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p110-gamma (36) 36
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Blood, ISSN 0006-4971, 03/2010, Volume 115, Issue 11, pp. 2203 - 2213
We have previously described critical and nonredundant roles for the phosphoinositide 3-kinase p110 delta during the activation and differentiation of naive T... 
RHEUMATOID-ARTHRITIS | TRANSCRIPTION FACTORS | B-CELL | PHOSPHATIDYLINOSITOL 3-KINASE | PHOSPHOINOSITIDE 3-KINASE P110-DELTA | P110-GAMMA | ISOFORM | GENERATION | ALLERGIC AIRWAY INFLAMMATION | HEMATOLOGY | CUTTING EDGE
Journal Article
European Journal of Immunology, ISSN 0014-2980, 05/2008, Volume 38, Issue 5, pp. 1215 - 1224
The p110δ isoform of class I phosphoinositide 3‐kinase (PI3K) plays a major role in B cell receptor signaling, while its p110γ counterpart is thought to... 
Autoimmunity | Kinases | Cell trafficking | Neutrophils | RHEUMATOID-ARTHRITIS | RECRUITMENT | ACTIVATION | ISOFORMS | PHOSPHATIDYLINOSITOL 3-KINASE | IMMUNOLOGY | CELL DEVELOPMENT | DEPENDENT ROLE | P110-DELTA | kinases | autoimmunity | INFL AMMATORY ARTHRITIS | P110-GAMMA | cell trafficking | neutrophils
Journal Article
by Yu, QH and Li, W and Jin, R and Yu, SY and Xie, DW and Zheng, XC and Zhong, W and Cheng, X and Hu, SB and Li, M and Zheng, QC and Li, GH and Song, ZF
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 03/2019, Volume 39, Issue 3, pp. E91 - E105
Objective Vascular smooth muscle cells (VSMCs) phenotype modulation is critical for the resolution of vascular injury. Genetic and pharmacological inhibition... 
cell proliferation | PHOSPHATIDYLINOSITOL 3-KINASE | HIPPO PATHWAY | carotid arteries | PROLIFERATION | GROWTH-FACTOR-BB | muscle cells | bone marrow | IN-VITRO | LYSOPHOSPHATIDIC ACID | GENE | cyclic AMP response element binding protein | P110-GAMMA | PERIPHERAL VASCULAR DISEASE | PI3K-GAMMA | HEMATOLOGY | EXPRESSION
Journal Article
Leukemia, ISSN 0887-6924, 09/2015, Volume 29, Issue 9, pp. 1811 - 1822
The functional relevance of the B-cell receptor (BCR) and the evolution of protein kinases as therapeutic targets have recently shifted the paradigm for... 
SURVIVAL | IN-VITRO | B-CELL | 3-KINASE P110-DELTA | ONCOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE-DELTA | P110-GAMMA | CHRONIC LYMPHOCYTIC-LEUKEMIA | TYROSINE KINASE INHIBITOR | PI3K-GAMMA | HEMATOLOGY | CUTTING EDGE | Chemokine CCL3 - secretion | Chemokine CCL4 - secretion | Leukocytes, Mononuclear - metabolism | Phosphorylation | Prognosis | Ribosomal Protein S6 Kinases - metabolism | Apoptosis - drug effects | Humans | Middle Aged | Male | Phosphatidylinositol 3-Kinases - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Receptors, Antigen, B-Cell - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Case-Control Studies | Isoquinolines - pharmacology | Aged, 80 and over | Female | Chemotaxis - immunology | Proto-Oncogene Proteins c-akt - metabolism | Quinazolinones - pharmacology | Pyrazoles - pharmacology | Cell Survival - drug effects | Leukocytes, Mononuclear - drug effects | Purines - pharmacology | Stromal Cells - metabolism | Chemotaxis - drug effects | Pyrimidines - pharmacology | Cell Survival - immunology | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Aged | Cell Proliferation - drug effects | Bone Marrow Cells - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Chronic lymphocytic leukemia | Development and progression | Genetic aspects | Cellular signal transduction | Properties | Health aspects | Phosphotransferases | BCR | microenvironment | PI3Kinase | CLL | p110γ | IPI-145 | p110δ | apoptosis | Duvelisib
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 06/2017, Volume 8
The class I phosphoinoside-3-kinases (PI3Ks) are important enzymes that relay signals from cell surface receptors to downstream mediators driving cellular... 
