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index medicus (165) 165
p70s6 kinase (164) 164
animals (104) 104
phosphorylation (97) 97
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ribosomal protein s6 kinases, 70-kda - metabolism (63) 63
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activation (45) 45
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phosphorylation - drug effects (27) 27
proto-oncogene proteins c-akt - metabolism (27) 27
rats, sprague-dawley (26) 26
ribosomal protein s6 kinases - metabolism (26) 26
insulin (25) 25
akt (24) 24
apoptosis (24) 24
inhibition (23) 23
cells, cultured (21) 21
s6 kinase (21) 21
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phosphatidylinositol 3-kinase (19) 19
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kinases (17) 17
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physiological aspects (17) 17
proteins (17) 17
research (17) 17
disease models, animal (16) 16
phosphatidylinositol 3-kinases - metabolism (16) 16
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signaling pathway (16) 16
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immunohistochemistry (15) 15
translation (15) 15
autophagy (14) 14
blotting, western (14) 14
middle aged (14) 14
protein-serine-threonine kinases - metabolism (14) 14
protein-synthesis (14) 14
cell proliferation - drug effects (13) 13
in-vitro (13) 13
ischemia (13) 13
p70 s6 kinase (13) 13
pathway (13) 13
pharmacology & pharmacy (13) 13
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ribosomal protein s6 kinases, 70-kda - genetics (13) 13
brain (12) 12
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health aspects (12) 12
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rats, wistar (11) 11
survival (11) 11
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mice, inbred c57bl (10) 10
muscle, skeletal - metabolism (10) 10
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Cancer Letters, ISSN 0304-3835, 2011, Volume 306, Issue 2, pp. 151 - 160
Abstract Paclitaxel, one of key drugs to treat a wide range of malignancies, exhibits relative low sensitivity for colorectal cancer. The present study was to... 
Hematology, Oncology and Palliative Medicine | p70S6 Kinase | PI3K | MAPK | Paclitaxel | Colorectal cancer | P70S6 Kinase | FUTURE-DIRECTIONS | INDUCED APOPTOSIS | ADJUVANT THERAPY | KAPPA-B | OVARIAN-CARCINOMA | COLON-CARCINOMA CELLS | INHIBITION | ONCOLOGY | TAXOL | GROWTH | MULTIDRUG-RESISTANCE | Paclitaxel - pharmacology | Apoptosis - drug effects | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Flow Cytometry | Colorectal Neoplasms - drug therapy | Flavonoids - pharmacology | Phosphorylation - drug effects | Tumor Cells, Cultured | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Colorectal Neoplasms - enzymology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Blotting, Western | Drug Synergism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Colorectal Neoplasms - pathology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Proteins | Chemotherapy | Cell growth | Medical prognosis | Mortality | Cytotoxicity | Kinases | Experiments | Drug dosages | Cancer therapies | Apoptosis | Index Medicus
Journal Article
Journal of Neuroendocrinology, ISSN 0953-8194, 01/2015, Volume 27, Issue 1, pp. 20 - 32
AMP‐activated protein kinase (AMPK) is activated under conditions that deplete cellular ATP levels and elevate AMP levels. We have recently shown that AMPK can... 
AMP | cell growth | activated kinase | AMPK | pituitary tumour | silencing | rapamycin | p70S6 kinase | Pituitary tumour | Cell growth | Rapamycin | P70S6 kinase | AMP-activated kinase | AMPK silencing | SURVIVAL | RAF/MEK/ERK | PI3K/AKT/MTOR | PROLIFERATION | CANCER | NEUROSCIENCES | IN-VITRO | SOMATOSTATIN | GROWTH | ENDOCRINOLOGY & METABOLISM | UP-REGULATION | ADENOMAS | AMP-Activated Protein Kinases - metabolism | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Antineoplastic Agents - therapeutic use | Aminoimidazole Carboxamide - pharmacology | Ribonucleotides - pharmacology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Imidazoles - therapeutic use | Catalytic Domain | Sirolimus - therapeutic use | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Down-Regulation | Rats | Pituitary Neoplasms - pathology | Imidazoles - pharmacology | Piperazines - therapeutic use | Piperazines - pharmacology | Sirolimus - pharmacology | Animals | Pituitary Neoplasms - drug therapy | Aminoimidazole Carboxamide - analogs & derivatives | Cell Line, Tumor | Cell Proliferation - drug effects | Enzyme Activation | Pituitary Neoplasms - enzymology | Somatotropin | Protein kinases | Analysis | Tumors | Index Medicus
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 04/2004, Volume 94, Issue 7, pp. 960 - 966
ABSTRACT—Glycogen synthase kinase (GSK) inhibition produced by ischemic preconditioning has been previously shown to be regulated through... 
