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1. Full Text Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
by Chang, Jianhui and Wang, Yingying and Shao, Lijian and Laberge, Remi-Martin and Demaria, Marco and Campisi, Judith and Janakiraman, Krishnamurthy and Sharpless, Norman E and Ding, Sheng and Feng, Wei and Luo, Yi and Wang, Xiaoyan and Aykin-Burns, Nukhet and Krager, Kimberly and Ponnappan, Usha and Hauer-Jensen, Martin and Meng, Aimin and Zhou, Daohong
Nature medicine, ISSN 1078-8956, 01/2016, Volume 22, Issue 1, pp. 78 - 83
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Whole-Body Irradiation | Apoptosis - drug effects | Humans | bcl-X Protein - genetics | Hematopoietic Stem Cells - pathology | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | Gene Knockdown Techniques | Myoblasts - drug effects | Cyclin-Dependent Kinase Inhibitor p16 - drug effects | Cellular Senescence | Ganciclovir - pharmacology | Antineoplastic Agents - pharmacology | Colony-Forming Units Assay | RNA, Messenger - drug effects | Hematopoietic Stem Cells - drug effects | Cell Line | Cell Survival - drug effects | Antiviral Agents - pharmacology | Aniline Compounds - pharmacology | Rejuvenation | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Myoblasts - pathology | Sulfonamides - pharmacology | Blotting, Western | B-Lymphocytes - drug effects | Animals | Cell Cycle | Microscopy | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Mice | DNA Damage | Proto-Oncogene Proteins c-bcl-2 - genetics | Physiological aspects | Aging | Genetic aspects | Research | Hematopoietic stem cells | Cells | Bone marrow | Cytotoxicity | Senescence | Molecular biology | Stem cells | Apoptosis | Index Medicus
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2. Full Text Immunohistochemically Detected Expression of 3 Major Genes (CDKN2A/p16, TP53, and SMAD4/DPC4) Strongly Predicts Survival in Patients With Resectable Pancreatic Cancer
by Oshima, Minoru and Okano, Keiichi and Muraki, Shinobu and Haba, Reiji and Maeba, Takashi and Suzuki, Yasuyuki and Yachida, Shinichi
Annals of surgery, ISSN 0003-4932, 08/2013, Volume 258, Issue 2, pp. 336 - 346
Smad4/Dpc4 | immunohistochemistry | p16 | p53 | pancreatic ductal adenocarcinoma | Life Sciences & Biomedicine | Surgery | Science & Technology | Immunohistochemistry | Multivariate Analysis | Pancreatic Neoplasms - metabolism | Follow-Up Studies | Humans | Middle Aged | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Male | Pancreaticoduodenectomy | Carcinoma, Pancreatic Ductal - surgery | Tumor Suppressor Protein p53 - genetics | Carcinoma, Pancreatic Ductal - genetics | Genes, p53 | Smad4 Protein - genetics | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Carcinoma, Pancreatic Ductal - mortality | Female | Pancreatic Neoplasms - mortality | Retrospective Studies | Pancreatic Neoplasms - surgery | Pancreatectomy | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Pancreatic Neoplasms - genetics | Treatment Outcome | Genetic Markers | Genes, p16 | Smad4 Protein - metabolism | Survival Analysis | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Aged | Biomarkers, Tumor - genetics | Mutation | Index Medicus | Abridged Index Medicus
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3. Full Text Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
by Jeon, O.H and Kim, C and Laberge, R.M and Demaria, M and Rathod, S and Vasserot, A.P and Chung, J.W and Kim, D.H and Poon, Y and David, N and Baker, D.J and Deursen, J.M.A. van and Campisi, J and Elisseeff, J.H
Nature medicine, ISSN 1078-8956, 2017, Volume 23, Issue 6, pp. 775 - 781
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Immunohistochemistry | Anterior Cruciate Ligament - surgery | Humans | Immunoblotting | Cartilage, Articular - metabolism | Regeneration - genetics | Anterior Cruciate Ligament Injuries - complications | Ganciclovir - pharmacology | Real-Time Polymerase Chain Reaction | Chondrocytes - metabolism | Extracellular Matrix Proteins - metabolism | Cellular Senescence - genetics | Antiviral Agents - pharmacology | Glycosaminoglycans - metabolism | Extracellular Matrix Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Mice, Transgenic | Osteoarthritis, Knee - etiology | Reverse Transcriptase Polymerase Chain Reaction | Animals | Osteoarthritis, Knee - genetics | Fluorescent Antibody Technique | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Weight-Bearing | Mice | In Vitro Techniques | Osteoarthritis, Knee - metabolism | Aging | Development and progression | Extracellular matrix | Phenotype | Research | Osteoarthritis | Index Medicus
