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Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 21, pp. 5117 - 5127
Abstract A highly tunable synthetic biomimetic hydrogel platform was developed to study the growth and morphogenesis of pancreatic ductal epithelial cells... 
Advanced Basic Science | Dentistry | Hydrogels | Cell encapsulation | Thiol-ene chemistry | Pancreatic cancer | Cell–material interactions | MATERIALS SCIENCE, BIOMATERIALS | METASTASIS | ENGINEERING, BIOMEDICAL | CROSS-LINKING | PANC-1 CELLS | CANCER | PEPTIDE YIGSR | BETA | IN-VITRO | Cell-material interactions | ENGINEERED PEG HYDROGELS | DIFFERENTIATION | TUMOR-GROWTH | Epithelial Cells - metabolism | Molecular Weight | Cross-Linking Reagents - pharmacology | Epithelial Cells - drug effects | Humans | Mesoderm - drug effects | Cell Aggregation - drug effects | Extracellular Matrix - metabolism | Molecular Sequence Data | Cell Culture Techniques - methods | Integrins - metabolism | Morphogenesis | Epithelial Cells - cytology | Biomarkers - metabolism | Amino Acid Sequence | Cell Line | Pancreatic Ducts - cytology | Peptides - chemistry | Click Chemistry | Cell Size - drug effects | Extracellular Matrix - drug effects | Biocompatible Materials - pharmacology | Peptides - pharmacology | Cell Shape - drug effects | Ligands | Cell Proliferation - drug effects | Mesoderm - metabolism | Hydrogels - pharmacology | Fibronectins | Evaluation | Thiols | Peptides | Biomimetics | Growth | Proteases | Analysis | Polymerization | Index Medicus | Encapsulation | Platforms | Aggregates | Clusters | Two dimensional | Culture | Three dimensional | cell encapsulation | thiol-ene chemistry | pancreatic cancer | cell-material interactions
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2011, Volume 108, Issue 48, pp. 19264 - 19269
Pancreatic β-cells are an essential source of insulin and their destruction because of autoimmunity causes type I diabetes. We conducted a chemical screen to... 
Larvae | Exocrine cells | Cell lines | Pancreas | Progenitor cells | Cellular differentiation | Insulin | Larval development | Endocrine cells | Type 1 diabetes mellitus | Development | Embryogenesis | Progenitor | Notch-signaling | APOPTOSIS | development | INOSINE MONOPHOSPHATE DEHYDROGENASE | ZEBRAFISH | ALDEHYDE DEHYDROGENASE | REGENERATION | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | progenitor | DISULFIRAM | embryogenesis | INHIBITION | PANC-1 | MYCOPHENOLIC-ACID | Green Fluorescent Proteins | Cell Proliferation | p-Aminoazobenzene - analogs & derivatives | Caffeic Acids - pharmacology | Drug Discovery - methods | DNA Primers - genetics | Dose-Response Relationship, Drug | Tretinoin - metabolism | Larva - drug effects | HMGB1 Protein - metabolism | Mycophenolic Acid - pharmacology | p-Aminoazobenzene - pharmacology | Dimethyl Sulfoxide | Insulin-Secreting Cells - cytology | Real-Time Polymerase Chain Reaction | Acetanilides - pharmacology | Guanosine Triphosphate - biosynthesis | Animals, Genetically Modified | Zebrafish | Sulfanilic Acids - pharmacology | Microscopy, Confocal | Pharmaceutical Preparations - metabolism | Animals | Insulin-Secreting Cells - drug effects | Cell Differentiation - drug effects | Fluorescent Antibody Technique | Cell Line, Tumor | Epirizole - pharmacology | Autoimmunity | Pancreatic beta cells | Type 1 diabetes | Physiological aspects | Genetic aspects | Research | Cell differentiation | Biosynthesis | FDA approval | Diabetes | Cells | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal Article
Journal Article
Oncology Letters, ISSN 1792-1074, 2017, Volume 14, Issue 2, pp. 1341 - 1346
Emerging evidence has suggested that pancreatic adenocarcinoma is sustained by pancreatic cancer stem cells. The present study aimed to investigate the... 
Pancreatic adenocarcinoma | Reactive oxygen species | Radiosensitivity | PANC-1 | Stem cell | pancreatic adenocarcinoma | radiosensitivity | PHENOTYPE | IDENTIFICATION | LINES | CANCER STEM-CELLS | BREAST-CANCER | stem cell | ONCOLOGY | RADIORESISTANCE | reactive oxygen species | TUMOR-GROWTH
Journal Article
Anticancer Research, ISSN 0250-7005, 09/2012, Volume 32, Issue 9, pp. 3847 - 3853
Journal Article
Drug Development Research, ISSN 0272-4391, 09/2018, Volume 79, Issue 6, pp. 287 - 294
Preclinical Research & Development Pancreatic cancer is the third leading cause of death in the US with a poor 5‐year survival rate of 8.5%. A novel... 
