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1. Full Text Inhibition of ABCB1 and ABCG2 at the Mouse Blood–Brain Barrier with Marketed Drugs To Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [11C]erlotinib
by Traxl, Alexander and Mairinger, Severin and Filip, Thomas and Sauberer, Michael and Stanek, Johann and Poschner, Stefan and Jäger, Walter and Zoufal, Viktoria and Novarino, Gaia and Tournier, Nicolas and Bauer, Martin and Wanek, Thomas and Langer, Oliver
Molecular pharmaceutics, ISSN 1543-8384, 03/2019, Volume 16, Issue 3, pp. 1282 - 1293
blood-brain barrier | P-glycoprotein | tyrosine kinase inhibitors | breast cancer resistance protein | C]erlotinib | [ | positron emission tomography | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Capillary Permeability - physiology | Quinolines - blood | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Cyclosporine - pharmacology | Quinolines - administration & dosage | Quinolines - pharmacology | Brain - metabolism | Cyclosporine - blood | Tissue Distribution | Radiopharmaceuticals - metabolism | Drug Interactions | Female | Models, Animal | ATP Binding Cassette Transporter, Subfamily G, Member 2 - antagonists & inhibitors | Cyclosporine - metabolism | Radiopharmaceuticals - pharmacology | Erlotinib Hydrochloride - administration & dosage | Solubility | Positron-Emission Tomography - methods | Protein Kinase Inhibitors - blood | Blood-Brain Barrier - metabolism | Erlotinib Hydrochloride - blood | Radiopharmaceuticals - blood | Quinolines - metabolism | Radiopharmaceuticals - administration & dosage | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Protein Kinase Inhibitors - administration & dosage | Animals | Erlotinib Hydrochloride - pharmacology | Cyclosporine - administration & dosage | Erlotinib Hydrochloride - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Protein Kinase Inhibitors - metabolism | Index Medicus
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2. Full Text Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial
by Wallentin, Lars, Prof and James, Stefan, MD and Storey, Robert F, MD and Armstrong, Martin, PhD and Barratt, Bryan J, PhD and Horrow, Jay, MD and Husted, Steen, MD and Katus, Hugo, Prof and Steg, P Gabriel, Prof and Shah, Svati H, MD and Becker, Richard C, Prof and for the PLATO investigators and PLATO Investigators and PLATO investigators
The Lancet (British edition), ISSN 0140-6736, 2010, Volume 376, Issue 9749, pp. 1320 - 1328
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Cardiology. Vascular system | Heart | General aspects | Biological and medical sciences | Myocarditis. Cardiomyopathies | Medical sciences | Coronary heart disease | Ticlopidine - therapeutic use | Cardiovascular Diseases - prevention & control | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Adenosine - adverse effects | Adenosine - therapeutic use | Ticlopidine - adverse effects | Female | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Cardiovascular Diseases - etiology | Pharmacogenetics | Genotype | Ticlopidine - analogs & derivatives | Randomized Controlled Trials as Topic | Acute Coronary Syndrome - drug therapy | Phenotype | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP2C19 | Adenosine - analogs & derivatives | ATP Binding Cassette Transporter, Sub-Family B | Aged | Polymorphism, Single Nucleotide | Acute Coronary Syndrome - genetics | Care and treatment | Patient outcomes | Physiological aspects | Clopidogrel | Dosage and administration | Single nucleotide polymorphisms | Health aspects | Studies | Heart attacks | Statistical analysis | Metabolites | Genetics | Drug therapy | Gene expression | Acute coronary syndromes | Myocardial infarction | Stroke | Single-nucleotide polymorphism | Arteries | Bleeding | Index Medicus | Abridged Index Medicus
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3. Full Text Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON–TIMI 38 trial: a pharmacogenetic analysis
by Mega, Jessica L, Dr and Close, Sandra L, PhD and Wiviott, Stephen D, MD and Shen, Lei, PhD and Walker, Joseph R, PharmD and Simon, Tabassome, Prof and Antman, Elliott M, Prof and Braunwald, Eugene, Prof and Sabatine, Marc S, Dr
The Lancet (British edition), ISSN 0140-6736, 2010, Volume 376, Issue 9749, pp. 1312 - 1319
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Prasugrel Hydrochloride | Thiophenes - therapeutic use | Thiophenes - adverse effects | Ticlopidine - therapeutic use | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Angioplasty, Balloon, Coronary | Genetic Variation | Ticlopidine - adverse effects | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Cardiovascular Diseases - etiology | Pharmacogenetics | Genotype | Piperazines - therapeutic use | Piperazines - adverse effects | Ticlopidine - analogs & derivatives | Randomized Controlled Trials as Topic | Acute Coronary Syndrome - drug therapy | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP2C19 | ATP Binding Cassette Transporter, Sub-Family B | Polymorphism, Single Nucleotide | Acute Coronary Syndrome - genetics | Physiological aspects | Clopidogrel | Dosage and administration | Cardiovascular diseases | Drug therapy | Patient outcomes | Studies | Fees & charges | Heart attacks | Stock options | Acute coronary syndromes | Mass spectrometry | Drugs | Pharmacodynamics | Clinical trials | P-Glycoprotein | Pharmacokinetics | Index Medicus | Abridged Index Medicus
