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Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, pp. 5712 - 5712
Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway... 
BRAF INHIBITION | TYROSINE KINASE AXL | RAF INHIBITION | CELLS | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | IMPROVED SURVIVAL | MEK INHIBITORS | UP-REGULATION | CONFERS RESISTANCE | Prognosis | Skin Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Melanoma - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Indoles - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Skin Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Signal Transduction | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Melanoma - pathology | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Skin Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins B-raf - genetics | Aminopyridines - pharmacology | Melanoma - drug therapy | Skin Neoplasms - genetics | Cell Line, Tumor | Oximes - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Microphthalmia-Associated Transcription Factor - genetics | Pyridones - pharmacology | Index Medicus
Journal Article
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 7/2011, Volume 384, Issue 1, pp. 47 - 57
In epilepsy, allegedly, a neurotransmitter imbalance between the inhibitory GABA and the excitatory glutamate prevails. Therefore, some antiepileptic drugs... 
Neurosciences | Veratridine | Biomedicine | Epilepsy | GABA | Neocortical synaptosomes | Pharmacology/Toxicology | Antiepileptic drugs | Potassium | ACTION-POTENTIALS | VOLTAGE-DEPENDENT LIMITATION | TEMPORAL-LOBE EPILEPSY | NEUROTRANSMITTER RELEASE | VALPROIC ACID | TRANSPORTER GAT-1 | MOUSE CENTRAL NEURONS | IN-VITRO | SODIUM VALPROATE | PHARMACOLOGY & PHARMACY | CALCIUM-CHANNEL | Synaptosomes - drug effects | Rats, Wistar | gamma-Aminobutyric Acid - metabolism | Humans | Middle Aged | Child, Preschool | Infant | Male | Pregabalin | Synaptosomes - metabolism | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Calcium - deficiency | Young Adult | Calcium - antagonists & inhibitors | Neocortex - metabolism | Neocortex - drug effects | Piracetam - pharmacology | Adult | Female | Phenytoin - pharmacology | Tetrodotoxin - pharmacology | Nipecotic Acids - pharmacology | Child | Carbamazepine - pharmacology | Triazines - pharmacology | Rats | gamma-Aminobutyric Acid - pharmacology | Tetanus Toxin - pharmacology | Potassium - pharmacology | Veratridine - pharmacology | GABA Antagonists - pharmacology | Animals | Cyclohexanecarboxylic Acids - pharmacology | Piracetam - analogs & derivatives | Adolescent | Oximes - pharmacology | Aged | gamma-Aminobutyric Acid - analogs & derivatives | Amines - pharmacology | Phenytoin - pharmacokinetics | Drugs | Brain | Anticonvulsants | Marine toxins | Neurons | Tetanus | Glutamate | Sodium channels | gamma -Aminobutyric acid | Calcium | lamotrigine | Cortex | veratridine | tetanus toxin | Antiepileptic agents | Exocytosis | Valproic acid | Etiracetam | Carbamazepine | Depolarization | Neurotransmitters | Neural networks | gabapentin | Synaptosomes | Phenytoin | Index Medicus
Journal Article
PLOS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0125021 - e0125021
The aim of combination drug treatment in cancer therapy is to improve response rate and to decrease the probability of the development of drug resistance.... 
CANCER-CELLS | COLON-CANCER | MELANOMA | MEK INHIBITION | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | SYNTHETIC LETHAL INTERACTION | RESISTANCE | BRAF | BETA-CATENIN | EGFR | Triazoles - administration & dosage | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Oximes - administration & dosage | Imidazoles - administration & dosage | Aza Compounds - pharmacology | Cell Line, Tumor - drug effects | Indazoles - administration & dosage | Quinolines - administration & dosage | Indoles - administration & dosage | Quinolines - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pyridones - administration & dosage | Benzimidazoles - administration & dosage | Melanoma - genetics | Indoles - pharmacology | Pyrimidinones - pharmacology | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Aza Compounds - administration & dosage | Imidazoles - pharmacology | Melanoma - pathology | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Indazoles - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Triazoles - pharmacology | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Oxazoles - administration & dosage | Oximes - pharmacology | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Oxazoles - pharmacology | Proto-Oncogene Proteins c-myc - genetics | Pyrimidinones - administration & dosage | Mutation | Pyridones - pharmacology | Sulfonamides - administration & dosage | Drug therapy, Combination | Drug resistance | Drug therapy | Health aspects | Analysis | Melanoma | Index Medicus
Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 06/2011, Volume 105, Issue 6, pp. 2715 - 2728
Noradrenergic (NAergic) A7 neurons that project axonal terminals to the dorsal horn of the spinal cord to modulate nociceptive signaling are suggested to... 
