gland - drug effects | Oral contraceptives | Usage | Hormones
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7. Full Text A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides
by Wilhelm, Christina M and Snider, Thomas H and Babin, Michael C and Jett, David A and Platoff, Gennady E and Yeung, David T
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2014, Volume 281, Issue 3, pp. 254 - 265
The currently fielded pre-hospital therapeutic regimen for the treatment of organophosphorus (OP) poisoning in the United States (U.S.) is the administration... 
Oxime | Efficacy | Guinea pig | Intramuscular | Toxicity | HYDROXAMIC ACIDS | PYRIDINIUM OXIMES | SOMAN | HUMAN ACETYLCHOLINESTERASE | NERVE AGENTS | TABUN | IN-VIVO REACTIVATION | CYCLOSARIN | SARIN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | BRAIN | Atropine - therapeutic use | Cholinesterase Reactivators - administration & dosage | Cholinesterase Inhibitors - toxicity | Atropine - adverse effects | Oximes - adverse effects | Muscarinic Antagonists - adverse effects | Cholinesterase Inhibitors - chemistry | Oximes - administration & dosage | Pyridinium Compounds - administration & dosage | Pyridinium Compounds - therapeutic use | Oximes - therapeutic use | Male | Organophosphate Poisoning - drug therapy | Pyridinium Compounds - adverse effects | Antidotes - administration & dosage | Muscarinic Antagonists - therapeutic use | Chemical Warfare Agents - chemistry | Cholinesterases - blood | Organophosphate Poisoning - physiopathology | Drug Therapy, Combination - adverse effects | Injections, Subcutaneous | Cholinesterase Reactivators - adverse effects | Guinea Pigs | Drug Administration Schedule | Cholinesterase Reactivators - therapeutic use | Injections, Intramuscular | Pesticides - antagonists & inhibitors | Random Allocation | Muscarinic Antagonists - administration & dosage | Animals | Cholinesterase Inhibitors - administration & dosage | Pesticides - toxicity | Organophosphate Poisoning - blood | Antidotes - adverse effects | Atropine - administration & dosage | Chemical Warfare Agents - toxicity | Drug Monitoring | Antidotes - therapeutic use | Analysis | Enzyme inhibitors | Pesticides | Index Medicus | CHOLINESTERASE | ATROPINE | GUINEA PIGS | CHLORINE | BLOOD-BRAIN BARRIER | CENTRAL NERVOUS SYSTEM | SYMPTOMS | TOXICITY | STANDARD OF LIVING | US FDA | 60 APPLIED LIFE SCIENCES | MOLECULAR WEIGHT | PESTICIDES | LETHAL DOSES | OXIMES | THERAPY | CHEMICAL WARFARE AGENTS | POISONING | BLOOD | toxicity | intramuscular | guinea pig | oxime | efficacy
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8. Full Text Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib
by Robert, Caroline and Karaszewska, Boguslawa and Schachter, Jacob and Rutkowski, Piotr and Mackiewicz, Andrzej and Stroiakovski, Daniil and Lichinitser, Michael and Dummer, Reinhard and Grange, Florent and Mortier, Laurent and Chiarion-Sileni, Vanna and Drucis, Kamil and Krajsova, Ivana and Hauschild, Axel and Lorigan, Paul and Wolter, Pascal and Long, Georgina V and Flaherty, Keith and Nathan, Paul and Ribas, Antoni and Martin, Anne-Marie and Sun, Peng and Crist, Wendy and Legos, Jeff and Rubin, Stephen D and Little, Shonda M and Schadendorf, Dirk
The New England Journal of Medicine, ISSN 0028-4793, 01/2015, Volume 372, Issue 1, pp. 30 - 39
In patients with melanomas containing activating BRAF mutations, the combination of a BRAF inhibitor and a MEK inhibitor improved overall survival, as compared... 
CRITERIA | BRAF-MUTATED MELANOMA | METASTATIC MELANOMA | RAF INHIBITION | MEDICINE, GENERAL & INTERNAL | MEK INHIBITION | ACQUIRED-RESISTANCE | V600E MUTATION | TUMORS | OVERCOME | VEMURAFENIB | Skin Neoplasms - drug therapy | Oximes - adverse effects | Humans | Middle Aged | Oximes - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Imidazoles - administration & dosage | Male | Protein Kinase Inhibitors - adverse effects | Young Adult | Pyridones - administration & dosage | Aged, 80 and over | Adult | Female | Skin Neoplasms - pathology | Imidazoles - adverse effects | Pyrimidinones - adverse effects | Kaplan-Meier Estimate | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - secondary | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Indoles - adverse effects | Sulfonamides - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Adolescent | Intention to Treat Analysis | Survival Analysis | Sulfonamides - adverse effects | Indoles - therapeutic use | Aged | Pyrimidinones - administration & dosage | Mutation | Pyridones - adverse effects | Melanoma - mortality | Patients | Health aspects | Risk factors | Melanoma | Toxicity | Medical treatment | MEK inhibitors | Antitumor activity | Metastasis | Kinases | Cancer therapies | Clinical outcomes | Metastases | Index Medicus | Abridged Index Medicus
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9. Full Text Severe gastrointestinal toxicity with administration of trametinib in combination with dabrafenib and ipilimumab
by Minor, David R and Puzanov, Igor and Callahan, Margaret K and Hug, Bruce A and Hoos, Axel
Pigment Cell & Melanoma Research, ISSN 1755-1471, 09/2015, Volume 28, Issue 5, pp. 611 - 612
SURVIVAL | CELLS | MELANOMA | MEK INHIBITION | ONCOLOGY | COMBINED BRAF | CELL BIOLOGY | DERMATOLOGY | Melanoma - complications | Immunotherapy - methods | Skin Neoplasms - drug therapy | Oximes - adverse effects | Humans | Imidazoles - adverse effects | Ipilimumab | Middle Aged | Pyrimidinones - adverse effects | Antibodies, Monoclonal - adverse effects | Colon - drug effects | Oximes - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Imidazoles - administration & dosage | Clinical Trials as Topic | Skin Neoplasms - complications | Pyridones - administration & dosage | Antibodies, Monoclonal - administration & dosage | Colitis - chemically induced | Melanoma - drug therapy | Female | Aged | Pyrimidinones - administration & dosage | Pyridones - adverse effects | Toxicity | Letter to the Editor | Letters to the Editor
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10. Full Text Management of Treatment‐Related Adverse Events with Agents Targeting the MAPK Pathway in Patients with Metastatic Melanoma
by Daud, Adil and Tsai, Katy
The Oncologist, ISSN 1083-7159, 07/2017, Volume 22, Issue 7, pp. 823 - 833
Tremendous progress has been made in the clinical landscape of advanced‐stage BRAF V600–mutant melanoma treatment over the past 5 years. Targeted therapies... 
