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Biochemical Pharmacology, ISSN 0006-2952, 2009, Volume 78, Issue 2, pp. 153 - 161
Journal Article
Journal Article
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9749, pp. 1320 - 1328
Summary Background In the PLATO trial of ticagrelor versus clopidogrel for treatment of acute coronary syndromes, ticagrelor reduced the composite outcome of... 
Internal Medicine | ALLELE | MEDICINE, GENERAL & INTERNAL | INHIBITION | ANTAGONIST | PLATELET-AGGREGATION | STENT THROMBOSIS | OF-FUNCTION POLYMORPHISM | P-GLYCOPROTEIN EXPRESSION | PRASUGREL | PHARMACOGENETICS | TREATED PATIENTS | Ticlopidine - therapeutic use | Cardiovascular Diseases - prevention & control | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Adenosine - adverse effects | Adenosine - therapeutic use | Ticlopidine - adverse effects | Female | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Cardiovascular Diseases - etiology | Pharmacogenetics | Genotype | Ticlopidine - analogs & derivatives | Randomized Controlled Trials as Topic | Acute Coronary Syndrome - drug therapy | Phenotype | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP2C19 | Adenosine - analogs & derivatives | ATP Binding Cassette Transporter, Sub-Family B | Aged | Polymorphism, Single Nucleotide | Acute Coronary Syndrome - genetics | Care and treatment | Patient outcomes | Physiological aspects | Clopidogrel | Dosage and administration | Single nucleotide polymorphisms | Health aspects | Coronary heart disease | Studies | Heart attacks | Statistical analysis | Metabolites | Genetics | Drug therapy | Gene expression | Acute coronary syndromes | Myocardial infarction | Stroke | Single-nucleotide polymorphism | Arteries | Bleeding | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal of Clinical Psychopharmacology, ISSN 0271-0749, 08/2009, Volume 29, Issue 4, pp. 319 - 326
Journal Article
Glia, ISSN 0894-1491, 08/2016, Volume 64, Issue 8, pp. 1298 - 1313
The efficacy of drugs targeting the CNS is influenced by their limited brain access, which can lead to complete pharmacoresistance. Recently a tissue‐specific... 
mutant SOD1 | endothelial cells | P‐glycoprotein | blood–brain barrier | amyotrophic lateral sclerosis | P-glycoprotein | Amyotrophic lateral sclerosis | Blood-brain barrier | Mutant SOD1 | Endothelial cells | blood-brain barrier | OXIDATIVE STRESS | MODEL | NEUROSCIENCES | SPORADIC ALS | DRUG EFFLUX TRANSPORTERS | PLURIPOTENT STEM-CELLS | IN-VITRO | MOTOR-NEURON DEGENERATION | DISEASE | MICE | EXPRESSION | Up-Regulation | Spinal Cord - metabolism | Capillaries - pathology | Coculture Techniques | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Astrocytes - pathology | NF-kappa B - metabolism | Spinal Cord - pathology | Superoxide Dismutase-1 - metabolism | Capillaries - metabolism | Disease Models, Animal | Induced Pluripotent Stem Cells - metabolism | Induced Pluripotent Stem Cells - pathology | Cell Line | Endothelial Cells - metabolism | Mice, Transgenic | RNA-Binding Protein FUS - metabolism | Blood-Brain Barrier - metabolism | Blood-Brain Barrier - pathology | Amyotrophic Lateral Sclerosis - pathology | Animals | Amyotrophic Lateral Sclerosis - metabolism | Superoxide Dismutase-1 - genetics | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Astrocytes - metabolism | Drug resistance in microorganisms | Nervous system diseases | Gene mutations | Neurons | Analysis | Superoxide | Endothelium | Glycoproteins
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2011, Volume 112, Issue 4, pp. 1076 - 1083
Euphorbia factor L1 (EFL1) belongs to diterpenoids of genus Euphorbia . In this article, its reversal activity against ABCB1‐mediated MDR in KBv200 and... 
multidrug resistance | Euphorbia factor L1 | ABCB1 | Multidrug resistance | CANCER-CELLS | APOPTOSIS | ATPASE ACTIVITY | TRANSPORTER | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | EUPHORBIA FACTOR L1 | TUMOR-CELLS | SUBFAMILY-B MEMBER-1 | P-GLYCOPROTEIN | CELL BIOLOGY | IN-VITRO | MULTIDRUG RESISTANCE | BINDING | Plant Extracts - chemistry | Antibiotics, Antineoplastic - pharmacology | Hydrolysis - drug effects | Plant Extracts - pharmacology | Drug Resistance, Multiple - drug effects | Humans | Phenylpropionates - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Dose-Response Relationship, Drug | Euphorbia - chemistry | Plant Extracts - metabolism | Flow Cytometry | Adenosine Triphosphate - metabolism | Doxorubicin - metabolism | Molecular Structure | Diterpenes - metabolism | Antibiotics, Antineoplastic - pharmacokinetics | Diterpenes - chemistry | Rhodamine 123 - pharmacokinetics | Diterpenes - pharmacology | Cell Survival - drug effects | Down-Regulation | Adenosine Triphosphatases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Doxorubicin - pharmacokinetics | Phenylpropionates - pharmacology | Rhodamine 123 - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Antibiotics, Antineoplastic - metabolism | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 10/2019, Volume 120, Issue 10, pp. 18406 - 18414
Journal Article
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9749, pp. 1312 - 1319
Summary Background Clopidogrel and prasugrel are subject to efflux via P-glycoprotein (encoded by ABCB1 , also known as MDR1 ). ABCB1 polymorphisms,... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | HEALTHY JAPANESE SUBJECTS | RESPONSIVENESS | STENT THROMBOSIS | DUODENAL ENTEROCYTES | OF-FUNCTION POLYMORPHISM | PLATELET INHIBITION | MDR1 GENE | EXPRESSION | P-GLYCOPROTEIN | Prasugrel Hydrochloride | Thiophenes - therapeutic use | Thiophenes - adverse effects | Ticlopidine - therapeutic use | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Angioplasty, Balloon, Coronary | Genetic Variation | Ticlopidine - adverse effects | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Cardiovascular Diseases - etiology | Pharmacogenetics | Genotype | Piperazines - therapeutic use | Piperazines - adverse effects | Ticlopidine - analogs & derivatives | Randomized Controlled Trials as Topic | Acute Coronary Syndrome - drug therapy | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP2C19 | ATP Binding Cassette Transporter, Sub-Family B | Polymorphism, Single Nucleotide | Acute Coronary Syndrome - genetics | Physiological aspects | Clopidogrel | Dosage and administration | Cardiovascular diseases | Drug therapy | Patient outcomes | Studies | Fees & charges | Heart attacks | Stock options | Acute coronary syndromes | Mass spectrometry | Drugs | Pharmacodynamics | Clinical trials | P-Glycoprotein | Pharmacokinetics
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2015, Volume 137, Issue 8, pp. 2007 - 2018
Journal Article