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Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2016, Volume 116, pp. 130 - 139
The P2X7 receptor (P2X7R) plays an important role in diverse conditions associated with tissue damage and inflammation, meaning that the human P2X7R (hP2X7R)... 
YO-PRO-1 dye uptake | Virtual screening | hP2X7R antagonists | Patch-clamp recording | Ca2+ imaging | imaging | ACTIVATION | RAT | EFFICACY | SAFETY | DOCKING | CELL-DEATH | P2X RECEPTOR | CHEMISTRY | PHARMACOLOGY & PHARMACY | INHIBITORS | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Purinergic P2X Receptor Antagonists - pharmacology | Thiophenes - metabolism | Structure-Activity Relationship | Hepatocytes - metabolism | Receptors, Purinergic P2X3 - genetics | Receptors, Purinergic P2X7 - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Adenosine Triphosphate - pharmacology | Hepatocytes - cytology | Indoles - metabolism | Adenosine Triphosphate - metabolism | HEK293 Cells | Amides - metabolism | Indoles - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Single-Cell Analysis | Binding Sites | Hepatocytes - drug effects | Amides - pharmacology | Recombinant Proteins - metabolism | Models, Molecular | Rats | Recombinant Proteins - chemistry | Thiophenes - pharmacology | Adenosine Triphosphate - analogs & derivatives | Patch-Clamp Techniques | Animals | Receptors, Purinergic P2X3 - chemistry | Image Processing, Computer-Assisted | Calcium Signaling - drug effects | Purinergic P2X Receptor Antagonists - chemistry | Receptors, Purinergic P2X3 - metabolism | Small Molecule Libraries | Receptors, Purinergic P2X4 - chemistry | Amides - chemistry | Purinergic P2X Receptor Antagonists - metabolism | Receptors, Purinergic P2X7 - metabolism | Ligands | Receptors, Purinergic P2X7 - chemistry | Adenosine Triphosphate - chemistry | Receptors, Purinergic P2X4 - metabolism | Thiophenes - chemistry | Indoles - chemistry | Microscopy, Fluorescence | Receptors, Purinergic P2X4 - genetics | Index Medicus | PI, propidium iodide | zfP2X4R, zebrafish P2X4 receptor | HEK293 cells, human embryonic kidney 293 cells | TNP-ATP, trinitrophenyl-ATP | BzATP, 2,3-O-(4-benzoylbenzoyl)-ATP | BBG, brilliant blue G | rP2X7R, rat P2X7R | P2X7R, P2X7 receptor | hP2X7R, human P2X7R
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 36, pp. 24035 - 24048
The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1β, macrophages need... 
GENE | LEUCINE-RICH PROTEOGLYCANS | CASPASE-1 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | HYALURONAN | IL-1-BETA | SECRETION | ATP | NALP3 INFLAMMASOME | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Index Medicus | Glycobiology and Extracellular Matrices
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 02/2016, Volume 99, Issue 2, pp. 289 - 299
Purinergic signaling controls macrophage differentiation resulting in inhibition of growth and M2 macrophage phenotype. Macrophages represent a highly... 
adenosine | purinergic receptors | Ym1 | adenosine receptors | extracellular ATP | Adenosine | Receptors | Extracellular ATP | Purinergic receptors | ADENOSINE RECEPTOR AGONISTS | KAPPA-B | IMMUNOLOGY | MURINE | CELL BIOLOGY | NUCLEOTIDE RECEPTORS | MONOCYTE | P2X RECEPTORS | GENE-EXPRESSION | HEMATOLOGY | ATP | POLARIZATION | beta-N-Acetylhexosaminidases - pharmacology | Inflammation - pathology | Receptors, Purinergic P2X7 - drug effects | Adenine Nucleotides - pharmacology | Lectins - biosynthesis | Receptors, Purinergic P2X7 - genetics | Interleukin-4 - pharmacology | Purinergic P2 Receptor Antagonists - pharmacology | Purinergic P2 Receptor Agonists - pharmacology | beta-N-Acetylhexosaminidases - genetics | Myelopoiesis - drug effects | Macrophages - classification | Specific Pathogen-Free Organisms | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Purinergic P1 Receptor Agonists - pharmacology | Cells, Cultured | Lectins - pharmacology | Receptors, Purinergic P1 - physiology | Receptors, Purinergic P2 - physiology | Adenine - pharmacology | Inflammation - immunology | Macrophages - cytology | Recombinant Proteins - pharmacology | beta-N-Acetylhexosaminidases - biosynthesis | Cell Division - drug effects | Mice, Knockout | Gene Expression Regulation - drug effects | Receptors, Purinergic P2X7 - deficiency | Phenotype | Animals | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Lectins - genetics | Macrophages - drug effects | Receptors, Purinergic P2X7 - biosynthesis | Mice | Cell Cycle - drug effects | Macrophage Activation - drug effects | Interferon-gamma - pharmacology | Index Medicus
Journal Article
Journal Article
Glia, ISSN 0894-1491, 04/2014, Volume 62, Issue 4, pp. 592 - 607
ATP is an important regulator of microglia and its effects on microglial cytokine release are currently discussed as important contributors in a variety of... 
