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Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1419 - 1432
The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an... 
GENE-MUTATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN-KINASE-C | ADENOSINE-DIPHOSPHATE | ALPHA-IIB-BETA-3 ACTIVATION | MICE | CALDAG-GEFI | PLASMA-MEMBRANE | ADENYLATE-CYCLASE | ADP | MOUSE MODELS | Thrombopoiesis | Ticlopidine - pharmacology | rap1 GTP-Binding Proteins - antagonists & inhibitors | Platelet Activation - physiology | Thrombocytopenia - surgery | Splenectomy | Thrombocytopenia - genetics | Cellular Senescence | Hemostasis | Platelet Aggregation Inhibitors - pharmacology | GTPase-Activating Proteins - physiology | Guanine Nucleotide Exchange Factors - deficiency | Mice, Inbred C57BL | Receptors, Purinergic P2Y12 - physiology | Proto-Oncogene Proteins c-akt - physiology | Ticlopidine - analogs & derivatives | Mice, Knockout | Platelet Activation - genetics | Animals | rap1 GTP-Binding Proteins - physiology | Saphenous Vein - injuries | Clopidogrel | Mice | Mice, Inbred BALB C | Platelet Activation - drug effects | GTPase-Activating Proteins - genetics | Lymphopenia - genetics | Cell receptors | Development and progression | Cellular signal transduction | Genetic aspects | Properties | Health aspects | Blood platelet disorders | Heart attacks | Laboratories | Cloning | Thrombosis | Embryos | Proteins | Studies | Blood platelets | Rodents | Technological change | Protein expression | Mutation | Infrared imaging systems | Veins & arteries
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 2015, Volume 113, Issue 1, pp. 37 - 52
Journal Article
International Journal of Cancer, ISSN 0020-7136, 01/2015, Volume 136, Issue 1, pp. 234 - 240
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 01/2014, Volume 12, Issue 1, pp. 2 - 13
Journal Article
JACC: Cardiovascular Interventions, ISSN 1936-8798, 2013, Volume 6, Issue 11, pp. 1111 - 1128
Journal Article
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 11/2010, Volume 56, Issue 19, pp. 1542 - 1551
Journal Article
Journal Article
JACC: Cardiovascular Interventions, ISSN 1936-8798, 05/2016, Volume 9, Issue 10, pp. 1036 - 1046
Objectives The study sought to compare the clinical efficacy and safety of P2Y inhibitors in patients with ST-segment elevation myocardial infarction (STEMI)... 
clopidogrel | inhibitors | percutaneous coronary intervention | prasugrel | P2Y | ticagrelor | ST-segment elevation myocardial infarction | thienopyridines | angioplasty | Recombinant Proteins - therapeutic use | Coronary Thrombosis - diagnosis | Markov Chains | Ticlopidine - therapeutic use | Hirudins | Percutaneous Coronary Intervention - mortality | Humans | Receptors, Purinergic P2Y12 - drug effects | ST Elevation Myocardial Infarction - diagnosis | ST Elevation Myocardial Infarction - blood | ST Elevation Myocardial Infarction - therapy | Purinergic P2Y Receptor Antagonists - adverse effects | Percutaneous Coronary Intervention - instrumentation | Receptors, Purinergic P2Y12 - blood | Adenosine - therapeutic use | Coronary Thrombosis - prevention & control | Network Meta-Analysis | Blood Platelets - drug effects | Odds Ratio | Platelet Aggregation Inhibitors - therapeutic use | Coronary Thrombosis - blood | Purinergic P2Y Receptor Antagonists - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Drug-Eluting Stents | Antithrombins - therapeutic use | Risk Factors | Treatment Outcome | Clinical Trials as Topic | Evidence-Based Medicine | Ticlopidine - analogs & derivatives | Prasugrel Hydrochloride - therapeutic use | ST Elevation Myocardial Infarction - mortality | Blood Platelets - metabolism | Adenosine - analogs & derivatives | Bayes Theorem | Coronary Thrombosis - etiology | Peptide Fragments - therapeutic use | Monte Carlo Method | Percutaneous Coronary Intervention - adverse effects
Journal Article
THROMBOSIS AND HAEMOSTASIS, ISSN 0340-6245, 02/2018, Volume 118, Issue 2, pp. 362 - 368
Background Reticulated platelets are associated with impaired antiplatelet response to irreversibly acting P2Y12-receptor inhibitors. However, the impact of RP... 
prasugrel | LOADING STRATEGIES | STENT THROMBOSIS | REACTIVITY | platelet reactivity | cangrelor | ticagrelor | ACUTE CORONARY SYNDROME | HETEROGENEITY | CLOPIDOGREL | THERAPY | immature platelets | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | reticulated platelets | ASSOCIATION | AGGREGATION
Journal Article
Medical Science Monitor, ISSN 1234-1010, 12/2009, Volume 15, Issue 12, pp. MS24 - MS30
Journal Article
Journal Article