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Experimental Cell Research, ISSN 0014-4827, 11/2019, Volume 384, Issue 1, p. 111547
Traumatic brain injury (TBI) is common and often fatal in current times. The role of poly(adenosine diphosphate-ribose) polymerase (PARP)-induced cell death... 
PARP | Traumatic brain injury | p53-MDM2 pathway | Parthanatos | Iduna | AIF | OXIDATIVE STRESS | ACTIVATION | HIPPOCAMPAL | DEATH | MESSENGER | P53 | CELL BIOLOGY | INTERACT | TRAUMATIC BRAIN-INJURY | ONCOLOGY | DEGRADATION | EXPRESSION
Journal Article
by Kim, E and Kim, JY and Lee, JY
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 10/2019, Volume 20, Issue 20, p. 5179
Cells have evolved balanced systems that ensure an appropriate response to stress. The systems elicit repair responses in temporary or moderate stress but... 
p53 dynamics | DNA damage response | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | MECHANISMS | SIMULATION | CHEMISTRY, MULTIDISCIPLINARY | GLYCOLYSIS | REGULATOR | INVASION | P53-MDM2 FEEDBACK LOOP | mathematical modeling | DYNAMICS | metabolism | EXPRESSION | dna damage response
Journal Article
Journal Article
Molecular BioSystems, ISSN 1742-206X, 03/2011, Volume 7, Issue 3, pp. 843 - 851
This paper presents a general theoretical framework for generating Boolean networks whose state transitions realize a set of given biological pathways or minor... 
CELLS | P53-MDM2 FEEDBACK LOOP | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOGICAL ANALYSIS | DNA-DAMAGE | DYNAMICS | MODEL | PROBABILISTIC BOOLEAN NETWORKS | OSCILLATIONS | INTERVENTION | CONTROL POLICY
Journal Article
Molecular bioSystems, ISSN 1742-206X, 03/2011, Volume 7, Issue 3, pp. 843 - 851
This paper presents a general theoretical framework for generating Boolean networks whose state transitions realize a set of given biological pathways or minor... 
Neoplasms - metabolism | Neoplasms - genetics | Humans | Tumor Suppressor Protein p53 - metabolism | Signal Transduction - genetics | Gene Regulatory Networks | Tumor Suppressor Protein p53 - genetics
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, p. e17320
Human VRK1 induces a stabilization and accumulation of p53 by specific phosphorylation in Thr18. This p53 accumulation is reversed by its downregulation... 
APOPTOSIS | P53-MDM2 FEEDBACK LOOP | PROTEIN | HUMAN VACCINIA-RELATED-KINASE-1 VRK1 | PHOSPHORYLATION | MDM-2 BINDING | IN-VIVO | BIOLOGY | AUTOREGULATORY LOOP | VACCINIA-RELATED KINASE-1 | CELL-DEATH | Cell Cycle - genetics | Autophagy - radiation effects | Humans | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | Gene Knockdown Techniques | Tumor Suppressor Protein p53 - physiology | Ultraviolet Rays | DNA Damage - physiology | Infrared Rays | Protein-Serine-Threonine Kinases - antagonists & inhibitors | DNA Damage - genetics | Antineoplastic Agents - pharmacology | Autophagy - genetics | Signal Transduction - radiation effects | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA Damage - drug effects | Proteins - physiology | Cell Cycle - radiation effects | Down-Regulation | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Etoposide - pharmacology | Signal Transduction - genetics | Gene Expression Regulation - drug effects | Membrane Proteins | Proteins - genetics | Signal Transduction - drug effects | Models, Biological | Cell Cycle - physiology | Gene Expression Regulation - radiation effects | Signal Transduction - physiology | Cell Cycle - drug effects | Proteins - antagonists & inhibitors | DNA Damage - radiation effects | Doxorubicin - pharmacology | Ionizing radiation | Memory (Computers) | Tumor proteins | DNA repair | DNA damage | DNA | Phosphorylation | U.V. radiation | p53 Protein | Etoposide | Lysosomes | Kinases | Gene expression | Cytosol | Doxorubicin | Accumulation | Mutants | Ovarian cancer | Leptomycin B | Skin cancer | Degradation | Cell cycle | Damage accumulation | Deoxyribonucleic acid--DNA | Apoptosis | Deoxyribonucleic acid
Journal Article