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1. Full Text Characterization of the UDP-glucose receptor (re-named here the P2Y 14 receptor) adds diversity to the P2Y receptor family
by Abbracchio, Maria P and Boeynaems, Jean-Marie and Barnard, Eric A and Boyer, José L and Kennedy, Charles and Miras-Portugal, Maria Teresa and King, Brian F and Gachet, Christian and Jacobson, Kenneth A and Weisman, Gary A and Burnstock, Geoffrey
Trends in Pharmacological Sciences, ISSN 0165-6147, 2003, Volume 24, Issue 2, pp. 52 - 55
The cloning of a human G-protein-coupled receptor (GPCR) that specifically responds to UDP-glucose and related sugar-nucleotides has been reported recently.... 
Receptors, Purinergic P2 - chemistry | Animals | Humans | Receptors, Purinergic P2 - genetics | Receptors, Purinergic P2 - metabolism | Binding Sites - physiology | Receptors, G-Protein-Coupled | Receptors, Purinergic P2Y | Uridine Diphosphate Glucose - metabolism | Physiological aspects | Glucose metabolism | G proteins
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2. Full Text Medicinal chemistry of adenosine, P2Y and P2X receptors
by Jacobson, Kenneth A and Müller, Christa E
Neuropharmacology, ISSN 0028-3908, 05/2016, Volume 104, pp. 31 - 49
Pharmacological tool compounds are now available to define action at the adenosine (ARs), P2Y and P2X receptors. We present a selection of the most commonly... 
Nucleosides | GPCR | Agonists | Antagonists | Nucleotides | Ion channel | ATP | PROTEIN-COUPLED RECEPTORS | ALLOSTERIC MODULATION | NEUROSCIENCES | NEUROPATHIC PAIN | NUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE | IN-VIVO | ION-CHANNEL | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | PURINERGIC RECEPTOR | P2Y RECEPTOR | STRUCTURE-BASED DESIGN | Purinergic P1 Receptor Agonists - chemistry | Receptors, Purinergic P2Y - chemistry | Receptors, Purinergic P2X - chemistry | Humans | Purinergic P1 Receptor Agonists - pharmacology | Receptors, Purinergic P2Y - metabolism | Purinergic P1 Receptor Antagonists - therapeutic use | Purinergic P2Y Receptor Agonists - chemistry | Purinergic P2Y Receptor Agonists - therapeutic use | Structure-Activity Relationship | Purinergic P1 Receptor Agonists - therapeutic use | Chemistry, Pharmaceutical | Purinergic P1 Receptor Antagonists - pharmacology | Purinergic P2Y Receptor Agonists - pharmacology | Receptors, Purinergic P1 - chemistry | Animals | Purinergic Agents - chemistry | Purinergic Agents - therapeutic use | Receptors, Purinergic P2X - metabolism | Receptors, Purinergic P1 - metabolism | Purinergic Agents - pharmacology | Purinergic P1 Receptor Antagonists - chemistry | Prevention | Brain | Purines | Enzymes | Injuries | Chronic pain | Cancer | antagonists | nucleosides | agonists | ion channel | nucleotides
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3. Full Text Purine and pyrimidine receptors
by Burnstock, G
Cellular and Molecular Life Sciences, ISSN 1420-682X, 06/2007, Volume 64, Issue 12, pp. 1471 - 1483
Adenosine 5′-triphosphate (ATP), in addition to its intracellular roles, acts as an extracellular signalling molecule via a rich array of receptors, which have... 
