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Molecular Cell, ISSN 1097-2765, 09/2013, Volume 51, Issue 5, pp. 618 - 631
Journal Article
Science, ISSN 0036-8075, 7/2011, Volume 333, Issue 6039, pp. 228 - 233
Journal Article
Journal Article
Hepatology, ISSN 0270-9139, 10/2018, Volume 68, Issue 4, pp. 1331 - 1346
Obesity commonly leads to hepatic steatosis, which often provokes lipotoxic injuries to hepatocytes that cause nonalcoholic steatohepatitis (NASH). NASH, in... 
OXIDATIVE STRESS | OBESITY | ACTIVATION | TBK1 | P62/SQSTM1 | FATTY LIVER | NONALCOHOLIC STEATOHEPATITIS | MECHANISMS | AUTOPHAGY | GASTROENTEROLOGY & HEPATOLOGY | P62 | Index Medicus
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 2010, Volume 21, Issue 4, pp. 195 - 201
Autophagy is a highly conserved process that allows cells, tissues and organs to survive onslaughts such as nutrient deprivation, inflammation, hypoxia and... 
Pathology | PARKIN | UBIQUITIN | PROTEIN-KINASE COMPLEX | P62/SQSTM1 | DEGRADATION | STARVATION | MITOPHAGY | INDUCTION | SELECTIVE AUTOPHAGY | CELL-DEATH | CELL BIOLOGY | Phosphorylation | Ubiquitination | Animals | Acetylation | Autophagy | Humans
Journal Article
Molecular and Cellular Neuroscience, ISSN 1044-7431, 07/2019, Volume 98, pp. 32 - 45
Elevated oxidative stress has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). In... 
ALS-FTLD | Keap1 | Oxidative stress | p62/SQSTM1 | Nrf2 | LIPID-PEROXIDATION | PB1 DOMAIN INTERACTION | AMYOTROPHIC-LATERAL-SCLEROSIS | MOTOR-NEURON | FRONTOTEMPORAL LOBAR DEGENERATION | NEUROSCIENCES | AUTOPHAGY RECEPTOR | TRANSCRIPTION FACTOR NRF2 | CUL3-BASED E3 LIGASE | HEXANUCLEOTIDE REPEAT
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 12/2017, Volume 37, Issue 23
Mechanistic target of rapamycin complex 1 (MTORC1) is a critical negative regulator of general autophagy. We hypothesized that MTORC1 may specifically regulate... 
TSC2 | MTORC1 | PINK1 | Rapamycin | Mitophagy | Autophagy | autophagy | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRESS-RESPONSE | P62/SQSTM1 | CELL-DEATH | CELL BIOLOGY | PARKIN | mitophagy | MITOCHONDRIAL DYNAMICS | INHIBITION | TUBEROUS SCLEROSIS COMPLEX | DISEASE | GROWTH | EXPRESSION | rapamycin
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 11/2014, Volume 1843, Issue 11, pp. 2765 - 2774
p62, also known as SQSTM1, is a multi-domain signalling scaffold protein involved in numerous critical cellular functions such as autophagy, apoptosis and... 
cAMP signalling | Protein kinase A | Autophagy | p62 | Protein–protein interaction | Phosphodiesterase | Protein-protein interaction | CAMP signalling | P62 | PROTEIN-KINASE-C | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | PROTEASOME DEGRADATION | SELECTIVE AUTOPHAGY | CELL BIOLOGY | P62 SQSTM1 | PDE4A4 | AGGREGATE | CAMP
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 33, pp. 13795 - 13808
In the adult brain, programmed death of neural stem cells is considered to be critical for tissue homeostasis and cognitive function and is dysregulated in... 
SURVIVAL | APOPTOSIS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | P62/SQSTM1 | MITOCHONDRIA | DEGRADATION | MITOPHAGY | PROLIFERATION | MECHANISMS | INSULIN WITHDRAWAL | AMP-Activated Protein Kinases - metabolism | Autophagy-Related Protein 7 - metabolism | Humans | Protein Transport - drug effects | Hippocampus - drug effects | Neural Stem Cells - cytology | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Protein Processing, Post-Translational - drug effects | RNA Interference | Gene Deletion | Phosphorylation - drug effects | Sequestosome-1 Protein - metabolism | Adult Stem Cells - drug effects | Autophagy-Related Protein 7 - antagonists & inhibitors | Cell Survival - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Adult Stem Cells - cytology | AMP-Activated Protein Kinases - antagonists & inhibitors | Sequestosome-1 Protein - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Hippocampus - cytology | Autophagy-Related Protein 7 - genetics | Nerve Tissue Proteins - genetics | AMP-Activated Protein Kinases - chemistry | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Point Mutation | Sequestosome-1 Protein - genetics | Adult Stem Cells - metabolism | Animals | Protein Kinase Inhibitors - pharmacology | Neural Stem Cells - metabolism | AMP-Activated Protein Kinases - genetics | Amino Acid Substitution | AMP-activated kinase (AMPK) | mitophagy | autophagy | phosphorylation | p62 (sequestosome 1 (SQSTM1)) | Protein Synthesis and Degradation
Journal Article
Journal Article