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03/2012
p73 shares many structural and functional similarities with its homologue, the p53 tumour suppressor. Many p73 protein isoforms result from both alternative... 
SATB2 | p73 | osteosarcoma
Dissertation
06/2011
Tumour suppressor 73 (Trp73) gene shares structural and functional homology with p53. Trp73 encodes multiple isoforms with opposing effects. The TAp73 isoform... 
OSE | ovarian cancer | 0719 | p73
Dissertation
Cancer Research, ISSN 0008-5472, 09/2017, Volume 77, Issue 17, pp. 4602 - 4612
Identifying critical factors involved in the metastatic progression of hepatocellular carcinoma (HCC) may offer important therapeutic opportunities. Here, we... 
TUMOR-PROTEIN-53-INDUCED-NUCLEAR-PROTEIN-1 | NUCLEAR-PROTEIN 1 | ONCOLOGY | MAP KINASE | PROSTATE-CANCER | KINASE PHOSPHATASES MKPS | GENE-EXPRESSION | TUMOR-SUPPRESSOR | STRESS | P53-INDUCED NUCLEAR-PROTEIN-1 | CELL-DEATH | Prognosis | Humans | Lung Neoplasms - metabolism | Tumor Protein p73 - genetics | Gene Expression Profiling | Tumor Protein p73 - metabolism | Heat-Shock Proteins - genetics | Neoplasm Metastasis | Lung Neoplasms - secondary | Carcinoma, Hepatocellular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Dual-Specificity Phosphatases - genetics | Liver Neoplasms - pathology | Tumor Cells, Cultured | Lung Neoplasms - genetics | Liver Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Dual-Specificity Phosphatases - metabolism | Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinase Phosphatases - genetics | Xenograft Model Antitumor Assays | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Protein Array Analysis | Mice | Mice, Inbred BALB C | Carcinoma, Hepatocellular - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinase Phosphatases - metabolism | Liver | Extracellular signal-regulated kinase | Hepatocellular carcinoma | Metastasis | Metastases | Liver cancer | Signal transduction | Signaling | Stress response | Binding sites | Cellular stress response | Tumors | Apoptosis | Cancer | Liver Neoplasms | Lung Neoplasms | Life Sciences | Tumor Protein p73 | Heat-Shock Proteins | Mitogen-Activated Protein Kinase Phosphatases | Carcinoma, Hepatocellular | Dual-Specificity Phosphatases | Mitogen-Activated Protein Kinase 1 | Mitogen-Activated Protein Kinase 3 | Carrier Proteins
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 09/2017, Volume 31, Issue 17, pp. 1738 - 1753
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2008, Volume 7, Issue 9, pp. 3047 - 3055
1α,25-Dihydroxyvitamin D 3 (1,25D 3 ) exhibits antitumor activity in a variety of cancers including squamous cell carcinoma (SCC). Intrinsic resistance of SCC... 
1,25D3 | cisplatin | p73
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 09/2002, Volume 196, Issue 6, pp. 765 - 780
p73 has significant homology to p53. However, tumor-associated up-regulation of p73 and genetic data from human tumors and 73-deficient mice exclude a... 
ΔNp73 | Ex2Del p73 | Deregulation in tumor | P73 | Apoptosis | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | PROTEIN | Delta Np73 | DNA-DAMAGE | apoptosis | P73 GENE | deregulation in tumor | NEUROBLASTOMA | INDUCE APOPTOSIS | IMMUNOLOGY | CELL-LINES | p73 | KINASE C-ABL | E2F-1 | EXPRESSION
Journal Article
Journal Article
MOLECULAR CELL, ISSN 1097-2765, 02/2008, Volume 29, Issue 3, pp. 350 - 361
Cells undergo apoptosis upon exposure to severe DNA damage stress. Under this condition, p73 is phosphorylated and activated by c-AbI. The transcription... 
YES-ASSOCIATED PROTEIN | APOPTOTIC RESPONSE | RNA INTERFERENCE | STABILIZES P73 | WW DOMAIN | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGULATES P73 | CELL-PROLIFERATION | INDUCE APOPTOSIS | TRANSCRIPTIONAL COACTIVATOR | CELL BIOLOGY
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2019, Volume 24, Issue 17, p. 3175
Tumor suppressor p53 plays an integral role in DNA-damage induced apoptosis, a biological process that protects against tumor progression. Cell shape... 
myosin | actin | DMPK | p73 | p53
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2010, Volume 403, Issue 1, pp. 13 - 17
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2019, Volume 508, Issue 1, pp. 203 - 209
Endoplasmic reticulum (ER) stress activation could be found in a wide range of human tumors. ER stress induces the splicing of X-box binding protein 1 (XBP1)... 
TAp73 | Spliced X box binding protein 1 (XBP1-s) | X box binding protein 1 (XBP1) | Tumorigenesis | p53 family | ISOFORMS | PROGNOSIS | ER STRESS |