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Saudi Pharmaceutical Journal, ISSN 1319-0164, 03/2019, Volume 27, Issue 3, pp. 326 - 340
Diabetes mellitus (DM) has emerged as a public healthcare problem. Sustained hyperglycemia has been linked with many complications including impaired male... 
Testosterone | Fertility | Sperm characteristics | P450scc and 17β-HSD | STZ | FBG | Diabetes | MALE-FERTILITY | STEROIDOGENESIS | P450scc and 17 beta-HSD | OXIDATIVE STRESS | QUALITY | REDUCTION | MEN | PHARMACOLOGY & PHARMACY | DYSFUNCTION | Olive | Type 2 diabetes | Complications and side effects | Usage | Research | Properties | Materia medica, Vegetable | Plant extracts | P450scc and 17β-HSD
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 08/2017, Volume 7
1 alpha, 20S-Dihydroxyvitamin D3 [1,20S(OH)(2)D-3], a natural and bioactive vitamin D3 metabolite, was chemically synthesized for the first time. X-ray... 
CYTOCHROME P450SCC | METABOLISM | ANALOGS | MULTIDISCIPLINARY SCIENCES | BIOLOGICAL-ACTIVITIES
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 09/2012, Volume 26, Issue 9, pp. 3901 - 3915
We define previously unrecognized in vivo pathways of vitamin D-3 (D3) metabolism generating novel D3-hydroxyderivatives different from 25-hydroxyvitamin D-3... 
TRANSFORMATION | 20-hydroxyvitamin D | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYDROXYLATION | keratinocytes | D-3 | CELL BIOLOGY | CYTOCHROME P450SCC | CYP11A1 | PRODUCT | BIOLOGY | 7-DEHYDROCHOLESTEROL | placenta | INHIBITS PROLIFERATION | SKIN | adrenals | KAPPA-B ACTIVITY
Journal Article
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, ISSN 0021-972X, 02/2013, Volume 98, Issue 2, pp. E298 - E303
Context: There is no effective treatment for systemic sclerosis and related fibrosing diseases. Recently the action of CYP11A1 on vitamin D-3 was shown to... 
CELLS | GROWTH-FACTOR-BETA | CYTOCHROME P450SCC | COMPLEX | METABOLISM | PATHWAY | HUMAN DERMAL FIBROBLASTS | ENDOCRINOLOGY & METABOLISM | INHIBITS PROLIFERATION | DIFFERENTIATION | SYSTEMIC-SCLEROSIS
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 04/2010, Volume 223, Issue 1, pp. 36 - 48
We have examined effects of the 20,23‐dihydroxyvitamin D3 (20,23(OH)2D3), on differentiation and proliferation of human keratinocytes and the anti‐inflammatory... 
SYSTEM | TRANSFORMATION | VITAMIN-D | CYTOCHROME P450SCC | PHYSIOLOGY | METABOLISM | PATHWAY | 7-DEHYDROCHOLESTEROL | ALPHA | ERGOSTEROL | EXPRESSION | CELL BIOLOGY
Journal Article
FEBS Journal, ISSN 1742-464X, 07/2006, Volume 273, Issue 13, pp. 2891 - 2901
We report an alternative, hydroxylating pathway for the metabolism of vitamin D 2 in a cytochrome P450 side chain cleavage (P450scc; CYP11A1) reconstituted... 
Keratinocytes | Skin | Vitamin D | Cytochrome P450scc | skin | keratinocytes | vitamin D2 | cytochrome P450scc
Journal Article