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The Journal of physiology, ISSN 0022-3751, 2004, Volume 556, Issue 3, pp. 983 - 1000
Muscular adaptation to physical exercise has previously been described as a repair process following tissue damage. Recently, evidence has been published to... 
INDUCED INJURY | PHYSIOLOGY | IMMUNOREACTIVITY | ECCENTRIC EXERCISE | REGENERATION | LEUKEMIA INHIBITORY FACTOR | DENERVATED HUMAN MUSCLE | SATELLITE CELLS | STRENGTH | FACTOR-I | EXPRESSION | NEUROSCIENCES | Immunohistochemistry | Granulocytes - cytology | Cytokines - analysis | Humans | Middle Aged | DNA-Binding Proteins - analysis | Ki-67 Antigen - metabolism | Male | Muscle, Skeletal - metabolism | Proteins - analysis | Pain - metabolism | fas Receptor - metabolism | Fascia - chemistry | Oxygen Consumption - physiology | fas Receptor - analysis | Antigens, CD - metabolism | Antigens, CD - analysis | Running - physiology | C-Reactive Protein - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator | CD11b Antigen - analysis | Receptors, Cytokine - metabolism | Testosterone - blood | C-Reactive Protein - analysis | Hormones - blood | Leukocytes - chemistry | Interleukin-6 - metabolism | Lymphocytes - metabolism | CD56 Antigen - analysis | Lymphocytes - cytology | Insulin-Like Growth Factor I - analysis | Muscle, Skeletal - physiology | CD3 Complex - metabolism | Leukemia Inhibitory Factor Receptor alpha Subunit | Regression Analysis | Pain - physiopathology | Receptors, Cytokine - analysis | Adolescent | Antigens, Differentiation, Myelomonocytic - analysis | Creatine Kinase - metabolism | Transcription Factors - analysis | Leukocytes - metabolism | Insulin-Like Growth Factor I - metabolism | Receptors, OSM-LIF | Interleukin-6 - analysis | Monocytes - cytology | Receptors, Cell Surface - analysis | Monocytes - metabolism | Receptors, Aryl Hydrocarbon - analysis | DNA-Binding Proteins - metabolism | Testosterone - metabolism | Flow Cytometry | Interleukin-6 - blood | Exercise Test - methods | Muscle, Skeletal - chemistry | Fascia - metabolism | Heart Rate - physiology | Receptors, Aryl Hydrocarbon - metabolism | Adult | Female | Leukocyte Count | Leukemia Inhibitory Factor | Isometric Contraction - physiology | Cytokines - blood | Leukocytes - cytology | CD56 Antigen - metabolism | Creatine Kinase - blood | Cytokines - metabolism | Receptors, Cell Surface - metabolism | Transcription Factors - metabolism | CD3 Complex - analysis | Ki-67 Antigen - analysis | Proteins - metabolism | Hormones - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | CD11b Antigen - metabolism | Growth Substances - metabolism | Pain - diagnosis | Research Papers
Journal Article
Cell metabolism, ISSN 1550-4131, 2005, Volume 1, Issue 2, pp. 107 - 119
.... Here, we developed mice with targeted mutations in two related adipocyte FABPs, aP2 and mal1, to resolve their role in systemic lipid, glucose, and energy metabolism... 
LEPTIN | OXIDATION | TARGETED DISRUPTION | GLUCOSE | ENDOCRINOLOGY & METABOLISM | MUSCLE | MICE | TNF-ALPHA | WEIGHT | INDUCED INSULIN-RESISTANCE | APOLIPOPROTEIN-E | CELL BIOLOGY | Fatty Acid-Binding Proteins | Phosphorylation | Body Weight | Adipose Tissue - cytology | Multienzyme Complexes - metabolism | Adipocytes - cytology | Immunoblotting | RNA, Messenger - metabolism | AMP-Activated Protein Kinases | Oxygen - metabolism | Tissue Distribution | Adipose Tissue - metabolism | Time Factors | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cytokines - metabolism | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Insulin Resistance | Diabetes Mellitus - metabolism | Lipid Metabolism | Mice, Transgenic | Inflammation | Macrophages - cytology | Obesity - metabolism | Triglycerides - metabolism | Insulin - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Adipocytes - metabolism | Glucose - metabolism | Stearoyl-CoA Desaturase - metabolism | Receptor, Insulin - metabolism | Arteriosclerosis - metabolism | Mice | Mutation | Type 2 diabetes | Obesity | Glucose | Macrophages | Fatty acids | Dextrose | Glucose metabolism | Atherosclerosis | Physiological aspects | Insulin resistance | Binding proteins | Public health | Protein binding | Diabetes therapy
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 3, pp. 312 - 318
Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production. UCP1 is... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | WHITE | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT HUMANS | BROWN ADIPOSE-TISSUE | IDENTIFICATION | CELL BIOLOGY | OBESITY | GENE | INFLAMMATION | EXPRESSION | Enkephalins - metabolism | Humans | Middle Aged | Ion Channels - genetics | Male | RNA, Messenger - metabolism | Enkephalins - genetics | Mitochondrial Proteins - metabolism | Diet, High-Fat | Iodide Peroxidase - metabolism | Adipocytes, Brown - transplantation | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Oxygen Consumption | Apoptosis Regulatory Proteins - metabolism | Protein Precursors - metabolism | Mice | Iodide Peroxidase - genetics | Blood Glucose - metabolism | Integrin beta1 - genetics | Adipocytes, White - metabolism | Glucose Intolerance - metabolism | Proprotein