Articles

The transcription factor Nrf2 and its repressor protein Keap1 play key roles in the regulation of antioxidant stress responses and both Keap1-Nrf2 signalling... 
ALS-FTLD | Oxidative stress | Keap1-Nrf2 | SQSTM1/p62 | ACTIVATE NRF2 | PHOSPHORYLATION | AUTOPHAGIC DEGRADATION | P62 | NEUROSCIENCES | UBIQUITINATION | TRANSCRIPTION FACTOR NRF2 | PATHWAY | ANTIOXIDANT RESPONSE | PAGETS-DISEASE | BONE | Response Elements | Signal Transduction | Amyotrophic Lateral Sclerosis - genetics | Humans | Kelch-Like ECH-Associated Protein 1 - metabolism | Mutation, Missense | Sequestosome-1 Protein - genetics | NF-E2-Related Factor 2 - metabolism | HEK293 Cells | Protein Binding | Frontotemporal Lobar Degeneration - genetics | Sequestosome-1 Protein - chemistry | Binding Sites | Sequestosome-1 Protein - metabolism | Antioxidants | Nervous system diseases | Genetic aspects | Analysis | Protein binding | ARE, Antioxidant response element | NFE2L2, Nuclear factor erythroid 2-like 2 | p62, Sequestosome 1 | IKKβ, Inhibitor of nuclear factor kappa-B kinase subunit beta | RBM45, RNA binding motif protein 45 | KIR, Keap1-interacting region | SALS, Sporadic ALS | UBA, Ubiquitin-associated (domain) | Keap1, Kelch-like ECH-associated protein 1 | Nrf2, Nuclear erythroid 2-related factor 2 | p62 protein | ALS, Amyotrophic lateral sclerosis | p62 | mTORC1, Mammalian target of rapamycin complex 1 | LIR, LC3-interacting region | NQO1, NAD(P)H dehydrogenase, Quinone 1 | FTLD, Frontotemporal lobar degeneration | SOD1, Superoxide dismutase 1 | SQSTM1 | PDB, Paget's disease of bone | TDP-43, TAR DNA-binding protein 43