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1. Full Text Ribonuclease A
by Raines, Ronald T
Chemical Reviews, ISSN 0009-2665, 05/1998, Volume 98, Issue 3, pp. 1045 - 1066
EOSINOPHIL-DERIVED NEUROTOXIN | AMINO-ACID-SEQUENCE | TRANSITION-STATE ANALOGS | SUBSTRATE-LEASH AMPLIFICATION | CIS PROLINE MUTANTS | LEUCINE-RICH REPEATS | DIFFUSION-DRIVEN MECHANISMS | BOVINE PANCREATIC RIBONUCLEASE | SITE-DIRECTED MUTAGENESIS | CHEMISTRY, MULTIDISCIPLINARY | X-RAY REFINEMENT | Usage | Ribonuclease | Research | Recombinant DNA | Nucleic acids
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2. Full Text Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation
by Hong Gu and Shuming Zhang and Kin-Yiu Wong and Brian K. Radak and Thakshila Dissanayake and Daniel L. Kellerman and Qing Dai and Masaru Miyagi and Vernon E. Anderson and Darrin M. York and Joseph A. Piccirilli and Michael E. Harris
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2013, Volume 110, Issue 32, pp. 13002 - 13007
Enzymes function by stabilizing reaction transition states; therefore, comparison of the transition states of enzymatic and nonenzymatic model reactions can... 
Protons | Enzymes | RNA | Active sites | Isotope effects | Chemical bases | Catalysis | Modeling | Electrostatics | Phosphoranes | MOLECULAR-DYNAMICS | MECHANISM | ALKALINE-PHOSPHATASE | MULTIDISCIPLINARY SCIENCES | ISOMERIZATION | HYDROLYSIS | REACTION-PATH | MODEL | CLEAVAGE | SOLVATION | PHOSPHORYL | Protein Structure, Tertiary | Phosphorylation | Biocatalysis | Models, Chemical | Models, Molecular | RNA - chemistry | Ribonuclease, Pancreatic - chemistry | Esterification | Molecular Dynamics Simulation | Oxygen Isotopes - chemistry | Ribonuclease, Pancreatic - metabolism | Oxygen Isotopes - metabolism | Molecular Structure | Kinetics | Nucleic Acid Conformation | RNA - metabolism | RNA sequencing | Research | Molecular genetics | Quantum theory | Biological Sciences
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3. Full Text Circular zymogens of human ribonuclease 1
by Windsor, Ian W and Graff, Crystal J and Raines, Ronald T
Protein Science, ISSN 0961-8368, 09/2019, Volume 28, Issue 9, pp. 1713 - 1719
The endogenous production of enzymes as zymogens provides a means to control catalytic activities. Here, we describe the heterologous production of... 
protease | HIV | circular protein | cytotoxin | zymogen | intein | ribonuclease | HIV-1 | DESIGN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN PANCREATIC RIBONUCLEASE | CLEAVAGE | SUBSTRATE | INHIBITOR | Ribonuclease A | Occlusion | Drugs | Prodrugs | Deactivation | Splicing | Proteinase | Cytotoxicity | Catalytic activity | Inactivation | Chemical compounds | Substrates | Thermal stability | Proenzymes | Molecular modelling | Protease | Human immunodeficiency virus--HIV | Catalysis
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4. Full Text Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor: Generation of inhibitor-resistant cytotoxic variants
by Gaur, Deepak and Swaminathan, Srividya and Batra, Janendra K
Journal of Biological Chemistry, ISSN 0021-9258, 07/2001, Volume 276, Issue 27, pp. 24978 - 24984
Mammalian ribonucleases interact very strongly with the intracellular ribonuclease inhibitor (RI), Eukaryotic cells exposed to mammalian ribonucleases are... 
EOSINOPHIL-DERIVED NEUROTOXIN | COMPLEX | AMINO-ACID-SEQUENCE | ANGIOGENIN | MECHANISM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | CATIONIC PROTEIN | BOVINE SEMINAL RIBONUCLEASE | CATALYTIC PROPERTIES | Placental Hormones - metabolism | Protein Binding - genetics | Mutagenesis, Site-Directed | Enzyme Inhibitors - metabolism | Electrophoresis, Polyacrylamide Gel | Humans | Ribonuclease, Pancreatic - genetics | Blotting, Western | Animals | Ribonuclease, Pancreatic - metabolism | Cattle | Protein Conformation | Catalysis | Circular Dichroism | Amino Acid Substitution
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5. Full Text An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract
by Spencer, John D and Schwaderer, Andrew L and Eichler, Tad and Wang, Huanyu and Kline, Jennifer and Justice, Sheryl S and Cohen, Daniel M and Hains, David S
Kidney International, ISSN 0085-2538, 05/2014, Volume 85, Issue 5, pp. 1179 - 1191
Recent studies stress the importance of antimicrobial peptides in protecting the urinary tract from infection. Previously, we have shown that ribonuclease 7... 