MIGRATION | P110-GAMMA ISOFORM | ACTIVATION | P110-ALPHA | PHOSPHATIDYLINOSITOL 3-KINASE | IMMUNOLOGY | P110-DELTA | RESPONSES | AUTOIMMUNE | B cell survival | PI3K | lipid kinase | phosphoinoside-3-kinase | B cell differentiation | B cell proliferation | PI3K-GAMMA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 47, pp. 18862 - 18867
Journal Article
Current Opinion in Immunology, ISSN 0952-7915, 2011, Volume 23, Issue 2, pp. 178 - 183
Journal Article
EXPERT OPINION ON INVESTIGATIONAL DRUGS, ISSN 1354-3784, 2017, Volume 26, Issue 11, pp. 1267 - 1279
Journal Article
BLOOD, ISSN 0006-4971, 12/2008, Volume 112, Issue 12, pp. 4655 - 4664
Specific inhibitors of PI3K isoforms are currently evaluated for their therapeutic potential in leukemia. We found that BCR/ABL(+) human leukemic cells express... 
GRANULE EXOCYTOSIS | B-CELL | INDUCED TRANSFORMATION | PHOSPHATIDYLINOSITOL 3-KINASE | PHOSPHOINOSITIDE 3-KINASE P110-DELTA | P110-GAMMA | EMBRYONIC LETHALITY | RECEPTOR | MICE | HEMATOLOGY | CYTOTOXICITY
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 07/2015, Volume 469, pp. 59 - 69
Class IB phosphoinositide 3-kinases gamma (PI3K gamma) are second-messenger-generating enzymes downstream of signalling cascades triggered by G-protein-coupled... 
G beta gamma | CATALYTIC SUBUNIT | CELLS | EXCHANGE MASS-SPECTROMETRY | ACTIVATION | signal transduction | RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | PHOSPHOLIPASE A | p87 | p101 | phosphoinositide 3-kinase gamma (PI3K gamma) | STRUCTURAL BASIS | P110-GAMMA | G-protein | BINDING
Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG) stimulate innate immune responses. Phosphoinositide 3-kinase (PI3K) has been... 
RHEUMATOID-ARTHRITIS | REGULATORY SUBUNIT | ACTIVATION | NEGATIVE REGULATION | KINASE | BIOLOGY | P110-GAMMA | PI3K-GAMMA INHIBITION | CELLS REQUIRES | BACTERIAL-DNA | I INTERFERON
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 01/2010, Volume 30, Issue 1, pp. 78 - 90
Upon ligand binding, G-protein-coupled receptors (GPCRs) impart the signal to heterotrimeric G proteins composed of alpha, beta, and gamma subunits, leading to... 
CELLS | ACTIVATION | HETEROTRIMERIC G-PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAFFICKING | P110-GAMMA | COUPLED RECEPTORS | ISOFORM | ADRENERGIC-RECEPTOR KINASE | PLASMA-MEMBRANE | COMPLEX TRANSLOCATION | CELL BIOLOGY
Journal Article
Science, ISSN 0036-8075, 10/2007, Volume 318, Issue 5847, pp. 64 - 66
Class I phosphoinositide 3-kinase (PI3K) signaling pathways regulate several important cellular functions, including cellular growth, division, survival, and... 
T lymphocytes | Receptors | Disease models | Neutrophils | Lipids | Ligands | Mast cells | Perspectives | Physiological regulation | Cells | Endothelial cells | PHOSPHOINOSITIDE 3-KINASE P110-GAMMA | INHIBITION | MULTIDISCIPLINARY SCIENCES | KINASE | SUBUNIT
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 01/2018, Volume 32, Issue 1, pp. 319 - 319
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2016, Volume 7, Issue 10, pp. 908 - 912
Dual inhibition of PI3K-δ and PI3K-γ is an established therapeutic strategy for treatment of hematological malignancies. Reported molecules targeting PI3K-δ/γ... 
PI3K-δ | kinase inhibitor | phosphatidylinositol-4,5-bisphosphate 3-kinase-delta | p110-γ | PI3K-γ | p110-δ | p110-delta | PI3K-gamma | POTENT | CHEMISTRY, MEDICINAL | MODELS | KINASE | p110-gamma | PI3K-GAMMA INHIBITION | PI3K-delta
Journal Article
Journal Article