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Nature Immunology, ISSN 1529-2908, 01/2014, Volume 15, Issue 1, pp. 88 - 97
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2010, Volume 16, Issue 4, pp. 438 - 445
Class Ia phosphoinositide 3-kinase (PI3K), an essential mediator of the metabolic actions of insulin, is composed of a catalytic (p110 alpha or p110 beta) and... 
MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | PHOSPHATIDYLINOSITOL 3-KINASE | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | P85-ALPHA SUBUNIT | CELL BIOLOGY | SKELETAL-MUSCLE | MESSENGER-RNA | INSULIN-RESISTANCE | PURIFICATION METHOD | ADIPOSE-TISSUE | Insulin - physiology | Endoplasmic Reticulum - metabolism | Activating Transcription Factor 6 | Phosphatidylinositol 3-Kinases - metabolism | Cell Nucleus - physiology | X-Box Binding Protein 1 | Endoribonucleases - physiology | Gene Knockdown Techniques | Trans-Activators - physiology | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Membrane Proteins - physiology | Stress, Physiological - physiology | Cell Line | Unfolded Protein Response - drug effects | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Protein-Serine-Threonine Kinases - physiology | Liver - metabolism | Endoplasmic Reticulum - physiology | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Animals | Tunicamycin - pharmacology | Liver - physiology | Phosphatidylinositol 3-Kinases - physiology | Mice | Apoptosis - physiology | Unfolded Protein Response - physiology | Transcription factors | Physiological aspects | Causes of | Insulin resistance | Genetic aspects | Research | Binding proteins | Protein kinases | Catalysis | Kinases | Metabolism | Protein folding | Insulin
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 47, pp. 16826 - 16829
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 12, pp. 5471 - 5476
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is deregulated in many human diseases including cancer, diabetes, obesity, and autoimmunity. PI3K... 
Proteins | Phosphatases | HeLa cells | Lipids | Insulin resistance | Gene expression regulation | Physiological regulation | Insulin | Phosphatidylinositols | Cancer | Explains mouse phenotypes | Lipid phosphatase | Protein:protein interactions | PTEN tumor suppressor | Insulin signaling | CATALYTIC SUBUNIT | MULTIDISCIPLINARY SCIENCES | P85-ALPHA SUBUNIT | PHOSPHOINOSITIDE 3-KINASE | CANCER | MICE LACKING | 3'-KINASE | insulin signaling | GENE | PI3K | NEOPLASIA | lipid phosphatase | protein:protein interactions | explains mouse phenotypes | INCREASED INSULIN SENSITIVITY | Protein Subunits | Sequence Deletion | Humans | Cercopithecus aethiops | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Phosphatidylinositol 3-Kinases - deficiency | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Peptide Fragments - metabolism | Signal Transduction | Phosphatidylinositol 3-Kinases - chemistry | PTEN Phosphohydrolase - metabolism | Epidermal Growth Factor - metabolism | Recombinant Fusion Proteins - chemistry | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Insulin - metabolism | Peptide Fragments - chemistry | Phenotype | Animals | Protein Binding | Recombinant Fusion Proteins - genetics | Mice | HeLa Cells | COS Cells | PTEN Phosphohydrolase - chemistry | Phosphatidylinositol | Chemical properties | Research | Phosphotransferases | Protein-protein interactions | Tumors | Biological Sciences
Journal Article
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 09/2019, Volume 9, Issue 1, pp. 12683 - 14
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2002, Volume 99, Issue 1, pp. 419 - 424
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/1999, Volume 274, Issue 16, pp. 10963 - 10968
Phosphatidylinositol 3,4,5-trisphosphate is a phospholipid signaling molecule involved in many cellular functions including growth factor receptor signaling,... 
P85-ALPHA GENE | PATHWAYS | REGULATORY SUBUNIT | INHIBITION | PHOSPHATIDYLINOSITOL 3-KINASE | 3,4,5-TRISPHOSPHATE | CROSS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | WORTMANNIN | KINASES
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2014, Volume 20, Issue 1, pp. 73 - 84
Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family that is known to play a role as tumor suppressors. Here, we... 
OBESITY | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | INSULIN-RESISTANCE | ER STRESS | ENDOCRINOLOGY & METABOLISM | TUMOR-SUPPRESSOR | ENDOPLASMIC-RETICULUM STRESS | PHOSPHOINOSITIDE 3-KINASE | LEPTIN RESISTANCE | P85-ALPHA | CELL BIOLOGY | Transcription Factors - chemistry | Humans | Male | RNA, Messenger - metabolism | Protein Subunits - metabolism | X-Box Binding Protein 1 | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | RNA Interference | HEK293 Cells | Phosphatidylinositol 3-Kinase - metabolism | Cell Line | Chromosomal Proteins, Non-Histone - metabolism | Liver - metabolism | Phosphatidylinositol 3-Kinase - deficiency | DNA-Binding Proteins - chemistry | Regulatory Factor X Transcription Factors | Chromosomal Proteins, Non-Histone - genetics | Phosphatidylinositol 3-Kinase - chemistry | Transcription Factors - metabolism | Animals | Endoplasmic Reticulum Stress | Protein Subunits - deficiency | Glucose - metabolism | Mice, Obese | Mice | Protein Subunits - chemistry | RNA, Small Interfering - metabolism | Homeostasis | Glucose metabolism | Cellular signal transduction | Blood sugar | Protein binding | Medical colleges | Liver | Diabetes | Bromodomain-containing protein 7 (BRD7) | X-box binding protein1 (XBP1) | Endoplasmic reticulum (ER) stress | Unfolded protein response (UPR)
Journal Article
Journal Article