BRAF | Mitogen‐activated protein kinase signaling system | Drug‐related side effects and adverse reactions | Protein kinase inhibitors | Melanoma | Mitogen-activated protein kinase signaling system | Drug-related side effects and adverse reactions | IMPROVED SURVIVAL | PHASE-3 | COMBINATION | COMBINED DABRAFENIB | THERAPY | MEK INHIBITION | ONCOLOGY | DOUBLE-BLIND | COBIMETINIB | BRAF-MUTANT MELANOMA | VEMURAFENIB | Oximes - adverse effects | Humans | Fever - therapy | Oximes - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Imidazoles - administration & dosage | Carbamates - administration & dosage | Protein Kinase Inhibitors - adverse effects | Fever - chemically induced | Pyridones - administration & dosage | Benzimidazoles - administration & dosage | Antineoplastic Agents - adverse effects | Benzimidazoles - adverse effects | Skin Diseases - chemically induced | Piperidines - administration & dosage | Imidazoles - adverse effects | Pyrimidinones - adverse effects | Azetidines - adverse effects | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Vemurafenib | Azetidines - administration & dosage | Indoles - adverse effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Piperidines - adverse effects | Sulfonamides - adverse effects | Carbamates - adverse effects | Pyrimidinones - administration & dosage | Pyridones - adverse effects | Sulfonamides - administration & dosage | Melanoma and Cutaneous Malignancies
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11. Full Text An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice
by Kassa, Jiri and Karasova, Jana and Musilek, Kamil and Kuca, Kamil
Toxicology, ISSN 0300-483X, 2007, Volume 243, Issue 3, pp. 311 - 316
Abstract The potency of newly developed monoxime bispyridinium compounds (K156, K203) in reactivating tabun-inhibited acetylcholinesterase and reducing... 
Emergency | Obidoxime | Tabun | K156 | K203 | Rats | Trimedoxime | Mice | HI-6 | Acetylcholinesterase | trimedoxime | ACETYLCHOLINESTERASE REACTIVATORS | EFFICACY | IN-VIVO METHODS | ANTIDOTAL TREATMENT | acetylcholinesterase | INHIBITED ACETYLCHOLINESTERASE | obidoxime | mice | NERVE AGENTS | H OXIMES | PHARMACOLOGY & PHARMACY | PRALIDOXIME | TOXICOLOGY | rats | ORGANOPHOSPHORUS COMPOUNDS | tabun | CURRENTLY AVAILABLE OXIMES | Atropine - therapeutic use | Cholinesterase Reactivators - administration & dosage | Atropine - chemistry | Seizures - prevention & control | Rats, Wistar | Species Specificity | Cholinesterase Inhibitors - chemistry | Oximes - administration & dosage | Pyridinium Compounds - administration & dosage | Pyridinium Compounds - therapeutic use | Oximes - therapeutic use | Male | Antidotes - administration & dosage | Chromatography, High Pressure Liquid | Toxicity Tests, Acute - methods | Seizures - chemically induced | Cholinesterase Inhibitors - poisoning | Molecular Structure | Obidoxime Chloride - therapeutic use | Drug Therapy, Combination | Pyridinium Compounds - chemistry | Organophosphates - administration & dosage | Antidotes - chemistry | Seizures - enzymology | Acetylcholinesterase - blood | Trimedoxime - chemistry | Cholinesterase Reactivators - therapeutic use | Obidoxime Chloride - chemistry | Injections, Intramuscular | Lethal Dose 50 | Trimedoxime - administration & dosage | Cholinesterase Reactivators - chemistry | Oximes - chemistry | Animals | Trimedoxime - therapeutic use | Cholinesterase Inhibitors - administration & dosage | Obidoxime Chloride - administration & dosage | Organophosphates - chemistry | Atropine - administration & dosage | Organophosphate Poisoning | Acetylcholinesterase - metabolism | Antidotes - therapeutic use
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