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Nature communications, ISSN 2041-1723, 12/2014, Volume 5, Issue 1, pp. 5712 - 5712
Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Prognosis | Skin Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Melanoma - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Indoles - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Skin Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Signal Transduction | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Melanoma - pathology | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Skin Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins B-raf - genetics | Aminopyridines - pharmacology | Melanoma - drug therapy | Skin Neoplasms - genetics | Cell Line, Tumor | Oximes - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Microphthalmia-Associated Transcription Factor - genetics | Pyridones - pharmacology | Index Medicus
Journal Article
Current pharmaceutical design, ISSN 1381-6128, 04/2008, Volume 14, Issue 10, pp. 1001 - 1047
Amidoximes are compounds bearing both a hydroxyimino and an amino group at the same carbon atom which makes them versatile building blocks for the synthesis of... 
Amidines | Biological activities | Prodrugs | Amidoximes | NO donors | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Antihypertensive Agents - pharmacology | Nitric Oxide Donors - chemistry | Antioxidants - chemistry | Anti-Arrhythmia Agents - pharmacology | Anti-Infective Agents - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Prodrugs - chemistry | Anti-Allergic Agents - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Platelet Aggregation Inhibitors - chemical synthesis | Anti-Allergic Agents - chemical synthesis | Anti-Infective Agents - chemistry | Anti-Allergic Agents - chemistry | Platelet Aggregation Inhibitors - pharmacology | Antineoplastic Agents - pharmacology | Nitric Oxide Donors - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Central Nervous System Agents - chemistry | Pesticides - chemical synthesis | Anti-Arrhythmia Agents - chemistry | Antihypertensive Agents - chemical synthesis | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Oximes - chemical synthesis | Antineoplastic Agents - chemistry | Anti-Infective Agents - chemical synthesis | Oximes - chemistry | Antihypertensive Agents - chemistry | Anti-Arrhythmia Agents - chemical synthesis | Central Nervous System Agents - pharmacology | Platelet Aggregation Inhibitors - chemistry | Oximes - pharmacology | Pesticides - chemistry | Prodrugs - chemical synthesis | Nitric Oxide Donors - chemical synthesis | Central Nervous System Agents - chemical synthesis | Prodrugs - pharmacology | Pesticides - pharmacology | Index Medicus
Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 06/2011, Volume 105, Issue 6, pp. 2715 - 2728
Noradrenergic (NAergic) A7 neurons that project axonal terminals to the dorsal horn of the spinal cord to modulate nociceptive signaling are suggested to... 
G protein-activated inwardrectifying K | Pain | Descending analgesic pathway | channels | Baclofen | Anisoles - pharmacology | Male | RNA, Messenger - metabolism | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | Neural Inhibition - physiology | GABA-B Receptor Agonists - pharmacology | Potassium Chloride - pharmacology | Dopamine beta-Hydroxylase - metabolism | Neurons - physiology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Organophosphorus Compounds - pharmacology | Female | Lysine - metabolism | Neurons - drug effects | Nipecotic Acids - pharmacology | Electric Stimulation - methods | Potassium Channel Blockers - pharmacology | Baclofen - pharmacology | Lysine - analogs & derivatives | Bee Venoms - pharmacology | Morpholines - pharmacology | Rats | gamma-Aminobutyric Acid - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Barium - pharmacology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Rats, Sprague-Dawley | GABA Antagonists - pharmacology | Gene Expression Regulation - drug effects | Animals | Norepinephrine - metabolism | Analysis of Variance | Oximes - pharmacology | In Vitro Techniques | Neural Inhibition - drug effects | Pons - cytology | Receptors, GABA-B - metabolism | Index Medicus
Journal Article
Journal Article
Clinical pharmacology and therapeutics, ISSN 1532-6535, 05/2007, Volume 82, Issue 1, pp. 21 - 32
The low productivity and escalating costs of drug development have been well documented over the past several years. Less than 10% of new compounds that enter... 
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Analgesics - pharmacology | Muscarinic Agonists - pharmacology | Cholesterol - blood | Humans | Glycoproteins - pharmacology | Caproates - therapeutic use | Amines - therapeutic use | Alzheimer Disease - psychology | Neutrophil Infiltration - drug effects | United States Food and Drug Administration | Glycoproteins - therapeutic use | Alzheimer Disease - drug therapy | gamma-Aminobutyric Acid - pharmacology | Stroke - drug therapy | Cognition - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Models, Biological | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Amines - pharmacology | Immunologic Factors - pharmacology | Clinical Trials as Topic - legislation & jurisprudence | Guidelines as Topic | Meta-Analysis as Topic | Clinical Trials as Topic - statistics & numerical data | United States | Caproates - pharmacology | Muscarinic Agonists - therapeutic use | Oximes - therapeutic use | Drug Approval | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Computer Simulation | Drug Design | gamma-Aminobutyric Acid - therapeutic use | Stroke - immunology | Analgesics - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Hypercholesterolemia - blood | Reproducibility of Results | Neuralgia, Postherpetic - drug therapy | Pharmacology | Models, Statistical | Animals | Anticholesteremic Agents - therapeutic use | Cyclohexanecarboxylic Acids - pharmacology | Oximes - pharmacology | Clinical Trials as Topic - methods | Pharmacokinetics | Research Design | Anticholesteremic Agents - pharmacology | Immunologic Factors - therapeutic use | Index Medicus | Abridged Index Medicus
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 02/2012, Volume 13, Issue 2, pp. 2219 - 2238
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 01/2012, Volume 55, Issue 1, pp. 153 - 168
We report the synthesis, theoretical calculations, the antioxidant, anti-inflammatory, and neuroprotective properties, and the ability to cross the blood–brain... 
Free Radical Scavengers - pharmacology | Antioxidants - chemistry | Rats, Inbred F344 | Male | Lipoxygenase Inhibitors - chemical synthesis | Neuroprotective Agents - pharmacology | Lipoxygenase Inhibitors - chemistry | Lipid Peroxidation - drug effects | Free Radical Scavengers - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Cell Survival - drug effects | Rats | Hydroxyl Radical - metabolism | Stroke - drug therapy | Oximes - chemical synthesis | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Oximes - chemistry | Nitrogen Oxides - chemical synthesis | Nitrogen Oxides - pharmacology | Nitric Oxide Donors - chemistry | Free Radical Scavengers - chemistry | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Neurons - cytology | Structure-Activity Relationship | Cerebral Cortex - cytology | Quinolines - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Necrosis | Cell Hypoxia | Superoxides - metabolism | Female | Nitric Oxide Donors - pharmacology | Neurons - drug effects | Neuroprotective Agents - chemistry | Quinolines - chemistry | Cells, Cultured | Nitrogen Oxides - chemistry | Edema - drug therapy | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Permeability | Quinolines - chemical synthesis | Neuroprotective Agents - chemical synthesis | Animals | Oximes - pharmacology | Nitric Oxide Donors - chemical synthesis | Lipoxygenase Inhibitors - pharmacology | Index Medicus
Journal Article