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Zaporozhye Medical Journal, ISSN 2306-4145, 02/2019, Volume 21, Issue 1, pp. 44 - 48
Purpose. To study the association between the plasma level of plasminogen activator inhibitor type-1 (PAI-1) and both body weight and PAI-1 -675 4G/5G gene... 
I. O. Karpeko Abstract Purpose. To study the association between the plasma level of plasminogen activator inhibitor type-1 (PAI-1) and both body weight and PAI-1 -675 4G/5G gene polymorphism in patients with cranio-cerebral trauma (CCT) over the treatment course. Materials and methods. The hemostasis system state was analyzed in 200 patients with CCT by studying the association between the plasma level of PAI-1 and both body weight and -675 4G/5G polymorphism of the PAI-1 gene. For statistical processing of the obtained study results | 7 and 14 after trauma. All patients were distributed into 3 clusters. Thus | O. O. Tsyndrenko | M. P. Khavro | the first cluster included patients with the average PAI-1 concentration within the normal range during the study. The second cluster included patients who presented significantly increased PAI-1 concentration at the time of an injury | the -675 4G/5G polymorphism of PAI-1 gene | T. V. Bereznyi | CCT | an association between an increase in PAI-1 level and both the 4G/4G | 4G/5G genotypes and overweight or obesity in patients was found. Increased levels of PAI-1 were observed in overweight or obese patients with the 4G/4G and 4G/5G genotypes over the course of treatment. Conclusions. The association between both overweight and -675 4G/5G polymorphism of the PAI-1 gene and plasma level of plasminogen activator inhibitor type-1 in patients with traumatic brain injury has been proven. Keywords CCT; PAI-1; the -675 4G/5G polymorphism of PAI-1 gene; obesity | PAI-1 | which tended to decrease rapidly and almost normalized by day 14. The third cluster consisted of patients with significantly increased plasma concentration of PAI-1 following an injury with the tendency to remain at a high level for 14 days. Due to statistical processing of the study results | O. P. Kmyta | obesity | a licensed version of the SPSS STATISTICA 17 program was used. K-means cluster analysis was also performed; the Euclidean distance was used as the distance measure. Results. Clustering of patients was performed depending on the plasma PAI-1 content on days 1
Journal Article
BMC Cancer, ISSN 1471-2407, 01/2019, Volume 19, Issue 1, pp. 71 - 13
Journal Article
The journal of trauma and acute care surgery, ISSN 2163-0755, 11/2018, Volume 85, Issue 5, pp. 888 - 893
Journal Article
The Journal of allergy and clinical immunology, ISSN 0091-6749, 7/2018, Volume 142, Issue 1, pp. 294 - 297.e5
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 09/2018, Volume 105, pp. 83 - 94
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2014, Volume 450, Issue 4, pp. 1696 - 1701
Tumor-infiltrating macrophages are potential candidates for cancer immunotherapy. However, the detailed molecular mechanism underlying macrophage infiltration... 
FAK | PAI-1 | LRP1 | Invasion | Melanoma | Macrophage
Journal Article
Gynecological Endocrinology, ISSN 0951-3590, 10/2019, Volume 35, Issue 10, pp. 909 - 912
The plasminogen activator inhibitor type 1 (PAI-1) is the major determinant of fibrinolytic activity. PAI-1 concentrations are elevated in obesity, type 2... 
atherosclerosis | fibrinolysis | metabolic syndrome | PAI-1 | menopause
Journal Article
Journal Article
International Heart Journal, ISSN 1349-2365, 2019
The mechanism underlying thrombosis in atrial fibrillation (AF) is not yet clearly understood. The apelin/APJ axis parallel and counter-regulate with the... 
Valve replacement | RAAS | PAI-1 | Angiotensin system
Journal Article
Molecular Biology Reports, ISSN 0301-4851, 5/2014, Volume 41, Issue 5, pp. 2859 - 2864
The most important feature of abdominal aortic aneurysm (AAA) pathogenesis is an enzymatic degradation of elastic lamellae and extracellular matrix proteins... 
Life Sciences | PAI - 1 −844 G/A polymorphism | Animal Biochemistry | Abdominal aortic aneurysm | t - PA −7351 C/T polymorphism | PAI - 1 −675 4G/5G polymorphism | u - PA 1788 C/T polymorphism | Animal Anatomy / Morphology / Histology | RFLP | PAI -1 -844 G/A polymorphism | t-PA -7351 C/T polymorphism | PAI-1 -675 4G/5G polymorphism | u-PA 1788 C/T polymorphism | t-PA-7351 C/T polymorphism | MYOCARDIAL-INFARCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PAI-1-844 G/A polymorphism | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | ENHANCER POLYMORPHISM | FIBRINOLYTIC SYSTEM | PAI-1-675 4G/5G polymorphism | MATRIX METALLOPROTEINASES | 4G/5G POLYMORPHISM | ISCHEMIC-STROKE | ASSOCIATION | SINGLE-NUCLEOTIDE POLYMORPHISMS | CORONARY-ARTERY-DISEASE | Gene Frequency | Humans | Middle Aged | Genotype | Male | Aortic Aneurysm, Abdominal - genetics | Urokinase-Type Plasminogen Activator - genetics | Tissue Plasminogen Activator - genetics | Case-Control Studies | INDEL Mutation | Polymorphism, Genetic | Alleles | Adult | Female | Aged | Polymorphism, Single Nucleotide | Plasminogen Activator Inhibitor 1 - genetics | Fibrin | Enzymes | Care and treatment | Tissue plasminogen activator | Analysis | Genes | Genetic research | Genetic aspects | Abdominal aneurysm | Genetic polymorphisms | Aneurysms | Genotype & phenotype | Risk factors | Veins & arteries | Polymorphism | PAI-1 −675 4G | u-PA 1788 C | T polymorphism | A polymorphism | PAI-1 −844 G | t-PA −7351 C | 5G polymorphism
Journal Article
Seminars in Thrombosis and Hemostasis, ISSN 0094-6176, 06/2013, Volume 39, Issue 4, pp. 356 - 364
Journal Article
Cell Cycle, ISSN 1538-4101, 04/2019, Volume 18, Issue 6-7, pp. 742 - 758
Mesenchymal stem cells (MSCs) hold a great promise for successful development of regenerative medicine. Among the plenty of uncovered MSCs sources, desquamated... 
senescence | CRISPR/Cas9 engineering | lentiviral transduction | secretome modification | PAI-1/SERPINE 1 | Human endometrium-derived mesenchymal stem cells | gene editing | CRISPR | TRANSCRIPTIONAL ACTIVATION | TISSUE | ACTIVATOR INHIBITOR TYPE-1 | SERPINE 1 | CELL BIOLOGY | GENE | DECIDUALIZATION | INTRAUTERINE | PAI-1 | KNOCKOUT | Cas9 engineering | EFFICIENCY
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 8/2017, Volume 37, Issue 8, pp. 1446 - 1452
Plasminogen Activator Inhibitor-1 (PAI-1) is a member of the evolutionarily conserved serine protease inhibitor (SERPIN) family, and a potent and rapid-acting... 
Endothelial dysfunction | Aging | PAI-1 | Senescence | Thrombosis | Arteriosclerosis
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 01/2018, Volume 119, Issue 1, pp. 17 - 27
Journal Article