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parc (6) 6
humans (5) 5
p53 (5) 5
index medicus (4) 4
biochemistry & molecular biology (3) 3
cell line, tumor (3) 3
tumor suppressor protein p53 - metabolism (3) 3
akt (2) 2
apoptosis (2) 2
calpain (2) 2
cancer-therapy (2) 2
carrier proteins - genetics (2) 2
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cell culture (2) 2
chemoresistance (2) 2
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cisplatin (2) 2
cullin proteins - chemistry (2) 2
cullin proteins - genetics (2) 2
expression (2) 2
fibroblasts (2) 2
gene expression regulation, neoplastic (2) 2
ovarian cancer (2) 2
protein transport - drug effects (2) 2
rna, small interfering - metabolism (2) 2
translocation (2) 2
tumor proteins (2) 2
tumor suppressor protein p53 - genetics (2) 2
60 applied life sciences (1) 1
activation (1) 1
alpha karyopherins - antagonists & inhibitors (1) 1
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alpha karyopherins - metabolism (1) 1
analysis (1) 1
anaphase-promoting complex (1) 1
animals (1) 1
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antineoplastic agents, phytogenic - pharmacology (1) 1
apc (1) 1
apc/c, anaphase-promoting complex/cyclosome (1) 1
apoptosis - drug effects (1) 1
apoptosis - genetics (1) 1
apoptosis regulatory proteins - agonists (1) 1
apoptosis regulatory proteins - genetics (1) 1
apoptosis regulatory proteins - metabolism (1) 1
article (1) 1
asb, ankyrin repeat and socs-box (1) 1
assembly (1) 1
association (1) 1
autophagy (1) 1
aux, auxin (1) 1
bacterial infections and mycoses (1) 1
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bcr, btb–cul3–rbx1 (1) 1
beta karyopherins - antagonists & inhibitors (1) 1
beta karyopherins - genetics (1) 1
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binding sites (1) 1
biochemical phenomena, metabolism, and nutrition (1) 1
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broad complex (1) 1
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btb, bric-a-brac/tramtrack/broad complex (1) 1
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cancer (1) 1
cand1, cullin-associated nedd8-dissociated protein 1 (1) 1
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cbfβ, core binding factor β (1) 1
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cks1, cyclin-dependent protein kinase regulatory subunit 1 (1) 1
cleavage (1) 1
coi1, coronatine-insensitive protein 1 (1) 1
collagen (1) 1
complex (1) 1
cop9 signalosome (1) 1
cpd, compound (1) 1
cph, conserved within cul7, parc and herc2 (1) 1
crbn, cereblon (1) 1
crl, cullin–ring e3 ubiquitin ligase (1) 1
csa, cockayne syndrome a (1) 1
csn, cop9 signalosome complex (1) 1
ctd, c-terminal domain (1) 1
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Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 6, pp. 3963 - 3975
Journal Article
BJU International, ISSN 1464-4096, 12/2010, Volume 106, Issue 11, pp. 1706 - 1713
Study Type – Aetiology (case control)
Level of Evidence 3b OBJECTIVE • To evaluate the impact of p53‐associated Parkin‐like cytoplasmic protein (Parc)... 
fibroblasts | translocation | Peyronie’s disease | cell culture | Parc | p53
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
Resistance to cisplatin (CDDP)-based therapy is a major hurdle to the successful treatment of human ovarian cancer (OVCA) and the chemoresistant phenotype in... 
ovarian cancer | PARC | p53-associated, parkin-like cytoplasmic protein | apoptosis | Akt | subcellular trafficking | p53 | calpain | chemoresistance | PI3K | cisplatin | chemosensitivity | chemosensitive
Dissertation
Scientific Reports, ISSN 2045-2322, 04/2014, Volume 4, Issue 1, p. 4419
Journal Article
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