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index medicus (239) 239
animals (166) 166
pacap (123) 123
pac1 protein (121) 121
cyclase-activating polypeptide (115) 115
pituitary adenylate cyclase-activating polypeptide (114) 114
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receptors, pituitary adenylate cyclase-activating polypeptide, type i - metabolism (58) 58
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pituitary adenylate cyclase-activating polypeptide - metabolism (56) 56
rats (56) 56
adenylate-cyclase (51) 51
vip (51) 51
pharmacology & pharmacy (50) 50
pituitary adenylate cyclase-activating polypeptide - pharmacology (50) 50
cell biology (45) 45
polypeptides (45) 45
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receptors, pituitary adenylate cyclase-activating polypeptide, type i - genetics (44) 44
expression (42) 42
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multidisciplinary sciences (37) 37
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physiological aspects (36) 36
receptors (36) 36
gene expression (35) 35
activation (34) 34
hormones, hormone substitutes, and hormone antagonists (34) 34
vasoactive intestinal peptide (34) 34
signal transduction (33) 33
article (32) 32
brain (31) 31
medicine (31) 31
neurons (31) 31
research article (31) 31
biomedicine (29) 29
peptides (28) 28
research (27) 27
cells, cultured (26) 26
physiology (26) 26
endocrine system (25) 25
receptor (25) 25
science (25) 25
endocrinology & metabolism (24) 24
messenger-rna (24) 24
neuroprotection (24) 24
blood platelets (22) 22
platelets (22) 22
cells (21) 21
neurons - metabolism (21) 21
rats, sprague-dawley (21) 21
splice variants (21) 21
vasoactive intestinal peptide - pharmacology (21) 21
apoptosis (20) 20
cho cells (20) 20
dose-response relationship, drug (20) 20
inflammation (20) 20
calcium (19) 19
flow cytometry (19) 19
gene-expression (19) 19
nervous system (19) 19
neurochemistry (19) 19
pharmacology (19) 19
pituitary adenylate cyclase-activating polypeptide - genetics (19) 19
psychiatry (19) 19
vasoactive intestinal polypeptide (19) 19
amino acid sequence (18) 18
cricetinae (18) 18
health aspects (18) 18
peptide (18) 18
pituitary adenylate cyclase-activating polypeptide - physiology (18) 18
proteomics (18) 18
rat (18) 18
cyclic amp (17) 17
life sciences (17) 17
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p-selectin (17) 17
phosphorylation (17) 17
receptors, pituitary adenylate cyclase-activating polypeptide - metabolism (17) 17
vasoactive intestinal peptide - metabolism (17) 17
vpac2 (17) 17
adult (16) 16
cricetulus (16) 16
cyclic amp - metabolism (16) 16
genetic aspects (16) 16
immunohistochemistry (16) 16
kinases (16) 16
mice, inbred c57bl (16) 16
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Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e41823 - e41823
The multiligand Receptor for Advanced Glycation End products (RAGE) is involved in various pathophysiological processes, including diabetic inflammatory... 
