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Journal of Pain, ISSN 1526-5900, 2008, Volume 9, Issue 12, pp. 1144 - 1154
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2010, Volume 160, Issue 4, pp. 919 - 930
Background and purpose:  The major drug-metabolizing enzymes for the oxidation of oxycodone are CYP2D6 and CYP3A. A high interindividual variability in the... 
CYP3A | drug-drug interactions | CYP2D6 | pharmacodynamics | oxycodone | oxymorphone | experimental pain | genetic polymorphism | drug–drug interactions | Pharmacodynamics | Oxycodone | Genetic polymorphism | Experimental pain | Drug-drug interactions | Oxymorphone | MORPHINE | CONTROLLED-RELEASE OXYCODONE | P-GLYCOPROTEIN | PAIN | METABOLISM | PHARMACOKINETICS | IN-VIVO | ORAL OXYCODONE | PHARMACOLOGY & PHARMACY | CODEINE | RECEPTOR-BINDING | Cytochrome P-450 CYP2D6 Inhibitors | Humans | Middle Aged | Analgesics, Opioid - pharmacology | Male | Young Adult | Analgesics, Opioid - adverse effects | Drug Interactions | Pain Threshold - drug effects | Adult | Oxycodone - adverse effects | Metabolic Detoxication, Phase I - genetics | Oxymorphone - blood | Cytochrome P-450 CYP2D6 - genetics | Oxycodone - therapeutic use | Reflex, Pupillary - drug effects | Oxycodone - pharmacology | Double-Blind Method | Enzyme Inhibitors - pharmacology | Analgesics, Opioid - therapeutic use | Genotype | Psychomotor Performance - drug effects | Polymorphism, Genetic | Cross-Over Studies | Oxycodone - pharmacokinetics | Phenotype | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Analgesics, Opioid - pharmacokinetics | Cytochrome P-450 CYP2D6 - metabolism | Drug therapy | Enzymes | Pain | Pain perception | Ketoconazole | Toxicity | Cytochrome P450 | Gene polymorphism | Electrical stimuli | Side effects | Analgesics | Metabolites | Quinidine | Drug interaction | Oxidation | Pharmacokinetics | CYP2D6 protein | Index Medicus | Research Papers
Journal Article
Journal Article
Current Medical Research and Opinion, ISSN 0300-7995, 12/2008, Volume 24, Issue 12, pp. 3503 - 3512
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2010, Volume 160, Issue 4, pp. 907 - 918
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 1/2011, Volume 67, Issue 1, pp. 63 - 71
Journal Article
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 1/2012, Volume 68, Issue 1, pp. 55 - 64
Opioids are recommended by the World Health Organization for moderate to severe cancer pain. Oxycodone is one of the most commonly used opioids and is... 
Biomedicine | Metabolites | Oxycodone | Pharmacodynamic | Cancer pain | Pharmacology/Toxicology | CYP2D6 genotypes | Pharmacokinetic | MINI-MENTAL-STATE | ALLELES | PHARMACODYNAMICS | ULTRARAPID METABOLIZERS | CYP3A ACTIVITIES | LONG-PCR | POLYMORPHISMS | PHARMACOKINETICS | ORAL OXYCODONE | PHARMACOLOGY & PHARMACY | RAPID DETECTION | Cytochrome P-450 CYP2D6 Inhibitors | Neoplasms - metabolism | Humans | Middle Aged | Male | Morphinans - blood | Analgesics, Opioid - adverse effects | Biotransformation | Aged, 80 and over | Adult | Female | Oxycodone - adverse effects | Neoplasms - physiopathology | Oxymorphone - blood | Chronic Pain - etiology | Severity of Illness Index | Cytochrome P-450 CYP2D6 - genetics | Oxycodone - therapeutic use | Chronic Pain - drug therapy | Cross-Sectional Studies | Genetic Association Studies | Oxycodone - administration & dosage | Europe | Analgesics, Opioid - therapeutic use | Polymorphism, Genetic | Oxycodone - pharmacokinetics | Analgesics, Opioid - administration & dosage | Analgesics, Opioid - pharmacokinetics | Cytochrome P-450 CYP2D6 - metabolism | Aged | Drug Monitoring | Cohort Studies | Care and treatment | Oncology, Experimental | Cytochrome P-450 | Fatigue | Genotype | Research | Cancer patients | Pain | Central nervous system depressants | Medical genetics | Genetic aspects | Universities and colleges | Public health | Cancer | Genotype & phenotype | Pharmacology | Narcotics | Pain management | Index Medicus | Pharmacogenetics
Journal Article