Convertase 1 - genetics | Adipocytes, Brown - metabolism | Homeostasis | Mitochondrial Proteins - genetics | DNA-Binding Proteins - metabolism | Polymerase Chain Reaction | Apoptosis Regulatory Proteins - genetics | Adult | Female | Capillaries | Glucose Tolerance Test | Protein Precursors - genetics | Proprotein Convertase 1 - metabolism | Cell Transplantation | Adipocytes, White - transplantation | DNA-Binding Proteins - genetics | Obesity - metabolism | Integrin beta1 - metabolism | Interleukin-33 - genetics | Animals | Ion Channels - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adipocytes - metabolism | Fluorescent Antibody Technique | Interleukin-33 - metabolism | Adipocytes - transplantation | Aged | Glucose Clamp Technique | Uncoupling Protein 1 | Neovascularization, Physiologic | Adipose tissues | Physiological aspects | Genetic aspects | Research | cytokine | human adipocyte | glucose | progenitors | adipokine | capillary | adrenergic | thermogenic adipose tissue | implant
Journal Article
Nature communications, ISSN 2041-1723, 01/2016, Volume 7, Issue 1, p. 10242
Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer's disease (AD). The molecular mechanism for this association remains... 
GLUTAMATE NEUROTOXICITY | METABOLIC SYNDROME | INSULIN-DEGRADING ENZYME | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | A-BETA | COGNITIVE IMPAIRMENT | SYNAPTIC PLASTICITY | NEURODEGENERATIVE DISEASES | MITOCHONDRIAL FISSION | Dynamins - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Cerebral Cortex - pathology | Immunoblotting | Male | Metabolic Syndrome - metabolism | Reactive Nitrogen Species | Diabetes Mellitus, Type 2 - metabolism | Cerebral Cortex - cytology | Case-Control Studies | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Brain - metabolism | Nitroso Compounds - metabolism | Synapses - metabolism | Mitochondrial Proteins - metabolism | Dendritic Spines | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Adult | Female | Neurons - metabolism | Disease Models, Animal | Insulysin - metabolism | Brain - cytology | Memantine - pharmacology | Oxygen Consumption | Rats | Mice, Transgenic | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - pathology | Hippocampus - cytology | Hyperglycemia - metabolism | Hippocampus - metabolism | Insulin - metabolism | Animals | GTP Phosphohydrolases - metabolism | Alzheimer Disease - metabolism | Long-Term Potentiation | Brain - pathology | Glucose - metabolism | Aged | Mice | Nitric Oxide - metabolism | Induced Pluripotent Stem Cells
Journal Article
Journal of hepatology, ISSN 0168-8278, 2011, Volume 54, Issue 4, pp. 773 - 794
... when the administered daily dosage is higher than 50 mg or when the drug undergoes significant liver metabolism [4]. The mechanisms of DILI are not always known... 
Gastroenterology and Hepatology | Drugs | Obesity | Oxidative stress | Mitochondria | Cell death | Lipids | Hepatotoxicity | Steatosis | TRIGLYCERIDE TRANSFER PROTEIN | DNA-POLYMERASE-GAMMA | PREGNANE X-RECEPTOR | PROLIFERATOR-ACTIVATED RECEPTOR | HEPATIC CYTOCHROME-P450 2E1 | ELEMENT-BINDING PROTEINS | FATTY-ACID OXIDATION | CONSTITUTIVE ANDROSTANE RECEPTOR | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RELATED PARAMETERS | GASTROENTEROLOGY & HEPATOLOGY | Carbohydrate Metabolism - drug effects | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Leptin - metabolism | Oxidative Phosphorylation - drug effects | Adipose Tissue - metabolism | Adiponectin - metabolism | Hepatitis C - complications | Cell Death - drug effects | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Diabetes Mellitus, Type 2 - complications | Genetic Predisposition to Disease | Fatty Liver - metabolism | Oxidation-Reduction | Obesity - complications | Insulin Resistance | Mitochondrial Membrane Transport Proteins - drug effects | Chemical and Drug Induced Liver Injury - genetics | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Models, Biological | Lipid Metabolism - drug effects | Alcoholic Intoxication - complications | Genome, Mitochondrial | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Fatty Liver - etiology | Divalproex | Liver diseases | Thiols | Liver | Cytochrome P-450 | Mitochondrial DNA | Triglycerides | Stavudine | Permeability | Valproic acid | Fatty acids | Cells | Carnitine | Metabolites | Glutathione transferase | Acetaminophen | Physiological aspects | DNA polymerases | Health aspects | Zidovudine | Index Medicus | Reactive Oxygen Species | Fatty Acids | Adiponectin | Mitochondria, Liver | Life Sciences | Mitochondrial Membrane Transport Proteins | Cell Death | Diabetes Mellitus, Type 2 | Adipose Tissue | Alcoholic Intoxication | Hépatology and Gastroenterology | Oxidative Phosphorylation | Carbohydrate Metabolism | Lipid Metabolism | Drug-Induced Liver Injury | Fatty Liver | Human health and pathology | Energy Metabolism | Leptin | Hepatitis C
Journal Article
Clinical and experimental pharmacology & physiology, ISSN 1440-1681, 09/2007, Volume 34, Issue 9, pp. 906 - 911
SUMMARY • Arginase is the focal enzyme of the urea cycle hydrolysingl-arginine to urea andl-ornithine. Emerging studies have identified arginase in the... 