Biochemistry, general | G protein-coupled receptors | heteromultimers | P2X receptor | Biomedicine general | Cell Biology | Life Sciences | Life Sciences, general | gene regulation | P2Y receptor | P1 receptor | Cloned receptors | ion channel receptors | Heteromultimers | Gene regulation | Ion channel receptors | cloned receptors | ATP RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADENOSINE RECEPTOR | HUMAN P2Y RECEPTOR | FUNCTIONAL-CHARACTERIZATION | SENSORY NEURONS | CELL BIOLOGY | NUCLEOTIDE RECEPTORS | PROTEIN-COUPLED RECEPTOR | P2X RECEPTORS | GATED ION CHANNELS | MOLECULAR-CLONING | Purines - metabolism | Humans | Transcriptional Activation | Gene Expression Regulation | Purinergic P2 Receptor Agonists | Pyrimidines - metabolism | Receptors, Purinergic P1 - chemistry | Receptors, Purinergic P2 - chemistry | Animals | Adenosine Triphosphate - metabolism | Receptors, Purinergic P2 - metabolism | Receptors, Purinergic P1 - metabolism | Purinergic P1 Receptor Agonists | Dimerization | Ions | Molecular biology | Cloning | Genomics
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4. Full Text GPCR crystal structures: Medicinal chemistry in the pocket
by Shonberg, Jeremy and Kling, Ralf C and Gmeiner, Peter and Löber, Stefan
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 14, pp. 3880 - 3906
Recent breakthroughs in GPCR structural biology have significantly increased our understanding of drug action at these therapeutically relevant receptors, and... 
Medicinal chemistry | Receptor activation | GPCR | Receptor selectivity | Drug discovery | Crystal structure | Ligand–receptor interactions | Ligand-receptor interactions | METABOTROPIC GLUTAMATE-RECEPTOR | BETA ADRENERGIC-RECEPTOR | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ADENOSINE A(2A) RECEPTOR | HUMAN P2Y RECEPTOR | HISTAMINE H-1 RECEPTOR | MUSCARINIC ACETYLCHOLINE-RECEPTOR | PROTEIN-COUPLED RECEPTOR | STRUCTURE-BASED DISCOVERY | CENTRAL-NERVOUS-SYSTEM | NOCICEPTIN/ORPHANIN FQ RECEPTOR | Receptors, Adrenergic, beta - chemistry | Chemistry, Pharmaceutical - methods | Receptors, G-Protein-Coupled - metabolism | Humans | Drug Design | Crystallography, X-Ray | Ligands | Protein Conformation | Receptors, Adrenergic, beta - metabolism | Receptors, G-Protein-Coupled - chemistry | Structure | Crystals
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5. Full Text Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors
by Alnouri, Mohamad Wessam and Jepards, Stephan and Casari, Alessandro and Schiedel, Anke C and Hinz, Sonja and Müller, Christa E
Purinergic Signalling, ISSN 1573-9538, 9/2015, Volume 11, Issue 3, pp. 389 - 407
Adenosine receptors (ARs) have emerged as new drug targets. The majority of data on affinity/potency and selectivity of AR ligands described in the literature... 
