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Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 03/2019, Volume 83, pp. 242 - 249
Poly(ADP-ribose)polymerase-1 inhibitor (PARPi) AZD2461 was designed to be a weak P-glycoprotein (P-gp) analogue of FDA approved olaparib. With this chemical... 
P-glycoprotein | PARP-1 inhibitor | Blood-brain barrier | MicroPET imaging | AZD2461 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PROVIDES | POLY(ADP-RIBOSE) POLYMERASE-1 PARP-1 | CHEMOTHERAPY
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 24, pp. 9704 - 9709
Multidrug resistance is a serious barrier to successful treatment of many human diseases, including cancer, wherein chemotherapeutics are exported from target... 
ATP binding cassette transporters | Molecules | Vapor phases | Micelles | Lipids | Mass spectroscopy | Ligands | Nucleotides | Detergents | Membrane proteins | Real time substrate monitoring | Mass spectrometry from native state | ABC TRANSPORTER | ATPASE ACTIVITY | MEMBRANE | MULTIDISCIPLINARY SCIENCES | COMPLEXES | mass spectrometry from native state | CONFORMATIONS | RECONSTITUTED P-GLYCOPROTEIN | GAS-PHASE | real time substrate monitoring | MACROMOLECULAR ASSEMBLIES | PROTEINS | MOLECULAR-BASIS | Detergents - chemistry | Drug Resistance, Multiple | Humans | Molecular Conformation | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pharmaceutical Preparations - classification | Nucleotides - chemistry | Lipids - chemistry | Biological Transport | Immunosuppressive Agents - metabolism | Lipids - classification | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Cyclosporine - metabolism | Binding, Competitive | Detergents - metabolism | Models, Molecular | Cardiolipins - metabolism | Nucleotides - metabolism | Cardiolipins - chemistry | Pharmaceutical Preparations - metabolism | Cyclosporine - chemistry | Pharmaceutical Preparations - chemistry | Protein Binding | Protein Conformation | Kinetics | Mass Spectrometry - methods | Immunosuppressive Agents - chemistry | Cluster Analysis | Physiological aspects | Research | Drug resistance | Mass spectrometry | Methods | Binding sites (Biochemistry) | ABC transporters | Glycoproteins | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 13767 - 15
The human ABC transporter ABCG2 (Breast Cancer Resistance Protein, BCRP) is implicated in anticancer resistance, in detoxification across barriers and linked... 
BINDING CASSETTE TRANSPORTER | YEAST | MULTIDRUG TRANSPORTER | GENE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | CELL-LINES | EXPRESSION | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | SUBSTRATE RECOGNITION | Mutagenesis | Gout | Detoxification | Breast cancer | ABC transporters | Elbow | ABC transporter | Crystal structure
Journal Article
Journal Article