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Journal of Clinical Pharmacology, ISSN 0091-2700, 06/2008, Volume 48, Issue 6, pp. 662 - 670
Predicting clinically significant drug interactions during drug development is a challenge for the pharmaceutical industry and regulatory agencies. Since the... 
P-glycoprotein | Cytochrome P450 enzymes | Pharmacogenetics | Transporter proteins | Induction | Drug interactions | Inhibition | Physiological aspects | Research
Journal Article
11/2012
Several families of highly effective anticancer drugs are selectively toxic to cancer cells because they interfere with nucleic acids synthesis. Many such... 
P-glycoprotein | Mitochondria | Mitochondria Penetrating Peptides | 0572 | Drug Efflux | Doxorubicin | Topoisomerase II | Drug Resistance
Dissertation
Xenobiotica, ISSN 0049-8254, 2019, pp. 1 - 9
1. More than 30% of epilepsy patients suffer pharmacoresistance. Transport of antileptic drugs by P-glycoprotein (P-gp) and MRP2 plays an important role in... 
drug-resistant epilepsy | P-glycoprotein | Hup-A | drug transporter | cell monolayer
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2019, Volume 62, Issue 1, pp. 247 - 265
Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are activated by hormones of the neurotrophin family: nerve growth factor (NGF), brain derived neurotrophic... 
SITE | NEUROTROPHIN-3 | CHEMISTRY, MEDICINAL | EFFICACY | CNS | ABSORPTION | EFFICIENCY | TANEZUMAB | P-GLYCOPROTEIN | PLASTICITY | PREDICTION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2013, Volume 56, Issue 1, pp. 2 - 12
This Perspective provides important concepts about the blood-brain barrier (BBB) in drug discovery and how they should be applied effectively in designing... 
CHEMISTRY, MEDICINAL | POSITRON-EMISSION-TOMOGRAPHY | PERMEABILITY ASSAY | IN-VIVO | LEAD OPTIMIZATION | UNBOUND CONCENTRATION | P-GLYCOPROTEIN EXPRESSION | RECEPTOR OCCUPANCY | PERFUSION TECHNIQUE | CACO-2 CELLS | CANCER RESISTANCE PROTEIN
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 12/2016, Volume 515, Issue 1-2, pp. 367 - 373
Intestinal P-glycoprotein is regio-selectively expressed and is a high affinity, low capacity efflux carrier for the cationic, poorly permeable trospium.... 
P-glycoprotein | Gastric infusion | Pharmacokinetics | Trospium chloride | OCT1 | Food effects
Journal Article
02/2012
Background: Mesial temporal lobe epilepsy (MTLE) is the most common medically refractory epilepsy syndrome in adults, and hippocampal sclerosis (HS) is the... 
epilepsy | P-glycoprotein | genetics | ABCB1 | refractory epilepsy | hippocampal sclerosis | corpora amylacea | mesial temporal lobe epilepsy
Web Resource
Chemical Biology and Drug Design, ISSN 1747-0277, 03/2019, Volume 93, Issue 3, pp. 283 - 289
P-glycoprotein (P-gp) is a multidrug resistance (MDR) transporter with unknown structural details. This macromolecule is normally responsible for extruding... 
P-glycoprotein | Tc-MIBI | flexible docking | homology modeling | Caco-2
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2009, Volume 15, Issue 24, pp. 7462 - 7468
Hyaluronan is a prominent component of the micro-environment in most malignant tumors and can be prognostic for tumor progression. Extensive experimental... 
BREAST-CANCER | STEM-CELLS | SOLID TUMORS | ONCOLOGY | CELL-SURFACE | EXTRACELLULAR-MATRIX | BIVATUZUMAB MERTANSINE | DRUG-RESISTANCE | MESENCHYMAL TRANSITION | HYALURONIC-ACID | P-GLYCOPROTEIN
Journal Article
Journal of Physical Chemistry B, ISSN 1520-6106, 10/2019, Volume 123, Issue 1, pp. 117 - 129
It is well reported that sugar molecules provide different types of stabilization to biomembranes both in vitro as well as in vivo. In the present article, our... 
PHASE | TREHALOSE | COMPLEX | SURFACE | CHEMISTRY, PHYSICAL | SOLVATION DYNAMICS | PROTON-TRANSFER | P-GLYCOPROTEIN | LIPID-BILAYER | WATER | SUCRALOSE
Journal Article
06/2013
Statins, common cholesterol control drugs, are appreciated to have promising anticancer activity through inhibition of the mevalonate pathway. Several lines of... 
P-glycoprotein | 0307 Molecular Biology | statin | HMG-CoA reductase | 0760 Medical Biophysics | breast cancer | drug resistance | mevalonate
Dissertation
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 89, pp. 691 - 700
6,7-Dimethoxytetrahydroisoquinoline is widely used as basic moiety in receptor ligands, in order to provide versus selectivity. This same moiety is also widely... 
P-glycoprotein | Conformational analysis | 67-Dimethoxytetrahydroisoquinoline | σ2 receptor
Journal Article
Meta Gene, ISSN 2214-5400, 09/2019, Volume 21, p. 100596
Breast cancer (BC) is the second most prevalent type of cancer worldwide and the most common among women. Also, BC shows different subtypes and patterns of... 
P-glycoprotein | Recurrence | Chemotherapy | Breast neoplasms | Polymorphism
Journal Article
Yaoxue Xuebao, ISSN 0513-4870, 07/2018, Volume 53, Issue 7, pp. 1107 - 1112
Journal Article
CANCER SCIENCE, ISSN 1349-7006, 01/2018, Volume 109, pp. 354 - 354
Conference Proceeding
Sensors and Actuators: B. Chemical, ISSN 0925-4005, 12/2019, Volume 301
We report an advanced flexible immunosensor for extreme low level detection of multidrug resistant myeloid leukemia cells. The detection mechanism is analyzed... 
Immunofluorescence analysis | Fermi-level fluctuations | Anti-P-glycoprotein | Electrochemical immunosensing | Doxorubicin
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 10/2019, Volume 91, pp. 103091 - 103091
Sensitizing activities exerted by 3,4-dihydro-7-hydroxycadalene ( ), -3,7-dihydroxy-3(4 )-isocadalen-4-one ( ) and (1 ,4 ) 4 1,2,3,4-tetrahydro... 
P-glycoprotein | Cancer resistance | Docking | Cadinanes | Index Medicus
Journal Article
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