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index medicus (99) 99
animals (73) 73
phosphorylation (71) 71
humans (58) 58
biochemistry & molecular biology (56) 56
p90 (49) 49
ribosomal protein s6 kinases, 90-kda - metabolism (45) 45
cell biology (43) 43
p90 ribosomal s6 kinase (42) 42
map kinase (40) 40
enzyme activation (28) 28
signal transduction (25) 25
ribosomal s6 kinase (24) 24
rsk (22) 22
activation (21) 21
female (20) 20
p90 rsk (20) 20
ribosomal protein s6 kinases, 90-kda - antagonists & inhibitors (20) 20
mitogen-activated protein kinases - metabolism (19) 19
protein-kinase (19) 19
activated protein-kinase (18) 18
in-vivo (18) 18
mice (18) 18
ribosomal protein s6 kinases, 90-kda - genetics (18) 18
map kinase signaling system (17) 17
biophysics (16) 16
cancer (16) 16
cell line, tumor (16) 16
protein-serine-threonine kinases - metabolism (16) 16
amino acid sequence (15) 15
meiosis (15) 15
molecular sequence data (15) 15
pathway (15) 15
mapk, mitogen-activated protein kinase (14) 14
protein kinase inhibitors - pharmacology (14) 14
research article (14) 14
rsk, p90 ribosomal s6 kinase (14) 14
cell line (13) 13
rats (13) 13
article (12) 12
cells, cultured (12) 12
enzyme inhibitors - pharmacology (12) 12
erk, extracellular-signal-regulated kinase (12) 12
expression (12) 12
male (12) 12
mapk (12) 12
oncology (12) 12
cells (11) 11
identification (11) 11
life sciences (11) 11
meiotic maturation (11) 11
mitogen-activated protein kinase (11) 11
mos (11) 11
oocytes - metabolism (11) 11
pkb, protein kinase b (11) 11
ribosomal protein s6 kinases - metabolism (11) 11
signal transduction - drug effects (11) 11
signal-transduction (11) 11
egf, epidermal growth factor (10) 10
inhibitor (10) 10
mouse oocytes (10) 10
oocytes - cytology (10) 10
protein kinases (10) 10
developmental biology (9) 9
mitogen-activated protein kinase 1 - metabolism (9) 9
models, biological (9) 9
proteins (9) 9
research (9) 9
apoptosis (8) 8
cell cycle (8) 8
cleaving xenopus-embryos (8) 8
cyclin b - metabolism (8) 8
docking site (8) 8
gst, glutathione s-transferase (8) 8
inhibition (8) 8
mitosis (8) 8
oocytes - physiology (8) 8
phosphorylation - drug effects (8) 8
protein binding (8) 8
rats, sprague-dawley (8) 8
receptor (8) 8
recombinant fusion proteins - metabolism (8) 8
s6 kinase (8) 8
xenopus laevis (8) 8
blotting, western (7) 7
cardiomyocyte (7) 7
erk (7) 7
growth (7) 7
maturation (7) 7
meiosis - physiology (7) 7
mitogen-activated protein kinase kinases - metabolism (7) 7
myocardium - metabolism (7) 7
oocyte (7) 7
oocyte maturation (7) 7
p70 s6 kinase (7) 7
phosphoserine - metabolism (7) 7
pkc, protein kinase c (7) 7
proto-oncogene proteins c-mos - metabolism (7) 7
ribosomal protein s6 kinases, 90-kda - chemistry (7) 7
signal transduction - physiology (7) 7
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Cellular Signalling, ISSN 0898-6568, 08/2015, Volume 27, Issue 8, pp. 1630 - 1642
The 90 kDa ribosomal S6 kinases (RSK) are effectors of the Ras-ERK1/2 signaling pathway. RSK signaling controls proliferation and protein synthesis, and is... 
p70 ribosomal S6 kinase (p70S6K) | Tuberin (TSC2) | SL0101 | BI-D1870 | Ribosomal protein S6 (rpS6) | p90 kDa ribosomal S6 kinase (RSK) | P70 ribosomal S6 kinase (p70S6K) | P90 kDa ribosomal S6 kinase (RSK) | ACTIVATION | RAS-ERK | PHOSPHORYLATION | PROTEIN-KINASE | CELL PROLIFERATION | CELL BIOLOGY | BREAST-CANCER | IN-VITRO | OVERCOMING RESISTANCE | RIBOSOMAL S6 KINASE | PHORBOL ESTERS | Glioblastoma - enzymology | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Humans | Substrate Specificity | Data Mining | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Transfection | Glioblastoma - genetics | RNA Interference | Time Factors | HEK293 Cells | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Benzopyrans - pharmacology | Pteridines - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction - drug effects | Glioblastoma - pathology | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Cell Line, Tumor | Monosaccharides - pharmacology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Tumor Suppressor Proteins | Phosphotransferases | Protein biosynthesis | Epidermal growth factor | Genetic translation | Mitogens | Protein kinases | Protein binding | Index Medicus
Journal Article
FEBS LETTERS, ISSN 0014-5793, 01/2010, Volume 584, Issue 1, pp. 124 - 128
Resistance to anti-estrogen therapy is a major clinical concern in treatment of breast cancer. Estrogen-independent phosphorylation of estrogen receptor alpha,... 
