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1. Full Text P-glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF-β signaling pathway inhibitor galunisertib
by Li, Wenlong and Tibben, Matthijs and Wang, Yaogeng and Lebre, Maria C and Rosing, Hilde and Beijnen, Jos H and Schinkel, Alfred H
International journal of cancer, ISSN 0020-7136, 2020, Volume 146, Issue 6, pp. 1631 - 1642
P-glycoprotein | brain accumulation | Oatp1a/1b | intestinal disposition | cytochrome P450-3A | oral availability | galunisertib | P‐glycoprotein | cytochrome P450‐3A | Life Sciences & Biomedicine | Oncology | Science & Technology | Quinolines - blood | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Quinolines - pharmacology | Brain - metabolism | Quinolines - pharmacokinetics | Tissue Distribution | Pyrazoles - blood | Madin Darby Canine Kidney Cells | Female | Pyrazoles - pharmacokinetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 - antagonists & inhibitors | Pyrazoles - pharmacology | Tetrahydroisoquinolines - pharmacology | ATP Binding Cassette Transporter, Subfamily B - metabolism | Brain - drug effects | Animals | Signal Transduction - drug effects | ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors | Cytochrome P-450 CYP3A - metabolism | Acridines - pharmacology | Herb-Drug Interactions | Dogs | Mice | Transforming Growth Factor beta - metabolism | Brain | Efflux | Animal models | Toxicity | Transforming growth factor-b | Glioblastoma | Oral administration | Clinical trials | Hepatocellular carcinoma | Pharmacology | Breast cancer | Glycoproteins | Accumulation | MDR1 protein | Signal transduction | Inhibitors | Intestine | Pharmacokinetics | Growth factors | Genetic modification | Acute toxicity | Index Medicus
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2. Full Text Concise Review: Clinical Relevance of Drug–Drug and Herb–Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P‐glycoprotein)
by Marchetti, Serena and Mazzanti, Roberto and Beijnen, Jos H and Schellens, Jan H. M
The oncologist (Dayton, Ohio), ISSN 1083-7159, 08/2007, Volume 12, Issue 8, pp. 927 - 941
Complementary and alternative medicine | P‐glycoprotein | Drug interaction | Pharmacokinetics Pharmacodynamics | CAM | P-glycoprotein | Pharmacodynamics | Pharmacokinetics | Life Sciences & Biomedicine | Oncology | Science & Technology | Drug Interactions | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Herb-Drug Interactions | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | ATP Binding Cassette Transporter, Sub-Family B | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Index Medicus
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3. Full Text Individual and combined roles of CYP3A, P‐glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel
by van Waterschoot, Robert A.B and Lagas, Jurjen S and Wagenaar, Els and Rosing, Hilde and Beijnen, Jos H and Schinkel, Alfred H
International journal of cancer, ISSN 0020-7136, 12/2010, Volume 127, Issue 12, pp. 2959 - 2964
CYP3A | MRP2 | docetaxel | drug metabolism | pharmacokinetics | P‐glycoprotein (MDR1) | drug transport | oral bioavailability | Drug transport | Oral bioavailability | P-glycoprotein (MDR1) | Docetaxel | Drug metabolism | Pharmacokinetics | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Tumors | Taxoids - pharmacology | Administration, Oral | Biological Availability | Male | ATP-Binding Cassette Transporters - physiology | ATP Binding Cassette Transporter, Subfamily B | Mice, Knockout | Taxoids - pharmacokinetics | Tissue Distribution | Animals | Multidrug Resistance-Associated Proteins - physiology | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Mice | Cytochrome P-450 Enzyme System - physiology | ATP Binding Cassette Transporter, Subfamily B, Member 1 - physiology | Index Medicus
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4. Full Text P-glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450-3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib
by Li, Wenlong and Sparidans, Rolf W and Wang, Yaogeng and Lebre, Maria C and Wagenaar, Els and Beijnen, Jos H and Schinkel, Alfred H
International journal of cancer, ISSN 0020-7136, 10/2018, Volume 143, Issue 8, pp. 2029 - 2038
P-glycoprotein | cytochrome P450-3A | brain accumulation | oral availability | lorlatinib | P‐glycoprotein | cytochrome P450‐3A | Life Sciences & Biomedicine | Oncology | Science & Technology | Plasma physics | Genetically modified organisms | Cytochrome P-450 | Lymphomas | Genetic engineering | Mice | Permeability | Lung cancer, Non-small cell | Cytochrome | Brain | Liver | Lung cancer | Membrane permeability | Clinical trials | Transgenic | Blood | Accumulation | Metastases | MDR1 protein | Intestine | Protein-tyrosine kinase | Genetic modification | Cytochromes P450 | Medical research | Efflux | Cytochrome P450 | Non-small cell lung carcinoma | Data processing | Pharmacology | Exposure | Glycoproteins | Lymphoma | Inhibitors | Plasma levels | Pharmacokinetics | Index Medicus
