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Biochemical journal, ISSN 1470-8728, 2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B (also known as Akt), PKC, S6K p70 (ribosomal S6 kinase), RSK... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
... (protein kinase A/protein kinase G/protein kinase Q family kinases such as Akt (protein kinase 13), S6K (p70 ribosomal S6 kinase... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | HYDROPHOBIC MOTIF | cancer | serum and glucocorticoid protein kinase (SGK) | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2012, Volume 76, Issue 2, pp. 325 - 337
.... We sought to perturb p70 ribosomal S6 kinase 1 (S6K1), a key translation initiation and elongation regulator, in FXS model mice... 
MAMMALIAN TARGET | RAPAMYCIN SIGNALING PATHWAY | FMR1 KNOCKOUT MOUSE | MESSENGER-RNA | MEMORY | LONG-TERM DEPRESSION | PHOSPHOINOSITIDE 3-KINASE-AKT-MAMMALIAN TARGET | TRANSLATION | MENTAL-RETARDATION PROTEIN | NEUROSCIENCES | MTOR | Electric Stimulation | Fragile X Syndrome - pathology | Male | Fragile X Mental Retardation Protein - metabolism | Synapses - genetics | Recognition (Psychology) - physiology | Phosphorylation - genetics | TOR Serine-Threonine Kinases - genetics | Ribosomal Protein S6 Kinases, 70-kDa - deficiency | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Membrane Potentials - drug effects | Synapses - drug effects | Maze Learning - physiology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Dendritic Spines - physiology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Behavior, Animal - physiology | Mice, Transgenic | Hippocampus - pathology | Mutation - genetics | Patch-Clamp Techniques | Phenotype | Analysis of Variance | Mice | Long-Term Synaptic Depression - genetics | Neurons - pathology | Membrane Potentials - genetics | Fragile X Syndrome - physiopathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Extracellular Signal-Regulated MAP Kinases - genetics | Exploratory Behavior - physiology | Neurons - classification | Female | Interpersonal Relations | Fragile X Syndrome - genetics | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Biophysics | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Motor Activity - genetics | Rotarod Performance Test | Animals | Fragile X Syndrome - prevention & control | Dendritic Spines - classification | Fragile X Mental Retardation Protein - genetics | In Vitro Techniques | Depression, Mental | Analysis | Genetic research | Protein biosynthesis | Genetic aspects | Fragile X syndrome | Genetic translation | Proteins | Phosphorylation | Brain research | Kinases | Protein synthesis | Rodents | Animal models | Translation | Translation initiation | Pattern recognition | Mental retardation | Ribosomal protein S6 kinase | Autism | Dendritic spines | Molecular modelling | Social interactions | Etiology | p70 S6 kinase | Long-term depression | Elongation
Journal Article
Biochemical journal, ISSN 1470-8728, 2010, Volume 433, Issue 2, pp. 357 - 369
... (p70 ribosomal S6 kinase) and SGK (serum- and glucocorticoid-induced protein kinase). In the present paper, we describe the small molecule GSK2334470, which inhibits PDK1 with an IC50... 
p70 ribosomal S6 kinase (S6K) | Akt/Akt1 | 3-phosphoinositide-dependent protein kinase | Phosphoinositide 3-kinase (PI3K) | p90 ribosomal S6 kinase (RSK) | Kinase inhibitor | Serum- and glucocorticoid-induced protein kinase (SGK) | Cancer | PDK1 | IN-VIVO ROLE | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | UCN-01 7-HYDROXYSTAUROSPORINE | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | KNOCKIN MUTATION | CAENORHABDITIS-ELEGANS | SMALL-MOLECULE INHIBITORS | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | Akt/Akt 1 | serum- and glucocorticoid-induced protein kinase (SGK) | Cyclic AMP-Dependent Protein Kinases - metabolism | Indazoles - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Humans | Cells, Cultured | Substrate Specificity | Pyrimidines - pharmacology | Pyrimidines - chemistry | Indazoles - pharmacology | Protein Kinase Inhibitors - chemistry | Animals | Signal Transduction - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Mice | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism
Journal Article
Journal of medicinal food, ISSN 1557-7600, 2012, Volume 15, Issue 3, pp. 231 - 241
... are linked with their ability to suppress constitutive AKT/mammalian target of rapamycin (mTOR)/ribosomal p70 S6 kinase... 
