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01/2013
Purpose: To investigate the influence of macrolides as P-glycoprotein inhibitors on the level of intestinal absorption of digoxin. Methods: Jejunal segments of... 
P-glycoprotein | Efflux | Digoxin | Macrolides | Intestinal permeability
Web Resource
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 181, p. 111584
Developing new therapeutic strategies to overcome drug resistance of cancer cells is an ongoing endeavor. From among 2 million chemicals, we identified ethyl... 
Microtubule-targeting agents | p-glycoprotein | Acquired resistance
Journal Article
AIDS, ISSN 0269-9370, 01/2019, Volume 33, Issue 1, pp. 159 - 160
Journal Article
BLOOD, ISSN 0006-4971, 01/2011, Volume 117, Issue 4, pp. 1250 - 1259
Mucosal-associated invariant T (MAIT) cells are very abundant in humans and have antimicrobial specificity, but their functions remain unclear. MAIT cells are... 
IMMUNE-RESPONSE | ACTIVATION | INFLAMMATION | RECEPTOR | HUMAN NKR-P1A | ACCUMULATION | HEMATOLOGY | EXPRESSION | P-GLYCOPROTEIN | CUTTING EDGE | LYMPHOCYTES
Journal Article
Journal of pharmaceutical sciences, ISSN 0022-3549, 04/2019
Rifampin (RIF) has been widely used for the treatment of bacterial infections, including tuberculosis (TB). Treatment of drug-resistant TB is a global problem... 
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 04/2014, Volume 465, Issue 1-2, pp. 306 - 316
Berberine (Ber), an isoquinoline alkaloid, arouses wide interests in many researchers in recent years because of its numerous new pharmacological actions.... 
P-glycoprotein | Berberine | Solid dispersions | Phospholipid-complex | Silica | TPGS 1000
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 8, pp. 1314 - 1319
Tadalafil and sildenafil are selective inhibitors of phosphodiesterase type 5, showing marked pharmacokinetic variability in patients with pulmonary arterial... 
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 02/2019, Volume 84, Issue 3, pp. 1624 - 1629
Two unusual ring C-seco and ring D-aromatic nor-triterpenoids, ebracpenes A (1) and B (2), were obtained from Euphorbia ebracteolata roots and elucidated by... 
CHEMISTRY, ORGANIC | ROOTS | SESQUITERPENE | DITERPENOIDS | DERIVATIVES | P-GLYCOPROTEIN
Journal Article
Yaoxue Xuebao, ISSN 0513-4870, 12/2015, Volume 50, Issue 12, pp. 1603 - 1606
Journal Article
by Shi, Li
11/2013
Cystic fibrosis is caused primarily by deletion of Phe508. An exciting discovery was that CFTR’s sister protein, the P-glycoprotein (P-gp) containing the... 
P-glycoprotein | 0566 | arginine mutagenesis | chloride channel | cystic fibrosis | VX-809 | membrane protein | Biochemistry | 0307 | CFTR
Dissertation
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 08/2019, Volume 172, pp. 206 - 213
Overexpression of leucine-zipper and sterile-α motif kinase (ZAK) in heart has been closely associated with the development of hypertrophic cardiomyopathy... 
P-glycoprotein | ZAK inhibitor | HPLC-MS/MS | Pharmacokinetics | Cytochrome P450
Journal Article
Drug and Chemical Toxicology, ISSN 0148-0545, 2019, pp. 1 - 12
P-glycoprotein (P-gp) is an efflux transporter involved in drug-resistant epilepsy and some flavonoids have been targeted as effective P-gp inhibitors. Herein,... 
P-glycoprotein | pharmacokinetics | silymarin | flavonoids | Antiepileptic drugs
Journal Article
Phytomedicine, ISSN 0944-7113, 06/2019, pp. 152998 - 152998
BACKGROUNDArtemisinin was isolated and identified in 1972, which was the starting point for a new era in antimalarial drug therapy. Furthermore, numerous... 
Journal Article
Pharmacological Reports, ISSN 1734-1140, 2012, Volume 64, Issue 3, pp. 751 - 757
Background: Cannabis is the most widely used illicit drug in the world that is often used by cancer patients in combination with conventional anticancer drugs.... 
P-glycoprotein | Cannabinoids
Journal Article
Journal of Clinical Pharmacology, ISSN 0091-2700, 06/2008, Volume 48, Issue 6, pp. 662 - 670
Predicting clinically significant drug interactions during drug development is a challenge for the pharmaceutical industry and regulatory agencies. Since the... 
P-glycoprotein | Cytochrome P450 enzymes | Pharmacogenetics | Transporter proteins | Induction | Drug interactions | Inhibition | Physiological aspects | Research
Journal Article
11/2012
Several families of highly effective anticancer drugs are selectively toxic to cancer cells because they interfere with nucleic acids synthesis. Many such... 
P-glycoprotein | Mitochondria | Mitochondria Penetrating Peptides | 0572 | Drug Efflux | Doxorubicin | Topoisomerase II | Drug Resistance
Dissertation
Xenobiotica, ISSN 0049-8254, 2019, pp. 1 - 9
1. More than 30% of epilepsy patients suffer pharmacoresistance. Transport of antileptic drugs by P-glycoprotein (P-gp) and MRP2 plays an important role in... 
drug-resistant epilepsy | P-glycoprotein | Hup-A | drug transporter | cell monolayer
Journal Article
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