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Nature, ISSN 0028-0836, 08/2008, Volume 454, Issue 7205, pp. 776 - 779
On activation by receptors, the ubiquitously expressed class IA isoforms (p110 alpha and p110 beta) of phosphatidylinositol-3-OH kinase (PI(3)K) generate lipid... 
BETA-GAMMA | CATALYTIC SUBUNIT | PHOSPHATIDYLINOSITOL 3-KINASES | LYSOPHOSPHATIDIC ACID | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | TUMOR-SUPPRESSOR GENE | EMBRYONIC LETHALITY | PI 3-KINASE | PHOSPHOINOSITIDE 3-KINASE | P110-ALPHA SUBUNIT
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 10/2017, Volume 140, Issue 4, pp. 1152 - 1152
Journal Article
SCIENCE SIGNALING, ISSN 1945-0877, 12/2012, Volume 5, Issue 253
Synergistic activation by heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) and receptor tyrosine kinases distinguishes... 
CATALYTIC SUBUNIT | P110-ALPHA | ISOFORMS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | PURIFICATION | GROWTH | PHOSPHOINOSITIDE 3-KINASE P110-BETA | CANCER | BINDING | CELL BIOLOGY
Journal Article
Journal Article
Journal Article
BLOOD, ISSN 0006-4971, 04/2019, Volume 133, Issue 16, pp. 1742 - 1752
This phase 1/2 study assessed parsaclisib (INCB050465), a next-generation, potent, and highly selective phosphatidylinositol 3-kinase delta (PI3K delta)... 
CLINICAL-PRACTICE GUIDELINES | DIAGNOSIS | P110-ALPHA | MANAGEMENT | IDELALISIB | RESPONSE ASSESSMENT | CHRONIC LYMPHOCYTIC-LEUKEMIA | HODGKIN | FOLLICULAR LYMPHOMA | COPANLISIB | HEMATOLOGY | Lymphoid Neoplasia
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2009, Volume 106, Issue 40, pp. 16996 - 17001
Mutations in oncogenes often promote tumorigenesis by changing the conformation of the encoded proteins, thereby altering enzymatic activity. The PIK3CA... 
Proteins | Enzymes | Sodium | Crystals | Lipids | Cell membranes | Biochemistry | Genetic mutation | Oncogenes | Phosphatidylinositols | p110 | p85 | Oncogene | Mutant | CATALYTIC SUBUNIT | P110-ALPHA | PIK3CA MUTATIONS | ISOFORMS | MECHANISM | MULTIDISCIPLINARY SCIENCES | oncogene | PHOSPHOINOSITIDE 3-KINASE | WORTMANNIN | CELL LUNG-CANCER | PATHWAY | mutant | INHIBITOR | Biological Sciences
Journal Article
ACS CHEMICAL BIOLOGY, ISSN 1554-8929, 03/2019, Volume 14, Issue 3, pp. 325 - 331
Activating mutations in RAS can lead to oncogenesis by enhancing downstream signaling, such as through the MAPK and PI3K pathways. Therefore, therapeutically... 
P110-ALPHA | ACTIVATION | NUCLEOTIDE EXCHANGE | RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | MUTATIONS | FEEDBACK | ERK
Journal Article
Biophysical Journal, ISSN 0006-3495, 11/2017, Volume 113, Issue 9, pp. 1956 - 1967
How calmodulin (CaM) acts in -driven cancers is a vastly important question. CaM binds to and stimulates PI3K /Akt signaling, promoting cell growth and... 
REGULATORY SUBUNIT | BIOPHYSICS | K-RAS | CALCIUM-CHANNELS | PHOSPHOINOSITIDE 3-KINASE P110-ALPHA | PHOSPHATIDYLINOSITOL 3-KINASE | CRYSTAL-STRUCTURE | HYPERVARIABLE REGION | DEPENDENT PROTEIN-KINASE | CELL-PROLIFERATION | MOLECULAR-BASIS | Proteins
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2018, Volume 61, Issue 12, pp. 5435 - 5441
In this paper, we describe the discovery and optimization of a new chemotype of isoform selective PI3K gamma inhibitors. Starting from an HTS hit, potency and... 
GAMMA | P110-ALPHA | CHEMISTRY, MEDICINAL | EMBRYONIC LETHALITY | TARGETS | PI3K-GAMMA | SUBUNIT
Journal Article
Journal Article
Journal Article