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Journal Article
Genes and Development, ISSN 0890-9369, 05/2013, Volume 27, Issue 10, pp. 1101 - 1114
Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or... 
Huwe1 | c-Myc | Mule | Ras | p21 | Miz1 | DNA-DAMAGE | KERATINOCYTE GROWTH | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | BASE EXCISION-REPAIR | HUWE1 UBIQUITIN LIGASE | NEGATIVE REGULATION | GENETICS & HEREDITY | ARF TUMOR-SUPPRESSOR | DIFFERENTIATION | MIZ-1 | HUMAN CANCER | Protein Inhibitors of Activated STAT - deficiency | Tetradecanoylphorbol Acetate - pharmacology | 9,10-Dimethyl-1,2-benzanthracene - pharmacology | Male | Protein Inhibitors of Activated STAT - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - biosynthesis | Oncogene Protein p21(ras) - metabolism | Cyclin-Dependent Kinase Inhibitor p16 | Oncogene Protein p21(ras) - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cell Transformation, Neoplastic - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Nuclear Proteins - deficiency | Protein Inhibitors of Activated STAT - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Nuclear Proteins - genetics | Protein Inhibitors of Activated STAT - antagonists & inhibitors | Skin Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Signal Transduction | Down-Regulation | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Skin Neoplasms - chemically induced | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Keratinocytes - pathology | Animals | Tumor Suppressor Protein p53 | Keratinocytes - drug effects | Keratinocytes - metabolism | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-myc - deficiency | Skin Neoplasms - genetics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Ubiquitin-Protein Ligases - deficiency | Mice | Proto-Oncogene Proteins c-myc - genetics | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Genes, ras | Ubiquitin-Protein Ligases - genetics | Oncogene Protein p21(ras) - genetics | Carcinogenesis | Ras genes | Analysis | Index Medicus | Research Paper
Journal Article
FEBS Journal, ISSN 1742-464X, 12/2015, Volume 282, Issue 24, pp. 4810 - 4821
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 139, Issue 2, pp. 586 - 597.e6
Background & Aims Patients carrying germline mutations of LKB1 have an increased risk of pancreatic cancer; however, it is unclear whether down-regulation of... 
Gastroenterology and Hepatology | Kras | Pancreatic Cancer | LKb1 | p21 | PEUTZ-JEGHERS-SYNDROME | MUTATION CARRIERS | KINASE | P53 | LUNG-CANCER | GENE | POLYPOSIS | TUMOR-SUPPRESSOR | MICE | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | Haplotypes | Protein-Serine-Threonine Kinases - deficiency | Pancreatic Neoplasms - metabolism | Prognosis | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - deficiency | Carcinoma, Pancreatic Ductal - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Time Factors | Cell Transformation, Neoplastic - genetics | Proto-Oncogene Proteins p21(ras) - deficiency | Trans-Activators - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Carcinoma, Pancreatic Ductal - mortality | Pancreatic Neoplasms - mortality | Genes, Tumor Suppressor | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Promoter Regions, Genetic | Risk Assessment | Pancreatic Neoplasms - pathology | Proportional Hazards Models | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Genotype | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | Cell Transformation, Neoplastic - metabolism | Disease Progression | Homeodomain Proteins - genetics | Mice, Knockout | Homozygote | Phenotype | Animals | Heterozygote | Mice | Cell Transformation, Neoplastic - pathology | Deregulation | Gene mutations | Pancreatic cancer | Oncology, Experimental | Research | Protein kinases | Cancer | Index Medicus | Abridged Index Medicus | Basic—Liver, Pancreas, and Biliary Tract | AMPK, adenosine monophosphate–activated protein kinase | PanIN, pancreatic intraepithelial neoplasia | PDAC, pancreatic ductal adenocarcinoma
Journal Article
Nature Communications, ISSN 2041-1723, 05/2016, Volume 7, Issue 1, pp. 11363 - 11363
No effective targeted therapies exist for cancers with somatic KRAS mutations. Here we develop a synthetic lethal chemical screen in isogenic KRAS-mutant and... 