Phosphatidylinositol-3 kinase | Reperfusion | Glycogen synthase kinase | Target of rapamycin | Opioids | LOCALIZATION | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTECTION | PHOSPHORYLATION | phosphatidylinositol-3 kinase | PHOSPHATIDYLINOSITOL 3-KINASE | CELL-SURVIVAL | KINASE-3-BETA | INSULIN | P70S6 KINASE | INDUCED DELAYED CARDIOPROTECTION | glycogen synthase kinase | PERIPHERAL VASCULAR DISEASE | target of rapamycin | HEMATOLOGY | reperfusion | opioids | Glycogen Synthase Kinase 3 - physiology | Maleimides - pharmacology | Receptors, Retinoic Acid - physiology | Glycogen Synthase Kinase 3 beta | Male | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, Thyroid Hormone - antagonists & inhibitors | Aminophenols - pharmacology | Cardiotonic Agents - therapeutic use | Myocardial Infarction - pathology | Indoles - pharmacology | Benzamides - pharmacology | Chromones - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 | Morphine - pharmacology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Morpholines - pharmacology | Rats | Receptors, Retinoic Acid - antagonists & inhibitors | Cardiotonic Agents - pharmacology | Myocardial Infarction - metabolism | Receptors, Opioid, delta - drug effects | Piperazines - pharmacology | Rats, Sprague-Dawley | Receptors, Thyroid Hormone - physiology | Sirolimus - pharmacology | Animals | Androstadienes - pharmacology | Signal Transduction - drug effects | Narcotic Antagonists - pharmacology | Phosphatidylinositol 3-Kinases - physiology | Premedication | Index Medicus
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 12/2001, Volume 89, Issue 12, pp. 1191 - 1198
The “metabolic cocktail” comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that... 
p70s6 kinase | Cardioprotection | Akt | BAD | Insulin | ISOLATED RAT-HEART | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | insulin | PHOSPHATIDYLINOSITOL 3-KINASE | PROTEIN-KINASE | GLUCOSE TRANSPORTERS | FLOW ISCHEMIA | INFARCT SIZE | IN-VITRO | FATTY-ACID | cardioprotection | PERIPHERAL VASCULAR DISEASE | S6 KINASE | HEMATOLOGY | Protein Kinases - metabolism | Rats, Wistar | Ribosomal Protein S6 Kinases - metabolism | Protein-Tyrosine Kinases - metabolism | Heart - physiology | Protein-Serine-Threonine Kinases | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Time Factors | Myocardial Infarction - pathology | Myocardium - metabolism | Pyruvic Acid - metabolism | Phosphorylation - drug effects | Cell Survival - physiology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Insulin - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Myocardium - pathology | Proto-Oncogene Proteins c-akt | Protein Kinase Inhibitors | Animals | Carrier Proteins - metabolism | Myocardial Reperfusion | Signal Transduction - drug effects | Glucose - metabolism | Heart - drug effects | Signal Transduction - physiology | Myocardial Infarction - prevention & control | TOR Serine-Threonine Kinases | In Vitro Techniques | bcl-Associated Death Protein | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 17, pp. 5191 - 5194
Journal Article
Cardiovascular Research, ISSN 0008-6363, 04/2011, Volume 90, Issue 1, pp. 49 - 56
Aims Ischaemic preconditioning (IPC) protects the heart against prolonged lethal ischaemia through a signalling cascade involving Akt, glycogen synthase... 
