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1. Full Text Inhibition of ABCB1 and ABCG2 at the Mouse Blood-Brain Barrier with Marketed Drugs to Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [ 11 C]erlotinib
by Traxl, Alexander and Mairinger, Severin and Filip, Thomas and Sauberer, Michael and Stanek, Johann and Poschner, Stefan and Jäger, Walter and Zoufal, Viktoria and Novarino, Gaia and Tournier, Nicolas and Bauer, Martin and Wanek, Thomas and Langer, Oliver
Molecular Pharmaceutics, ISSN 1543-8384, 03/2019, Volume 16, Issue 3, pp. 1282 - 1293
P-Glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters at the blood brain barrier (BBB), which effectively restrict... 
blood-brain barrier | P-glycoprotein | tyrosine kinase inhibitors | positron emission tomography | breast cancer resistance protein | C]erlotinib | MEDICINE, RESEARCH & EXPERIMENTAL | [C-11]erlotinib | PENETRATION | SUBFAMILY-B MEMBER-1 | IN-VITRO | EFFLUX | TRANSPORT ACTIVITY | PHARMACOLOGY & PHARMACY | REVERSES MULTIDRUG-RESISTANCE | PET | ERLOTINIB | CANCER RESISTANCE PROTEIN
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2. Full Text Nilotinib (AMN107, Tasigna ®) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters
by Tiwari, Amit K and Sodani, Kamlesh and Wang, Si-Rong and Kuang, Ye-Hong and Ashby, Charles R and Chen, Zhe-Sheng and Chen, Xiang
Biochemical Pharmacology, ISSN 0006-2952, 2009, Volume 78, Issue 2, pp. 153 - 161
Nilotinib, a BCR-Abl tyrosine kinase inhibitor (TKI), was developed to surmount resistance or intolerance to imatinib in patients with Philadelphia positive... 
Nilotinib | ABCB1 | Tyrosine kinase inhibitor | Multidrug resistance | BCR-Abl | ABC transporters | ABCG2 | DRUG-RESISTANCE | SUBFAMILY-B MEMBER-1 | P-GLYCOPROTEIN | TYROSINE KINASE INHIBITORS | BREAST-CANCER | HIGH-AFFINITY INTERACTION | IN-VITRO | ABCG2 BCRP | PHARMACOLOGY & PHARMACY | IMATINIB MESYLATE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Cell Line | Cell Survival - drug effects | Drug Resistance, Multiple - drug effects | Humans | KB Cells | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Neoplasm Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | ATP-Binding Cassette Transporters - metabolism | ATP Binding Cassette Transporter, Sub-Family B | Drug Resistance, Multiple - physiology | Drug Resistance, Neoplasm - physiology | Cell Survival - physiology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Tyrosine | Drug resistance in microorganisms | Hormones, Sex | Epidermal growth factor | Antineoplastic antibiotics
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3. Full Text Genetic association of NOS1 exon18, NOS1 exon29, ABCB1 1236C/T, and ABCB1 3435C/T polymorphisms with the risk of Parkinson's disease: A meta-analysis
by Huang, Hongbin and Peng, Cong and Liu, Yong and Liu, Xu and Chen, Qicong and Huang, Zunnan
Medicine (United States), ISSN 0025-7974, 2016, Volume 95, Issue 40, p. e4982
Background:Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Previous publications have investigated the association of NOS1 and... 