pyelonephritis | ribonuclease 7 | antimicrobial peptide | intercalated cells | ribonuclease inhibitor | Ribonuclease inhibitor | Intercalated cells | Ribonuclease 7 | Pyelonephritis | Antimicrobial peptide | DEFENSE | OXIDATIVE STRESS | PROTEIN | CRYSTAL-STRUCTURE | ESCHERICHIA-COLI | PANCREATIC RIBONUCLEASE | ELASTASE | LEUCINE-RICH REPEATS | RNASE-A SUPERFAMILY | UROLOGY & NEPHROLOGY | INFECTION | Leukocyte Elastase - metabolism | Ribonucleases - urine | Ribonucleases - genetics | Carrier Proteins - urine | Humans | Kidney - enzymology | Middle Aged | Child, Preschool | Male | Cell Wall - enzymology | Pyelonephritis - microbiology | RNA, Messenger - metabolism | Case-Control Studies | Pyelonephritis - urine | Ribonucleases - metabolism | Ribonucleases - antagonists & inhibitors | Time Factors | Proteolysis | Escherichia coli - pathogenicity | Urothelium - enzymology | Adult | Female | Urinary Bladder - microbiology | Urothelium - microbiology | Urinary Bladder - enzymology | Child | Enterococcus faecalis - enzymology | Recombinant Proteins - metabolism | Pyelonephritis - enzymology | Enterococcus faecalis - pathogenicity | Escherichia coli - enzymology | Gene Expression Regulation, Enzymologic | Host-Pathogen Interactions | Carrier Proteins - genetics | Kidney - microbiology | Carrier Proteins - metabolism | Adolescent | Protein Binding | Aged | Pyelonephritis - genetics | Ribonuclease Inhibitor | Intercalated Cells | Antimicrobial Peptide | Innate Immunity | Urinary Tract Infection
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6. Full Text Back to the future: Ribonuclease A
by Marshall, Garland R and Feng, Jiawen A and Kuster, Daniel J
Peptide Science, ISSN 0006-3525, 2008, Volume 90, Issue 3, pp. 259 - 277
Pancreatic ribonuclease A (EC 3.1.27.5, RNase) is, perhaps, the best‐studied enzyme of the 20th century. It was isolated by René Dubos, crystallized by Moses... 
chimeric enzyme | S‐protein | S‐peptide | ribonuclease A | protein dynamics | Ribonuclease A | S-protein | Protein dynamics | Chimeric enzyme | S-peptide | RESIDUAL DIPOLAR COUPLINGS | ELECTRON-SPIN-RESONANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN PEPTIDE INTERACTIONS | CIS AMIDE BOND | BOVINE PANCREATIC RIBONUCLEASE | DOMAIN-SWAPPED DIMER | ALPHA-AMINOISOBUTYRIC-ACID | COOH-TERMINAL TETRADECAPEPTIDE | BIOPHYSICS | RESTRICTED CONFORMATIONAL FREEDOM | HELIX-COIL TRANSITION | Amino Acid Sequence | Protein Structure, Secondary | History, 20th Century | Models, Molecular | Entropy | Ribonuclease, Pancreatic - chemistry | Ribonuclease, Pancreatic - history | Forecasting | Ribonuclease, Pancreatic - isolation & purification | Animals | Cattle | Computer Simulation | Protein Engineering | Protein Conformation
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7. Full Text Bovine brain Ribonuclease is the functional homolog of human Ribonuclease 1
by Eller, Chelcie H and Lomax, Jo E and Raines, Ronald T
Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 38, pp. 25996 - 26006
Mounting evidence suggests that human pancreatic ribonuclease (RNase 1) plays important roles in vivo, ranging from regulating blood clotting and inflammation... 