mTOR | Signalling pathways | GSK-3β | Wnt | Preconditioning | CARDIAC-FUNCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | TRANSLATION INITIATION | POTASSIUM-TRANSPORT | GLYCOGEN-SYNTHASE KINASE-3-BETA | RAT HEARTS | P70S6 KINASE | MITOCHONDRIAL PERMEABILITY TRANSITION | SENSITIVE K+ CHANNEL | INDUCED CARDIOPROTECTION | GSK-3 beta | ISCHEMIA-REPERFUSION | Free Radical Scavengers - pharmacology | Phosphorylation | Diazoxide - pharmacology | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Glycogen Synthase Kinase 3 beta | Phosphoproteins - metabolism | Wnt Proteins - metabolism | Myocardial Reperfusion Injury - enzymology | Potassium Channels - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Myocardial Reperfusion Injury - pathology | Myocardial Infarction - pathology | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Myocardial Infarction - enzymology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Mice, Transgenic | Myocardium - pathology | Glycogen Synthase Kinase 3 - metabolism | Potassium Channels - drug effects | Proteins - genetics | Myocardium - enzymology | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Glycogen Synthase Kinase 3 - genetics | Signal Transduction - drug effects | Ischemic Preconditioning, Myocardial | Perfusion | Mice | Myocardial Infarction - prevention & control | Protein Kinase Inhibitors - pharmacology | Myocardial Reperfusion Injury - prevention & control | Index Medicus
Journal Article
中华医学杂志:英文版, ISSN 0366-6999, 2015, Volume 128, Issue 5, pp. 664 - 669
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2017, Volume 313, Issue 2, pp. H283 - H292
PRKAG2 encodes the gamma(2)-subunit isoform of 5'-AMP-activated protein kinase (AMPK), a heterotrimeric enzyme with major roles in the regulation of energy... 
P70S6 kinase | PRKAG2 gene mutation | Cardiac hypertrophy | Rapamycin | AMP-activated protein kinase | Eukaryotic translation initiation factor 4E-binding protein | H9c2 cells | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | VENTRICULAR PREEXCITATION | ACTIVATED-PROTEIN-KINASE | IDENTIFICATION | GLYCOGEN-STORAGE | PARKINSON-WHITE-SYNDROME | CBS DOMAINS | eukaryotic translation initiation factor 4E-binding protein | MIMICKING HYPERTROPHIC CARDIOMYOPATHY | CARDIAC-HYPERTROPHY | AMPK | PERIPHERAL VASCULAR DISEASE | CONDUCTION SYSTEM DISEASE | cardiac hypertrophy | p70S6 kinase | rapamycin | AMP-Activated Protein Kinases - metabolism | Fibroblasts - enzymology | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Humans | Cardiomyopathy, Hypertrophic - enzymology | Structure-Activity Relationship | Mutation, Missense | Phosphoproteins - metabolism | Cardiomyopathy, Hypertrophic - drug therapy | Case-Control Studies | Myocytes, Cardiac - enzymology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Transfection | DNA Mutational Analysis | HEK293 Cells | Infant, Newborn | Cardiomyopathy, Hypertrophic - genetics | Genetic Predisposition to Disease | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Adenosine Monophosphate - metabolism | Models, Molecular | Fibroblasts - pathology | Sirolimus - pharmacology | AMP-Activated Protein Kinases - chemistry | Phenformin - pharmacology | Myocytes, Cardiac - pathology | Phenotype | Carrier Proteins - metabolism | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Cardiomyopathy, Hypertrophic - physiopathology | Protein Conformation | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | AMP-Activated Protein Kinases - genetics | Genotype & phenotype | Signal transduction | Mutation | Genes | Cells | Index Medicus
Journal Article