ABCB1 | Parkinson's disease | NOS1 | Statistically significant correction | Meta-analysis | Polymorphism | TRANSPORTER | meta-analysis | polymorphism | ALPHA-SYNUCLEIN | INOS | BLOOD-BRAIN-BARRIER | P-GLYCOPROTEIN | ENVIRONMENTAL-FACTORS | MEDICINE, GENERAL & INTERNAL | MDR1 | statistically significant correction | NITRIC-OXIDE SYNTHASES | EXPRESSION | EXPOSURE | Asian Continental Ancestry Group | Genetic Predisposition to Disease | Humans | Alleles | European Continental Ancestry Group | Nitric Oxide Synthase Type I - genetics | Parkinson Disease - genetics | ATP Binding Cassette Transporter, Sub-Family B - genetics | Polymorphism, Genetic | Complications and side effects | Usage | Genetic polymorphisms | Risk factors
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4. Full Text Jatrophane diterpenes and cancer multidrug resistance – ABCB1 efflux modulation and selective cell death induction
by Reis, Mariana Alves and Ahmed, Omar Bauomy and Spengler, Gabriella and Molnár, Joseph and Lage, Hermann and Ferreira, Maria-José U
Phytomedicine, ISSN 0944-7113, 08/2016, Volume 23, Issue 9, pp. 968 - 978
Modulation of P-glycoprotein (ABCB1) and evaluation of the collateral sensitivity effect are among the most promising approaches to overcome multidrug... 
12,17-cyclojatrophane | Collateral sensitivity | Jatrophane | ABCB1 | Multidrug resistance | Apoptosis | CHEMISTRY, MEDICINAL | MACROCYCLIC DITERPENES | EUPHORBIA | P-GLYCOPROTEIN | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | BIOLOGICAL-ACTIVITY | PHARMACOLOGY & PHARMACY | AGENTS | COLON ADENOCARCINOMA | Diterpenes - pharmacology | Drug Resistance, Multiple - genetics | Apoptosis - drug effects | Humans | Molecular Conformation | Antineoplastic Agents, Phytogenic - chemistry | Structure-Activity Relationship | Drug Resistance, Neoplasm - genetics | Euphorbia - chemistry | Animals | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Cell Death - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | ATP Binding Cassette Transporter, Sub-Family B - drug effects | Diterpenes - chemistry | Diterpenes | Research | Drug resistance | Health aspects | Oncology, Experimental | Cancer
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5. Full Text Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial
by Wallentin, Lars, Prof and James, Stefan, MD and Storey, Robert F, MD and Armstrong, Martin, PhD and Barratt, Bryan J, PhD and Horrow, Jay, MD and Husted, Steen, MD and Katus, Hugo, Prof and Steg, P Gabriel, Prof and Shah, Svati H, MD and Becker, Richard C, Prof and PLATO Investigators and PLATO investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Uppsala kliniska forskningscentrum (UCR)
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9749, pp. 1320 - 1328
Summary Background In the PLATO trial of ticagrelor versus clopidogrel for treatment of acute coronary syndromes, ticagrelor reduced the composite outcome of... 
Internal Medicine | ALLELE | MEDICINE, GENERAL & INTERNAL | INHIBITION | ANTAGONIST | PLATELET-AGGREGATION | STENT THROMBOSIS | OF-FUNCTION POLYMORPHISM | P-GLYCOPROTEIN EXPRESSION | PRASUGREL | PHARMACOGENETICS | TREATED PATIENTS | Ticlopidine - therapeutic use | Cardiovascular Diseases - prevention & control | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Adenosine - adverse effects | Adenosine - therapeutic use | Ticlopidine - adverse effects | Female | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Cardiovascular Diseases - etiology | Pharmacogenetics | Genotype | Ticlopidine - analogs & derivatives | Randomized Controlled Trials as Topic | Acute Coronary Syndrome - drug therapy | Phenotype | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP2C19 | Adenosine - analogs & derivatives | ATP Binding Cassette Transporter, Sub-Family B | Aged | Polymorphism, Single Nucleotide | Acute Coronary Syndrome - genetics | Care and treatment | Patient outcomes | Physiological aspects | Clopidogrel | Dosage and administration | Single nucleotide polymorphisms | Health aspects | Coronary heart disease | Studies | Heart attacks | Statistical analysis | Metabolites | Genetics | Drug therapy | Gene expression | Acute coronary syndromes | Myocardial infarction | Stroke | Single-nucleotide polymorphism | Arteries | Bleeding | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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6. Full Text ABCB1 and cytochrome P450 polymorphisms: Clinical pharmacogenetics of clozapine
by Jaquenoud Sirot, Eveline and Knezevic, Branka and Morena, Gina Perla and Harenberg, Sabine and Oneda, Beatrice and Crettol, Séverine and Ansermot, Nicolas and Baumann, Pierre and Eap, Chin B
Journal of Clinical Psychopharmacology, ISSN 0271-0749, 08/2009, Volume 29, Issue 4, pp. 319 - 326
To examine the genetic factors influencing clozapine kinetics in vivo, 75 patients treated with clozapine were genotyped for CYPs and ABCB1 polymorphisms and... 
