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Journal of Neuroscience Research, ISSN 0360-4012, 12/2014, Volume 92, Issue 12, pp. 1690 - 1702
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2016, Volume 116, pp. 130 - 139
The P2X7 receptor (P2X7R) plays an important role in diverse conditions associated with tissue damage and inflammation, meaning that the human P2X7R (hP2X7R)... 
YO-PRO-1 dye uptake | Virtual screening | hP2X7R antagonists | Patch-clamp recording | Ca2+ imaging | imaging | ACTIVATION | RAT | EFFICACY | SAFETY | DOCKING | CELL-DEATH | P2X RECEPTOR | CHEMISTRY | PHARMACOLOGY & PHARMACY | INHIBITORS | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Purinergic P2X Receptor Antagonists - pharmacology | Thiophenes - metabolism | Structure-Activity Relationship | Hepatocytes - metabolism | Receptors, Purinergic P2X3 - genetics | Receptors, Purinergic P2X7 - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Adenosine Triphosphate - pharmacology | Hepatocytes - cytology | Indoles - metabolism | Adenosine Triphosphate - metabolism | HEK293 Cells | Amides - metabolism | Indoles - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Single-Cell Analysis | Binding Sites | Hepatocytes - drug effects | Amides - pharmacology | Recombinant Proteins - metabolism | Models, Molecular | Rats | Recombinant Proteins - chemistry | Thiophenes - pharmacology | Adenosine Triphosphate - analogs & derivatives | Patch-Clamp Techniques | Animals | Receptors, Purinergic P2X3 - chemistry | Image Processing, Computer-Assisted | Calcium Signaling - drug effects | Purinergic P2X Receptor Antagonists - chemistry | Receptors, Purinergic P2X3 - metabolism | Small Molecule Libraries | Receptors, Purinergic P2X4 - chemistry | Amides - chemistry | Purinergic P2X Receptor Antagonists - metabolism | Receptors, Purinergic P2X7 - metabolism | Ligands | Receptors, Purinergic P2X7 - chemistry | Adenosine Triphosphate - chemistry | Receptors, Purinergic P2X4 - metabolism | Thiophenes - chemistry | Indoles - chemistry | Microscopy, Fluorescence | Receptors, Purinergic P2X4 - genetics | PI, propidium iodide | zfP2X4R, zebrafish P2X4 receptor | HEK293 cells, human embryonic kidney 293 cells | TNP-ATP, trinitrophenyl-ATP | BzATP, 2,3-O-(4-benzoylbenzoyl)-ATP | BBG, brilliant blue G | rP2X7R, rat P2X7R | P2X7R, P2X7 receptor | hP2X7R, human P2X7R
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 36, pp. 24035 - 24048
The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1β, macrophages need... 
GENE | LEUCINE-RICH PROTEOGLYCANS | CASPASE-1 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | HYALURONAN | IL-1-BETA | SECRETION | ATP | NALP3 INFLAMMASOME | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Glycobiology and Extracellular Matrices
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2013, Volume 110, Issue 36, pp. E3455 - E3463
The identity and forms of activating ligands for ion channels are fundamental to their physiological roles in rapid electrical signaling. P2X receptor channels... 
magnesium regulation | magnesium ATP | EXTRACELLULAR ATP | CELLS | MULTIDISCIPLINARY SCIENCES | STABILITY-CONSTANTS | KNOCKOUT MICE | SENSORY NEURONS | FUNCTIONAL-PROPERTIES | DIVALENT-CATIONS | MOLECULAR PHYSIOLOGY | ION-CHANNEL | PURINERGIC RECEPTOR | Receptors, Purinergic P2X - chemistry | Humans | Protein Multimerization | Ganglia, Spinal - cytology | Receptors, Purinergic P2X3 - genetics | Receptors, Purinergic P2X - genetics | Adenosine Triphosphate - pharmacology | Receptors, Purinergic P2X1 - chemistry | Adenosine Triphosphate - metabolism | HEK293 Cells | Neurons - physiology | Receptors, Purinergic P2X - metabolism | Neurons - metabolism | Neurons - drug effects | Membrane Potentials - drug effects | Receptors, Purinergic P2X2 - genetics | Cells, Cultured | Models, Molecular | Rats | Magnesium - metabolism | Magnesium - pharmacology | Receptors, Purinergic P2X2 - chemistry | Patch-Clamp Techniques | Receptors, Purinergic P2X1 - genetics | Animals | Receptors, Purinergic P2X1 - metabolism | Receptors, Purinergic P2X3 - chemistry | Signal Transduction - drug effects | Receptors, Purinergic P2X3 - metabolism | Receptors, Purinergic P2X2 - metabolism | Receptors, Purinergic P2X4 - chemistry | Protein Conformation | Receptors, Purinergic P2X4 - metabolism | Receptors, Purinergic P2X4 - genetics | Ion Channel Gating - drug effects | Biological Sciences | PNAS Plus
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 2015, Volume 22, Issue 7, pp. 866 - 877
Journal Article
Glia, ISSN 0894-1491, 04/2014, Volume 62, Issue 4, pp. 592 - 607
ATP is an important regulator of microglia and its effects on microglial cytokine release are currently discussed as important contributors in a variety of... 
