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Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2016, Volume 59, Issue 22, pp. 9981 - 10005
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2018, Volume 61, Issue 11, pp. 4860 - 4882
The P2Y14 receptor (P2Y14R) mediates inflammatory activity by activating neutrophil motility, but few classes of antagonists are known... 
G protein-coupled receptor | molecular dynamics | inflammation | nucleotides | P2Y receptor
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2014, Volume 64, Issue 10, pp. 1005 - 1014
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2013, Volume 61, Issue 20, pp. 2060 - 2066
... a so-called triple therapy consisting of aspirin, OAC, and an adenosine diphosphate (ADP) receptor antagonist. The most common combination currently consists of aspirin... 
Cardiovascular | Internal Medicine | clopidogrel | aspirin | prasugrel | high platelet reactivity | vitamin K antagonist | drug-eluting stent(s) | CARDIAC & CARDIOVASCULAR SYSTEMS | BLEEDING RISK | DOSE CLOPIDOGREL | EUROPEAN-SOCIETY | ANTIPLATELET THERAPY | CONSENSUS DOCUMENT | ATRIAL-FIBRILLATION | ANTITHROMBOTIC MANAGEMENT | PERCUTANEOUS CORONARY INTERVENTION | TASK-FORCE | Piperazines - administration & dosage | Prasugrel Hydrochloride | Drug-Eluting Stents | Purinergic P2Y Receptor Antagonists - administration & dosage | Anticoagulants - administration & dosage | Humans | Middle Aged | Male | Thiophenes - administration & dosage | Ticlopidine - analogs & derivatives | Aspirin - administration & dosage | Patient Selection | Vitamin K - antagonists & inhibitors | Myocardial Ischemia - etiology | Platelet Aggregation Inhibitors - administration & dosage | Myocardial Ischemia - therapy | Aged, 80 and over | Ticlopidine - administration & dosage | Female | Aged | Myocardial Ischemia - mortality | Drug Therapy, Combination | Percutaneous Coronary Intervention | Cohort Studies | Aspirin | Anticoagulants (Medicine) | Stent (Surgery) | Adenosine triphosphatase | Studies | Confidence intervals | Heart attacks | Blood platelets | Mortality | Population | Drug therapy | Acute coronary syndromes | Thrombosis | Drug dosages
Journal Article
Pharmacology, ISSN 1423-0313, 2015, Volume 97, Issue 1-2, pp. 84 - 100
Background: In asthma and chronic obstructive pulmonary disease (COPD), airway mucus hypersecretion contributes to impaired mucociliary clearance, mucostasis... 
Review | Airways | MARCKS | Mucin | Macrolides | Bio-11006 | Chronic obstructive pulmonary disease | Mucus | Epidermal growth factor receptor | Asthma | CONTROLLED-TRIAL | RESPIRATORY-DISEASE | MUCIN EXPRESSION | EGFR INHIBITOR | OBSTRUCTIVE PULMONARY-DISEASE | EPITHELIAL-CELLS | MOUSE MODEL | ALLERGIC-ASTHMA | PHARMACOLOGY & PHARMACY | GOBLET CELL HYPERPLASIA | MACROLIDE ANTIBIOTICS | Ginkgolides - pharmacology | HSP70 Heat-Shock Proteins - antagonists & inhibitors | Myristoylated Alanine-Rich C Kinase Substrate | Humans | Mucus - drug effects | Intracellular Signaling Peptides and Proteins - metabolism | Pulmonary Disease, Chronic Obstructive - physiopathology | Lactones - pharmacology | Mitogen-Activated Protein Kinase 13 - antagonists & inhibitors | Inflammation Mediators - metabolism | Macrolides - pharmacology | Membrane Proteins - metabolism | Airway Remodeling - physiology | Ellagic Acid - pharmacology | Chloride Channels - antagonists & inhibitors | Asthma - physiopathology | Receptors, Purinergic P2Y | Mucus - secretion | Mucins - antagonists & inhibitors | Munc18 Proteins - antagonists & inhibitors | Mucins - biosynthesis | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Hypoxia-Inducible Factor 1 - antagonists & inhibitors | GABA Antagonists | Protein-Tyrosine Kinases - antagonists & inhibitors | Body fluids | Signal transduction | Pharmacology | Epidermal growth factor
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2016, Volume 375, Issue 25, pp. 2423 - 2434
Journal Article
Journal Article
Platelets, ISSN 0953-7104, 7/2015, Volume 26, Issue 5, pp. 392 - 398
Abstract Platelet P2Y12 inhibitors have become a central component of the treatment strategy for patients with atherothrombosis due to the importance of... 
Antiplatelet therapy | clopidogrel | inhibitors | prasugrel | P2Y | ticagrelor | platelets | Prasugrel | P2Y12 inhibitors | Clopidogrel | Platelets | Ticagrelor | Purinergic P2Y Receptor Antagonists - pharmacology | Animals | Humans | Purinergic P2Y Receptor Antagonists - therapeutic use
Journal Article