smooth muscle cell proliferation | arginine | nitric oxide synthase | diabetes | endothelial dysfunction | hypertension | arginase | Hypertension | Arginine | Endothelial dysfunction | Smooth muscle cell proliferation | Arginase | Nitric oxide synthase | Diabetes | PHYSIOLOGY | MEDIATED DILATION | I EXPRESSION | TRANSLATIONAL CONTROL | AMINO-ACID TRANSPORTER | INTIMAL HYPERPLASIA | SYNTHASE ACTIVITY | MOUSE MODEL | L-ARGININE TRANSPORT | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | Cardiovascular Diseases - physiopathology | Cell Proliferation | Reactive Oxygen Species - metabolism | Cardiovascular Diseases - metabolism | Muscle, Smooth, Vascular - metabolism | Humans | Arginase - metabolism | Endothelium, Vascular - physiopathology | Homeostasis | Cardiovascular Diseases - enzymology | Endothelium, Vascular - enzymology | Muscle, Smooth, Vascular - physiopathology | Arginine - analogs & derivatives | Collagen - metabolism | Animals | Endothelium, Vascular - metabolism | Urea - metabolism | Nitric Oxide Synthase Type III - metabolism | Nitric Oxide - metabolism | Muscle, Smooth, Vascular - enzymology | Arginine - metabolism | Muscle, Smooth, Vascular, metabolism | Collagen, metabolism | Endothelium, Vascular, physiopathology | Arginine, analogs and derivatives | Nitric Oxide, metabolism | Endothelium, Vascular, metabolism | Urea, metabolism | Nitric Oxide Synthase Type III, metabolism | Arginine, metabolism | Cardiovascular Diseases, enzymology | Endothelium, Vascular, enzymology | Muscle, Smooth, Vascular, physiopathology | Cardiovascular Diseases, physiopathology | Cardiovascular Diseases, metabolism | Arginase, metabolism | Muscle, Smooth, Vascular, enzymology | Reactive Oxygen Species, metabolism | Deicing chemicals | Physiological aspects | Endothelium-derived relaxing factors | Nitric oxide
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 23, pp. 5438 - 5458
Abstract Oxidative stress is a major component of harmful cascades activated in neurodegenerative disorders. We sought to elucidate possible effects of... 
Advanced Basic Science | Dentistry | Oxidative stress | Mitochondria | Caspase-dependent apoptosis | Endoplasmic reticulum | Alginate oligosaccharide | PC12 cells | LOCALIZATION | ACTIVATION | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | STABILIZATION | CHAPERONE | APOPTOSOME | CA2 | BAX | CYTOCHROME-C RELEASE | PROTEINS | MEMBRANE PERMEABILIZATION | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Calcium - metabolism | Glutathione - metabolism | Amyloid beta-Peptides - pharmacology | Oxidative Stress - physiology | Caspase 3 - metabolism | Endoplasmic Reticulum - metabolism | NF-kappa B - metabolism | Neurons - cytology | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | Oligosaccharides - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Apoptosis Inducing Factor - pharmacology | Cell Nucleus - metabolism | Endoplasmic Reticulum - drug effects | Oxidation-Reduction - drug effects | Neurons - metabolism | Phosphorylation - drug effects | Glucuronic Acid - chemistry | Neurons - drug effects | Polysaccharide-Lyases - chemistry | Apoptosis Inducing Factor - metabolism | Cell Survival - drug effects | Cytochromes c - metabolism | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Rats | Mitochondria - metabolism | Caspase 12 - metabolism | Hexuronic Acids - chemistry | Mitochondria - drug effects | HSP70 Heat-Shock Proteins - metabolism | Cell Shape - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Animals | Models, Biological | Alginates - chemistry | NF-E2-Related Factor 2 - metabolism | HSP90 Heat-Shock Proteins - metabolism | Apoptosis - physiology | Oxidative Stress - drug effects | Cell Nucleus - drug effects | Neurosciences | Nervous system diseases | Biological products | Hydrogen peroxide | Heat shock proteins | Nerve growth factor | Superoxide | Mitochondrial DNA | Biochemistry | Antioxidants | Tumor proteins | Protein kinases | Alzheimer's disease | Apoptosis | Stresses | Surgical implants | Biomedical materials | Cell death | Cascades | Blocking | Activation | Kinases
Journal Article