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Scientific Reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, pp. 34933 - 34933
PAK1 confers resistance to the estrogen antagonist tamoxifen in breast cancer. However, a role for PAK1 remains to be elucidated for chemoresistance and... 
EPITHELIAL-MESENCHYMAL TRANSITION | APOPTOSIS | ACTIVATION | INDUCE | PHOSPHORYLATION | COLORECTAL-CANCER | P21-ACTIVATED-KINASE-1 | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | DRUG-RESISTANCE | BREAST | Index Medicus
Journal Article
Journal Article
Journal of Cancer, ISSN 1837-9664, 2017, Volume 8, Issue 8, pp. 1484 - 1491
Objective: p21-activated kinases (PAKs) are serine/threonine protein kinases. PAK1 and epithelial-mesenchymal transition (EMT) are key therapeutic targets in... 
Epithelial-mesenchymal transition | PAK1 | Prognosis | Metastasis | Non-small cell lung cancer | non-small cell lung cancer | P21-ACTIVATED-KINASE-1 PAK1 | ONCOLOGY | metastasis | STATISTICS | RESISTANCE | epithelial-mesenchymal transition | prognosis | ASSOCIATION
Journal Article
Leukemia Research, ISSN 0145-2126, 04/2019, Volume 79, pp. 6 - 16
The BCR-ABL fusion gene (BCR-ABL) has different subtypes such as p210 and p190 with p190 appear to lead to a worse prognosis. To explore the mechanism of... 
Acute lymphocytic leukemia (ALL) | BCR-ABL subtype | PAK1 gene | Chronic myelogenous leukeamia (CML) | SURVIVAL | ADULT PATIENTS | CELLS | PHOSPHORYLATION | DEATH | ONCOLOGY | P21-ACTIVATED-KINASE-1 | HEMATOLOGY | IMATINIB MESYLATE | SIGNALING NETWORKS | KINASES | Anopheles | DNA microarrays | Gene expression | Analysis | Genes | Leukemia
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7674, pp. 133 - 136
Targeted BRAF inhibition (BRAFi) and combined BRAF and MEK inhibition (BRAFi and MEKi) therapies have markedly improved the clinical outcomes of patients with... 
METASTATIC MELANOMA | MEK | EPITHELIAL-CELLS | PHOSPHORYLATION | PATHWAY | RAF | P21-ACTIVATED-KINASE-1 | MULTIDISCIPLINARY SCIENCES | KINASE | MECHANISMS | THERAPIES | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | p21-Activated Kinases - antagonists & inhibitors | Melanoma - enzymology | JNK Mitogen-Activated Protein Kinases - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Proto-Oncogene Proteins c-raf - chemistry | Female | beta Catenin - chemistry | Phosphorylation - drug effects | p21-Activated Kinases - genetics | JNK Mitogen-Activated Protein Kinases - chemistry | Enzyme Activation - drug effects | p21-Activated Kinases - metabolism | beta Catenin - metabolism | Proto-Oncogene Proteins c-raf - metabolism | Mitogen-Activated Protein Kinase Kinases - chemistry | Drug Resistance, Neoplasm - genetics | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Drug Resistance, Neoplasm - drug effects | Melanoma | Physiological aspects | Cellular signal transduction | Drug resistance | Observations | Health aspects | Mitogen-activated protein kinases | TOR protein | Therapy | Phosphorylation | Activation | Metastasis | Drug development | Kinases | Cancer therapies | Metastases | Proteins | β-catenin | Signal transduction | Inhibition | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Patients | Signaling | Protein arrays | Molecular modelling | Biopsy | Cell lines | Apoptosis | Index Medicus
Journal Article
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, ISSN 1943-8141, 2019, Volume 11, Issue 6, pp. 3353 - 3364
Background/objective: Pancreatic ductal adenocarcinoma (PDA) remains the most lethal malignancy due to lack of an effective treatment. P21-activated kinases... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | PF-3758309 | ACTIVATION | P21-ACTIVATED-KINASE-1 PAK1 | p21-activated kinase | chemotherapy | KINASE 4 PAK4 | pancreatic cancer | ONCOLOGY | RESISTANCE | gemcitabine | HIF-1-ALPHA | NF-KAPPA-B | UP-REGULATION | EXPRESSION
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1727 - 1743
Anaplasma phagocytophilum, the agent of human anaplasmosis, persists in ticks and mammals. We show that A. phagocytophilum induces the phosphorylation of actin... 
BACTERIAL PATHOGENS | MEDICINE, RESEARCH & EXPERIMENTAL | NUCLEAR ACTIN | RICKETTSIA-CONORII | TYROSINE PHOSPHORYLATION | P21-ACTIVATED-KINASE-1 PAK1 | HOST-CELL | HUMAN GRANULOCYTIC ANAPLASMOSIS | INTRACELLULAR PATHOGENS | IMMUNOLOGY | MAMMALIAN-CELLS | DICTYOSTELIUM CELLS | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 08/2004, Volume 15, Issue 8, pp. 3509 - 3519
The small G proteins Cdc42, Rac1, and Rac2 regulate the rearrangements of actin and membrane necessary for Fcgamma receptor-mediated phagocytosis by... 
Index Medicus
Journal Article