ABCB1 | Clozapine | CYP2C19 | CYP3A4 | CYP1A2 | Plasma concentration | CAFFEINE TEST | SMOKING-CESSATION | SCHIZOPHRENIC-PATIENTS | CYP1A2 ACTIVITY | GENETIC POLYMORPHISMS | PSYCHIATRY | plasma concentration | MASS-SPECTROMETRY | P-GLYCOPROTEIN | MAJOR METABOLITES | PLASMA-CONCENTRATIONS | clozapine | PHARMACOLOGY & PHARMACY | DOSE REQUIREMENT | Cytochrome P-450 Enzyme Inhibitors | Antipsychotic Agents - blood | Cytochrome P-450 CYP3A | Clozapine - administration & dosage | Humans | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Substrate Specificity | Male | Enzyme Inhibitors - administration & dosage | Young Adult | Fluvoxamine - administration & dosage | Cytochrome P-450 CYP1A2 - genetics | Aged, 80 and over | Adult | Female | Clozapine - blood | Clozapine - pharmacokinetics | Caffeine - metabolism | Genotype | Antipsychotic Agents - pharmacokinetics | Clozapine - analogs & derivatives | Switzerland | Polymorphism, Genetic | Antipsychotic Agents - administration & dosage | Phenotype | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP2C19 | Cytochrome P-450 Enzyme System - genetics | Midazolam - metabolism | ATP Binding Cassette Transporter, Sub-Family B | Aged
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7. Full Text Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P‐Glycoprotein) in endothelial cells of the blood–brain barrier in mutant superoxide dismutase 1‐linked amyotrophic lateral sclerosis
by Qosa, Hisham and Lichter, Jessica and Sarlo, Mark and Markandaiah, Shashirekha S and McAvoy, Kevin and Richard, Jean‐Philippe and Jablonski, Michael R and Maragakis, Nicholas J and Pasinelli, Piera and Trotti, Davide
Glia, ISSN 0894-1491, 08/2016, Volume 64, Issue 8, pp. 1298 - 1313
The efficacy of drugs targeting the CNS is influenced by their limited brain access, which can lead to complete pharmacoresistance. Recently a tissue‐specific... 