CEREBELLAR GRANULE NEURONS | ALPHA-SECRETASE | PATHWAY | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | GROWTH | POLYPEPTIDE PACAP | AMYLOID PRECURSOR PROTEIN | CLEAVAGE | GLYCATION END-PRODUCTS | SOLUBLE RECEPTOR | ADAM17 Protein | Amyloid Precursor Protein Secretases - genetics | Humans | Receptors, Vasopressin - metabolism | Male | Phosphatidylinositol 3-Kinases - metabolism | Gene Knockdown Techniques | MAP Kinase Signaling System | Protease Inhibitors - pharmacology | Matrix Metalloproteinase 9 - metabolism | RNA Interference | Matrix Metalloproteinase 9 - genetics | Proteolysis | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | HEK293 Cells | Lung - metabolism | Membrane Proteins - metabolism | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Hydroxamic Acids - pharmacology | Receptor for Advanced Glycation End Products | Calcium Signaling | Cyclic AMP-Dependent Protein Kinases - metabolism | ADAM Proteins - antagonists & inhibitors | Matrix Metalloproteinase 2 - metabolism | Membrane Proteins - genetics | Dipeptides - pharmacology | ADAM10 Protein | Adenylyl Cyclases - metabolism | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Matrix Metalloproteinase 2 - genetics | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Receptors, Oxytocin - metabolism | Animals | Membrane Proteins - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - physiology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | ADAM Proteins - genetics | Receptors, Immunologic - metabolism | Alzheimer's disease | Health aspects | G proteins | Protein kinase C | G protein-coupled receptors | Disease | Lung | Biochemistry | Odorant receptors | Proteins | Adenylate cyclase | Receptors | Cell activation | Growth factors | Vasopressin V2 receptors | Immunoglobulins | Advanced glycosylation end products | Polypeptides | Oxytocin | Medical treatment | Glycosylation | Insulin | Membrane proteins | Studies | Pituitary adenylate cyclase-activating polypeptide | Pharmacy | Ligands | Shedding | Biotechnology | PAC1 protein | Calcium | Medical services | Stimulation | Kinases | Cell surface | Inflammatory diseases | Calcium signalling | Rodents | Cascades | Atherosclerosis | Vomeronasal organ | Recombinant | Diabetes mellitus | siRNA | Pharmacology | Vasopressin | Gelatinase B | Phospholipase C | Phospholipase | Cell lines | Diabetes | Ca2+/calmodulin-dependent protein kinase II | Index Medicus
Journal Article
Cellular Signalling, ISSN 0898-6568, 09/2019, Volume 61, pp. 48 - 56
Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) plays a crucial role in the endocrine system. The present study aimed to investigate the effect of... 
PACAP | Voltage-dependent potassium channels | PAC1 receptor | Insulin secretion
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 2008, Volume 34, Issue 6, pp. 833 - 843
Summary Exposure to chronic stress has been argued to produce maladaptive anxiety-like behavioral states, and many of the brain regions associated with... 
Endocrinology & Metabolism | Psychiatry | Fear | PAC 1 receptor | Corticotropin-releasing hormone | Extended amygdala | Plasticity | Vasoactive intestinal peptide | PAC | receptor | PAC receptor | RAT | PSYCHIATRY | IN-SITU HYBRIDIZATION | SYMPATHETIC NEURONS | NEUROSCIENCES | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS | RECEPTOR-DEFICIENT MICE | NEURITE OUTGROWTH | ENDOCRINOLOGY & METABOLISM | POLYPEPTIDE PACAP | GENE-EXPRESSION | AMYGDALA | Brain-Derived Neurotrophic Factor - genetics | Septal Nuclei - drug effects | Neuronal Plasticity - drug effects | Male | Receptor, trkB - genetics | RNA, Messenger - metabolism | Septal Nuclei - metabolism | Neuronal Plasticity - genetics | Time Factors | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Stress, Psychological - metabolism | Behavior, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Anxiety - metabolism | Stress, Psychological - chemically induced | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Adaptation, Psychological - drug effects | Rats | Behavior, Animal - physiology | Up-Regulation - genetics | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Rats, Sprague-Dawley | Up-Regulation - drug effects | Stress, Psychological - genetics | Anxiety - genetics | Animals | Models, Biological | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Anxiety - chemically induced | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Chronic Disease | Receptor, trkB - metabolism | Anxiety - etiology | Tyrosine | Adenylate cyclase | Messenger RNA | Polypeptides | ACTH | Hormones | Growth factors | Index Medicus | corticotropin-releasing hormone | PAC1 receptor
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0146981 - e0146981
Journal Article
NEUROSCIENCE, ISSN 0306-4522, 03/2016, Volume 316, pp. 279 - 295
Journal Article
Journal Article
BBA - General Subjects, ISSN 0304-4165, 11/2019, Volume 1863, Issue 11, pp. 129398 - 129398
The pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1), a class B G protein-coupled receptor (GPCR), has emerged as a promising... 
BRET-based biosensor | Neuroprotection | Parkinson's disease | PACAP | Pepducin | PAC1 receptor | Index Medicus
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 2014, Volume 47, pp. 151 - 165
Summary Chronic or repeated stressor exposure can induce a number of maladaptive behavioral and physiological consequences and among limbic structures, the bed... 