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4. Full Text Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
by Molofsky, Anna V and Slutsky, Shalom G and Joseph, Nancy M and He, Shenghui and Pardal, Ricardo and Krishnamurthy, Janakiraman and Sharpless, Norman E and Morrison, Sean J
Nature (London), ISSN 0028-0836, 09/2006, Volume 443, Issue 7110, pp. 448 - 452
Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Cell Proliferation | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Neurons - cytology | Stem Cells - cytology | Regeneration - physiology | Animals | Aging - physiology | Prosencephalon - cytology | Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Olfactory Bulb - physiology | Mice | Prosencephalon - metabolism | Olfactory Bulb - cytology | Aging | Brain | Neurology | Gene expression | Rodents | Index Medicus
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5. Full Text Geriatric muscle stem cells switch reversible quiescence into senescence
by Sousa-Victor, Pedro and Gutarra, Susana and GarcĆ­a-Prat, Laura and Rodriguez-Ubreva, Javier and Ortet, Laura and Ruiz-Bonilla, Vanessa and JardĆ­, MercĆØ and Ballestar, Esteban and GonzĆ”lez, Susana and Serrano, Antonio L and Perdiguero, Eusebio and MuƱoz-CĆ”noves, Pura
Nature (London), ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 316 - 321
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Humans | Mice, Inbred C57BL | Retinoblastoma Protein - metabolism | Satellite Cells, Skeletal Muscle - cytology | Cells, Cultured | Rejuvenation | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Male | Satellite Cells, Skeletal Muscle - metabolism | E2F1 Transcription Factor - metabolism | Progeria - metabolism | Young Adult | Regeneration | Animals | Progeria - pathology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Adult | Mice | Aging - metabolism | Aging | Physiological aspects | Muscles | Stem cells | Musculoskeletal system | Rodents | Homeostasis | Muscular system | Gene expression | Age | Binding sites | Index Medicus
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6. Full Text p16INK4A inactivation mechanisms in non-small-cell lung cancer patients occupationally exposed to asbestos
by Andujar, Pascal and Wang, Jinhui and Descatha, Alexis and Galateau-SallĆ©, FranƧoise and Abd-Alsamad, Issam and Billon-Galland, Marie-Annick and Blons, HĆ©lĆØne and Clin, BĆ©nĆ©dicte and Danel, Claire and Housset, Bruno and Laurent-Puig, Pierre and Le Pimpec-Barthes, FranƧoise and Letourneux, Marc and Monnet, Isabelle and RĆ©gnard, Jean-FranƧois and Renier, Annie and Zucman-Rossi, Jessica and Pairon, Jean-Claude and Jaurand, Marie-Claude
Lung cancer (Amsterdam, Netherlands), ISSN 0169-5002, 2009, Volume 67, Issue 1, pp. 23 - 30
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | Occupation | Asbestos | Lung cancer | Tobacco smoking | Deletion | INK4A | P16/CDKN2A | Hypermethylation | Toxicology | Tumors of the respiratory system and mediastinum | Biological and medical sciences | Medical sciences | Tobacco, tobacco smoking | Tumors | Pneumology | Lung Neoplasms - genetics | Asbestos - toxicity | Lung Neoplasms - chemically induced | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Lung Neoplasms - metabolism | Middle Aged | Occupational Exposure | Carcinoma, Non-Small-Cell Lung - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Male | Cyclin-Dependent Kinase Inhibitor p16 - antagonists & inhibitors | Loss of Heterozygosity | Promoter Regions, Genetic - drug effects | Carcinogens - toxicity | DNA Methylation | Gene Deletion | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Female | Aged | Carcinoma, Non-Small-Cell Lung - chemically induced | Smoking | Index Medicus | Promoter Regions, Genetic | Carcinoma, Non-Small-Cell Lung | Lung Neoplasms | Cyclin-Dependent Kinase Inhibitor p16 | Life Sciences | Carcinogens | Cancer
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7. Full Text HPV-DNA Positive/p16 IHC Negative Oral Squamous Cell Carcinoma: A Case Report
by Olga, Di Fede and Ylenia, Giardina and Luigi, Laino and Marco, Mascitti and Michele, Melillo and Giuseppina, Capra and Vera, Panzarella
Proceedings, ISSN 2504-3900, 12/2019, Volume 35, Issue 1, p. 58
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8. Full Text MIAT lncRNA is overexpressed in breast cancer and its inhibition triggers senescence and G1 arrest in MCF7 cell line