antagonists | purine receptors | neuroinflammation | neuroprotection | Neuroprotection | Neuroinflammation | Antagonists | Purine receptors | EXTRACELLULAR ATP | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | FOCAL CEREBRAL-ISCHEMIA | NEUROSCIENCES | P2X7 RECEPTOR | TUMOR-NECROSIS-FACTOR | P2X RECEPTOR | PURINERGIC RECEPTORS | INTERLEUKIN-1-BETA RELEASE | ACTIVATED MICROGLIA | CYTOKINE RELEASE | Tumor Necrosis Factor-alpha - metabolism | Calcium - metabolism | Tumor Necrosis Factor-alpha - genetics | Purinergic P2X Receptor Antagonists - pharmacology | Receptors, Purinergic P2X4 - deficiency | Receptors, Purinergic P2X7 - genetics | Adenosine Triphosphate - pharmacology | Dose-Response Relationship, Drug | Microglia - physiology | Chemokine CCL2 - metabolism | Cell Differentiation - physiology | Interleukin-6 - metabolism | Animals, Newborn | Brain - cytology | Interleukin-6 - genetics | Microglia - drug effects | Mice, Inbred C57BL | Cells, Cultured | Connexins - genetics | Chemokine CCL2 - genetics | Nerve Tissue Proteins - genetics | Purinergic P2X Receptor Agonists - pharmacology | Adenosine Triphosphate - analogs & derivatives | Receptors, Purinergic P2X7 - physiology | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Receptors, Purinergic P2X7 - deficiency | Animals | Cell Differentiation - drug effects | Mice | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 11/2010, Volume 116, Issue 18, pp. 3475 - 3484
Engagement of T cells with antigen-presenting cells requires T-cell receptor (TCR) stimulation at the immune synapse. We previously reported that TCR... 
EXTRACELLULAR ATP | OPERATED CA2+ ENTRY | LIPID-RAFTS | P2X RECEPTORS | CALCIUM | STORE | CRAC CHANNELS | IMMUNOLOGICAL SYNAPSE | HEMATOLOGY | PLASMA-MEMBRANE | LYMPHOCYTES | Humans | Calcium - immunology | Connexins - immunology | T-Lymphocytes - ultrastructure | Receptors, Purinergic P2X7 - genetics | Interleukin-2 - immunology | NFATC Transcription Factors - immunology | T-Lymphocytes - metabolism | Neoplasm Proteins - genetics | Calcium Channels - genetics | Receptors, Purinergic P2X7 - immunology | Stromal Interaction Molecule 1 | Gene Expression | Receptors, Purinergic P2X5 - immunology | Immunological Synapses - ultrastructure | Nerve Tissue Proteins - immunology | Jurkat Cells | Lymphocyte Activation | Membrane Proteins - genetics | Receptors, Purinergic P2X4 - immunology | Adenosine Triphosphate - immunology | ORAI1 Protein | Receptors, Purinergic P2X1 - immunology | Connexins - metabolism | Protein Transport | Receptors, Purinergic P2X5 - genetics | Nerve Tissue Proteins - metabolism | Interleukin-2 - genetics | Receptors, Purinergic P2X1 - genetics | T-Lymphocytes - cytology | Immunological Synapses - immunology | T-Lymphocytes - immunology | Receptors, Purinergic P2X4 - genetics | Translocation | Calcium channels | Transcription factors | Immunological synapses | Lymphocytes T | NF-AT protein | Cell surface | Blood | Calcium influx | Purine P2X receptors | T-cell receptor | Cell activation | Interleukin 2 | Antigen-presenting cells | Feedback | Autocrine signalling | Mutation | ATP | Index Medicus | Abridged Index Medicus | Immunobiology
Journal Article