Endocrinology & Metabolism | Psychiatry | Bed nucleus of the stria terminalis (BNST) | Anxiety-related behavior | Hypothalamic–pituitary–adrenal (HPA) axis | Pituitary adenylate cyclase activating polypeptide (PACAP) | PAC1 receptor | Chronic variate stress | Hypothalamic-pituitary-adrenal (HPA) axis | CORTICOTROPIN-RELEASING HORMONE | CEREBRAL HEMISPHERE INTEGRATION | CYCLASE-ACTIVATING POLYPEPTIDE | VASOACTIVE-INTESTINAL-PEPTIDE | EXTENDED AMYGDALA | PSYCHIATRY | FOOD-INTAKE | PREDICTS ANXIOUS TEMPERAMENT | NEUROSCIENCES | MICE LACKING | PLASMA-CORTICOSTERONE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | Septal Nuclei - drug effects | Stress, Psychological - blood | Rats | Male | Stress, Psychological - psychology | Rats, Sprague-Dawley | Septal Nuclei - metabolism | Animals | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Behavior, Animal - drug effects | Corticosterone - metabolism | Pituitary Adenylate Cyclase-Activating Polypeptide - administration & dosage | Hormones - blood | Infusions, Intraventricular | Anxiety - metabolism | Chronic Disease | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - antagonists & inhibitors | Stress, Psychological - physiopathology | Corticosterone | Analysis | Post-traumatic stress disorder | Physiological aspects | Neurohormones | ACTH | Stress (Psychology) | Index Medicus | bed nucleus of the stria terminalis (BNST) | hypothalamic-pituitary-adrenal (HPA) axis | pituitary adenylate cyclase activating polypeptide (PACAP) | anxiety-related behavior | chronic variate stress
Journal Article
Cephalalgia, ISSN 0333-1024, 1/2011, Volume 31, Issue 2, pp. 181 - 189
Objective: We pharmacologically characterized pituitary adenylate cyclase–activating polypeptides (PACAPs), vasoactive intestinal peptide (VIP) and the VPAC1,... 
PAC1 | PACAP38 | VPAC1 | VIP | VPAC2 | CYCLASE-ACTIVATING POLYPEPTIDE | RAT | IMMUNOHISTOCHEMICAL LOCALIZATION | MIGRAINE | NEUROSCIENCES | PEPTIDE | CLINICAL NEUROLOGY | PAC | VPAC | MESSENGER-RNA | HEADACHE | CEREBRAL-ARTERIES | HEALTHY-VOLUNTEERS | EXPRESSION | Pituitary Adenylate Cyclase-Activating Polypeptide - antagonists & inhibitors | Receptors, Vasoactive Intestinal Polypeptide, Type I - antagonists & inhibitors | Gene Expression - drug effects | Receptors, Vasoactive Intestinal Peptide, Type II - agonists | Humans | Middle Aged | Male | Peptide Fragments - pharmacology | Receptors, Vasoactive Intestinal Peptide - genetics | RNA, Messenger - metabolism | Receptors, Vasoactive Intestinal Peptide, Type II - genetics | Meningeal Arteries - physiology | Vasoactive Intestinal Peptide - pharmacology | Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists | Gene Expression - physiology | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Migraine Disorders - physiopathology | Adult | Female | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - agonists | Vasodilation - physiology | Coronary Vessels - drug effects | Receptors, Vasoactive Intestinal Peptide, Type II - antagonists & inhibitors | Vasodilator Agents - pharmacology | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Coronary Vessels - physiology | Pituitary Adenylate Cyclase-Activating Polypeptide - adverse effects | Meningeal Arteries - drug effects | Migraine Disorders - drug therapy | Receptors, Vasoactive Intestinal Polypeptide, Type I - genetics | Aged | Receptors, Vasoactive Intestinal Peptide - antagonists & inhibitors | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Vasodilation - drug effects | Receptors, Vasoactive Intestinal Peptide - agonists | Vasoactive Intestinal Peptide - analogs & derivatives | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - antagonists & inhibitors | Index Medicus
Journal Article