antagonists | EXTRACELLULAR ATP | purine receptors | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | FOCAL CEREBRAL-ISCHEMIA | P2X7 RECEPTOR | TUMOR-NECROSIS-FACTOR | neuroinflammation | neuroprotection | P2X RECEPTOR | PURINERGIC RECEPTORS | INTERLEUKIN-1-BETA RELEASE | ACTIVATED MICROGLIA | CYTOKINE RELEASE | Neuroprotection | Neuroinflammation | Antagonists | Purine receptors | NEUROSCIENCES | Tumor Necrosis Factor-alpha - metabolism | Calcium - metabolism | Tumor Necrosis Factor-alpha - genetics | Purinergic P2X Receptor Antagonists - pharmacology | Receptors, Purinergic P2X4 - deficiency | Receptors, Purinergic P2X7 - genetics | Adenosine Triphosphate - pharmacology | Dose-Response Relationship, Drug | Microglia - physiology | Chemokine CCL2 - metabolism | Cell Differentiation - physiology | Interleukin-6 - metabolism | Animals, Newborn | Brain - cytology | Interleukin-6 - genetics | Microglia - drug effects | Mice, Inbred C57BL | Cells, Cultured | Connexins - genetics | Chemokine CCL2 - genetics | Nerve Tissue Proteins - genetics | Purinergic P2X Receptor Agonists - pharmacology | Adenosine Triphosphate - analogs & derivatives | Receptors, Purinergic P2X7 - physiology | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Receptors, Purinergic P2X7 - deficiency | Animals | Cell Differentiation - drug effects | Mice
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2018, Volume 128, Issue 8, pp. 3583 - 3594
T cells must migrate in order to encounter antigen-presenting cells (APCs) and to execute their varied functions in immune defense and inflammation. ATP... 
BRONCHIOLITIS | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-TRANSPLANT | ACTIVATION | CHEMOKINES | CHEMOATTRACTANT | INFLAMMATION | IMMUNE SYNAPSE | DYNAMICS | NEUTROPHIL CHEMOTAXIS | RELEASE | Jurkat Cells | CD4-Positive T-Lymphocytes - cytology | Humans | Receptors, Purinergic P2X4 - immunology | Adenosine Triphosphate - genetics | Adenosine Triphosphate - immunology | Inflammation - immunology | Mitochondria - immunology | Autocrine Communication - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Movement - immunology | Animals | Autocrine Communication - immunology | Mitochondria - genetics | Inflammation - genetics | Mice | Mice, Inbred BALB C | Receptors, Purinergic P2X4 - genetics | Mitochondria | Usage | Analysis | Transplantation of organs, tissues, etc | Research | T cells | Adenosine triphosphate | Cell migration | Chemokines | Transplants & implants | Leukocyte migration | Syngeneic grafts | Purine receptors | Lung transplantation | Lymphocytes T | Calcium influx | Inflammatory diseases | Cell adhesion & migration | Cell activation | Lymphocytes | Xenografts | Autocrine signalling | Immune system | Antigens | Lymphatic system | Immunomodulation | Therapeutic applications | Neutrophils | Inflammation | T cell receptors | SDF-1 protein | Calcium (mitochondrial) | CD4 antigen | Graft rejection | Lungs | Antigen-presenting cells
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2019, Volume 151, Issue 5, pp. 584 - 594
Pyroptosis is a type of programmed cell death, displaying caspase‐1‐dependent and pro‐inflammatory features. Purinergic 2X4 (P2X4) receptor activation in... 
pyroptosis | gp120 | dorsal root ganglia | P2X4 receptor | satellite glial cells
Journal Article
FASEB Journal, ISSN 0892-6638, 07/2012, Volume 26, Issue 7, pp. 2951 - 2962
Prostaglandins (PGs) are important lipid mediators involved in the development of inflammatory associated pain and fever. PGE2 is a well-established endogenous... 
Inflammation | Purinergic receptors | Macrophages | Pyrogen | In vivo bioluminescence | EXTRACELLULAR ATP | purinergic receptors | ACTIVATED PROTEIN-KINASE | CYCLOOXYGENASE-2 | pyrogen | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | macrophages | MESSENGER-RNA | inflammation | in vivo bioluminescence | P2X RECEPTOR | MOUSE MODEL | BIOLOGY | ANTIINFLAMMATORY DRUGS | PROSTAGLANDIN E-2 | Adenosine Triphosphate - administration & dosage | Dinoprostone - physiology | Humans | Lipopolysaccharides - administration & dosage | Purinergic P2X Receptor Antagonists - pharmacology | Leukotriene B4 - biosynthesis | Fever - physiopathology | Receptors, Purinergic P2X7 - genetics | MAP Kinase Signaling System | Adenosine Triphosphate - metabolism | Inflammation Mediators - physiology | Calcium Signaling | Macrophages - physiology | Interleukin-1beta - physiology | Mice, Inbred C57BL | Injections, Intraperitoneal | Receptors, Purinergic P2X4 - physiology | Thromboxane B2 - biosynthesis | Purinergic P2X Receptor Agonists - pharmacology | Receptors, Purinergic P2X7 - physiology | Recombinant Proteins - administration & dosage | Mice, Knockout | Receptors, Purinergic P2X7 - deficiency | Animals | Interleukin-1beta - administration & dosage | Cyclooxygenase 2 - metabolism | Fever - etiology | Macrophages - drug effects | Mice | In Vitro Techniques
Journal Article