CELL LUNG-CANCER | SURVIVAL | COMBINATION THERAPY | STRATEGY | MULTIDISCIPLINARY SCIENCES | SYNTHETIC LETHAL INTERACTION | RESISTANCE | MUTATIONS | RAS ONCOGENES | EXPRESSION | REVEALS | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Male | Antineoplastic Agents - administration & dosage | Lung Neoplasms - physiopathology | G2 Phase - drug effects | Tumor Suppressor Protein p53 - genetics | rho-Associated Kinases - antagonists & inhibitors | Cell Cycle Proteins - antagonists & inhibitors | Enzyme Inhibitors - administration & dosage | Cyclin-Dependent Kinase Inhibitor p21 - genetics | rho-Associated Kinases - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Lung Neoplasms - enzymology | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | rho-Associated Kinases - genetics | Proto-Oncogene Proteins - genetics | Cell Division - drug effects | Animals | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Mutation | Transcription | Polo-like kinase 1 | Lung cancer | Cyclin-dependent kinases | RhoA protein | Kinases | Rho-associated kinase | Cyclin-dependent kinase | Organic chemistry | Synergistic effects | Cyclin-dependent kinase inhibitor p21 | Transfection | DNA microarrays | Polo-like kinase | Rocks | Inhibition | Tumors | Cancer | Index Medicus
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2016, Volume 18, Issue suppl_4, pp. iv83 - iv83
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2016, Volume 18, Issue suppl_4, pp. iv83 - iv84
Intracranial malignant peripheral nerve sheath tumors are extremely a rare disease with high morbidity and mortality. Epidemiological, clinical and prognostic... 
P21 Miscellaneous
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2016, Volume 18, Issue suppl_4, pp. iv83 - iv83
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2016, Volume 18, Issue suppl_4, pp. iv82 - iv82
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2016, Volume 18, Issue suppl_4, pp. iv81 - iv81
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2016, Volume 18, Issue suppl_4, pp. iv81 - iv81
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2016, Volume 18, Issue suppl_4, pp. iv81 - iv82
Characterizing a working-team concept in the practice of neuro-oncology requires continued interdisciplinary efforts. The Neuro-Oncology Scientific Club (NOSC)... 
P21 Miscellaneous
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2016, Volume 18, Issue suppl_4, pp. iv84 - iv84
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2016, Volume 18, Issue suppl_4, pp. iv82 - iv83
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2016, Volume 18, Issue suppl_4, pp. iv82 - iv82
Tumor Boards or Multidisciplinary Cancer Meetings (MCM) are the model of care for the management of cancer patients worldwide. Many neuro-oncology conditions... 
P21 Miscellaneous
Journal Article
Aging Cell, ISSN 1474-9718, 10/2017, Volume 16, Issue 5, pp. 1094 - 1103
Cellular senescence has been implicated in normal aging, tissue homeostasis, and tumor suppression. Although p53 has been shown to be a central mediator of... 
senescence | Akt | NOX | reactive oxygen species | p53 | NOX4 | CELLS | ACTIVATION | P53-INDUCED SENESCENCE | MTOR | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | OVEREXPRESSION | INHIBITION | ONCOGENIC RAS | GROWTH ARREST | ACCUMULATION | Interleukin-8 - genetics | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Proto-Oncogene Proteins p21(ras) - genetics | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | NF-kappa B - metabolism | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cell Cycle Checkpoints - genetics | Interleukin-8 - metabolism | Epithelial Cells - cytology | Mechanistic Target of Rapamycin Complex 2 - genetics | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Fibroblasts - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Lymphocytes - metabolism | Cellular Senescence - genetics | Promoter Regions, Genetic | NADPH Oxidase 4 - genetics | Interleukin-6 - genetics | Signal Transduction | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors | Lymphocytes - cytology | Morpholines | Mechanistic Target of Rapamycin Complex 2 - metabolism | NADPH Oxidase 4 - metabolism | NF-kappa B - genetics | Cell Cycle Checkpoints - drug effects | Fibroblasts - drug effects | Lymphocytes - drug effects | Cell Line, Tumor | Protein Binding | Fibroblasts - cytology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Chromones | RNA, Small Interfering - metabolism | Tumor proteins | Analysis | TOR protein | NF-κB protein | Senescence | H-Ras protein | p53 Protein | Homeostasis | AKT protein | Rapamycin | Interleukin 6 | Signal transduction | Cyclin-dependent kinase inhibitor p21 | NOX4 protein | Cell cycle | Fibroblasts | Interleukin 8 | Index Medicus | Original
Journal Article