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1. Full Text A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies
by Karlgren, Maria and Simoff, Ivailo and Backlund, Maria and Wegler, Christine and Keiser, Markus and Handin, Niklas and Müller, Janett and Lundquist, Patrik and Jareborg, Anne-Christine and Oswald, Stefan and Artursson, Per
Journal of pharmaceutical sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2909 - 2913
P-glycoprotein | MDCK cells | proteomics | permeability | membrane transporter | drug transport | genomics | ABC transporters | multidrug resistance transporters | efflux pumps | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Gene Expression | Pharmaceutical Preparations - metabolism | Animals | Biological Transport | Madin Darby Canine Kidney Cells - metabolism | Humans | CRISPR-Cas Systems | Dogs | ATP Binding Cassette Transporter, Sub-Family B - metabolism | ATP Binding Cassette Transporter, Sub-Family B - genetics | Drug Discovery | Index Medicus
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2. Full Text MiR-27a modulates the MDR1/P-glycoprotein expression by inhibiting FZD7/β-catenin pathway in hepatocellular carcinoma cells
by Chen, Zhaolin and Ma, Taotao and Huang, Cheng and Zhang, Lei and Lv, Xiongwen and Xu, Tao and Hu, Tingting and Li, Jun
Cellular signalling, ISSN 0898-6568, 12/2013, Volume 25, Issue 12, pp. 2693 - 2701
P-glycoprotein | Hepatocellular carcinoma | miR-27a | β-Catenin | FZD7 | Multiple drug resistance | MiR-27a | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Liver Neoplasms - genetics | Signal Transduction | Apoptosis - drug effects | Drug Resistance, Multiple | Humans | Gene Expression Regulation, Neoplastic | Liver Neoplasms - drug therapy | Frizzled Receptors - metabolism | Drug Resistance, Neoplasm | MicroRNAs - metabolism | beta Catenin - metabolism | Carcinoma, Hepatocellular - drug therapy | Frizzled Receptors - genetics | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Line, Tumor | Antimetabolites, Antineoplastic - pharmacology | Fluorouracil - pharmacology | MicroRNAs - genetics | ATP Binding Cassette Transporter, Sub-Family B - genetics | Carcinoma, Hepatocellular - metabolism | Index Medicus | Obstacles | Biotechnology | Chemotherapy | Pathways | Ribonucleic acids | Gene expression | Apoptosis | Cancer
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3. Full Text Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells
by Zhu, Hua and Wu, Hao and Liu, Xiuping and Evans, Brad R and Medina, Daniel J and Liu, Chang-Gong and Yang, Jin-Ming
Biochemical pharmacology, ISSN 0006-2952, 2008, Volume 76, Issue 5, pp. 582 - 588
P-glycoprotein | MDR1 | Chemotherapy | MicroRNA | Gene expression | Drug resistance | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Humans | Gene Expression Regulation, Neoplastic | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Rhodamine 123 - metabolism | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Base Sequence | Cell Line, Tumor | MicroRNAs - genetics | MicroRNAs - physiology | Doxorubicin - pharmacology | Index Medicus
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4. Full Text P-glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF-β signaling pathway inhibitor galunisertib
by Li, Wenlong and Tibben, Matthijs and Wang, Yaogeng and Lebre, Maria C and Rosing, Hilde and Beijnen, Jos H and Schinkel, Alfred H
International journal of cancer, ISSN 0020-7136, 2020, Volume 146, Issue 6, pp. 1631 - 1642
P-glycoprotein | brain accumulation | Oatp1a/1b | intestinal disposition | cytochrome P450-3A | oral availability | galunisertib | P‐glycoprotein | cytochrome P450‐3A | Life Sciences & Biomedicine | Oncology | Science & Technology | Quinolines - blood | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Quinolines - pharmacology | Brain - metabolism | Quinolines - pharmacokinetics | Tissue Distribution | Pyrazoles - blood | Madin Darby Canine Kidney Cells | Female | Pyrazoles - pharmacokinetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 - antagonists & inhibitors | Pyrazoles - pharmacology | Tetrahydroisoquinolines - pharmacology | ATP Binding Cassette Transporter, Subfamily B - metabolism | Brain - drug effects | Animals | Signal Transduction - drug effects | ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors | Cytochrome P-450 CYP3A - metabolism | Acridines - pharmacology | Herb-Drug Interactions | Dogs | Mice | Transforming Growth Factor beta - metabolism | Brain | Efflux | Animal models | Toxicity | Transforming growth factor-b | Glioblastoma | Oral administration | Clinical trials | Hepatocellular carcinoma | Pharmacology | Breast cancer | Glycoproteins | Accumulation | MDR1 protein | Signal transduction | Inhibitors | Intestine | Pharmacokinetics | Growth factors | Genetic modification | Acute toxicity | Index Medicus
