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chemistry, organic (81) 81
d-lyxo-phytosphingosine (57) 57
pachastrissamine (50) 50
stereoselective-synthesis (48) 48
jaspine-b pachastrissamine (43) 43
marine sponge (42) 42
asymmetric-synthesis (37) 37
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cytotoxic anhydrophytosphingosine (30) 30
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synthesis (26) 26
conjugate addition (23) 23
pachastrissamine jaspine-b (20) 20
humans (19) 19
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biochemistry & molecular biology (17) 17
tetrahedrons (17) 17
chemistry, medicinal (16) 16
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lithium amide (15) 15
asymmetric synthesis (14) 14
cyclization (14) 14
formal synthesis (14) 14
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sphingosine - pharmacology (14) 14
homochiral lithium amides (13) 13
sphingosine (13) 13
chemistry, multidisciplinary (12) 12
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esters (12) 12
pachastrissamine jaspine b (12) 12
asymmetry (11) 11
biological evaluation (11) 11
cell line, tumor (11) 11
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enantioselective synthesis (11) 11
animals (10) 10
ceramide (10) 10
d-ribo-phytosphingosine (10) 10
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chemistry, applied (9) 9
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2-epi-jaspine-b (8) 8
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lithium (8) 8
2-epi-jaspine b (7) 7
acid (7) 7
amides (7) 7
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antineoplastic agents - chemical synthesis (7) 7
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beta-amino acids (7) 7
cancer (7) 7
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phosphotransferases - antagonists & inhibitors (7) 7
ring-closing iodoamination (7) 7
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lithium compounds (6) 6
mice (6) 6
molecular structure (6) 6
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stereoselective synthesis (6) 6
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aldehydes (5) 5
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antineoplastic agents - chemistry (5) 5
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chemistry, inorganic & nuclear (5) 5
d-erythro-sphingosine (5) 5
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diels-alder reactions (5) 5
route (5) 5
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sugars (5) 5
total synthesis (5) 5
-jaspine b (4) 4
1-phosphate (4) 4
activation (4) 4
alkaloids (4) 4
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Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 2018, Volume 19, Issue 23, pp. 2438 - 2442
Journal Article
Synlett, ISSN 0936-5214, 01/2019, Volume 30, Issue 2, pp. 185 - 188
Journal Article
Journal Article
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 2018, Volume 19, Issue 23, pp. 2421 - 2421
The front cover picture shows how, thanks to new Jaspine B‐derived cellular probes, click chemistry illuminates the yet unknown cytotoxic mode of action of this potential anticancer agent... 
click chemistry | bioorthogonality | Jaspine B | fluorescent probes | pachastrissamine
Journal Article
Synthesis, ISSN 0039-7881, 07/2008, Volume 2008, Issue 14, pp. 2278 - 2282
Journal Article
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 11/2013, Volume 9, Issue 1, pp. 2564 - 2569
Herein we present the synthesis of the anhydrophytosphingosine jaspine B and three of its stereoisomers using a carbohydrate-derived alkoxyallene in order to obtain the products in enantiopure form... 
Gold catalysis | Natural product synthesis | Pachastrissamine | Chiral auxiliaries | Lithiated alkoxyallenes | Jaspine B | Tetrahydrofurans | jaspine B | lithiated alkoxyallenes | chiral auxiliaries | tetrahydrofurans | gold catalysis | natural product synthesis | pachastrissamine
Journal Article
Tetrahedron: asymmetry, ISSN 0957-4166, 2014, Volume 25, Issue 9, pp. 750 - 766
The total synthesis of the HCl salts of (−)-jaspine B ent-1 and its 4-epi-congener ent-4 was accomplished starting from the common template 13 derived from d-xylose... 
CROSS-METATHESIS | ASYMMETRIC-SYNTHESIS | FORMAL SYNTHESIS | CHEMISTRY, ORGANIC | CHEMISTRY, PHYSICAL | PACHASTRISSAMINE JASPINE-B | D-LYXO-PHYTOSPHINGOSINE | CHEMISTRY, INORGANIC & NUCLEAR | ACID IBX | CYTOTOXIC ANHYDROPHYTOSPHINGOSINE | 2-EPI-JASPINE B | STEREOSELECTIVE-SYNTHESIS | CONJUGATE ADDITION | Synthesis | Sugars | Organic compounds | Monosaccharides
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 11/2011, Volume 52, Issue 48, pp. 6370 - 6371
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2011, Volume 52, Issue 38, pp. 4861 - 4864
...)-phytosphingosine and 2- epi-jaspine B was achieved by using Grignard addition on N-benzyl sugar lactamine and Wittig olefination as key steps. 
BIOLOGICAL SIGNIFICANCE | ASYMMETRIC-SYNTHESIS | D-XYLOSE | CYTOTOXIC ANHYDROPHYTOSPHINGOSINE | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | PACHASTRISSAMINE JASPINE-B | D-LYXO-PHYTOSPHINGOSINE | D-RIBO-PHYTOSPHINGOSINE | MARINE SPONGE | CONJUGATE ADDITION | Tetrahedrons | Strategy | Synthesis (chemistry) | Sugars
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2016, Volume 64, Issue 2, pp. 179 - 188
The practical syntheses of pachastrissamine (jaspine B), 2-epi-pachastrissamine, and the 2-epimer of the pyrrolidine analogue were accomplished via... 
Journal Article
Biochemical pharmacology, ISSN 0006-2952, 2009, Volume 78, Issue 5, pp. 477 - 485
.... In the present study, the mechanism of action of Jaspine B, an anhydrophytosphingosine derivative isolated from the marine sponge Jaspis sp., was investigated... 
Ceramide | Sphingomyelin | Jaspine B | Melanoma | Apoptosis | CANCER-CELLS | GLUCOSYLCERAMIDE SYNTHASE | DEATH | KAPPA-B | COMBINATION | SPHINGOMYELIN SYNTHASE-1 | CYTOTOXIC ANHYDROPHYTOSPHINGOSINE | PHARMACOLOGY & PHARMACY | PACHASTRISSAMINE | PHYTOSPHINGOSINE | STEREOSELECTIVE-SYNTHESIS | Physiological aspects | Phospholipids | Sphingosine
Journal Article
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