by Alipoor, Firooz J and Asadi, Malek H and Torkzadehā€Mahani, Masoud
Journal of cellular biochemistry, ISSN 0730-2312, 08/2018, Volume 119, Issue 8, pp. 6470 - 6481
MIAT lncRNA | breast cancer | cellular senescence | P16 | G1 arrest | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasm Proteins - biosynthesis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Cyclin-Dependent Kinase Inhibitor p16 - genetics | RNA, Long Noncoding - genetics | Breast Neoplasms - metabolism | Cyclooxygenase 2 - biosynthesis | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | MCF-7 Cells | Breast Neoplasms - pathology | Cellular Senescence | Cyclooxygenase 2 - genetics | RNA, Long Noncoding - biosynthesis | Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis | G1 Phase Cell Cycle Checkpoints | RNA, Neoplasm - genetics | Adult | Female | Neoplasm Proteins - genetics | Prevention | Development and progression | Breast cancer | Tumor proteins | Cancer | Cell proliferation | Myocardial infarction | Regulators | Senescence | Tumor markers | p53 Protein | INK4a protein | p16 Protein | ErbB-2 protein | Metastases | Cell cycle | Infarction | Cyclooxygenase-2 | Cell migration | Tumors | Apoptosis | Index Medicus
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9. Full Text T-helper-1-cell cytokines drive cancer into senescence
by BraumĆ¼ller, Heidi and Wieder, Thomas and Brenner, Ellen and AƟmann, Sonja and Hahn, Matthias and Alkhaled, Mohammed and Schilbach, Karin and Essmann, Frank and Kneilling, Manfred and Griessinger, Christoph and Ranta, Felicia and Ullrich, Susanne and Mocikat, Ralph and Braungart, Kilian and Mehra, Tarun and Fehrenbacher, Birgit and Berdel, Julia and Niessner, Heike and Meier, Friedegund and Van Den Broek, Maries and HƤring, Hans-Ulrich and Handgretinger, Rupert and Quintanilla-Martinez, Leticia and Fend, Falko and Pesic, Marina and Bauer, JĆ¼rgen and Zender, Lars and Schaller, Martin and Schulze-Osthoff, Klaus and Rƶcken, Martin
Nature (London), ISSN 0028-0836, 02/2013, Volume 494, Issue 7437, pp. 361 - 365
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Proliferation | Humans | Male | Receptors, Tumor Necrosis Factor, Type I - metabolism | Th1 Cells - immunology | Cellular Senescence - immunology | STAT1 Transcription Factor - metabolism | Time Factors | Tumor Necrosis Factor-alpha - immunology | Female | Tumor Cells, Cultured | Retinoblastoma Protein - chemistry | Cytokines - immunology | Disease Models, Animal | Oncogenes - genetics | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Antigens, Polyomavirus Transforming - genetics | Antigens, Polyomavirus Transforming - metabolism | Retinoblastoma Protein - metabolism | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Mice, Transgenic | Mice, SCID | Phosphoserine - metabolism | Disease Progression | Animals | Cell Cycle | Neoplasms - immunology | Interferon-gamma - immunology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Mice, Inbred NOD | Mice | Neoplasms - pathology | Care and treatment | Cytokines | Cellular control mechanisms | Cancer cells | Research | Observations | Testing | Cancer | Proteins | Medical research | Incorporation | Cytotoxicity | Arrests | Chemokines | Tumors | Apoptosis | Index Medicus
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10. Full Text The Ink4/Arf locus is a barrier for iPS cell reprogramming
by Serrano, Manuel and Li, Han and Collado, Manuel and Blasco, Maria A and CaƱamero, Marta and Ortega, Sagrario and Strati, Katerina and Villasante, Aranzazu
Nature (London), ISSN 0028-0836, 08/2009, Volume 460, Issue 7259, pp. 1136 - 1139
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Embryonic Stem Cells - cytology | Pluripotent Stem Cells - cytology | Cell Count | Epigenesis, Genetic | Humans | Mice, Inbred C57BL | Gene Silencing | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Keratinocytes | Pluripotent Stem Cells - metabolism | Animals | Aging - physiology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Cell Differentiation | Fibroblasts - cytology | Mice | Kinetics | Cellular Reprogramming - physiology | Fibroblasts - metabolism | Physiological aspects | Fibroblasts | Tumor suppressor genes | Genetic aspects | Research | Tumor proteins | Gene expression | Kinases | Binding sites | Cells | Apoptosis | Tumors | Index Medicus
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