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5. Full Text MDR1 gene C3435T polymorphism and cancer risk: a meta-analysis of 34 case–control studies
by Wang, Jun and Wang, Baocheng and Bi, Jingwang and Li, Kainan and Di, Jianshi
Journal of cancer research and clinical oncology, ISSN 0171-5216, 6/2012, Volume 138, Issue 6, pp. 979 - 989
Cancer susceptibility | MDR1 | Medicine & Public Health | Hematology | Cancer Research | Oncology | Internal Medicine | Polymorphism | Meta-analysis | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Genetic Predisposition to Disease | Neoplasms - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Gene Frequency | Humans | Genotype | ATP Binding Cassette Transporter, Sub-Family B | Polymorphism, Single Nucleotide | Odds Ratio | Case-Control Studies | Cohort Studies | Oncology, Experimental | Genes | Leukemia | Colorectal cancer | Genetic research | Genetic aspects | Disease susceptibility | Research | Xenobiotics | Health aspects | Risk factors | Cancer | Index Medicus | Acute lymphatic leukemia | Colorectal carcinoma | Data processing | Breast cancer | Gene polymorphism | Kidney | Homozygotes | MDR1 protein | Reviews | Pumps | Ethnic groups | Models | Toxins | P-Glycoprotein | Gastric cancer
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6. Full Text Polymorphisms in Human MDR1 (P‐glycoprotein): Recent Advances and Clinical Relevance
by Marzolini, Catia and Paus, Erik and Buclin, Thierry and Kim, Richard B
Clinical pharmacology and therapeutics, ISSN 0009-9236, 01/2004, Volume 75, Issue 1, pp. 13 - 33
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Humans | Substrate Specificity | Continental Population Groups - genetics | Genes, MDR - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - pharmacokinetics | Polymorphism, Genetic | Index Medicus | Abridged Index Medicus
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7. Full Text Individual and combined roles of CYP3A, P‐glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel
by van Waterschoot, Robert A.B and Lagas, Jurjen S and Wagenaar, Els and Rosing, Hilde and Beijnen, Jos H and Schinkel, Alfred H
International journal of cancer, ISSN 0020-7136, 12/2010, Volume 127, Issue 12, pp. 2959 - 2964
CYP3A | MRP2 | docetaxel | drug metabolism | pharmacokinetics | P‐glycoprotein (MDR1) | drug transport | oral bioavailability | Drug transport | Oral bioavailability | P-glycoprotein (MDR1) | Docetaxel | Drug metabolism | Pharmacokinetics | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Tumors | Taxoids - pharmacology | Administration, Oral | Biological Availability | Male | ATP-Binding Cassette Transporters - physiology | ATP Binding Cassette Transporter, Subfamily B | Mice, Knockout | Taxoids - pharmacokinetics | Tissue Distribution | Animals | Multidrug Resistance-Associated Proteins - physiology | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Mice | Cytochrome P-450 Enzyme System - physiology | ATP Binding Cassette Transporter, Subfamily B, Member 1 - physiology | Index Medicus
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8. Full Text Bufalin reverses multidrug resistance by regulating stemness through the CD133/nuclear factor‐κB/MDR1 pathway in colorectal cancer
by Zhan, Yueping and Qiu, Yanyan and Wang, Haijing and Wang, Ziyuan and Xu, Jian and Fan, Guohua and Xu, Jianhua and Li, Wei and Cao, Yijun and Le, Van‐Minh and Ly, Hai‐Trieu and Yuan, Zeting and Xu, Ke and Yin, Peihao
Cancer science, ISSN 1347-9032, 05/2020, Volume 111, Issue 5, pp. 1619 - 1630
multidrug resistance | MDR1 | colorectal cancer | bufalin | CD133 | Life Sciences & Biomedicine | Oncology | Science & Technology | Statistical analysis | Colorectal carcinoma | Multidrug resistance | Colorectal cancer | Chemoresistance | AKT protein | Drug resistance | Proteins | MDR1 protein | Chemotherapy | Stem cells | P-Glycoprotein | Laboratory animals | Tumors | Apoptosis | Cancer | Index Medicus | Original
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9. Full Text Concise Review: Clinical Relevance of Drug–Drug and Herb–Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P‐glycoprotein)
by Marchetti, Serena and Mazzanti, Roberto and Beijnen, Jos H and Schellens, Jan H. M
The oncologist (Dayton, Ohio), ISSN 1083-7159, 08/2007, Volume 12, Issue 8, pp. 927 - 941
Complementary and alternative medicine | P‐glycoprotein | Drug interaction | Pharmacokinetics Pharmacodynamics | CAM | P-glycoprotein | Pharmacodynamics | Pharmacokinetics | Life Sciences & Biomedicine | Oncology | Science & Technology | Drug Interactions | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Herb-Drug Interactions | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | ATP Binding Cassette Transporter, Sub-Family B | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Index Medicus
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