G protein-activated inwardrectifying K | Pain | Descending analgesic pathway | channels | Baclofen | Anisoles - pharmacology | Male | RNA, Messenger - metabolism | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | Neural Inhibition - physiology | GABA-B Receptor Agonists - pharmacology | Potassium Chloride - pharmacology | Dopamine beta-Hydroxylase - metabolism | Neurons - physiology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Organophosphorus Compounds - pharmacology | Female | Lysine - metabolism | Neurons - drug effects | Nipecotic Acids - pharmacology | Electric Stimulation - methods | Potassium Channel Blockers - pharmacology | Baclofen - pharmacology | Lysine - analogs & derivatives | Bee Venoms - pharmacology | Morpholines - pharmacology | Rats | gamma-Aminobutyric Acid - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Barium - pharmacology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Rats, Sprague-Dawley | GABA Antagonists - pharmacology | Gene Expression Regulation - drug effects | Animals | Norepinephrine - metabolism | Analysis of Variance | Oximes - pharmacology | In Vitro Techniques | Neural Inhibition - drug effects | Pons - cytology | Receptors, GABA-B - metabolism | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/2013, Volume 19, Issue 5, pp. 1225 - 1231
Journal Article
Glia, ISSN 0894-1491, 04/2012, Volume 60, Issue 4, pp. 605 - 614
Journal Article
Toxicology, ISSN 0300-483X, 09/2018, Volume 408, pp. 113 - 124
Journal Article
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 1/2019, Volume 59, Issue 1, pp. 341 - 360
Organophosphorus insecticide self-poisoning is a major global health problem, killing over 100,000 people annually. It is a complex multi-organ condition,... 
organophosphate | insecticide | highly hazardous pesticides | suicide | OXIME THERAPY | NERVE AGENT | N-ACETYLCYSTEINE | TOXICITY | BOLUS INJECTION | CARBAMATE PESTICIDE | PHARMACOLOGY & PHARMACY | AGENT-INDUCED SEIZURES | HUMAN LIVER | PRALIDOXIME | TOXICOLOGY | RESPIRATORY-FAILURE
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e69150 - e69150
O-GlcNAcylation (addition of N-acetyl-glucosamine on serine or threonine residues) is a post-translational modification that regulates stability, activity or... 
TRANSCRIPTION FACTORS | GLCNAC MODIFICATION | INSULIN-RECEPTOR | TYROSINE-PHOSPHATASE 1B | SP1 | MULTIDISCIPLINARY SCIENCES | FOXO1 INCREASES | CYCLE ARREST | C-MYC | LINKED N-ACETYLGLUCOSAMINE | GENE-TRANSCRIPTION | Insulin-Like Growth Factor I - pharmacology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Breast Neoplasms - metabolism | MCF-7 Cells | Protein Processing, Post-Translational - drug effects | Acetylglucosamine - analogs & derivatives | Estrogen Receptor alpha - metabolism | Female | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Promoter Regions, Genetic | Antineoplastic Agents, Hormonal - pharmacology | Acetylglucosamine - pharmacology | Biosynthetic Pathways | Phenylcarbamates - pharmacology | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Signal Transduction - drug effects | Tamoxifen - pharmacology | Oximes - pharmacology | Tamoxifen - analogs & derivatives | Hexosamines - biosynthesis | Selective Estrogen Receptor Modulators - pharmacology | Therapy | Phosphorylation | Glucosamine | N-Acetylglucosamine | Estrogens | Serine | Estrogen | AKT protein | mRNA | Kinases | Proteins | Cell growth | Post-translation | Inhibition | Localization | Sensitivity analysis | Cell survival | N-Acetylglucosaminidase | Threonine | Phosphatidylinositol 3,4,5-triphosphate | Mortality | Breast cancer | siRNA | Tamoxifen | Gene expression | Sensitivity | Cell death | Breast | Cancer | Apoptosis | Index Medicus | Life Sciences | Pharmacology | Pharmaceutical sciences
Journal Article
Journal Article
Journal Article