Neurosciences | Agonist | Biomedicine | Human Physiology | Cancer Research | Selectivity | Potency | Antagonist | Pharmacology/Toxicology | Species differences | Biomedicine general | XANTHINE DERIVATIVES | NEUROSCIENCES | STRIATAL MEMBRANES | PROTEIN-COUPLED ADENOSINE | P2Y RECEPTORS | A(2B) RECEPTORS | INTERNATIONAL UNION | LIGANDS | A(2A) RECEPTOR | HIGHLY POTENT | PARKINSONS-DISEASE | Cricetulus | Species Specificity | Humans | DNA, Complementary - genetics | Adenosine A1 Receptor Antagonists - pharmacology | Adenosine A2 Receptor Agonists - metabolism | Receptor, Adenosine A2B - genetics | Structure-Activity Relationship | Adenosine A1 Receptor Antagonists - metabolism | Adenosine A2 Receptor Antagonists - metabolism | Adenosine A2 Receptor Agonists - pharmacology | Adenosine A3 Receptor Agonists - pharmacology | Adenosine A1 Receptor Agonists - pharmacology | Receptor, Adenosine A2B - drug effects | Receptor, Adenosine A2A - genetics | Adenosine A3 Receptor Antagonists - pharmacology | Cell Membrane - metabolism | Adenosine A3 Receptor Agonists - metabolism | Cyclic AMP - metabolism | Arrestin - metabolism | Cell Membrane - drug effects | DNA, Complementary - drug effects | CHO Cells | Cricetinae | Receptors, Purinergic P1 - genetics | Rats | Receptor, Adenosine A2A - metabolism | Receptor, Adenosine A2B - metabolism | Receptor, Adenosine A2A - drug effects | Binding, Competitive - drug effects | Adenosine A2 Receptor Antagonists - pharmacology | Animals | Adenosine A1 Receptor Agonists - metabolism | Adenosine A3 Receptor Antagonists - metabolism | Mice | Receptors, Purinergic P1 - metabolism | Receptors, Purinergic P1 - drug effects | Adenosine | Original
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6. Full Text G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions
by Jacobson, Kenneth A and Balasubramanian, Ramachandran and Deflorian, Francesca and Gao, Zhan-Guo
Purinergic Signalling, ISSN 1573-9538, 9/2012, Volume 8, Issue 3, pp. 419 - 436
The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors (ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range... 
Clinical trials, nucleosides | Neurosciences | Adenosine receptors | Human Physiology | P2Y receptors | Antagonists | Nucleotides | Biomedicine general | Biomedicine | GPCR structure | Cancer Research | Agonists | Pharmacology/Toxicology | PHYLOGENETIC ANALYSIS | A(2B) ADENOSINE | ANTAGONIST RECOGNITION | SITE-DIRECTED MUTAGENESIS | MUTATIONAL ANALYSIS | NEUROSCIENCES | NUCLEOTIDE RECEPTORS | INTERNATIONAL UNION | SUBTYPE SELECTIVITY | MOLECULAR RECOGNITION | PURINERGIC RECEPTORS | Receptors, G-Protein-Coupled - metabolism | Humans | Purinergic P2Y Receptor Agonists - therapeutic use | Purinergic P1 Receptor Agonists - therapeutic use | Purinergic P1 Receptor Antagonists - pharmacology | Receptors, Purinergic P1 - chemistry | Receptors, Purinergic P2 - chemistry | Drug Design | Receptors, G-Protein-Coupled - drug effects | Purinergic P2Y Receptor Antagonists - therapeutic use | Purinergic P2Y Receptor Antagonists - pharmacology | Purinergic P1 Receptor Agonists - chemistry | Purinergic P1 Receptor Agonists - pharmacology | Purinergic P1 Receptor Antagonists - therapeutic use | Purinergic P2Y Receptor Agonists - chemistry | Clinical Trials as Topic | Receptors, Purinergic P2 - drug effects | Purinergic P2Y Receptor Agonists - pharmacology | Animals | Purinergic P2Y Receptor Antagonists - chemistry | Receptors, Purinergic P2 - metabolism | Ligands | Receptors, Purinergic P1 - metabolism | Receptors, Purinergic P1 - drug effects | Receptors, G-Protein-Coupled - chemistry | Purinergic P1 Receptor Antagonists - chemistry | Glaucoma | Heart | Adenosine | Parkinson's disease | Psoriasis | Cystic fibrosis | Rheumatoid factor | Hepatitis | Alkaloids | Pyrimidines | Heterocyclic compounds | Emissions (Pollution) | Rheumatoid arthritis | Respiratory tract diseases | Eye diseases | G proteins | Diabetes | Ophthalmology | Kidney diseases | Hepatitis C | DNA-ligand interactions | Arrhythmia | Clinical trials | Ionizing radiation | Reperfusion | Ischemia | pyrimidines | Injuries | Movement disorders | Neurodegenerative diseases | Diabetes mellitus | Lung diseases | Pharmacology | Thrombosis | imaging | Stress | Purine P2Y receptors | purines | Hypoxia | Receptor mechanisms | ATP | Cancer | Pharmaceuticals | Original
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7. Full Text Pharmacology and structure of P2Y receptors
by von Kügelgen, Ivar and Hoffmann, Kristina
Neuropharmacology, ISSN 0028-3908, 05/2016, Volume 104, pp. 50 - 61
P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y , P2Y , P2Y , P2Y ,... 
