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phosphorylation (25) 25
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Oncogene, ISSN 0950-9232, 02/1999, Volume 18, Issue 5, pp. 1131 - 1138
The cyclin-dependent kinase inhibitor p21(Waf1/Cip1) is a downstream effector of the p53-dependent cell growth arrest. We report herein that p21 was cleaved by... 
Caspases | DNA damage | p21 | Apoptosis | p53 | P53-INDUCED APOPTOSIS | NUCLEAR ANTIGEN | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | DNA-REPLICATION | CELL BIOLOGY | CYCLIN-DEPENDENT KINASES | CYTOCHROME-C | INHIBITION | ONCOLOGY | P53-MEDIATED G ARREST | IN-VIVO | GENETICS & HEREDITY | caspases | PROTEASE ACTIVATION
Journal Article
APOPTOSIS, ISSN 1360-8185, 10/2017, Volume 22, Issue 10, pp. 1225 - 1234
Hyperthermia induced by heat stress (HS) is known to inhibit proliferation and induce cell death in cancer. We previously demonstrated that checkpoint kinase 1... 
CANCER-CELLS | DNA damage response | PHOSPHORYLATION | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | Chk2 | p53 | CELL BIOLOGY | P53-MEDIATED APOPTOSIS | INHIBITION | Cell cycle | ATM | Heat stress | Hyperthermia | T-CELLS
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 02/2013, Volume 14, Issue 2, pp. 2980 - 2995
Compound K (20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, CK), an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, has been shown to... 
Cell cycle arrest | Xenograft | Compound K | Ginsenoside | Colorectal cancer | P53/p21 | CARCINOMA-CELLS | APOPTOSIS | colorectal cancer | SAPONIN METABOLITE | cell cycle arrest | compound K | CHEMISTRY, MULTIDISCIPLINARY | INTESTINAL BACTERIA | IN-VITRO | xenograft | CISPLATIN | P53-MEDIATED G ARREST | COLORECTAL-CANCER | ginsenoside | CELL-CYCLE | TUMOR-GROWTH | p53/p21
Journal Article
ONCOGENE, ISSN 0950-9232, 07/1998, Volume 16, Issue 26, pp. 3461 - 3469
Cells expressing the R273H mutant of p53, which lacks sequence specific DNA binding capacity, do not undergo cell cycle arrest in G(1) following exposure to... 
WILD-TYPE P53 | TRANSCRIPTIONAL ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | PARP | RNA polymerase III apoptosis | HUMAN CANCER-CELLS | POTENTIAL MEDIATOR | p53 | CELL BIOLOGY | P53-MEDIATED APOPTOSIS | ONCOLOGY | DNA | GENETICS & HEREDITY | CELLULAR TUMOR-ANTIGEN | CASEIN KINASE-II | ATAXIA-TELANGIECTASIA | DEPENDENT KINASES | p21(Waf1/Cip1)
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/1998, Volume 95, Issue 12, pp. 6791 - 6796
Journal Article
CURRENT CANCER DRUG TARGETS, ISSN 1568-0096, 02/2012, Volume 12, Issue 2, pp. 85 - 96
p21(CDKN1A) (WAF1/CIP1/SDI1), the cyclin-dependent kinase (CDK) inhibitor belonging to the Cip/Kip family, was first described as a potent inhibitor of cell... 
CANCER-CELLS | p21(CDKN1A) | CARCINOMA CELLS | cell cycle regulator | DNA-DAMAGE | TUMOR-FORMATION | Anti-cancer target | FAS-MEDIATED APOPTOSIS | NUCLEOTIDE EXCISION-REPAIR | IN-VITRO | CDK inhibitor | ONCOLOGY | P53-MEDIATED G ARREST | CELL-CYCLE | HISTONE DEACETYLASE INHIBITORS
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/1996, Volume 227, Issue 2, pp. 564 - 569
Proteasome-dependent degradation of regulatory proteins is a known mechanism of cell cycle control. We found that the proteasome-specific inhibitor lactacystin... 
APOPTOSIS | BIOPHYSICS | GROWTH ARREST | PATHWAY | P53-MEDIATED G ARREST | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | LACTACYSTIN | CELL-LINES | INHIBITOR | CYCLIN | P53
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/1998, Volume 101, Issue 4, pp. 777 - 782
The p21 protein is found in the nucleus of most cells at low levels and is induced to elevated levels after DNA damage, causing cell-cycle arrest. We have... 
Cyclin-dependent kinase | DNA damage | Cell cycle | Apoptosis | Necrosis | WILD-TYPE P53 | MEDICINE, RESEARCH & EXPERIMENTAL | cell cycle | TUMOR-SUPPRESSOR GENE | CYCLE ARREST | apoptosis | CDK INHIBITOR | DEPENDENT KINASE INHIBITOR | P21 | DNA-REPLICATION | necrosis | GROWTH ARREST | P53-MEDIATED G ARREST | LEUKEMIA-CELLS | cyclin-dependent kinase
Journal Article
ONCOGENE, ISSN 0950-9232, 10/1998, Volume 17, Issue 13, pp. 1691 - 1703
p21(Waf1/Cip1) is a major transcriptional target of p53 and has been shown to be one of the principal mediators of the p53 induced G1 cell cycle arrest. We... 
WILD-TYPE P53 | endoreduplication | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN CANCER-CELLS | cell cycle arrest | CELL BIOLOGY | cyclin dependent kinase | senescence | CDK INHIBITORS | RETINOBLASTOMA PROTEIN | ONCOLOGY | GROWTH ARREST | P53-MEDIATED G ARREST | IN-VIVO | GENETICS & HEREDITY | DEPENDENT-KINASE INHIBITOR | S-PHASE | HUMAN FIBROBLASTS | p21(Waf1/Cip1)
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 02/2012, Volume 11, Issue 2, pp. 370 - 382
Journal Article
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