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4. Full Text Estimation of ABCB1 concentration in plasma membrane
by Mlejnek, Petr and Kosztyu, Petr and Dolezel, Petr and Kimura, Yasuhisa and Cizkova, Katerina and Ruzickova, Eliska
Journal of cellular biochemistry, ISSN 0730-2312, 10/2019, Volume 120, Issue 10, pp. 18406 - 18414
ABCB1 plasma membrane concentration | ABC transporters | P‐glycoprotein | drug resistance | K562 cells | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Immunohistochemistry | Cell membranes | Drug resistance | Analysis | Leukemia | Plasma | Membranes | Level (quantity) | RNA-mediated interference | Lipids | Immunoblotting | Gene expression | Substrates | Lysates | Plasma membranes | Transporter | Quantitative analysis | Index Medicus
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5. Full Text P-glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF-β signaling pathway inhibitor galunisertib
by Li, Wenlong and Tibben, Matthijs and Wang, Yaogeng and Lebre, Maria C and Rosing, Hilde and Beijnen, Jos H and Schinkel, Alfred H
International journal of cancer, ISSN 0020-7136, 2020, Volume 146, Issue 6, pp. 1631 - 1642
P-glycoprotein | brain accumulation | Oatp1a/1b | intestinal disposition | cytochrome P450-3A | oral availability | galunisertib | P‐glycoprotein | cytochrome P450‐3A | Life Sciences & Biomedicine | Oncology | Science & Technology | Quinolines - blood | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Quinolines - pharmacology | Brain - metabolism | Quinolines - pharmacokinetics | Tissue Distribution | Pyrazoles - blood | Madin Darby Canine Kidney Cells | Female | Pyrazoles - pharmacokinetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 - antagonists & inhibitors | Pyrazoles - pharmacology | Tetrahydroisoquinolines - pharmacology | ATP Binding Cassette Transporter, Subfamily B - metabolism | Brain - drug effects | Animals | Signal Transduction - drug effects | ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors | Cytochrome P-450 CYP3A - metabolism | Acridines - pharmacology | Herb-Drug Interactions | Dogs | Mice | Transforming Growth Factor beta - metabolism | Brain | Efflux | Animal models | Toxicity | Transforming growth factor-b | Glioblastoma | Oral administration | Clinical trials | Hepatocellular carcinoma | Pharmacology | Breast cancer | Glycoproteins | Accumulation | MDR1 protein | Signal transduction | Inhibitors | Intestine | Pharmacokinetics | Growth factors | Genetic modification | Acute toxicity | Index Medicus
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6. Full Text Concise Review: Clinical Relevance of Drug–Drug and Herb–Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P‐glycoprotein)
by Marchetti, Serena and Mazzanti, Roberto and Beijnen, Jos H and Schellens, Jan H. M
The oncologist (Dayton, Ohio), ISSN 1083-7159, 08/2007, Volume 12, Issue 8, pp. 927 - 941
Complementary and alternative medicine | P‐glycoprotein | Drug interaction | Pharmacokinetics Pharmacodynamics | CAM | P-glycoprotein | Pharmacodynamics | Pharmacokinetics | Life Sciences & Biomedicine | Oncology | Science & Technology | Drug Interactions | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Herb-Drug Interactions | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | ATP Binding Cassette Transporter, Sub-Family B | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Index Medicus
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7. Full Text Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P‐Glycoprotein) in endothelial cells of the blood–brain barrier in mutant superoxide dismutase 1‐linked amyotrophic lateral sclerosis
by Qosa, Hisham and Lichter, Jessica and Sarlo, Mark and Markandaiah, Shashirekha S and McAvoy, Kevin and Richard, Jean‐Philippe and Jablonski, Michael R and Maragakis, Nicholas J and Pasinelli, Piera and Trotti, Davide
Glia, ISSN 0894-1491, 08/2016, Volume 64, Issue 8, pp. 1298 - 1313
mutant SOD1 | endothelial cells | P‐glycoprotein | blood–brain barrier | amyotrophic lateral sclerosis | P-glycoprotein | Amyotrophic lateral sclerosis | Blood-brain barrier | Mutant SOD1 | Endothelial cells | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Up-Regulation | Spinal Cord - metabolism | Capillaries - pathology | Coculture Techniques | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Astrocytes - pathology | NF-kappa B - metabolism | Spinal Cord - pathology | Superoxide Dismutase-1 - metabolism | Capillaries - metabolism | Disease Models, Animal | Induced Pluripotent Stem Cells - metabolism | Induced Pluripotent Stem Cells - pathology | Cell Line | Endothelial Cells - metabolism | Mice, Transgenic | RNA-Binding Protein FUS - metabolism | Blood-Brain Barrier - metabolism | Blood-Brain Barrier - pathology | Amyotrophic Lateral Sclerosis - pathology | Animals | Amyotrophic Lateral Sclerosis - metabolism | Superoxide Dismutase-1 - genetics | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Astrocytes - metabolism | Drug resistance in microorganisms | Nervous system diseases | Gene mutations | Neurons | Analysis | Superoxide | Endothelium | Glycoproteins | Index Medicus | blood-brain barrier
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