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Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 62, pp. 32010 - 32023
Protease activated receptor-1 (PAR1) expression is associated with disease progression and overall survival in a variety of cancers. However, the importance of... 
Thrombin receptor | PAR1 | EMT | Pancreatic cancer
Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 09/2018, Volume 120, Issue 3, pp. 998 - 1009
Astrocytes modulate many neuronal networks, including spinal networks responsible for the generation of locomotor behavior. Astrocytic modulation of spinal... 
Central pattern generator | Gliotransmission | PAR1 | Motor control | Neuromodulation | Metamodulation | neuromodulation | central pattern generator | motor control | metamodulation | gliotransmission
Journal Article
ACS medicinal chemistry letters, ISSN 1948-5875, 01/2019, Volume 10, Issue 1, pp. 121 - 126
A novel class of bivalent ligands targeting putative protease-activated receptor (PAR) heteromers has been prepared based upon reported antagonists for the... 
Bivalent ligand | restenosis | calcium mobilization | metastasis | PAR2 antagonist | protease-activated receptor | PAR1 antagonist | CHEMISTRY, MEDICINAL | RECEPTOR | DISCOVERY | DEPENDENCE | POTENT | PAR1 | BIVALENT LIGANDS | TRANSACTIVATION | HETERODIMER | AGONIST
Journal Article
The EMBO Journal, ISSN 1460-2075, 2004, Volume 23, Issue 4, pp. 833 - 843
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and... 
cancer | cell polarity | PAR1/MARK kinase | Peutz–Jeghers syndrome | TOF–TOF mass spectrometry | diabetes | TOF-TOF mass spectrometry | Cell polarity | Diabetes | Peutz-Jeghers syndrome | Cancer | SERINE-THREONINE KINASE | PEUTZ-JEGHERS-SYNDROME | CYTOPLASMIC LOCALIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | UPSTREAM KINASES | CELL BIOLOGY | GENE | SALT-INDUCIBLE KINASE | C-ELEGANS EMBRYOS | TUMOR-SUPPRESSOR | YEAST SNF1 | Amino Acid Sequence | Cell Line | Phosphorylation | Humans | Adaptor Proteins, Vesicular Transport - genetics | Protein-Serine-Threonine Kinases - genetics | Molecular Sequence Data | Multienzyme Complexes - metabolism | Substrate Specificity | Multienzyme Complexes - genetics | Adaptor Proteins, Vesicular Transport - metabolism | AMP-Activated Protein Kinases | Protein Subunits - metabolism | Peptides - metabolism | Protein Binding | Enzyme Activation | Mutation | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Protein Subunits - genetics | BRSK1 protein | MARK4 protein | QIK protein | SIK protein | MARK2 protein | MARK3 protein | LKB1 protein | NUAK2 protein | NUAK1 protein | phenformin | MARK1 protein | BRSK2 protein | MELK protein | QSK protein | PAR1 | MARK kinase | Biological Sciences | Naturvetenskap | Biokemi och molekylärbiologi | Biochemistry and Molecular Biology | Biologi | Natural Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 9, pp. 3622 - 3627
Journal Article
Traffic (Copenhagen, Denmark), ISSN 1398-9219, 2/2019, Volume 20, Issue 2, pp. 101 - 109
Ubiquitin is covalently attached to substrate proteins in the form of a single ubiquitin moiety or polyubiquitin chains and has been generally linked to... 
E3 ligases | ALIX | ESCRT | PAR1 | NEDD4 | ARRDC3 | HRS | β-arrestins | Exosomes | G protein
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 2017, Volume 37, Issue 10, pp. 1809 - 1811
Journal Article
Cancer Research, ISSN 0008-5472, 08/2009, Volume 69, Issue 15, pp. 6223 - 6231
Journal Article
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, ISSN 1128-3602, 01/2016, Volume 20, Issue 2, pp. 243 - 249
OBJECTIVE: Protease-activated receptors (PAR) are G protein coupled receptors and they regulate many biological processes, including coagulation and cell... 
MIGRATION | METASTASIS | Lung cancer | Diagnostic | NASOPHARYNGEAL CARCINOMA | INVASION | SIGNALING AXIS | PAR1 | MATRIX METALLOPROTEINASE-1 | SQUAMOUS-CELL CARCINOMA | Serum | PHARMACOLOGY & PHARMACY | PROTEASE-ACTIVATED-RECEPTOR-1 PAR1 | THROMBIN RECEPTOR | EXPRESSION
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 41, pp. 10948 - 10953
C4a is a small protein released from complement component C4 upon activation of the complement system’s classical and lectin pathways, which are important... 
C4a | Complement | PAR1 | PAR4 | Endothelial cells | SYSTEM | endothelial cells | THROMBIN | MULTIDISCIPLINARY SCIENCES | GUINEA-PIG | HUMAN ENDOTHELIAL-CELLS | C5A | HUMAN C3A RECEPTOR | ANAPHYLATOXIN C4A | OPERATED CALCIUM-ENTRY | PEPTIDES | COAGULATION | complement | Proteins | Physiological aspects | Vascular endothelium | Cell receptors | Biological Sciences
Journal Article
Thrombosis and haemostasis, ISSN 0340-6245, 11/2014, Volume 112, Issue 5, pp. 883 - 892
Despite years of research and efforts to translate stroke research to clinical therapy, ischemic stroke remains a major cause of death, disability, and... 
EPCR | PAR1 | stroke | PAR3 | activated protein C
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 07/2015, Volume 15, Issue 20, pp. 2080 - 2114
Journal Article