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Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 8057 - 18
CAS is a docking protein downstream of the proto-oncogene Src with a role in invasion and metastasis of cancer cells. The CAS SH3 domain is indispensable for... 
DIRECT BINDING | TYROSINE PHOSPHORYLATION | EPITHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | SRC-TRANSFORMED CELLS | SUBCELLULAR-LOCALIZATION | FOCAL ADHESION KINASE | SUBSTRATE P130(CAS) | FREE-ENERGIES | V-SRC | MOLECULAR-MECHANICS | Tyrosine | Phosphorylation | Arginine | Lysine | Ligands | Leucine | Metastases | Cancer | Index Medicus
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 2/2014, Volume 71, Issue 4, pp. 727 - 744
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2017, Volume 7, Issue 1, pp. 46233 - 46233
CAS is a docking protein, which was shown to act as a mechanosensor in focal adhesions. The unique assembly of structural domains in CAS is important for its... 
LOCALIZATION | DIRECT BINDING | PROTEIN | TYROSINE PHOSPHORYLATION | SRC | CELL-MIGRATION | MULTIDISCIPLINARY SCIENCES | KINASE | DYNAMICS | P130(CAS) | SH3 DOMAIN | Mechanotransduction | Clonal deletion | Localization | Cellular apoptosis susceptibility protein | Index Medicus
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 1998, Volume 19, Issue 4, pp. 361 - 365
p130(Cas) (Cas), the protein encoded by the Crkas gene (also known as Gas), is an adaptor molecule with a unique structure that contains a Src homology (SH)-3... 
STABLE ASSOCIATION | DISRUPTION | CRK-ASSOCIATED SUBSTRATE | TYROSINE PHOSPHORYLATION | CELL-TRANSFORMATION | MOLECULE | GROWTH | GENETICS & HEREDITY | P130 | MONOCLONAL-ANTIBODIES | PROTEINS
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 2/1998, Volume 140, Issue 4, pp. 961 - 972
Carcinoma cells selected for their ability to migrate in vitro showed enhanced invasive properties in vivo. Associated with this induction of migration was the... 
COS cells | Cell motility | Molecules | Phosphorylation | Cell lines | Cell adhesion | Collagens | Antibodies | Cellular immunity | Cells | GROWTH-FACTOR RECEPTOR | PROTEIN-TYROSINE KINASES | V-CRK | SRC | C-CRK | SH3 DOMAINS | EXTRACELLULAR-MATRIX | FOCAL ADHESION KINASE | BINDING PROTEIN | PC12 CELLS | CELL BIOLOGY | Crk-Associated Substrate Protein | Phosphoproteins - drug effects | Pancreas - physiopathology | Gene Expression - genetics | Humans | Pancreas - cytology | ras Proteins - metabolism | Phosphoproteins - metabolism | Cell Movement - physiology | Membrane Proteins - analysis | Cell Membrane - chemistry | Proteins | Neoplasm Metastasis | ras Proteins - chemistry | Extracellular Matrix - physiology | Gene Expression - physiology | Cell Membrane - metabolism | Tumor Cells, Cultured | Proto-Oncogene Proteins - metabolism | rac GTP-Binding Proteins | Insulin - pharmacology | Rabbits | Proto-Oncogene Proteins - drug effects | GTP-Binding Proteins - chemistry | Pancreatic Neoplasms - pathology | Proto-Oncogene Proteins c-crk | Pancreas - pathology | Proto-Oncogene Proteins - genetics | Phosphoproteins - genetics | Hypoglycemic Agents - pharmacology | src Homology Domains | Cell Movement - drug effects | Tyrosine - metabolism | Animals | Retinoblastoma-Like Protein p130 | Protein Binding | COS Cells | GTP-Binding Proteins - metabolism | Tyrosine | Physiological aspects | Research | Cancer invasiveness | Cell migration | Cancer cells | Cellular biology | Index Medicus
Journal Article
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 2/2002, Volume 156, Issue 4, pp. 725 - 736
Initiation of cell migration requires morphological polarization with formation of a dominant leading pseudopodium and rear compartment. A molecular... 
COS cells | Chemotactic factors | Phosphorylation | Cell growth | 3T3 cells | NIH 3T3 cells | Antibodies | Pseudopodia | Cells | Integrins | Rac GTPase | Signal transduction | Pseudopodium | Chemotaxis | Cell migration | PROTEIN | signal transduction | PHOSPHORYLATION | INTEGRIN | TYROSINE KINASES | P130(CAS) | CELL BIOLOGY | pseudopodium | MIGRATING CELLS | cell migration | FOCAL ADHESION KINASE | RHO-GTPASES | BINDING | chemotaxis | Crk-Associated Substrate Protein | Protein Kinases - metabolism | Cell Polarity | Cercopithecus aethiops | rac GTP-Binding Proteins - metabolism | cdc42 GTP-Binding Protein - metabolism | Phosphoproteins - metabolism | Proteins | Pseudopodia - drug effects | Chemotactic Factors - pharmacology | Chemotaxis - physiology | Proto-Oncogene Proteins c-cbl | Lysophospholipids - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins c-crk | Ubiquitin-Protein Ligases | Animals | Pseudopodia - metabolism | rho GTP-Binding Proteins - metabolism | Retinoblastoma-Like Protein p130 | Mice | Enzyme Activation | Pseudopodia - physiology | COS Cells | 3T3 Cells | rac1 GTP-Binding Protein - metabolism | Physiological aspects | Polarity (Biology) | Cytoskeletal proteins | Cellular signal transduction | Analysis | Membranes | Biochemistry | Cellular biology | Index Medicus | cell migration; chemotaxis; signal transduction; pseudopodium; Rac GTPase
Journal Article
by Liu, GF and Li, WQ and Gao, X and Li, XL and Jurgensen, C and Park, HT and Shin, NY and Yu, J and He, ML and Hanks, SK and Wu, JY and Guan, KL and Rao, Y
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 01/2007, Volume 27, Issue 4, pp. 957 - 968
Netrins are an important family of axon guidance cues. Here, we report that netrin- 1 induces tyrosine phosphorylation of p130(CAS) (Crk-associated substrate).... 
NERVOUS-SYSTEM | STABLE ASSOCIATION | signaling | DCC | SPINAL-CORD | TYROSINE PHOSPHORYLATION SITES | NEUROSCIENCES | COLORECTAL-CANCER | IN-VIVO | C-ELEGANS | Rac1 | commissural axons | FOCAL ADHESION KINASE | p130(CAS) | GUIDES CELL | netrin-1 | Cdc42
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2000, Volume 275, Issue 16, pp. 11706 - 11712
Journal Article
Journal Article