DOUBLE-STRANDED-RNA | PROTEIN | SEMINAL RIBONUCLEASE | HIGH-THROUGHPUT | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | EXTRACELLULAR RNA | HUMAN PANCREATIC RIBONUCLEASE | DIFFERENTIAL SCANNING FLUOROMETRY | ANTITUMOR-ACTIVITY | EXPRESSION | Ribonuclease, Pancreatic - physiology | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Cells, Cultured | Brain - enzymology | RNA Stability | Ribonuclease, Pancreatic - chemistry | Protein Transport | Liposomes - chemistry | Animals | Cattle | Protein Binding | Kinetics | RNA, Double-Stranded - chemistry | Hydrogen-Ion Concentration | Ribonuclease | RNA | Enzymology | Double-stranded RNA (dsRNA) | Heparin-binding Protein | Enzyme Catalysis
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8. Full Text Inhibition of Human Pancreatic Ribonuclease by the Human Ribonuclease Inhibitor Protein
by Johnson, R. Jeremy and McCoy, Jason G and Bingman, Craig A and Phillips, George N and Raines, Ronald T
Journal of Molecular Biology, ISSN 0022-2836, 2007, Volume 368, Issue 2, pp. 434 - 449
The ribonuclease inhibitor protein (RI) binds to members of the bovine pancreatic ribonuclease (RNase A) superfamily with an affinity in the femtomolar range.... 
X-ray crystallography | protein–protein interaction | cytotoxin | cancer | tight-binding inhibitor | protein-protein interaction | ELECTROSTATIC INTERACTIONS | MAXIMUM-LIKELIHOOD | MEDIATED CYTOTOXICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | 3-DIMENSIONAL STRUCTURE | ANGSTROM RESOLUTION | CYTOTOXIC RIBONUCLEASES | MOLECULAR RECOGNITION | CONFORMATIONAL STABILITY | BOVINE SEMINAL RIBONUCLEASE | CATALYTIC-ACTIVITY | Amino Acid Sequence | Placental Hormones - metabolism | Placental Hormones - chemistry | Protein Structure, Secondary | Humans | Enzyme Stability | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Mutant Proteins - metabolism | Ribonuclease, Pancreatic - chemistry | Static Electricity | Animals | Hydrogen Bonding | Ribonuclease, Pancreatic - metabolism | Cattle | Swine | Cell Death | K562 Cells | Protein Binding | Kinetics | Ribonuclease, Pancreatic - antagonists & inhibitors | Proteins
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9. Full Text Protein–Surfactant Interaction: Sodium Dodecyl Sulfate-Induced Unfolding of Ribonuclease A
by Tejaswi Naidu, K and Prakash Prabhu, N
The Journal of Physical Chemistry B, ISSN 1520-6106, 12/2011, Volume 115, Issue 49, pp. 14760 - 14767
Protein–surfactant interaction is widely studied to understand stability and structural changes in proteins. In this Article, we have investigated SDS-induced... 
B: Biophysical Chemistry | POLYACRYLAMIDE GEL-ELECTROPHORESIS | CONFORMATIONAL-CHANGES | MOLTEN GLOBULE | SDS | FLUORESCENCE | N-ALKYL SULFATES | COMPLEXES | GUANIDINE-HYDROCHLORIDE | CHEMISTRY, PHYSICAL | BETA-LACTOGLOBULIN | PROBE | Animals | Protein Structure, Secondary | Cattle | Protein Unfolding | Sodium Dodecyl Sulfate - chemistry | Hydrophobic and Hydrophilic Interactions | Spectrometry, Fluorescence | Surface-Active Agents - chemistry | Ribonuclease, Pancreatic - chemistry | Circular Dichroism | Micelles | Fluorescence | Hydrophobic effect | Research | Chemical properties | Ribonuclease | Binding proteins | Structure | Proteins | Absorbance | Sodium | Anisotropy | Agglomeration | Beads | Surfactants
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10. Full Text Unfolding of Ribonuclease A on Silica Nanoparticle Surfaces
by Shang, Wen and Nuffer, Joseph H and Dordick, Jonathan S and Siegel, Richard W
Nano Letters, ISSN 1530-6984, 07/2007, Volume 7, Issue 7, pp. 1991 - 1995
This paper reports on the unfolding behavior of ribonuclease A (RNase A) on silica nanoparticle surfaces and quantitively demonstrates that nanoscale size and... 