mutant SOD1 | endothelial cells | P‐glycoprotein | blood–brain barrier | amyotrophic lateral sclerosis | P-glycoprotein | Amyotrophic lateral sclerosis | Blood-brain barrier | Mutant SOD1 | Endothelial cells | blood-brain barrier | OXIDATIVE STRESS | MODEL | NEUROSCIENCES | SPORADIC ALS | DRUG EFFLUX TRANSPORTERS | PLURIPOTENT STEM-CELLS | IN-VITRO | MOTOR-NEURON DEGENERATION | DISEASE | MICE | EXPRESSION | Up-Regulation | Spinal Cord - metabolism | Capillaries - pathology | Coculture Techniques | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Astrocytes - pathology | NF-kappa B - metabolism | Spinal Cord - pathology | Superoxide Dismutase-1 - metabolism | Capillaries - metabolism | Disease Models, Animal | Induced Pluripotent Stem Cells - metabolism | Induced Pluripotent Stem Cells - pathology | Cell Line | Endothelial Cells - metabolism | Mice, Transgenic | RNA-Binding Protein FUS - metabolism | Blood-Brain Barrier - metabolism | Blood-Brain Barrier - pathology | Amyotrophic Lateral Sclerosis - pathology | Animals | Amyotrophic Lateral Sclerosis - metabolism | Superoxide Dismutase-1 - genetics | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Astrocytes - metabolism | Drug resistance in microorganisms | Nervous system diseases | Gene mutations | Neurons | Analysis | Superoxide | Endothelium | Glycoproteins
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8. Full Text Euphorbia factor L1 reverses ABCB1‐mediated multidrug resistance involving interaction with ABCB1 independent of ABCB1 downregualtion
by Zhang, Jian‐ye and Mi, Yan‐jun and Chen, Shu‐peng and Wang, Fang and Liang, Yong‐ju and Zheng, Li‐sheng and Shi, Cheng‐jun and Tao, Li‐yang and Chen, Li‐ming and Chen, Hu‐biao and Fu, Li‐wu
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2011, Volume 112, Issue 4, pp. 1076 - 1083
Euphorbia factor L1 (EFL1) belongs to diterpenoids of genus Euphorbia . In this article, its reversal activity against ABCB1‐mediated MDR in KBv200 and... 
multidrug resistance | Euphorbia factor L1 | ABCB1 | Multidrug resistance | CANCER-CELLS | APOPTOSIS | ATPASE ACTIVITY | TRANSPORTER | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | EUPHORBIA FACTOR L1 | TUMOR-CELLS | SUBFAMILY-B MEMBER-1 | P-GLYCOPROTEIN | CELL BIOLOGY | IN-VITRO | MULTIDRUG RESISTANCE | BINDING | Plant Extracts - chemistry | Antibiotics, Antineoplastic - pharmacology | Hydrolysis - drug effects | Plant Extracts - pharmacology | Drug Resistance, Multiple - drug effects | Humans | Phenylpropionates - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Dose-Response Relationship, Drug | Euphorbia - chemistry | Plant Extracts - metabolism | Flow Cytometry | Adenosine Triphosphate - metabolism | Doxorubicin - metabolism | Molecular Structure | Diterpenes - metabolism | Antibiotics, Antineoplastic - pharmacokinetics | Diterpenes - chemistry | Rhodamine 123 - pharmacokinetics | Diterpenes - pharmacology | Cell Survival - drug effects | Down-Regulation | Adenosine Triphosphatases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Doxorubicin - pharmacokinetics | Phenylpropionates - pharmacology | Rhodamine 123 - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Antibiotics, Antineoplastic - metabolism | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects
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9. Full Text Estimation of ABCB1 concentration in plasma membrane
by Mlejnek, Petr and Kosztyu, Petr and Dolezel, Petr and Kimura, Yasuhisa and Cizkova, Katerina and Ruzickova, Eliska
Journal of Cellular Biochemistry, ISSN 0730-2312, 10/2019, Volume 120, Issue 10, pp. 18406 - 18414
The interaction between ABCB1 transporter and its substrates takes place in cell membranes but the available data precludes quantitative analysis of the... 