TARGET | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | Rapamycin | Breast cancer | TRANSLATION | NUTRIENT | CELL BIOLOGY | p70 S6 kinase 1 | BREAST-CANCER CELLS | MEK | INHIBITION | BIOPHYSICS | Mammalian target of rapamycin | Estrogen receptor alpha | p90 ribosomal S6 kinase | GROWTH-FACTOR | S6 KINASE | Phenols | Care and treatment | Protein kinases | Estrogen | Cancer
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 05/2019, Volume 294, Issue 28, pp. 10846 - 10862
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 48, pp. 41171 - 41182
Open reading frame 45 (ORF45) of Kaposi sarcoma-associated herpesvirus (KSHV) causes sustained activation of p90 ribosomal 56 kinase (RSK), which is crucial... 
ENTRY SITE | HELICASE ACTIVITY | BACTERIAL ARTIFICIAL CHROMOSOME | FACTOR EIF-4B | INFECTED CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COUPLED RECEPTOR | PRIMARY EFFUSION LYMPHOMA | GENE-EXPRESSION | TUBEROUS SCLEROSIS | VACCINIA VIRUS | Gene Expression Regulation, Viral - drug effects | Protein Biosynthesis | TOR Serine-Threonine Kinases - metabolism | Humans | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Signaling System | TOR Serine-Threonine Kinases - antagonists & inhibitors | Immediate-Early Proteins - metabolism | Phosphorylation - genetics | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | TOR Serine-Threonine Kinases - genetics | HEK293 Cells | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Immunosuppressive Agents - pharmacology | Herpesvirus 8, Human - physiology | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Gene Expression Regulation, Viral - physiology | Virus Replication - drug effects | Sirolimus - pharmacology | Immediate-Early Proteins - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Cell Line, Tumor | Mutation | Virus Replication - physiology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | Gene Regulation | Virus | MAP Kinases (MAPKs) | eIF4B | Phosphorylation | Tegument | Translation Regulation | Kaposi Sarcoma Associated Herpesvirus (KSHV) | p90 Ribosomal S6 Kinase (RSK) | ORF45 | Translation Initiation Factors
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 03/2009, Volume 69, Issue 6, pp. 2244 - 2251
Journal Article
BIOCHEMICAL SOCIETY TRANSACTIONS, ISSN 0300-5127, 02/2013, Volume 41, Issue 1, pp. 124 - 126
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2007, Volume 15, Issue 14, pp. 5018 - 5034
Through the preparation and study of a number of analogues of SL0101, the structural elements essential for its activity and selectivity in vitro and in cells... 
Kaempferol 3- O-(3″,4″-di- O-acetyl-α- l-rhamnopyranoside) | RSK | SL0101 | Kinase inhibitor | Structure–activity relationship | Structure-activity relationship | Kaempferol 3-O-(3″,4″-di-O-acetyl-α-l-rhamnopyranoside) | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | FLAVONOL GLYCOSIDES | IDENTIFICATION | kinase inhibitor | SIGNALING PATHWAY | IN-VIVO | DISEASE | RIBOSOMAL S6 KINASE | CANCER-CELL-PROLIFERATION | P90 RSK | kaempferol 3-O-(3",4"-di-O-acetyl-alpha-L-rhamnopyranoside) | ACTIVATED PROTEIN-KINASES | structure-activity relationship | ERK | Rhamnose - chemistry | Monosaccharides - chemical synthesis | Ribosomal Protein S6 Kinases - metabolism | Humans | Rhamnose - chemical synthesis | Structure-Activity Relationship | Alkylation | Benzopyrans - chemistry | Benzopyrans - chemical synthesis | Protein Kinase Inhibitors - chemistry | Adenosine Triphosphate - metabolism | Molecular Structure | Ribosomal Protein S6 Kinases - chemistry | Benzopyrans - pharmacology | Protein Kinase Inhibitors - chemical synthesis | Hydroxylation | Kaempferols - chemistry | Rhamnose - pharmacology | Models, Molecular | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Monosaccharides - pharmacology | Kaempferols - pharmacology | Protein Kinase Inhibitors - pharmacology | Adenosine Triphosphate - chemistry | Monosaccharides - chemistry | Ribosomal Protein S6 Kinases - antagonists & inhibitors | Kaempferols - chemical synthesis | Heterocyclic compounds | Index Medicus
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2013, Volume 4, Issue 2, pp. 175 - 179
Journal Article
Oncotarget, ISSN 1949-2553, 2013, Volume 4, Issue 2, pp. 329 - 345
Triple-negative breast cancers (TNBC) are notoriously difficult to treat because they lack hormone receptors and have limited targeted therapies. Recently, we... 
Tumor-initiating cells | Drug repositioning | Y-box binding protein-1 | p90 ribosomal S6 kinase | Triple-negative breast cancer | Index Medicus
Journal Article
Journal Article
DEVELOPMENT, ISSN 0950-1991, 05/2006, Volume 133, Issue 9, pp. 1823 - 1830
The cell cycle in oocytes generally arrests at a particular meiotic stage to await fertilization. This arrest occurs at metaphase of meiosis II (meta-II) in... 
ACTIVATED PROTEIN-KINASE | FROG OOCYTES | fertilization | G1 arrest | CLEAVING XENOPUS-EMBRYOS | MAP kinase | p90(Rsk) | DEVELOPMENTAL BIOLOGY | MICROTUBULE ORGANIZATION | Mos | parthenogenesis | starfish oocytes | MEIOTIC METAPHASE ARREST | meiotic cell cycle | MEIOSIS-II | MOUSE OOCYTES | VERTEBRATE EGGS | CYTOSTATIC FACTOR
Journal Article
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