synergism | pancreatic cancer | actinomycin‐D | NFκB | Panc‐1 cells | DMAPT | actinomycin-D | Panc-1 cells | CHEMISTRY, MEDICINAL | PHASE-III | NFB | GEMCITABINE | TRIAL | LUNG-CANCER | INHIBITION | DNA | PHARMACOLOGY & PHARMACY | MELAMPOMAGNOLIDE B | NF-KAPPA-B | DRUG-COMBINATION | TUMOR-GROWTH | Apoptosis - drug effects | Humans | Pancreatic Neoplasms - pathology | Antibiotics, Antineoplastic - adverse effects | Dactinomycin - administration & dosage | Aminopyrine - administration & dosage | Antibiotics, Antineoplastic - administration & dosage | Drug Synergism | Pancreatic Neoplasms - drug therapy | Growth Inhibitors - administration & dosage | Dactinomycin - adverse effects | Growth Inhibitors - adverse effects | Tumor Cells, Cultured | Drug Combinations | Drugs | Drug delivery systems | Care and treatment | RNA | Protein biosynthesis | B cells | Dactinomycin | Vehicles | Cell death | Analysis | Pancreatic cancer | Cancer cells | Drug therapy, Combination | Cancer | Oxidative stress | Actinomycin | Phosphorylation | Transcription | Toxicity | Drug delivery | Kinases | DNA-directed RNA polymerase | Synergism | Proteins | Inhibition | Chemical synthesis | Deoxyribonucleic acid--DNA | Glutathione | Mortality | RNA polymerase | Beta cells | Polymerase | Antibiotics | Ribonucleic acids | Lymphocytes B | Protein synthesis | RNA polymerase II | Apoptosis | Index Medicus | Actinomycin-D
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 07/2017, Volume 15, Issue 7, pp. 929 - 941
We examined the impact of crosstalk between the insulin receptor and G protein-coupled receptor (GPCR) signaling pathways on the regulation of Yes-associated... 
SIGNAL-TRANSDUCTION | LINE PANC-1 | ONCOLOGY | PROTEIN-COUPLED RECEPTOR | DUCTAL ADENOCARCINOMA | ONCOGENIC KRAS | GROWTH IN-VITRO | HIPPO PATHWAY | DNA-SYNTHESIS | PANC-1 CELLS | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | Protein Kinase C - genetics | Class I Phosphatidylinositol 3-Kinases - genetics | Humans | Antigens, CD - genetics | Carcinoma, Pancreatic Ductal - genetics | Neurotensin - metabolism | Pancreatic Neoplasms - drug therapy | Receptor, Insulin - genetics | Neurotensin - administration & dosage | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Pyrimidines - administration & dosage | Cysteine-Rich Protein 61 - genetics | Pancreatic Neoplasms - pathology | Insulin - administration & dosage | Pancreatic Neoplasms - genetics | Protein Kinase C - antagonists & inhibitors | Phosphoproteins - genetics | Carcinoma, Pancreatic Ductal - pathology | Chemokine CXCL5 - genetics | Carcinoma, Pancreatic Ductal - drug therapy | Insulin - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Connective Tissue Growth Factor - genetics | Receptors, G-Protein-Coupled - genetics | Adenocarcinoma | Phosphorylation | G protein-coupled receptors | Transcription | Genes | Crosstalk | Stimulation | Kinases | Proteins | Connective tissues | Phosphatidylinositol | Angiogenesis | CYR61 protein | Localization | Phosphatidylinositol 3,4,5-triphosphate | Connective tissue growth factor | siRNA | Neurotensin | Signalling systems | Gene expression | Insulin | 1-Phosphatidylinositol 3-kinase | Yes-associated protein | Inhibitors | Protein kinase | Pancreatic cancer | Position (location) | Cancer | Index Medicus | MiaPaCa-2 cells | Hippo pathway | PKD family inhibitors | PANC-1 cells | TAZ | YAP phosphorylation | PI3K inhibitor A66 | CYR61 | CXCL5 | CTGF
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 03/2015, Volume 56, Issue 13, pp. 1720 - 1723
Several derivatives of (1 )-1,2-dihydro-1-naphthalenol (( )- ) have been synthesized and evaluated against human pancreatic adenocarcinoma cell line PANC-1... 
Spiroxins | Preferential cytotoxicity | PANC-1 | Pancreatic cancer | Naphthoquinols | ANTICANCER | CHEMISTRY, ORGANIC | CYTOTOXICITY
Journal Article
Tetrahedron, ISSN 0040-4020, 01/2018, Volume 74, Issue 2, pp. 217 - 223
Our quest to isolate and characterize natural products with in vitro solid tumor selectivity is driven by access to repositories of Indo-Pacific sponge... 
Synthetic halogenated indoles | PANC-1 cytotoxicity | Sponge-derived halogenated indoles | CHEMISTRY, ORGANIC | MARINE SPONGE | ALKALOIDS
Journal Article