Uracil nucleotides | Adenine nucleotides | P2Y receptors | Platelet aggregation | Inflammation | Receptor ligands | Neuromodulation | Crystal structure | PLATELET ADP RECEPTOR | ATP RECEPTOR | HUMAN P2Y RECEPTOR | NEUROSCIENCES | PROTEIN-COUPLED RECEPTOR | REVERSE CHOLESTEROL TRANSPORT | ADENYLYL-CYCLASE | PHARMACOLOGY & PHARMACY | MOLECULAR-CLONING | PURINERGIC RECEPTOR | HUMAN MAST-CELLS | URACIL NUCLEOTIDE DERIVATIVES | Purinergic P2Y Receptor Antagonists - pharmacology | Microglia - metabolism | Receptors, Purinergic P2Y - chemistry | Uridine Triphosphate - metabolism | Cardiovascular Diseases - metabolism | Humans | Receptors, Purinergic P2Y - metabolism | Neurodegenerative Diseases - metabolism | Receptors, Purinergic P2Y - physiology | Purinergic P2Y Receptor Agonists - pharmacology | Brain - metabolism | Platelet Aggregation | Animals | Adenosine Triphosphate - metabolism | Neurons - metabolism | Adenosine Diphosphate - metabolism | Physiological aspects | Purines | Pharmacology | Nucleotides | Structure | Crystals | Pyrimidines
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8. Full Text Structure-Based Prediction of G-Protein-Coupled Receptor Ligand Function: A β-Adrenoceptor Case Study
by Kooistra, Albert J and Leurs, Rob and De Esch, Iwan J P and de Graaf, C
Journal of Chemical Information and Modeling, ISSN 1549-9596, 05/2015, Volume 55, Issue 5, pp. 1045 - 61
The spectacular advances in G-protein-coupled receptor (GPCR) structure determination have opened up new possibilities for structure-based GPCR ligand... 
CHEMISTRY, MEDICINAL | CRYSTAL-STRUCTURE | COMPUTER SCIENCE, INFORMATION SYSTEMS | HUMAN P2Y RECEPTOR | ADRENERGIC-RECEPTOR | 2 SERINE RESIDUES | CHEMISTRY, MULTIDISCIPLINARY | A(2A) ADENOSINE RECEPTOR | MOLECULAR INTERACTION FINGERPRINTS | MUSCARINIC ACETYLCHOLINE-RECEPTOR | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | STRUCTURE-BASED DISCOVERY | BETA-ADRENERGIC RECEPTOR | PARTIAL AGONIST ACTIVITY | Computational Biology - methods | Humans | Adrenergic beta-1 Receptor Antagonists - pharmacology | Adrenergic beta-2 Receptor Agonists - metabolism | Crystallography, X-Ray | Receptors, Adrenergic, beta-1 - metabolism | Receptors, Adrenergic, beta-1 - chemistry | Adrenergic beta-1 Receptor Agonists - pharmacology | Receptors, Adrenergic, beta-2 - metabolism | Adrenergic beta-2 Receptor Agonists - pharmacology | Receptors, Adrenergic, beta-2 - chemistry | Animals | Adrenergic beta-2 Receptor Antagonists - metabolism | Adrenergic beta-1 Receptor Antagonists - metabolism | Ligands | Protein Conformation | Molecular Docking Simulation | Adrenergic beta-1 Receptor Agonists - metabolism | Drug Evaluation, Preclinical | Adrenergic beta-2 Receptor Antagonists - pharmacology
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