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Nephron, ISSN 0028-2766, 2003, Volume 93, Issue 4, pp. p87 - p93
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 17, pp. 7486 - 7502
The development of glycine transporter 1 (GlyT1) inhibitors may offer putative treatments for schizophrenia and other disorders associated with hypofunction of... 
CHEMISTRY, MEDICINAL | ANTAGONIST | MICROSOMES | SCHIZOPHRENIA | CANDIDATES | GLYT1 | BINDING | BRAIN | L-687,414 | P-GLYCOPROTEIN | KETAMINE
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 03/2005, Volume 65, Issue 6, pp. 2412 - 2421
Activating mutations of the B-PIAF gene are observed in > 60% of human melanomas. Approximately 90% of these mutations occur in the activation segment of the... 
METASTATIC MELANOMA | APOPTOSIS | GENE | ANGIOGENESIS | ONCOLOGY | BRAF MUTATIONS | RAS MUTATIONS | KINASE | MELANOCYTIC LESIONS | CANCER | P-GLYCOPROTEIN
Journal Article
Journal of Emergency Medicine, ISSN 0736-4679, 2017, Volume 53, Issue 1, pp. 73 - 84
Abstract Background Despite its opioid properties, loperamide has long been thought to have low abuse potential due to its poor absorption from the... 
Emergency | P-glycoprotein | drug abuse | opioid dependence | loperamide
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 09/2019, Volume 139, Issue 9, pp. 1985 - 1992.e10
ABCB5 is an ABC transporter that was shown to confer low-level multidrug resistance in cancer. In this study, we show that ABCB5 was mutated in 13.75% of the... 
CELLS | GENE | DRUG-RESISTANCE | EXPRESSION | ATP-BINDING | P-GLYCOPROTEIN | REVEALS | DERMATOLOGY | Index Medicus
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 10, pp. 4915 - 4935
Anaplastic lymphoma kinase (ALK), a member of the receptor tyrosine kinase family, is predominantly expressed in the brain and implicated in neuronal... 
REFINEMENT | TRANSPORT | DESIGN | IMPACT | CHEMISTRY, MEDICINAL | C-MET | BARRIER | PROLIFERATION | PF-2341066 | RECEPTOR TYROSINE KINASE | P-GLYCOPROTEIN
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2019, Volume 62, Issue 8, pp. 4174 - 4192
The natural product primary sulfonamide, psammaplin C (1), when used in combination with clinically used chemotherapeutic drugs, including temozolomide,... 
TARGET | CHEMISTRY, MEDICINAL | TRANSMEMBRANE | CHEMORESISTANCE | CLEAVAGE | CANCER | P-GLYCOPROTEIN | BENZYL ETHERS
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 07/2019, Volume 139, Issue 7, pp. 1506 - 1515.e7
Among the molecular signals underlying cutaneous inflammation is the transcription complex NF-κB, its upstream modulators, and cytokines and chemokines that... 
CELLS | ACTIVATION | DISEASE | KERATINOCYTES | MODEL | PROTEINS | EXPRESSION | P-GLYCOPROTEIN ABCB1 | MICE LACKING | DERMATOLOGY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 17, pp. 7503 - 7524
The glycine transporter 1 (GlyT1) has emerged as a key novel target for the treatment of schizophrenia. Herein, we report the synthesis and biological... 
INTERNALIZATION | CHEMISTRY, MEDICINAL | ANTAGONIST | HYDROGENATION | PHARMACOLOGY | SCHIZOPHRENIA | CNS | OPTIMIZATION | D-ASPARTATE RECEPTOR | BRAIN | P-GLYCOPROTEIN
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 01/2018, Volume 36, Issue 1, pp. 112 - 125
Journal Article
European Journal of Clinical Nutrition, ISSN 0954-3007, 01/2004, Volume 58, Issue 1, pp. 1 - 9
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, pp. 111668 - 111668
In this study, we synthesized 23 fusidic acid ( ) derivatives and screened them for tumor drug resistance reversal activity and cytotoxicity toward the KBV... 
P-glycoprotein | Fusidic acid | Tumor | Synthesis | Tumor resistance reversal activity | Index Medicus
Journal Article
TRENDS IN PARASITOLOGY, ISSN 1471-4922, 06/2016, Volume 32, Issue 6, pp. 458 - 469
Triclabendazole (TCBZ) is the only chemical that kills early immature and adult Fasciola hepatica (liver fluke) but widespread resistance to the drug greatly... 
P-GLYCOPROTEIN INHIBITOR | GENETIC DIVERSITY | LIVER FLUKE | IN-VITRO TREATMENT | SULFOXIDE METABOLITE | TRICLABENDAZOLE-RESISTANT | COPROANTIGEN ELISA | FECAL EGG COUNT | PARASITOLOGY | AMINO-ACID SUBSTITUTION | ANTHELMINTIC RESISTANCE
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2018, Volume 61, Issue 22, pp. 9931 - 9951
A 300-member flavonoid dimer library of multidrug resistance-associated protein 1 (MRP1, ABCC1) modulators was rapidly assembled using "click chemistry".... 
BCRP | LUNG-CANCER | TRANSPORT | CHEMISTRY, MEDICINAL | APIGENIN HOMODIMERS | BIVALENT MODULATORS | INHIBITORS | MEMBRANE TOPOLOGY | EXPRESSION | P-GLYCOPROTEIN
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 05/2019, Volume 180, pp. 350 - 366
Overexpression of P-glycoprotein (P-gp) is one of the major causes for multidrug resistance (MDR), which has become a major obstacle in cancer therapy. One... 
Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2018, Volume 61, Issue 16, pp. 7043 - 7064
Studies indicate that MAO-B is induced in peripheral inflammatory diseases. To target peripheral tissues using MAO-B inhibitors that do not permeate the blood... 
LOCALIZATION | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | EFFICIENT PROCEDURE | CETIRIZINE | MITOCHONDRIAL | MOCLOBEMIDE | SAFINAMIDE | EXPRESSION | P-GLYCOPROTEIN | REMISSION
Journal Article
AMERICAN JOURNAL OF PATHOLOGY, ISSN 0002-9440, 06/2018, Volume 188, Issue 6, pp. 1486 - 1496
Psoriasis is a chronic inflammatory skin disorder associated with several comorbidities, including atherosclerosis. Disease mechanisms that may affect both... 
MOUSE MODEL | DIGOXIN | VASCULAR INFLAMMATION | RISK | MECHANISMS | HYPERCHOLESTEROLEMIA | DIFFERENTIATION | PATHOLOGY | P-GLYCOPROTEIN
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 04/2008, Volume 36, Issue 4, pp. 695 - 701
Lapatinib [ N -{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine, GW572016, Tykerb] is a... 
TYROSINE KINASE INHIBITORS | P-GLYCOPROTEIN INHIBITOR | BREAST-CANCER | GEFITINIB | PHARMACOKINETICS | IMATINIB | PHARMACOLOGY & PHARMACY | ANTICANCER DRUGS | ABC TRANSPORTERS | PHASE-I | DOCETAXEL
Journal Article
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