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5. Full Text Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir
by van Waterschoot, RAB and ter Heine, R and Wagenaar, E and van der Kruijssen, CMM and Rooswinkel, RW and Huitema, ADR and Beijnen, JH and Schinkel, AH
British journal of pharmacology, ISSN 0007-1188, 07/2010, Volume 160, Issue 5, pp. 1224 - 1233
CYP3A | MDR1 | MRP2 (ABCC2) | lopinavir | P-glycoprotein (ABCB1 | intestinal metabolism | P‐glycoprotein (ABCB1 | Intestinal metabolism | Lopinavir | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Antiviral agents | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Intestinal Mucosa - metabolism | Liver - enzymology | Humans | Liver - metabolism | Biological Availability | Male | Mice, Transgenic | Mice, Inbred Strains | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Animals | Drug Interactions | Pyrimidinones - pharmacokinetics | Cytochrome P-450 CYP3A - genetics | HIV Protease Inhibitors - pharmacokinetics | Dogs | Multidrug Resistance-Associated Proteins - genetics | Ritonavir - pharmacology | Mice | Cytochrome P-450 CYP3A - drug effects | Multidrug Resistance-Associated Proteins - metabolism | Intestines - enzymology | Medical research | Rodents | Index Medicus | Research Papers
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6. Full Text Polymorphisms and haplotypes in the multidrug resistance 1 gene ( MDR1 / ABCB1 ) and risk of multiple myeloma
by Jamroziak, Krzysztof and Balcerczak, Ewa and Calka, Karolina and Piaskowski, Sylwester and Urbanska-Rys, Halina and Salagacka, Aleksandra and Mirowski, Marek and Robak, Tadeusz
Leukemia research, ISSN 0145-2126, 2008, Volume 33, Issue 2, pp. 332 - 335
Hematology, Oncology and Palliative Medicine | P-glycoprotein | Genetic predisposition | MDR1 | ABCB1 | SNP | Multiple myeloma | Haplotype | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Haplotypes | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Humans | Polymerase Chain Reaction | Polymorphism, Single Nucleotide | Case-Control Studies | Multiple Myeloma - genetics | Polymorphism, Genetic | Drug resistance in microorganisms | Pharmacogenetics | Algorithms | Genes | Genetic aspects | Cancer | Index Medicus
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7. Full Text Associations between variants in the ABCB1 (MDR1) gene and corticosteroid dependence in children with Crohn's disease
by Krupoves, Alfreda and Mack, David and Seidman, Ernest and Deslandres, Colette and Amre, Devendra
Inflammatory bowel diseases, ISSN 1078-0998, 11/2011, Volume 17, Issue 11, pp. 2308 - 2317
gene/drug response | Crohn's disease | steroids in IBD | ABCB1 | pharmacogenetics | pediatric | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Crohn Disease - genetics | Genetic Predisposition to Disease | Glucocorticoids - therapeutic use | Prognosis | Humans | Genotype | Male | DNA - genetics | Haplotypes - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | DNA - analysis | Budesonide - therapeutic use | Crohn Disease - drug therapy | Adolescent | Polymerase Chain Reaction | Polymorphism, Single Nucleotide - genetics | Female | ATP Binding Cassette Transporter, Sub-Family B | Retrospective Studies | Child | Prednisone - therapeutic use | Cohort Studies | Corticoids | Drugs | Haplotypes | Pediatrics | Inflammatory bowel diseases | Single-nucleotide polymorphism | Metabolism | Blood | Side effects | Intestine | Gastroenterology | Remission | Children | P-Glycoprotein | Saliva | Age | Index Medicus
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8. Full Text Association of the MDR1 (ABCB1) gene 3435C> T polymorphism with male infertility
by Droździk, Marek and Stefankiewicz, Joanna and Kurzawa, Rafał and Górnik, Wanda and Bączkowski, Tomasz and Kurzawski, Mateusz
Pharmacological reports, ISSN 1734-1140, 07/2009, Volume 61, Issue 4, pp. 690 - 696
P-glycoprotein | male infertility | genetic polymorphism | MDR1 (ABCB1) | Male infertility | Genetic polymorphism | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Thymidine - genetics | Humans | Middle Aged | Genotype | Male | ATP Binding Cassette Transporter, Subfamily B | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | Young Adult | Infertility, Male - genetics | Alleles | Polymorphism, Single Nucleotide - genetics | Adult | Semen - physiology | Infertility, Male - diagnosis | Index Medicus
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