Full Communications | Guava leaves | Prostate cancer | AKT/mammalian target of rapamycin/ribosomal p70 S6 kinase | Apoptosis | MAMMALIAN TARGET | PHOSPHATIDYLINOSITOL 3-KINASE/AKT | ANDROGEN RECEPTOR | AQUEOUS EXTRACT | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | FOOD SCIENCE & TECHNOLOGY | apoptosis | ACTION MECHANISM | prostate cancer | IN-VITRO | NUTRITION & DIETETICS | ANTIMICROBIAL ACTIVITIES | NF-KAPPA-B | guava leaves | LEAF EXTRACT | Plant Extracts - chemistry | Prostatic Neoplasms - metabolism | TOR Serine-Threonine Kinases - metabolism | Antineoplastic Agents, Phytogenic - analysis | Apoptosis - drug effects | Plant Extracts - pharmacology | Humans | Male | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Protein Processing, Post-Translational - drug effects | Sesquiterpenes - analysis | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Prostatic Neoplasms - drug therapy | Plant Leaves - chemistry | Cell Survival - drug effects | Prostatic Neoplasms - pathology | Sesquiterpenes - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - chemistry | Down-Regulation - drug effects | Drug Discovery | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Cell Line, Tumor | Psidium - chemistry | Sesquiterpenes - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Guava | Usage | Care and treatment | Research | Chemical properties | Health aspects | mammalian target of rapamycin | AKT | ribosomal p70 S6 kinase | 식품과학
Journal Article
Biochemical journal, ISSN 0264-6021, 12/2004, Volume 384, Issue 3, pp. 477 - 488
... (serum- and glucocorticoid-induced kinase 1), but not by protein kinase Balpha, and identified it as NDRG2... 
Phosphorylation | Glycogen synthase kinase 3 (GSK3) | N-myc down-stream-regulated gene (NDRG) | p53 | Serum- and glucocorticoid-induced kinase 1 (SGK1) | glycogen synthase kinase 3 (GSK3) | SPECIFICITY | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | TRANSCRIPTION | SERUM | n-myc downstream-regulated gene (NDRG) | GENE | serum- and glucocorticoid-induced kinase 1 (SGK1) | MAPKAP KINASE-1 | DIFFERENTIATION | INHIBITORS | phosphorylation | Antibody Specificity | Multigene Family | Molecular Weight | Humans | Molecular Sequence Data | Substrate Specificity | Cell Cycle Proteins - classification | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Immediate-Early Proteins | Cell Cycle Proteins - immunology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Antibodies - immunology | Cell Cycle Proteins - genetics | Proteins - classification | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Rabbits | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Nuclear Proteins - metabolism | Glycogen Synthase Kinase 3 - metabolism | Phosphoserine - metabolism | Proteins - immunology | Proteins - genetics | Proto-Oncogene Proteins c-akt | Animals | Proteins - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Mice | HeLa Cells | Tumor Suppressor Proteins | SGK1, serum- and glucocorticoid-induced kinase 1 | PDK1, 3-phosphoinositide-dependent kinase 1 | LDS, lithium dodecyl sulphate | RSK, p90 ribosomal S6 kinase | ENaC, epithelial sodium channel | FOXO3a, forkhead box O3a | ERK, extracellular-signal-regulated kinase | MALDI-TOF, matrix-assisted laser-desorption ionization–time-of-flight | PKB, protein kinase B | SAPK, stress-activated protein kinase | CDK, cyclin-dependent kinase | IGF-1, insulin-like growth factor-1 | DYRK1A, dual-specificity tyrosine phosphorylated and regulated kinase 1A | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | GSK3, glycogen synthase kinase 3 | siRNA, small interfering RNA | KESTREL, kinase substrate tracking and elucidation | MAPK, mitogen-activated protein kinase | NDRG, n-myc downstream-regulated gene
Journal Article
EMBO reports, ISSN 1469-221X, 04/2007, Volume 8, Issue 4, pp. 360 - 365
... (TOR)/S6 kinase (S6K) pathway. Our Drosophila studies have shown that ATG1 inhibits TOR/S6K... 
cell growth | S6K | autophagy | TOR | RAPAMYCIN | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN PROTEIN | INDUCTION | PROTEIN-KINASES