P61A MUTATION | PROTEIN ADSORPTION | PARTICLES | SOLID-SURFACES | STABILITY | MATERIALS SCIENCE, MULTIDISCIPLINARY | DENATURATION | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | Nanoparticles | Animals | Adsorption | Cattle | Silicon Dioxide | Enzyme Stability | Ribonuclease, Pancreatic - pharmacokinetics | Ribonuclease, Pancreatic - chemistry | Protein Folding
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11. Full Text Ribonuclease A Inhibition by Carboxymethylsulfonyl‐Modified Xylo‐ and Arabinopyrimidines
by Datta, Dhrubajyoti and Dasgupta, Swagata and Pathak, Tanmaya
ChemMedChem, ISSN 1860-7179, 09/2014, Volume 9, Issue 9, pp. 2138 - 2149
A group of acidic nucleosides were synthesized to develop a new class of ribonuclease A (RNase A) inhibitors. Our recent study on... 
docking | inhibitors | modified nucleosides | RNase A | pyrimidines | carboxymethylsulfonyls | Carboxymethylsulfonyls | Docking | Pyrimidines | Inhibitors | Modified nucleosides | RNaseA | COMPLEX | DESIGN | CHEMISTRY, MEDICINAL | MECHANISM | CRYSTAL-STRUCTURE | BOVINE PANCREATIC RIBONUCLEASE | HUMAN ANGIOGENIN | CLEAVAGE | EOSINOPHIL-DERIVED NEUROTOXIN | PYRIMIDINE NUCLEOSIDES | BINDING SITES | PHARMACOLOGY & PHARMACY | RNase A | Catalytic Domain - drug effects | Cytidine - chemistry | Arabinonucleotides - pharmacology | Computational Biology | Enzyme Inhibitors - pharmacology | Models, Molecular | Kinetics | Enzyme Inhibitors - chemical synthesis | Ribonuclease, Pancreatic - antagonists & inhibitors | Arabinonucleotides - chemical synthesis | Uridine - chemistry
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12. Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity
by Rutkoski, Thomas J and Raines, Ronald T
Current Pharmaceutical Biotechnology, ISSN 1389-2010, 06/2008, Volume 9, Issue 3, pp. 185 - 199
Onconase (R) (ONC) is an amphibian member of the bovine pancreatic ribonuclease ( RNase A) superfamily that exhibits innate antitumoral activity. ONC has been... 
Ribonuclease A | Ribonuclease inhibitor | Cytotoxin | Pancreatic ribonuclease | Cancer | RANA-CATESBEIANA BULLFROG | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN PANCREATIC RIBONUCLEASE | cytotoxin | FIBROBLAST-GROWTH-FACTOR | pancreatic ribonuclease | ribonuclease inhibitor | EOSINOPHIL-DERIVED NEUROTOXIN | PROTEIN-PROTEIN RECOGNITION | INSERTIONAL FUSION PROTEIN | AMINO-ACID-SEQUENCE | LEUCINE-RICH REPEATS | PHARMACOLOGY & PHARMACY | cancer | BOVINE SEMINAL RIBONUCLEASE | TUMOR VASCULAR-PERMEABILITY | ribonuclease A | Amino Acid Sequence | Cytosol - classification | Ribonucleases - genetics | Mutagenesis, Site-Directed | Ribonucleases - chemistry | Humans | Cytosol - drug effects | Enzyme Stability | Models, Molecular | Molecular Sequence Data | Antineoplastic Agents - chemistry | Ribonucleases - antagonists & inhibitors | Cytosol - enzymology | Sequence Alignment | Animals | Antineoplastic Agents - isolation & purification | Protein Binding | Cytosol - metabolism | Antineoplastic Agents - pharmacology | Ribonucleases - pharmacology | Ribonucleases - isolation & purification
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13. Full Text Protein Denaturation by Ionic Liquids and the Hofmeister Series: A Case Study of Aqueous Solutions of Ribonuclease A
by Constantinescu, Diana and Weingärtner, Hermann and Herrmann, Christian
Angewandte Chemie International Edition, ISSN 1433-7851, 11/2007, Volume 46, Issue 46, pp. 8887 - 8889
The rating game: The effect of cations and anions of ionic liquids (ILs) on the stability of ribonuclease A in aqueous solutions was studied by differential... 
ionic liquids | differential scanning calorimetry | Hofmeister series | proteins | ribonuclease A | Proteins | Ribonuclease A | Ionic liquids | Differential scanning calorimetry | STABILITY | LIPASE-B | CYTOTOXICITY | CHEMISTRY, MULTIDISCIPLINARY | ribonuclease A | Ionic Liquids | Ribonuclease, Pancreatic - chemistry | Protein Denaturation | Water - chemistry
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