ABCB1 plasma membrane concentration | ABC transporters | P‐glycoprotein | drug resistance | K562 cells | CELLS | ATPASE ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | EHRLICH ASCITES TUMOR | DAUNORUBICIN | CANCER | NILOTINIB | CELL BIOLOGY | P-glycoprotein | TRANSPORT | EXPRESSION | MULTIDRUG-RESISTANCE GENE | Immunohistochemistry | Cell membranes | Drug resistance | Analysis | Leukemia | Plasma | Membranes | Level (quantity) | RNA-mediated interference | Lipids | Immunoblotting | Gene expression | Substrates | Lysates | Plasma membranes | Transporter | Recombinant | Quantitative analysis
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10. Full Text Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON–TIMI 38 trial: a pharmacogenetic analysis
by Mega, Jessica L, Dr and Close, Sandra L, PhD and Wiviott, Stephen D, MD and Shen, Lei, PhD and Walker, Joseph R, PharmD and Simon, Tabassome, Prof and Antman, Elliott M, Prof and Braunwald, Eugene, Prof and Sabatine, Marc S, Dr
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9749, pp. 1312 - 1319
Summary Background Clopidogrel and prasugrel are subject to efflux via P-glycoprotein (encoded by ABCB1 , also known as MDR1 ). ABCB1 polymorphisms,... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | HEALTHY JAPANESE SUBJECTS | RESPONSIVENESS | STENT THROMBOSIS | DUODENAL ENTEROCYTES | OF-FUNCTION POLYMORPHISM | PLATELET INHIBITION | MDR1 GENE | EXPRESSION | P-GLYCOPROTEIN | Prasugrel Hydrochloride | Thiophenes - therapeutic use | Thiophenes - adverse effects | Ticlopidine - therapeutic use | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Angioplasty, Balloon, Coronary | Genetic Variation | Ticlopidine - adverse effects | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Cardiovascular Diseases - etiology | Pharmacogenetics | Genotype | Piperazines - therapeutic use | Piperazines - adverse effects | Ticlopidine - analogs & derivatives | Randomized Controlled Trials as Topic | Acute Coronary Syndrome - drug therapy | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP2C19 | ATP Binding Cassette Transporter, Sub-Family B | Polymorphism, Single Nucleotide | Acute Coronary Syndrome - genetics | Physiological aspects | Clopidogrel | Dosage and administration | Cardiovascular diseases | Drug therapy | Patient outcomes | Studies | Fees & charges | Heart attacks | Stock options | Acute coronary syndromes | Mass spectrometry | Drugs | Pharmacodynamics | Clinical trials | P-Glycoprotein | Pharmacokinetics
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11. Full Text ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors
by Zhang, Ping and De Gooijer, Mark C and Buil, Levi C M and Beijnen, Jos H.|info:eu-repo/dai/nl/071919570 and Li, Gang and Van Tellingen, Olaf
International Journal of Cancer, ISSN 0020-7136, 10/2015, Volume 137, Issue 8, pp. 2007 - 2018
Enhancer of Zeste Homolog 2 (EZH2) has emerged as a promising therapeutic target for treatment of a broad spectrum of tumors including gliomas. We explored the... 
pharmacokinetics | ABCB1 | EZH2 inhibitor | brain penetration | ABCG2 | Brain penetration | Pharmacokinetics | SELECTIVE-INHIBITION | H3K27 METHYLATION | TRANSPORTERS | RESISTANCE PROTEIN ABCG2 | BARRIER | CANCER | P-GLYCOPROTEIN ABCB1 | ONCOLOGY | ACCUMULATION | INHIBITOR VEMURAFENIB | EZH2 | Polycomb Repressive Complex 2 - antagonists & inhibitors | Benzamides - pharmacokinetics | Humans | Biological Availability | Indazoles - administration & dosage | Indoles - administration & dosage | Enzyme Inhibitors - administration & dosage | Pyridones - administration & dosage | Benzamides - administration & dosage | ATP-Binding Cassette Transporters - genetics | Enzyme Inhibitors - pharmacokinetics | Madin Darby Canine Kidney Cells | ATP-Binding Cassette Transporters - metabolism | Drug Evaluation, Preclinical | Cell Line | Pyridones - pharmacokinetics | Administration, Oral | Blood-Brain Barrier - drug effects | Enhancer of Zeste Homolog 2 Protein | Mice, Knockout | Animals | Indazoles - pharmacokinetics | Dogs | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Indoles - pharmacokinetics | Mice | ATP Binding Cassette Transporter, Sub-Family B - genetics | Rodents | Permeability | Tumors | Index Medicus
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